• 제목/요약/키워드: National Basic S&E Research

검색결과 170건 처리시간 0.019초

Direct characterization of E2-dependent target specificity and processivity using an artificial p27-linker-E2 ubiquitination system

  • Ryu, Kyoung-Seok;Choi, Yun-Seok;Ko, Jun-Sang;Kim, Seong-Ock;Kim, Hyun-Jung;Cheong, Hae-Kap;Jeon, Young-Ho;Choi, Byong-Seok;Cheong, Chae-Joon
    • BMB Reports
    • /
    • 제41권12호
    • /
    • pp.852-857
    • /
    • 2008
  • Little attention has been paid to the specificity between E2 and the target protein during ubiquitination, although RING-E3 induces a potential intra-molecular reaction by mediating the direct transfer of ubiquitin from E2 to the target protein. We have constructed artificial E2 fusion proteins in which a target protein (p27) is tethered to one of six E2s via a flexible linker. Interestingly, only three E2s (UbcH5b, hHR6b, and Cdc34) are able to ubiquitinate p27 via an intra-molecular reaction in this system. Although the first ubiquitination of p27 (p27-Ub) by Cdc34 is less efficient than that of UbcH5b and hHR6b, the additional ubiquitin attachment to p27-Ub by Cdc34 is highly efficient. The E2 core of Cdc34 provides specificity to p27, and the residues 184-196 are required for possessive ubiquitination by Cdc34. We demonstrate direct E2 specificity for p27 and also show that differential ubiquitin linkages can be dependent on E2 alone.

한국형 그랜트 지원방식 도입에 따른 선정평가 효율화를 위한 정량적 가이드라인 수립에 관한 연구 (Establishing the Supplementary Quantitative Guidelines for Successful Establishment of NRF Grant Funding Mechanism on Basic Research)

  • 서옥이;박귀순;신숙경;이성종;이원근;이윤희
    • 기술혁신학회지
    • /
    • 제16권2호
    • /
    • pp.424-443
    • /
    • 2013
  • 교육과학기술부와 한국연구재단은 창의적 도전적 연구를 적극 장려하고자 2012년 기초연구사업 중점 추진방향으로 '한국형 그랜트' 지원 방식을 도입하였으며, 이에 따라 연구자가 추후 과제 신청시 기존 연구수행 성과를 집중적으로 평가 받게 되었다. 이에, 선정평가에서 과제관리 및 종료평가에 이르는 전주기적 성과관리 시스템의 필요성이 크게 대두되었다. 본 연구에서는 전주기적 성과관리 시스템의 첫 단계로 분야별 연구실적의 정량적 가이드라인를 제시하여 연구역량평가의 보조적 수단으로 사용할 방안을 도출하고자 하였다. 그 결과, 상위그룹 간 비교 시에는 순위보정영향력지수(Ranked Normalized Impact Factor, rnIF), 하위그룹 간 비교 시에는 영향력지수(Impact Factor, IF) 또는 rnIF를 정량가이드라인으로 제안하였다. SCI급 논문 수는 동일 분류 내 위상비교 또는 동일 위상내 분류별 비교 등에 사용할 것을 제안하였다.

  • PDF

A Study on Development of E-Learning Training Course of Shop-master Certificate

  • Son, Mi-Young
    • International Journal of Costume and Fashion
    • /
    • 제9권2호
    • /
    • pp.1-18
    • /
    • 2009
  • Since the 1990s, the domestic fashion industry has been changing rapidly and has become more competitive. Due to these circumstances, the roles of Shop masters were intensified and a training course to acquire a certificate of qualification as a Shop master was in great demand. The 1st Shop master certification exam took place in the year 2001. The purpose of this study was to research the formality of Shop master certificate training courses via e-learning, which is a hot topic in 21st century education, and to provide a development example. First, an analysis was made of the definition and basic characteristics needed of a Shop-master. Next, we noted the problems of former Shop master training facilities and their training process. Thirdly, we did a research on the definition of e-learning and the elements to embody the system. Based on the information obtained through this research, we provided a development example on Shop-master certificate training courses via e-learning that overcame the problems of courses that are currently provided.

Improved Photolysis of Water from Ti Incorporated Double Perovskite Sr2FeNbO6 Lattice

  • Borse, P.H.;Cho, C.R.;Yu, S.M.;Yoon, J.H.;Hong, T.E.;Bae, J.S.;Jeong, E.D.;Kim, H.G.
    • Bulletin of the Korean Chemical Society
    • /
    • 제33권10호
    • /
    • pp.3407-3412
    • /
    • 2012
  • The Ti incorporation at Fe-site in the double perovskite lattice of $Sr_2FeNbO_6$ (SFNO) system is studied. The Ti concentration optimization yielded an efficient photocatalyst. At an optimum composition of Ti as x = 0.07 in $Sr_2Fe_{1-x}Ti_xNbO_6$, the photocatalyst exhibited 2 times the quantum yield for photolysis of $H_2O$ in presence of $CH_3OH$, than its undoped counterpart under visible light (${\lambda}{\geq}420nm$). Heavily Ti-doped $Sr_2Fe_{1-x}Ti_xNbO_6$ lattice exhibited poor photochemical properties due to the existence of constituent impurity phases as observed in the structural characterization, as well as deteriorated optical absorption. The higher electron-density acquired by n-type doping seem to be responsible for the more efficient charge separation in $Sr_2Fe_{1-x}Ti_xNbO_6$ (0.05 < x < 0.4) and thus consequently displays higher photocatalytic activity. The Ti incorporated structure also found to yield stable photocatalyst.

이용자의 금융거래정보 보호를 위한 확장 종단간(End-to-End) 암호화 기술과 보안고려사항 (Extensional End-to-End Encryption Technologies to Enhance User's Financial Information Security and Considerable Security Issues)

  • 성재모;이수미;노봉남;안승호
    • 정보보호학회논문지
    • /
    • 제20권4호
    • /
    • pp.145-154
    • /
    • 2010
  • 종단간 암호화는 계좌 비밀번호 및 계좌번호 등 주요 금융거래정보를 암호화하여 이용자 PC에서부터 전자금융거래 서버까지 보호하는 것을 의미한다. 초기에 적용된 종단간 암호화는 이용자 PC내에 평문으로 존재하는 구간이 없어야 한다는 기본적인 보안요구사항을 만족하지 못하여 전자금융거래 시 여러 해킹기법에 의해 취약함이 발견되었다. 따라서 확장 종단간 암호화 기술은 이용자의 금융거래정보에 대해 기밀성 및 무결성을 제공하여 유출, 위 변조 등의 위협으로부터 보호하고 있다. 본 논문에서 확장 종단간 암호화 기술에 대해 살펴보고 금융회사에서 확장 종단간 암호화 기술 적용 시 고려해야 할 보안 고려사항에 대해 알아본다.

U.S. Forest Service Research : Its Administration and Management

  • Krugman, Stanley L.
    • 한국산림과학회지
    • /
    • 제76권3호
    • /
    • pp.243-248
    • /
    • 1987
  • The U.S. Forest Service administers the world's largest forestry research organization. From its modest beginning in 1876, some 30 years before the United States national forest system was established, the research branch has devoted its effort to meet current and future information needs of the forestry community of the United States, not just for the U.S. Forest Service. The research branch is one of three major administrative units of the U.S. Forest Service. The others being the National Forest System and State and Private Forestry. Currently the National Forest System comprises 155 national forests, 19 national grasslands, and 18 utilization projects located in 44 states. Puerto Rico, and the Virgin Islands. The National Forest System manages these areas for a large array of uses and benefits including timber, water, forage, wildlife, recreation, minerals, and wilderness. It is through the State and Private Forestry branch that the U.S. Forest Service cooperates and coordinates forestry activities and programs with state and local governments, forest industries, and private landowners. These activities include financial and technical assistance in disease, insect, and fire protection ; plan forestry programs ; improve harvesting and marketing practices ; and transfer forestry research results to user groups. Forestry research is carried out through eight regional Forest Experiment Stations and the Forest Product Laboratory. Studies are maintained at 70 administrative sites, and at 115 experimental forest and grasslands. All of the current sciences that composed modern forestry are included in the research program. These range from forest biology (i. e. silviculture, ecology, physiology, and genetics) to the physical, mathematical, engineering, managerial, and social sciences. The levels of research range from application, developmental, and basic research. Research planning and priority identification is an ongoing process with elements of the research program changing to meet short-term critical information needs(i. e. protection research) to long-term opportunities(i. e. biotechnology). Research planning and priority setting is done in cooperation with National Forest Systems, forest industries, universities, and individual groups such as environmental, wilderness, or wildlife organizations. There is an ongoing review process of research administration, organization, and science content to maintain quality of research. In the U.S. Forest Service the research responsibility is not completed until the new information is being applied by the various user group : I. e. technology transfer program. Research planning and development in the U.S. Forest Service is a dynamic activity. Porgrams for the year 2000 and beyond are now in the planning stage.

  • PDF

Photocatalytic Hydrogen Production in Water-Methanol Mixture over Iron-doped CaTiO3

  • Jang, J. S.;Borse, P. H.;Lee, J. S.;Lim, K. T.;Jung, O. S.;Jeong, E. D.;Bae, J. S.;Kim, H. G.
    • Bulletin of the Korean Chemical Society
    • /
    • 제32권1호
    • /
    • pp.95-99
    • /
    • 2011
  • $CaTi_{1-x}Fe_xO_3(0{\leq}x{\leq}0.4)$ solid solution photocatalysts were synthesized by iron doping during the conventional solid state reaction at $1100^{\circ}C$ for 5 h and characterized by ultraviolet-visible (UV-vis) absorption spectroscopy, X-ray diffraction, morphological analysis. We found that $CaTi_{1-x}Fe_xO_3$ samples not only absorb UV but also the visible light photons. This is because the Fe substitution at Ti-site in $CaTi_{1-x}Fe_xO_3$ lattice induces the band transition from Fe3d to the Fe3d + Ti3d hybrid orbital. The photocatalytic activity of Fe doped $CaTiO_3$ samples for hydrogen production under UV light irradiation decreased with the increase in the Fe concentration. There exists an optimized concentration of iron in $CaTiO_3$, which yields a maximum photocatalytic activity under visible light ($\lambda\geq420nm$) photons.

Expression of the Novel Basic Helix-Loop-Helix Gene dHAND in Neural Crest Derivatives and Extraembryonic Membranes during Mouse Development

  • S.I Yun;Kim, S.K;Kim, S.K.;K.T Chang;B.H Hyun;D.S Son;Kim, M.K;D.S Suh
    • 한국동물번식학회:학술대회논문집
    • /
    • 한국동물번식학회 2001년도 발생공학 국제심포지움 및 학술대회 발표자료집
    • /
    • pp.53-54
    • /
    • 2001
  • Expression of HAND genes in sympathetic adrenal lineage suggests that HAND genes may regulate Mash-I independent neuronal genes. HAND genes are also expressed in other cell types, e.g. Cardiac cells, trophoblasts, and decidua, suggesting that HAND genes are not cell fate determination factors. It is unclear how HAND genes function specifically in different types of cells. Combinational actions of HANDs with other cell-lineage specific transcription factor may determine each cell fate and differentiation processes. Identifying the transcription target genes of HANDs and Mash-I will be important to elucidate the function of these bHLH factors in SNS factors in SNS development. (omitted)

  • PDF

Ferromagnetism and Magnetotransport of GaMnN

  • Kim, K. H.;Lee, K. J.;Kim, D. J.;Kim, C. S.;Kim, C. G.;S. H. Yoo;Lee, H. C.;Kim, H. J.;Y. E. Ihm
    • 한국자기학회:학술대회 개요집
    • /
    • 한국자기학회 2002년도 동계연구발표회 논문개요집
    • /
    • pp.146-147
    • /
    • 2002
  • III-V magnetic semiconductors initiated by GaMnAs growth at low temperatures via molecular beam epitaxy (MBE) has been a hot issue recently for their possible application to spntronics. GaMnN may be one of the candidates for room temperature operating ferromagnetic semiconductors as proposed by a theoretical calculation, However, since GaN was grown at very high temperatures above ∼750$^{\circ}C$ even with MBE, it is expected that the incorporation of Mn into GaN will be limited. (omitted)

  • PDF