• Herbal Formula Science
• /
• v.25 no.3
• /
• pp.363-374
• /
• 2017

Dried fruits of Schizandra chinensis Baillon, Fructus Schisandrae, have been widely used for many years to prevent and treat various diseases in Asian countries including Korea and Russia. It has recently been reported that extracts of Fructus Schisandrae are effective for controlling muscle and skeletal diseases. In this study, we investigated the efficacy of ethanol extract of Fructus Schisandrae (EEFS) on apoptosis and inflammatory response in gastrocnemius muscle of dexamethasone-induced catabolic muscle atrophy mice as part of natural substance discovery and functional analysis for improving muscle function. According to the results of this study, EEFS supplementation attenuated body weight gains and suppressed calf thickness loss in dexamethasone-induced muscle atrophic mice. Gastrocnemius muscle immunohistochemistry showed that expression of caspase-3 and poly(ADP-ribose) polymerase, which are representative apoptotic markers, was markedly increased in dexamethasone control mice; however, their expression was effectively reduced in the EEFS-fed mice. EEFS supplementation also prevented dexamethasone-induced increases in immunoreactivity of muscle fibers for myostatin, an important negative regulator of skeletal muscle mass. In addition, EEFS significantly normalized the increased numbers of nitrotyrosine, 4-hydroxynonenal and inducible nitric oxide synthase-positive muscle fibers compared to that found in dexamethasone control mice. These results suggest that EEFS protects dexamethasone-induced muscular atrophy by decreasing apoptosis and inflammatory responses, and EEFS is more likely to be developed as a muscle strengthening agent.

• The Korean Journal of Physiology and Pharmacology
• /
• v.13 no.6
• /
• pp.497-502
• /
• 2009

Exercise-mediated physical treatment has attracted much recent interest. In particular, swimming is a representative exercise treatment method recommended for patients experiencing muscular and cardiovascular diseases. The present study sought to design a swimming-based exercise treatment management system. A survey questionnaire was completed by participants to assess the prevalence of muscular and cardiovascular diseases among adult males and females participating in swimming programs at sport centers in metropolitan regions of country. Using the Fuzzy Analytic Hierarchy Process (AHP) technique, weighted values of indices were determined, to maximize participant clarity. A patient management system model was devised using information technology. The favorable results are evidence of the validity of this approach. Additionally, the swimming-based exercise management system can be supplemented together with analyses of weighted values considering connectivity between established indices.

• The Journal of Korean Medicine
• /
• v.25 no.1
• /
• pp.172-187
• /
• 2004

Objectives : To characterize four types of obesity and to effectively improve the treatment of obesity through Oriental medicine Methods : At 00 Oriental Medical Center, 203 female subjects who intented to lose weight were requested to complete a questionnaire. These participants were also given physical tests. The Questionnaire consisted of questions both about general life style and obesity in oriental medicine framework. The physical tests were blood tests, a body composition via Inbody 2.0, and physical strength tests. One-way analysis of variance was done to compare the means of items and physical tests between four types of obesity. Duncan was used by post hoc test. Results : 1. Significant differences between obesity type III and obesity type IV in ever tried to lose weight, childhood obesity and excercise times were observed in the questionnaire of general life style(p<0.05). 2. Ducan test showed significant differences between four obesity types in diseases (p<0.05). 3. Significant differences between four obesity types in height, % body fat muscular endurance, soft lean mass, fat mass, Trigliceride, Total cholesterol and ${\gamma}-GTP$ were observed (p<0.05). Conclusions : Further clinical research is necessary in the four types of obesity explored. The diagnosis and treatment based on these types should be further studied.

• Journal of Life Science
• /
• v.11 no.2
• /
• pp.87-91
• /
• 2001

We conducted this study to analyze the effectiveness of a treatment called 12-week therapeutic recreation dance movement (TRDM) to elderly people in terms of health care and recovery. Forty two elderly people were participated in this study and divided into two groups with healthy (twelve) and unhealthy (thirty). After TRDM treatment, the muscular power was increased in both groups without statistical significance within and between groups. The flexibility, agility and balance were slightly increased in both groups. Although the elevation of muscular endurance was not significant between groups, it was statistically meaningful within groups. The results of body composition comparison did not reveal meaningful difference within and between groups. However, the amount of fat in serum and fat distribution percentages ware decreased in both groups. Both group appeared to be increased muscle mass. The level of body water was decreased in healthy group and increased in unhealthy group. Unhealthy group appeared to be decreased level of T-C, TG and LDL-C. In contrast, the unhealthy group revealed the increased level of HDL-C. These results demonstrate the effect of TRDM to elderly people. This effectiveness can be adapted for the protection and treatment of geriatics-related adult diseases such as diabetes, hypertension and hyperlipidemia.

• Journal of the Korea Safety Management & Science
• /
• v.12 no.2
• /
• pp.49-54
• /
• 2010

WMSD occurs by accumulating the visible position and movements. Therefore, it is easier to prevent WMSD from occurring than other diseases when each employee is aware of the factors which cause WMSD. Hence, We need to develop exercise remedy, which can be done without using any exercise equipments and regardless places. The exercise prescription for those for LBP was to do the upper body exercise remedy twice in the morning and another twice in the afternoon and the spinal exercise remedy and the lower body exercise remedy once in the morning and once in the afternoon. We measured their maximum muscular strength every second week using a fitness machine so that we could compare the differences of the muscular strength of the test group and the comparison group. Therefore this research presented the fact that the exercise remedy is effective to prevent and cure LBP through a scientific test. And it confirmed that the exercise remedy by the Ergonomic exercise prescriptions is effective on LBP.

• Annals of Clinical Neurophysiology
• /
• v.17 no.1
• /
• pp.1-16
• /
• 2015

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is characterized by progressive death of motor neurons in the cortex, brainstem, and spinal cord. Until now, many treatment strategies have been tested in ALS, but so far only Riluzole has shown efficacy of slightly slowing disease progression. The pathophysiological mechanisms underlying ALS are multifactorial, with a complex interaction between genetic factors and molecular pathways. Other motor neuron disease such as spinal muscular atrophy (SMA) and spinobulbar muscular atrophy (SBMA) are also progressive neurodegenerative disease with loss of motor neuron as ALS. This common thread of motor neuron loss has provided a target for the development of therapies for these motor neuron diseases. A better understanding of these pathogenic mechanisms and the potential pathological relationship between the various cellular processes have suggested novel therapeutic approaches, including stem cell and genetics-based strategies, providing hope for feasible treatment of ALS.

• Child Health Nursing Research
• /
• v.7 no.4
• /
• pp.421-433
• /
• 2001

The purpose of this phenomenological study was to understand the lived experience of mothers of children with muscular dystrophy. The participants were 11 mothers recruited by snowball sampling, who agreed with the objectives of the research and could verbally communicate with the researcher and who lived with their sons who had muscular dystrophy. Data collection was done through in-depth interviews with participants in their own homes. Each interview took 50 to 120 minutes. All of the interviews were audiotaped and then transcribed. Data were analyzed using Colaizzi's (1978) method of phenomenology. From the transcripts 109 significant sentences and phrases were selected and 13 clusters of themes were categorized from 67 significant statements. These results were integrated into the essential structure of the lived experience of mothers of children with muscular dystrophy. 1. Anxious and relying on chance due to indefinite diagnosis. 2. Only able to cry with shock because of son's fatal disease. 3. Seeing the future as dismal and feeling resentment that this disease in transmitted through the mother. 4. Feeling caught between a husband who is distancing himself from his family and the family which is disintegrating. 5. Feeling like a sinner for transmission of genetic disease(Feeling guilt for conceiving a son with a genetically transmitted fatal disease). 6. Empathizing with other suffers of muscular dystropy and their parents in their grief and helping to dissipate their heavy feelings. 7. Deciding to sacrifice self as a way of taking responsibility for giving birth to a handi-capped son. 8. Losing hope (feeling despair) as son's condition deteriorates in spite of all attempts to help him. 9. Wishing to die with son who becomes progressively immobile. 10. Accumulating Han*(한, 恨), because of rising Hwa(화, anger), and becoming sick both mentally and physically. 11. Seeing events as destiny and finding self-control through faith. 12. Finally, giving up sacrificing self for son and becoming concerned(involved) with other children in the family. 13. Feeling fear at son's impending death. This is the first research on the experience of Korean mothers of children with muscular dystrophy. In applying the phenomenology research method, this study not only helps health professionals understand the experience of these mothers in the Korean patriarchal social system, but the researcher, as a nurse, can share their agony and grief through identification of their inner world through in-depth personal interviews. The results obtained in this study will not only help in the development of family nursing practice for families with genetically transmitted diseases but also prepare basic data for family nursing practice in the Korean sociocultural context.

• BMB Reports
• /
• v.51 no.7
• /
• pp.327-337
• /
• 2018

Lamin A and its alternative splicing product Lamin C are the key intermediate filaments (IFs) of the inner nuclear membrane intermediate filament. Lamin A/C forms the inner nuclear mesh with Lamin B and works as a frame with a nuclear shape. In addition to supporting the function of nucleus, nuclear lamins perform important roles such as holding the nuclear pore complex and chromatin. However, mutations on the Lamin A or Lamin B related proteins induce various types of human genetic disorders and diseases including premature aging syndromes, muscular dystrophy, lipodystrophy and neuropathy. In this review, we briefly overview the relevance of genetic mutations of Lamin A, human disorders and laminopathies. We also discuss a mouse model for genetic diseases. Finally, we describe the current treatment for laminopathies.

• Journal of Korean Medical classics
• /
• v.23 no.1
• /
• pp.129-132
• /
• 2010

This article aims at clarifying the formation and accumulation of the "phlegm" in the body. If the phlegm can't be dispelled, it would do great harm to the body health in many aspects, even leading to various diseases which are complex and hard to cure. "phlegm blocking the orifices of the heart", "Gi(氣) activities blocking", "the blood vessels choking", "muscular striae[肌腠] overflowing", " tumor accumulated", "inveterate phlegm loss the path", are the outstanding pathogenic characteristics of the "phlegm". Ancient and modern physicians accumulated rich experiences on preventing and treating the phlegm diseases. Those are worth excavating, organizing and clarifying deeply for the prevention, diagnosis and treatment of the phlegm diseases efficiently.

• The Korean Journal of Pain
• /
• v.24 no.1
• /
• pp.1-6
• /
• 2011

Botulinum toxin has been used for the treatment of many clinical disorders by producing temporary skeletal muscle relaxation. In pain management, botulinum toxin has demonstrated an analgesic effect by reducing muscular hyperactivity, but recent studies suggest this neurotoxin could have direct analgesic mechanisms different from its neuromuscular actions. At the moment, botulinum toxin is widely investigated and used in many painful diseases such as myofascial syndrome, headaches, arthritis, and neuropathic pain. Further studies are needed to understand the exact analgesic mechanisms, efficacy and complications of botulinum toxin in chronic pain disorders.