• 한국임상약학회지
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• 제31권1호
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• pp.61-78
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• 2021

Background and Objective: The use of potentially inappropriate medications (PIMs) increases the risk of negative health outcomes, including drug-related admissions. Tools for structured medication review have been developed to ensure optimal medication use and safety. Here, we aimed to evaluate medication use review (MUR) tools for community-dwelling older patients. Methods: We performed a systematic review of the literature according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement (PRISMA). We searched PubMed, Embase, and the Cochrane Library from 1991 to 2020, excluding tools that are specifically applied to hospitalized patients or nursing home residents. We identified the most common inappropriate medications, drug-disease interactions, drug-drug interactions and prescribing omissions presented among tools. Results: From among 9,788 identified reports screened, 60 met our inclusion criteria; finally, 27 were eligible for data analysis considering originality and up-to-dateness. Most tools presented explicit criteria (93%), and only one was specific to community-dwelling elderly. The most common PIM was tricyclic antidepressants. Use of diltiazem and verapamil in patients with heart failure and the combination of nonsteroidal anti-inflammatory analgesics and warfarin were the most frequent disease-specific PIM and drug-interaction, respectively. Conclusions: Although several medication review tools have been developed for older adults, specific guidelines for community-dwelling populations remain limited. Furthermore, the list of PIMs differed among available tools. In future, specific but integrating MUR tools need to be developed for clinical practice considering this population.

• 전자공학회논문지A
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• 제33A권5호
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• pp.94-101
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• 1996

The purpose of this paper is to analyze the field distribution and the current distribution of leaky coaxial cable with the finite difference-tiem domain(FDTD) algorithm. finite difference equations of maxwell's equations are defined in cylindrical coordinate systems. To simulate the unbounded problem like a free space, the Mur's absorbing boundary conditon is also used. After modeling the leaky coaxial cable with the three dimensional grid structure, the transient resoponse of th efield distribution and the current distribution are depicted in the time domain.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 1996년도 춘계공동학술대회논문집; 공군사관학교, 청주; 26-27 Apr. 1996
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• pp.147-150
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• 1996

Human posture prediction and motion simulation methods try to solve inverse kinematic problems using the optimization technique based on the concept of minimum principle. It is very important to select a cost function which relfects the human posture acurately. In this study, lifting postures were predicted using the five biomechanical cost functions and compared with real human postures in order to evaluate the predictivities of the cost functions. The result showed that all the biomechanical cost functions used in this study could not predict lifting postures accurately. The cost function which minimizes the sum of joint moments showed the smallest mean prediction error, while the one which minimizes the MUR showed statistically better performance.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 1999년도 춘계종합학술대회
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• pp.276-279
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• 1999

This paper proposes a design for microstrip patch antenna with dual resonance and dual polarization fed by proximity coupled quarter wavelength stub. The antenna characteristics are analyzed by the FDTD method with Mur's 2nd order ABC. From the simulation results based on the FDTD method, frequency characteristics of structure parameters such as the patch size and the offset feed are investigated. The numerical results are compared with the experimental results, and the comparison shows reasonable agreement for a design frequency.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회 2004년도 추계학술대회 및 정기총회
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• pp.349-352
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• 2004

In this paper, we propose a newly energy-efficient routing protocol, which is called Maximum Utility Routing(MUR), in mobile ad hoc networks (MANETs) so as to investigate the minimum energy and maximum lifetimes issues together. We present a utility-based framework so as to meet various incompatible constraints simultaneously and fairly. To explore this issue, we use the concepts and mathematics of microeconomics and game theory. Though simulation results, we show that our routing scheme has much better performance especially in terms of network efficiency, network lifetime, and average power consumption.

• 대기
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• 제34권3호
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• pp.305-317
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• 2024

The study examines the effects of parameters that define the characteristics of raindrops on the simulated precipitation during the summer season over Korea using the Weather Research and Forecasting (WRF) Double-Moment 6-class (WDM6) cloud microphysics scheme. Prescribed parameters, defining the characteristics of hydrometeors in the WDM6 scheme such as a_R, b_R, and f_R in the fall velocity (V_R) - diameter (D_R) relationship and shape parameter (𝜇_R) in the number concentration (N_R) - D_R relationship, presents different values compared to the observed data from Two-Dimensional Video Disdrometer (2DVD) at Boseong standard meteorological observatory during 2018~2019. Three experiments were designed for the heavy rainfall event on August 8, 2022 using WRF version 4.3. These include the control (CNTL) experiment with original parameters in the WDM6 scheme; the MUR experiment, adopting the 50th percentile observation value for 𝜇_R; and the MEDI experiment, which uses the same 𝜇_R as MUR, but also includes fitted values for a_R, b_R, and f_R from the 50th percentile of the observed V_R - D_R relationship. Both sensitivity experiments show improved precipitation simulation compared to the CNTL by reducing the bias and increasing the probability of detection and equitable threat scores. In these experiments, the raindrop mixing ratio increases and its number concentration decreases in the lower atmosphere. The microphysics budget analysis shows that the increase in the rain mixing ratio is due to enhanced source processes such as graupel melting, vapor condensation, and accretion between cloud water and rain. Our study also emphasizes that applying the solely observed 𝜇_R produces more positive impact in the precipitation simulation.

• Journal of Microbiology and Biotechnology
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• 제22권4호
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• pp.484-493
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• 2012

BolA protein homologs are widely distributed in nature. In this report, we have studied for the first time YrbA, the only BolA homolog present in Escherichia coli, which we have renamed ibaG. We have constructed single and multiple ibaG mutants, and overexpressed ibaG in wild-type strains, in order to characterize this gene. The ibaG phenotypes are different from the bolA-associated round morphologies or growth profiles. Interestingly, ibaG and bolA single-and double-deletion mutants grow faster and have higher viabilities in rich media, whereas the overexpressed strains are significantly growth impaired. However, the mutant strains have lower viabilities than the wild type in the late stationary phase, indicating that both bolA and ibaG are important for survival in difficult growth conditions. bolA, as a transcription factor, binds to some promoters, but ibaG does not interact with the same DNA regions. We have determined that ibaG is transcribed in an operon with the murA gene, involved in the synthesis of peptidoglycan precursors. ibaG was also seen to change its mRNA expression pattern in response to acidic stress. ibaG may thus represent a new gene involved in cell resistance against acid stress.

• Genomics & Informatics
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• 제11권4호
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• pp.272-276
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• 2013

Sequence analysis of the 16S rRNA gene has been widely used for the classification of microorganisms. However, we have been unable to clearly identify five Flavobacterium species isolated from a freshwater by using the gene as a single marker, because the evolutionary history is incomplete and the pace of DNA substitutions is relatively rapid in the bacteria. In this study, we tried to classify Flavobacterium species through multilocus sequence analysis (MLSA), which is a practical and reliable technique for the identification or classification of bacteria. The five Flavobacterium species isolated from freshwater and 37 other strains were classified based on six housekeeping genes: gyrB, dnaK, tuf, murG, atpA, and glyA. The genes were amplified by PCR and subjected to DNA sequencing. Based on the combined DNA sequence (4,412 bp) of the six housekeeping genes, we analyzed the phylogenetic relationship among the Flavobacterium species. The results indicated that MLSA, based on the six housekeeping genes, is a trustworthy method for the identification of closely related Flavobacterium species.

• Journal of Microbiology
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• 제43권5호
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• pp.398-405
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• 2005

Polyamines such as putrescine are small, ubiquitous polycationic molecules that are required for optimal growth of eukaryotic and prokaryotic cells. These molecules have diverse effects on cell physiology and their intracellular content is regulated by de novo synthesis and uptake from the environment. The studies presented here examined the structure of a putative polyamine transporter (Pot) operon in Streptococcus pneumoniae (pneumococcus) and growth of pneumococci in medium containing putrescine substituted for choline. RT-PCR experiments demonstrated that the four genes encoding the Pot system are co-transcribed with murB, a gene involved in an intermediary step of peptidoglycan synthesis. Pneumococci grown in chemically-defined media (CDM) containing putrescine without choline enter logarithmic phase growth after 36-48 hs. However, culture density at stationary phase eventually reaches that of choline-containing medium. Cells grown in CDM-putrescine formed abnormally elongated chains in which the daughter cells failed to separate and the choline-binding protein PspA was no longer cell-associated. Experiments with CDM containing radiolabeled putrescine demonstrated that pneumococci concentrate this polyamine in cell walls. These data suggest that pneumococci can replicate without choline if putrescine is available and this polyamine may substitute for aminoalcohols in the cell wall teichoic acids.

• The Plant Pathology Journal
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• 제33권6호
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• pp.543-553
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• 2017

Sesame (Sesamum indicum) is an important oil seed crop of Asia. Yields can be negatively impacted by various factors, including disease, particularly those caused by fungi which create problems in both production and storage. Foliar diseases of sesame such as Alternaria leaf blight may cause significant yield losses, with reductions in plant health and seed quality. The work reported here determined the incidence of Alternaria species infecting sesame seeds grown in the Punjab, Pakistan. A total of 428 Alternaria isolates were obtained from 105 seed samples and grouped into 36 distinct taxonomic groups based on growth pattern and morphological characters. Isolation frequency and relative density of surface sterilized and non-surface sterilized seeds showed that three isolates (A13, A47 and A215) were the most common morphological groups present. These isolates were further identified using sequencing of the Internal Transcribed Spacer (ITS) region of ribosomal DNA (rDNA) and the Alternaria major allergen gene (Alt a 1). Whilst ITS of rDNA did not resolve the isolates into Alternaria species, the Alt a 1 sequences exhibited > 99% homology with Alternaria alternata (KP123850.1) in GenBank accessions. The pathogenicity and virulence of these isolates of Alternaria alternata was confirmed in inoculations of sesame plants resulting in typical symptoms of leaf blight disease. This work confirms the identity of a major source of sesame leaf blight in Pakistan which will aid in formulating effective disease management strategies.