Quantitative Analysis of amphetamines in hair by EI-GC-MS using SIM mode with uncertainty estimation

  • Yang, Won-Kyung (Division of Narcotics analysis, National Institute of Scientific Investigation) ;
  • Han, Eun-Young (Department of Narcotics Analysis, National Institute of Scientific Investigation) ;
  • Lee, Jae-Sin (Department of Narcotics Analysis, National Institute of Scientific Investigation) ;
  • Park, Yong-Hoon (Department of Narcotics Analysis, National Institute of Scientific Investigation) ;
  • Kim, Eun-Mi (Department of Narcotics Analysis, National Institute of Scientific Investigation) ;
  • Lim, Mi-Ae (Department of Narcotics Analysis, National Institute of Scientific Investigation) ;
  • Chung, Hee-Sun (Department of Narcotics Analysis, National Institute of Scientific Investigation)
  • Published : 2003.04.01

Abstract

A method using EI-GC-MS is described for the determination of amphetamines in hair. The method is applied to simultaneous quantify amphetamines (methamphetamine, amphetamine, MDMA and MDA). Drugs were extracted in 1 % HCl in methanol from hair. After derivertization with TFAA, the resulting drugs were separated on HP-5MS column during a 16 min program and identified by mass spectrometry with the SIM mode(EI-GC-MS). (omitted)

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