• Proceedings of the PSK Conference
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• 2003.04a
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• pp.281.2-282
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• 2003

Recently, ‘bokbanggamchopyeon’, chinese analgesic which is carried in korea by travelers becomes a problem when they pass customs because it contains opiate alkaloids morphine and codeine. At this time, opium is assigned as narcitics in korea according to the rule concerning narcotics control, and its major component morphine and codeine too. (omitted)

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.169.1-169.1
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• 2003

This study was designed to compare the results and concentraions of methamphetamine (MA) and its metabolite amphetamine (AP) in head hair and hair collected from different parts of the body (axullae, pubis, and leg). Hair of subjects (N=15) suspected for MA abuse was simultaneously collected. (omitted)

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.169.2-169.2
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• 2003

A method using EI-GC-MS is described for the determination of amphetamines in hair. The method is applied to simultaneous quantify amphetamines (methamphetamine, amphetamine, MDMA and MDA). Drugs were extracted in 1 ％ HCl in methanol from hair. After derivertization with TFAA, the resulting drugs were separated on HP-5MS column during a 16 min program and identified by mass spectrometry with the SIM mode(EI-GC-MS). (omitted)

• Proceedings of the PSK Conference
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• 2001.04a
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• pp.220.3-221
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• 2001

• The Journal of Internal Korean Medicine
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• v.26 no.4
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• pp.864-874
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• 2005

This study was done as a general survey on oriental medical approaches for the detoxification and treatment of narcotics addiction. The treatment of narcotics addiction comprises the detoxification and the restoration of normal health. Medical detoxification in common use nowadays is largely divided into substitution therapy using opiate detoxicants and symptomatic therapy using non-opiate detoxicants. Experimentation was done on the supposition that non-opiate detoxicants provide a more viable therapy than opiate detoxicants in the treatment of narcotics addiction, because opiate detoxicants also produce a great dependency on a narcotic. At present, although the medication of oriental medicine that includes non-opiate detoxicants is not more effective in the detoxification than the opiate detoxicants, withdrawal symptoms are slight and few and there is a very low ratio of relapse, so treatment and restoration are relatively brief. Results of this survey suggest that detoxicants derived from oriental medical approaches are safe and effective, though further development of therapy with such detoxicants will be needed to provide reliable methods of treating narcotics addiction. Based on this survey, it is hoped that many more studies will be done on the issue of medication in the field of narcotics addiction treatment.

• Korean Security Journal
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• no.2
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• pp.211-226
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• 1999

Troublesome problems are being caused by hallucinogenic drugs which come not only from illegal narcotics but also from unprohibited general drug-kinds such as cough-remedy agents of textromerupan, namely, Lamina, Rubi-king and the likes. Abuse and misuse of narcotics permeated into and threatens mental health of socially-known peoples, actor, actress, talents and businessmen as well. This study especially dealt with problems related with Mesampetamin, Rurajaepam, Texstrometropan and Karisofrodol which affects mental behaviour, and considered counter-measures through analysis and developed appropriate system of goods circulation for guidance to be complied by the medicine professionalists. The guidance sought here is recommended to the government ministries for further enforcement of crack-down of the drug crimes. Arquesa in method is recommend as a method of identifying behaviors and facial expressions of abusers and misusers of narcotics at the spot in place. This study is directed to curtailing hallucinogenic drugs use for absolute preventive security by detecting out black dealers of narcotics supplying to the abusers and misusers. There is a need of special education program to cut off the flow of narcotics or drugs crimes into official security force as well as private security personnel. This study introduced a priority and emphasis of real augmentation to theory and practice of the modern scientific security which can protect the mental health of the guarded persons as well especially in the light of security safety curriculum at the school.

• Korean Journal of Clinical Pharmacy
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• v.25 no.4
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• pp.280-285
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• 2015

Objectives: To suggest direction for improving policies by understanding current management of narcotics or psychotropic drugs and analyzing their distributions and usage. Method: We conducted a comparison analysis between health insurance claims and the amount supplied to health care institutions for narcotics or psychotropic drugs through health insurance claims data and drug distribution supply data from 2010 to 2012 collected from Korea Pharmaceutical Information Service Center (KPIS). Furthermore, we carried out literature investigation and online search to comprehend the current management of narcotics drugs in Korea. Results: The amount supplied to medical institutions for all drugs in 2012 was 19.4 trillion won, which increased from 19.5 trillion in 2011 by 0.54%. For narcotic drugs, the amount supplied was 318.4 billion won in 2011 and increased to 335.1 billion won by 5.3% in 2012, which exceeded the rate of increase for the amount supplied for all drugs. The proportion of amount claimed in the total amount supplied to medical institutions for all drugs was 60.5% in 2012, whereas the proportion of amount claimed for narcotic drugs was 55.6%, which showed that narcotic drugs were used relatively less within health insurance. Furthermore, management of the current domestic distribution supply data focuses on manufacturing and medical institution supply stages. Conclusion: Hereafter, the management of narcotics or psychotropic drugs needs to be improved by reinforcing active monitoring in optimal prescription and usage in patients by collecting and analyzing information on drug usage of patients.

• YAKHAK HOEJI
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• v.54 no.4
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• pp.226-231
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• 2010

Oral fluid has become increasingly popular as an alternative specimen in the field of driving under the influence of drugs (DUID) and work place drug testing. In this study, an analytical method for the detection and quantification of ${\Delta}^9$-tetrahydrocannabinol (THC) and its metabolite, 11-nor-9-carboxy-${\Delta}^9$-tetrahydrocannabinol (THC-COOH) in oral fluid by SPE and GC-MS was established and fully validated. The stability of THC and THC-COOH in oral fluid during storage was also determined by examining the THC and THC-COOH concentration changes depending on time and container materials. Oral fluid samples were kept over 21 days at room temperature, $-4^{\circ}C$ and $-20^{\circ}C$ in two different specimen collection tubes; glass and polypropylene tubes. Three replicates for each condition with different temperature and types of a container were analyzed at five different time points over 21 days. When oral fluid samples were stored in glass tubes, the loss of both THC and THC-COOH was less than 10% at all room temperature, $-4^{\circ}C$ and $-20^{\circ}C$. However, in polypropylene tubes, the loss of both THC and THC-COOH increased significantly over the study period. In particular, the concentration of THC decreased more rapidly than that of THC-COOH at room temperature and the maximal percentage of THC lost was 90.3% after 21 days. The result indicates that it would be necessary to collect oral fluid samples in glass containers and cool the samples until analysis in order to prevent the degradation of analytes.

• The Journal of the Korea Contents Association
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• v.20 no.2
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• pp.462-471
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• 2020

The Zolpidem, commonly used as a sleeping pill, binds to GABA receptors to increase neuro-inhibiting transporters. There are many cases where people take Zolpidem for more than four weeks in a row. The Drug Utilization Review, currently in effect in South Korea, can identify the use patterns of Zolpidem. It is necessary to prevent Zolpidem's misuse. The study was conducted from May 10, 2019 to May 15, 2019. Primary and secondary screening was performed out of 125,197 total retrieved documents. The final 254 literature cases directly related to Zolpidem's misuse were selected. Through systematic literature research through meta-analysis, we tried to find a way to prevent Zolpidem's misuse through the Drug Utilization Review. The distortion was minimized by applying it in the screening process. Zolpidem's misuse was severe and continued to increase its use. There has also been an increase in crime using Zolpidem. It has been analyzed that Zolpidem can be managed through Narcotics Integrated Management System and Drug Utilization Review. In order to reduce the use of Zolpidem, the supply through the Narcotics Integrated Management System and the demand through long-term user education should be suppressed.

• YAKHAK HOEJI
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• v.55 no.2
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• pp.145-153
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• 2011

A simultaneous detection and quantification method for determining the Phenylalkylamine derivatives, such as methamphetamine (MA), amphetamine (AM), 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA), ketamine (KT), norketamine (NKT), phentermine (PT), fenfluramine (FFA) and phenmetrazine (PM), in oral fluid was developed and validated according to international guidelines. The validated method was applied to actual oral fluid samples collected from drug abuse suspects. The recovery of phenylalkylamines from oral fluid collection devices was also assessed. Oral fluid specimens from 20 drug abuse suspects submitted by the police were collected using Salivette$^{TM}$, Quantisal$^{TM}$ or direct expectoration. The samples were screened using a biochip array analyzer. For confirmation, the samples were analyzed by GC-MS in selected-ion monitoring (SIM) mode after extraction using automated SPE with a mixed-mode cation exchange cartridge and derivatization with trifluoroacetic anhydride (TFAA). The results from the immunoassay were consistent with those from GC-MS. All the oral fluid samples gave positive results for MA, AM, PT and/or PM. The detection of phenylalkylamines in oral fluid can provide a better indication of recent use than urine or hair. Therefore, the oral fluid specimen was useful for demonstrating phenylalkylamines abuse in the driving under the influence of drug (DUID) as an alternative specimen for urine.