• Title/Summary/Keyword: National Basic S&E Research

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Direct characterization of E2-dependent target specificity and processivity using an artificial p27-linker-E2 ubiquitination system

  • Ryu, Kyoung-Seok;Choi, Yun-Seok;Ko, Jun-Sang;Kim, Seong-Ock;Kim, Hyun-Jung;Cheong, Hae-Kap;Jeon, Young-Ho;Choi, Byong-Seok;Cheong, Chae-Joon
    • BMB Reports
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    • v.41 no.12
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    • pp.852-857
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    • 2008
  • Little attention has been paid to the specificity between E2 and the target protein during ubiquitination, although RING-E3 induces a potential intra-molecular reaction by mediating the direct transfer of ubiquitin from E2 to the target protein. We have constructed artificial E2 fusion proteins in which a target protein (p27) is tethered to one of six E2s via a flexible linker. Interestingly, only three E2s (UbcH5b, hHR6b, and Cdc34) are able to ubiquitinate p27 via an intra-molecular reaction in this system. Although the first ubiquitination of p27 (p27-Ub) by Cdc34 is less efficient than that of UbcH5b and hHR6b, the additional ubiquitin attachment to p27-Ub by Cdc34 is highly efficient. The E2 core of Cdc34 provides specificity to p27, and the residues 184-196 are required for possessive ubiquitination by Cdc34. We demonstrate direct E2 specificity for p27 and also show that differential ubiquitin linkages can be dependent on E2 alone.

Establishing the Supplementary Quantitative Guidelines for Successful Establishment of NRF Grant Funding Mechanism on Basic Research (한국형 그랜트 지원방식 도입에 따른 선정평가 효율화를 위한 정량적 가이드라인 수립에 관한 연구)

  • Seo, Ok-Ee;Park, Kwisun;Shin, Suk Kyung;Lee, Sung Jong;Rhie, Won Geun;Lee, Yun Hee
    • Journal of Korea Technology Innovation Society
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    • v.16 no.2
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    • pp.424-443
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    • 2013
  • National Research Foundation of Korea (NRF) provides underpinning to boost international and domestic competitiveness in basic science and engineering (S&E) research. In 2012, NRF came up with the idea about implementing koreanized grant funding system and a NRF grant funding mechanism on basic research was applied to General Researcher program. The main components of the mechanism are 1) no final evaluation, instead intensive evaluation for next proposal submission, 2) no paper account report, instead reporting it online, 3) no lengthy final report, instead unloading a brief overview of research achievements. For successful establishment of the NRF grant funding mechanism, the quality and quantity-based quantitative guidelines of research achievement for various research areas are essential. In this study, we suggest 3 quantitative indexes and these quantitative guidelines provides a supplementary tool for researcher's capability review. These guidelines will be also useful to elevate the reliability and objectivity of peer review.

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A Study on Development of E-Learning Training Course of Shop-master Certificate

  • Son, Mi-Young
    • International Journal of Costume and Fashion
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    • v.9 no.2
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    • pp.1-18
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    • 2009
  • Since the 1990s, the domestic fashion industry has been changing rapidly and has become more competitive. Due to these circumstances, the roles of Shop masters were intensified and a training course to acquire a certificate of qualification as a Shop master was in great demand. The 1st Shop master certification exam took place in the year 2001. The purpose of this study was to research the formality of Shop master certificate training courses via e-learning, which is a hot topic in 21st century education, and to provide a development example. First, an analysis was made of the definition and basic characteristics needed of a Shop-master. Next, we noted the problems of former Shop master training facilities and their training process. Thirdly, we did a research on the definition of e-learning and the elements to embody the system. Based on the information obtained through this research, we provided a development example on Shop-master certificate training courses via e-learning that overcame the problems of courses that are currently provided.

Improved Photolysis of Water from Ti Incorporated Double Perovskite Sr2FeNbO6 Lattice

  • Borse, P.H.;Cho, C.R.;Yu, S.M.;Yoon, J.H.;Hong, T.E.;Bae, J.S.;Jeong, E.D.;Kim, H.G.
    • Bulletin of the Korean Chemical Society
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    • v.33 no.10
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    • pp.3407-3412
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    • 2012
  • The Ti incorporation at Fe-site in the double perovskite lattice of $Sr_2FeNbO_6$ (SFNO) system is studied. The Ti concentration optimization yielded an efficient photocatalyst. At an optimum composition of Ti as x = 0.07 in $Sr_2Fe_{1-x}Ti_xNbO_6$, the photocatalyst exhibited 2 times the quantum yield for photolysis of $H_2O$ in presence of $CH_3OH$, than its undoped counterpart under visible light (${\lambda}{\geq}420nm$). Heavily Ti-doped $Sr_2Fe_{1-x}Ti_xNbO_6$ lattice exhibited poor photochemical properties due to the existence of constituent impurity phases as observed in the structural characterization, as well as deteriorated optical absorption. The higher electron-density acquired by n-type doping seem to be responsible for the more efficient charge separation in $Sr_2Fe_{1-x}Ti_xNbO_6$ (0.05 < x < 0.4) and thus consequently displays higher photocatalytic activity. The Ti incorporated structure also found to yield stable photocatalyst.

Extensional End-to-End Encryption Technologies to Enhance User's Financial Information Security and Considerable Security Issues (이용자의 금융거래정보 보호를 위한 확장 종단간(End-to-End) 암호화 기술과 보안고려사항)

  • Seung, Jae-Mo;Lee, Su-Mi;Noh, Bong-Nam;Ahn, Seung-Ho
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.20 no.4
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    • pp.145-154
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    • 2010
  • End-to-End(E2E) encryption is to encrypt private and important financial information such as user's secret access numbers and account numbers from user's terminal to financial institutions. There has been found significant security vulnerabilities by various hacking in early E2E encryption system since early E2E encryption is not satisfied the basic security requirement which is that there does not exist user's financial information on plaintext in user's terminal. Extensional E2E encryption which is to improve early E2E encryption provides confidentiality and integrity to protect user's financial information from vulnerabilities such as alteration, forgery and leakage of confidential information. In this paper, we explain the extensional E2E encryption technology and present considerable security issues when the extensional E2E encryption technology is applied to financial systems.

U.S. Forest Service Research : Its Administration and Management

  • Krugman, Stanley L.
    • Journal of Korean Society of Forest Science
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    • v.76 no.3
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    • pp.243-248
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    • 1987
  • The U.S. Forest Service administers the world's largest forestry research organization. From its modest beginning in 1876, some 30 years before the United States national forest system was established, the research branch has devoted its effort to meet current and future information needs of the forestry community of the United States, not just for the U.S. Forest Service. The research branch is one of three major administrative units of the U.S. Forest Service. The others being the National Forest System and State and Private Forestry. Currently the National Forest System comprises 155 national forests, 19 national grasslands, and 18 utilization projects located in 44 states. Puerto Rico, and the Virgin Islands. The National Forest System manages these areas for a large array of uses and benefits including timber, water, forage, wildlife, recreation, minerals, and wilderness. It is through the State and Private Forestry branch that the U.S. Forest Service cooperates and coordinates forestry activities and programs with state and local governments, forest industries, and private landowners. These activities include financial and technical assistance in disease, insect, and fire protection ; plan forestry programs ; improve harvesting and marketing practices ; and transfer forestry research results to user groups. Forestry research is carried out through eight regional Forest Experiment Stations and the Forest Product Laboratory. Studies are maintained at 70 administrative sites, and at 115 experimental forest and grasslands. All of the current sciences that composed modern forestry are included in the research program. These range from forest biology (i. e. silviculture, ecology, physiology, and genetics) to the physical, mathematical, engineering, managerial, and social sciences. The levels of research range from application, developmental, and basic research. Research planning and priority identification is an ongoing process with elements of the research program changing to meet short-term critical information needs(i. e. protection research) to long-term opportunities(i. e. biotechnology). Research planning and priority setting is done in cooperation with National Forest Systems, forest industries, universities, and individual groups such as environmental, wilderness, or wildlife organizations. There is an ongoing review process of research administration, organization, and science content to maintain quality of research. In the U.S. Forest Service the research responsibility is not completed until the new information is being applied by the various user group : I. e. technology transfer program. Research planning and development in the U.S. Forest Service is a dynamic activity. Porgrams for the year 2000 and beyond are now in the planning stage.

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Photocatalytic Hydrogen Production in Water-Methanol Mixture over Iron-doped CaTiO3

  • Jang, J. S.;Borse, P. H.;Lee, J. S.;Lim, K. T.;Jung, O. S.;Jeong, E. D.;Bae, J. S.;Kim, H. G.
    • Bulletin of the Korean Chemical Society
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    • v.32 no.1
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    • pp.95-99
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    • 2011
  • $CaTi_{1-x}Fe_xO_3(0{\leq}x{\leq}0.4)$ solid solution photocatalysts were synthesized by iron doping during the conventional solid state reaction at $1100^{\circ}C$ for 5 h and characterized by ultraviolet-visible (UV-vis) absorption spectroscopy, X-ray diffraction, morphological analysis. We found that $CaTi_{1-x}Fe_xO_3$ samples not only absorb UV but also the visible light photons. This is because the Fe substitution at Ti-site in $CaTi_{1-x}Fe_xO_3$ lattice induces the band transition from Fe3d to the Fe3d + Ti3d hybrid orbital. The photocatalytic activity of Fe doped $CaTiO_3$ samples for hydrogen production under UV light irradiation decreased with the increase in the Fe concentration. There exists an optimized concentration of iron in $CaTiO_3$, which yields a maximum photocatalytic activity under visible light ($\lambda\geq420nm$) photons.

Expression of the Novel Basic Helix-Loop-Helix Gene dHAND in Neural Crest Derivatives and Extraembryonic Membranes during Mouse Development

  • S.I Yun;Kim, S.K;Kim, S.K.;K.T Chang;B.H Hyun;D.S Son;Kim, M.K;D.S Suh
    • Proceedings of the KSAR Conference
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    • 2001.10a
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    • pp.53-54
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    • 2001
  • Expression of HAND genes in sympathetic adrenal lineage suggests that HAND genes may regulate Mash-I independent neuronal genes. HAND genes are also expressed in other cell types, e.g. Cardiac cells, trophoblasts, and decidua, suggesting that HAND genes are not cell fate determination factors. It is unclear how HAND genes function specifically in different types of cells. Combinational actions of HANDs with other cell-lineage specific transcription factor may determine each cell fate and differentiation processes. Identifying the transcription target genes of HANDs and Mash-I will be important to elucidate the function of these bHLH factors in SNS factors in SNS development. (omitted)

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Ferromagnetism and Magnetotransport of GaMnN

  • Kim, K. H.;Lee, K. J.;Kim, D. J.;Kim, C. S.;Kim, C. G.;S. H. Yoo;Lee, H. C.;Kim, H. J.;Y. E. Ihm
    • Proceedings of the Korean Magnestics Society Conference
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    • 2002.12a
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    • pp.146-147
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    • 2002
  • III-V magnetic semiconductors initiated by GaMnAs growth at low temperatures via molecular beam epitaxy (MBE) has been a hot issue recently for their possible application to spntronics. GaMnN may be one of the candidates for room temperature operating ferromagnetic semiconductors as proposed by a theoretical calculation, However, since GaN was grown at very high temperatures above ∼750$^{\circ}C$ even with MBE, it is expected that the incorporation of Mn into GaN will be limited. (omitted)

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