• Asian Pacific Journal of Cancer Prevention
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• 제13권1호
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• pp.199-203
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• 2012

Purpose: To evaluate the prognostic value of serum CYFRA21-1, CEA and hemoglobin levels regarding long-term survival of patients with esophageal squamous cell carcinoma (ESCC) treated with concurrent chemoradiotherapy (CRT). Methods: Age, gender, Karnofsky Performance Status (KPS), tumor location, tumor length, T stage, N stage and serum hemoglobin, and CYFRA21-1 and CEA levels before concurrent CRT were retrospectively investigated and related to outcome in 113 patients receiving 5-fluorouracil and cisplatin combined with radiotherapy for ESCC. The Kaplan-Meier method was used to analyze prognosis, the log-rank to compare groups, the Cox proportional hazards model for multivariate analysis, and ROC curve analysis for assessment of predictive performance of biologic markers. Results: The median survival time was 20.1 months and the 1-, 2-, 3-, 5- year overall survival rates were 66.4%, 43.4%, 31.9% and 15.0%, respectively. Univariate analysis showed that factors associated with prognosis were KPS, tumor length, T-stage, N-stage, hemoglobin, CYFRA21-1 and CEA level. Multivariate analysis showed T-stage, N-stage, hemoglobin, CYFRA21-1 and CEA level were independent predictors of prognosis. By ROC curve, CYFRA21-1 and hemoglobin showed better predictive performance for OS than CEA (AUC= 0.791, 0.704, 0.545; P=0.000, 0.000, 0.409). Conclusions: Of all clinicopathological and molecular factors, T stage, N stage, hemoglobin, CYFRA21-1 and CEA level were independent predictors of prognosis for patients with ESCC treated with concurrent CRT. Among biomarkers, CYFRA21-1 and hemoglobin may have a better predictive potential than CEA for long-term outcomes.

• 한국물환경학회지
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• 제28권3호
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• pp.409-417
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• 2012

SWAT model was applied for the Nakdong River Basin to characterize water quality variability and assess the feasibility of using the load duration curve to water quality management. The basin was divided into 67 sub-basins considering various watershed environment, and rainfall runoff and pollutant loading were simulated based on 6 year measurements of meteo-hydrological data, discharge data of treatment plants, and water quality data (SS, T-N and T-P). The results demonstrate that non-point source loads during wet season increase by 80 ~ 95% of total loads. Although the rate of water flow governs the amount of SS that is transported to the main streams, nutrient concentrations are highly elevated during dry season by being concentrated. This phenomenon is more pronounced in the lower basin, receiving large amounts of urban point source discharges such as treated sewages. Also, the load duration curves (LDC) demonstrate dominant source problems based on the load exceedances, showing that SS concentrations are associated with the rainy season and nutrients, such as T-P, may be more concentrated at low flow and more diluted at higher flow. Overall, the LDC method could be used conveniently to assess watershed characteristics and pollutant loads in watershed scale.

• 한국간담췌외과학회지
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• 제27권3호
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• pp.251-257
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• 2023

Backgrounds/Aims: This is a retrospective analysis of whether the 8th edition American Joint Committee on Cancer (AJCC) was a significant improvement over the 7th AJCC distal extrahepatic cholangiocarcinoma classification. Methods: In total, 111 patients who underwent curative resection of mid-distal bile duct cancer from 2002 to 2019 were included. Cases were re-classified into 7th and 8th AJCC as well as clinicopathological univariate and multivariate, and Kaplan-Meier survival curve and log rank were calculated using R software. Results: In patient characteristics, pancreaticoduodenectomy/pylorus preserving pancreaticoduodenectomy had better survival than segmental resection. Only lymphovascular invasion was found to be significant (hazard ratio 2.01, p = 0.039) among all clinicopathological variables. The 8th edition AJCC Kaplan Meier survival curve showed an inability to properly segregate stage I and IIA, while there was a large difference in survival probability between IIA and IIB. Conclusions: The 8th distal AJCC classification did resolve the anatomical issue with the T stage, as T1 and T3 showed improvement over the 7th AJCC, and the N stage division of the N1 and N2 category was found to be justified, with poorer survival in N2 than N1. Meanwhile, in TMN staging, the 8th AJCC was able differentiate between early stage (I and IIA) and late stage (IIB and III) to better explain the patient prognosis.

• 스마트미디어저널
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• 제9권4호
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• pp.126-133
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• 2020

병원에서는 폐암 환자의 최종병기를 기준으로 치료방침 및 예후를 결정하고 있다. 폐암 환자의 최종병기는 미국 암 연합회(AJCC)에서 제공하는 TNM 분류방법을 바탕으로 7단계로 나누어 진단된다. 이런 접근 방법은 환자의 치료, 예후 및 생존일 예측 등 다양한 분야에서 사용하기에 한계가 있다. 이 논문에서는 데이터 과학적 접근을 통해 T, N, M병기를 사용하여 생존일수별 환자집단을 나눌 수 있는지 알아보기 위해 비지도 학습 중 하나인 군집분석(Clustering)을 진행한 후 군집분석의 결과를 Cox비례위험모형을 사용하여 비교 하였다. 환자들의 최종병기를 사용하지 않고, T, N, M병기 정보만 사용하였을 때 생존시간 예측정확도가 더 높은 것을 확인하였다. 특히, AJCC의 최종병기 7단계와 같이 군집의 개수를 7로 설정했을 때보다 군집의 수를 축소하거나 확장했을 때 T, N, M 병기 군집분석을 통한 생존시간 예측정확도가 향상하는 것을 확인하였다.

• 대한의용생체공학회:의공학회지
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• 제25권4호
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• pp.243-251
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• 2004

자기공명 관류영상기법을 이용하여 고양이 뇌 지방색전증 유발한 후 대뇌혈류량을 정량적으로 분석하고 동적특성 변화를 구현하고자 하였다. 고양이 44마리를 대상으로 일측 내경동맥에 트리올레인 (n=15), 올레익 (n=9) 및 리노레익 (n=11)을 주입하여 뇌 지방색전을 유발시켰고, 대조군으로는 이바론 입자 (n=9)를 주입하여 색전이 유발되게 하였다. 그 후 30분과 2시간에 각각 T2강조, 확산강조영상을 획득하고 가장 색전이 많이 일어난 부위에서 관류강조영상을 얻었다. 획득한 데이터는 자체 개발한 영상처리 프로그램과 IDL 소프트웨어를 이용하여 신호강도 곡선을 ΔR$_2$＊ 곡선으로 변환한 후 적분하여 뇌혈류량을 측정하였다. 모든 군에서 병변부위의 뇌혈류량은 정상부위에 비해 감소하였다. 실험 각 군별 뇌혈류량 비는 시간경과에 따라 유의한 차이가 있었으며 (P＜0.005), 2시간에서는 30분에 비해 뇌혈류량이 다소 회복되었다. 뇌 지방색전증의 초기에는 혈류량이 감소하였다. 뇌경색 발생시 조기에 DWI와 PWI을 획득하여 뇌 혈류량의 다양한 동적변화 특성 및 혈류역학적 변화에 대한 정보를 임상적으로 제공 할 수 있으리라 여겨진다.

• 한국컴퓨터그래픽스학회논문지
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• 제8권2호
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• pp.1-7
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• 2002

컴퓨터 그래픽스 및 애니메이션에서 물체의 윤곽선 계산은 많은 응용분야에서 빈번히 사용되고 있으며, 윤곽선의 효율적인 계산 방법은 현재까지 많은 연구자들의 관심을 끌어왔다. 본 논문에서는 이동하는 관측점에 대해 다면체 모델의 투시 윤곽선을 계산하는 효율적인 알고리즘을 제시한다. 관측점이 시간에 따라 이동하는 경로는 시간을 나타내는 매개변수 t를 이용하여 곡선 q(t)로 표현한다. 다면체의 각 에지(edge)가 윤곽선에 포함되는 시간 간격 (time-interval)은 에지에 인접한 두 면의 supporting plane들과 q(t)의 교점 계산, 그리고 몇 차례의 벡터 내적을 수행함으로써 구해진다. 곡선 q(t)가 차수 n의 곡선이라면, 한 에지가 윤곽선에 포함되는 시간 간격은 최대 n + 1 개 존재할 수 있다. 미리 구해진 시간 간격들에 대해 고정된 시점 $t_i$를 포함하는 시간 간격들을 검색함으로써 관측점이 $q(t_i)$일 때 모델의 윤곽선에 포함되는 모든 에지를 구할 수 있다. 윤곽선 계산의 효율성은 시간 간격을 저장하는 자료구조 (data structure)와 밀접한 관련이 있으므로, 시간 간격을 저장하는 자료구조로서 인터벌 트리 (interval tree)의 사용을 제안한다. 또한, 제시된 알고리즘에 의해 윤곽선을 계산한 실험결과를 보인다.

• 한국환경과학회지
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• 제21권10호
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• pp.1203-1212
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• 2012

Yongsan ward is located at central place connecting south and north ecology axis of seoul. Various environment-friendly Yongsan development could pose positive effects on NPS(non pollutant source) pollutant reductions and water quality improvement at Han-rive because BOD, T-N, and T-P NPS discharges took 90% of total pollutant from this area. In this study, direct runoff and NPS pollutant loads were evaluated before and after development using spatio-tamporal change in CN(curve number) and EMC(event mean concentration) data. It was found that direct runoff value is $23,584,724m^3$, and BOD, T-N and T-P loads are 104,456 kg/year, 111,483 kg/year and 7,500 kg/year under pre-development condition, respectively. Annual runoff, BOD, T-N and T-P reducing rate were 12.9%, 33.3%, 35.6% and 40.7% under integrated post-development condition, respectively. Based on the results obtained in this study, environment-friendly urban development could be achieved at Yongsan area.

• 대한물리의학회지
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• 제4권4호
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• pp.275-280
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• 2009

Purpose：We have investigated to analysis biomechanics for pinch strength due to elbow flexion degree. Methods：Pinch strength was measured by Electro Dynamometer(G-100) using four elbow flexion degree ($0^{\circ}$, $45^{\circ}$, $90^{\circ}$, $135^{\circ}$). Results：In experimental results, we found that pinch strengths were 5.4kg($0^{\circ}$), 4.8kg($45^{\circ}$), 5.6kg($90^{\circ}$) and 5.2kg($135^{\circ}$), respectively. The Pinch strengths got maximum at $90^{\circ}$ degree, minimum at $45^{\circ}$ degree. We have calculated F1 values using $\sum$T=0. As a result F1 values were 540N($0^{\circ}$), 480N($45^{\circ}$), 560N($90^{\circ}$) and 520N($135^{\circ}$), respectively. F1 values got maximum at $90^{\circ}$ degree, minimum at $45^{\circ}$ degree. Data curve line of $F_1$ values was increased in 45~90 section and decreased in 0~45, 90~135 sections, respectively. Conclusion：$F_1$ (Flexor digitorum superficialis and profundus) values were 10 times bigger than pinch strengths. Data curve line of $F_1$ values was similar to active length-tension curve in 45~90, 90~135 sections.

• Journal of Oral Medicine and Pain
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• 제25권4호
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• pp.345-353
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• 2000

This study was to investigate normal salivary flow rates and normal indices of Quantitative analysis of salivary scintigraphy. 96 adult volunteers were studied by Questionnaire evaluating salivary conditions and clinical examinations. 35(male 23, female 12, age range 23-31years) that absented subjective and objective symptoms related saliva were classified as normal group. The normal group underwent measurement unstimulated and stimulated salivary flow rates and salivary scintigraphy. The obtained results were as follows: 1. There were not significant in sex differences of unstimulated and stimulated salivary flow rates. The unstimulated salivary flow rate was $0.66{\pm}0.41g/min$, stimulated salivary flow rates was $1.61{\pm}0.69g/min$. 2. As comparing of parameters of salivary scintigraphy, the Uptake ratio(UR), $T_{max}$, $T_{min}$, Maximum accumulation (MA), Maximum secretion(MS) of parotid and submandibular glands were not significant in sex and side-ralated differences. 3. The UR, $T_{max}$, MA, MS of parotid gland were significantly higher than those of submandibular gland; in the parotid gland, UR, $3.67{\pm}0.88$, $T_{max}$, $18.77{\pm}0.43min$, MA, $41.35{\pm}9.22%$, MS, $43.13{\pm}9.13%$; in the submandibular gland, UR, $3.04{\pm}0.10$, $T_{max}$, $18.48{\pm}0.52min$, MA, $36.47{\pm}14.18%$, MS, $36.88{\pm}12.20%$. 4. As classifying of time-activity curve, the most of parotid gland was N-type(97.1%), submandibular gland was observed in order of M-type(67.1%), N-type(21.4%), F-type(11.4%), however, was not observed S-type. 5. As the type of time-activity curve of submandibular gland was more flattened, the UR, $T_{max}$, MA, MS were significantly decresed.

• Structural Engineering and Mechanics
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• 제9권4호
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• pp.375-382
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• 2000

Experimental investigation into the cyclic behaviour of sand plast brick masonry was performed on forty two square panels. The panels were subjected to cyclic uniaxial compression for two cases of loading: normal to bed joint and parallel to bed joint. Experimental data were used to plot the unloading-reloading curves for the entire range of the stress-strain curve. Mathematical expressions to predict the reloading and unloading stress-strain curves at various values of residual strain are proposed. A simple parabola and an exponential type formula are found adequate to model the unloading and reloading curves respectively. The models account for the potential effects of residual strain on these curves. Comparison of test results with the proposed mathematical expression shows good correspondence.