• International Journal of Quality Innovation
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• v.7 no.3
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• pp.46-57
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• 2006

The desirability function approach to multiple response optimization is a useful technique for the analysis of experiments in which several responses are optimized simultaneously. But the existing methods have some defects, and have to be modified to some extent. This paper proposes a new method to combine the individual desirabilities.

• Journal of Korean Society for Quality Management
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• v.23 no.3
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• pp.84-92
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• 1995

A method is proposed for the simultaneous optimization of several response functions that depend on the same set of controllable variables and are adequately represented by a response surface model (polynomial regression model) with the same degree and with constraint that the individual responses have the target values. First, the multiple responses data are checked for linear dependencies among the responses by eigenvalue analysis. Thus a set of responses with no linear functional relationships is used in developing a function that measures the distance estimated responses from the target values. We choose the optimal condition that minimizes this measure. Also, under the different degree of importance two step procedures are proposed.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.8
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• pp.989-996
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• 2010

Statistical regression and/or interpolation models have been used for data analysis and response prediction using the results of the physical experiments and/or computer simulations in structural engineering fields. These models have been employed during the last decade to develop a variety of design methodologies. However, these models only handled responses with respect to space variables such as size and shape of structures and cannot handle time-variant dynamic responses, i.e. response varying with time. In this research, statistical space-time metamodels based on multiple response approach that can handle responses with respect to both space variables and a time variable are proposed. Regression and interpolation models such as the response surface model (RSM) and kriging model were developed for handling time-variant dynamic responses of structural engineering. We evaluate the accuracies of the responses predicted by the two statistical space-time metamodels by comparing them with the responses obtained by the physical experiments and/or computer simulations.

• School Mathematics
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• v.19 no.3
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• pp.533-551
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• 2017

The statistical education researchers advise instructors to educate informal statistical inference and they are paying close attention to the progress of the statistical inference in general. This study was conducted by analyzing the levels and the traits of each levels of the informal statistical inference of the middle and high school students for comparing the samples of data and estimating the graph of a population. Research has shown that five levels of the informal statistical inference were identified for comparing the samples of data: responses that are distracted or misled by an irrelevant aspect, responses that focus on frequencies of individual data points and hold a local view of the sample data sets, responses that the student's view of the data is transitioning from local to global, responses that hold a global view but do not clearly integrate multiple aspects of the distribution, and responses that integrate multiple aspects of the distribution. Another five levels of the informal statistical inference were identified for estimating the graph of a population: responses that are distracted or misled by an irrelevant aspect, responses that focus only on representativeness, responses that consider both representativeness and variability and focus on one particular aspect of the distribution, responses that focus on multiple aspects of distribution but do not clearly integrate them, and responses that integrate multiple aspects of the distribution.

• Journal of Mechanical Science and Technology
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• v.17 no.8
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• pp.1164-1170
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• 2003

The objectives of this work here focus on the differences in responses to multiple cyclic tests of different sections along the length of the same tendon. Tendon specimens were obtained from the hindlimbs of canines and frozen to -70$^{\circ}C$. After thawing, specimens were mounted in the immersion bath at room temperature (22$^{\circ}C$) , preloaded to 0.13 N and then subjected to 3% or 4% of the initial length at a strain rate of 5%/sec. It was found that different sections of the same long tendons had different resistances to deformation. In general, the bone end sections were stiffer and carried greater loads for a given strain than the muscle end sections, and the mid-portions were the least stiff and carried the smallest loads for a given strain. The results of this study offer new information about the mechanical responses of collagenous tissues. We know more about their responses to multiple cyclic extensions and how their responses are different from the positions along the length of the tendon specimen. The nature and causes of these differences in the stiffness are not fully known. However, it is clear that differences in the mechanical response of tendons and other connective tissues are significant to musculoskeletal performance.

• Molecules and Cells
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• v.39 no.3
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• pp.179-185
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• 2016

Posttranscriptional regulation of RNA metabolism, including RNA processing, intron splicing, editing, RNA export, and decay, is increasingly regarded as an essential step for fine-tuning the regulation of gene expression in eukaryotes. RNA-binding proteins (RBPs) are central regulatory factors controlling posttranscriptional RNA metabolism during plant growth, development, and stress responses. Although functional roles of diverse RBPs in living organisms have been determined during the last decades, our understanding of the functional roles of RBPs in plants is lagging far behind our understanding of those in other organisms, including animals, bacteria, and viruses. However, recent functional analysis of multiple RBP family members involved in plant RNA metabolism and elucidation of the mechanistic roles of RBPs shed light on the cellular roles of diverse RBPs in growth, development, and stress responses of plants. In this review, we will discuss recent studies demonstrating the emerging roles of multiple RBP family members that play essential roles in RNA metabolism during plant growth, development, and stress responses.

• Earthquakes and Structures
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• v.22 no.5
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• pp.517-526
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• 2022

In this paper, nonlinear P-delta effects are studied on the seismic performance, and the modal responses of a flexural frame, considering large deformations. Using multiple scales method, the nonlinear differential equations of motion are estimated, and the nonlinear interactions between the frame's degrees of freedom are outcropped. The results of time and frequency domain analyzes of a dynamic model are examined under internal resonance cases, and the linear and nonlinear responses are investigated in each modal cases. Also, changing the modal responses with respect to the amplitude and frequency of the harmonic forces is evaluated. It is shown that the dominant absorption of energy is in the first natural frequency of the frame, in the case of earthquake excitation, and when a harmonic force is applied to the frame, the peaks of the frequency domain responses depending on the frequency of harmonic force are in the first, and second or third natural frequency of the structure.

• Journal of the Korean Statistical Society
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• v.25 no.4
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• pp.557-566
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• 1996

The aim of this paper is to find a suitable design which minimizes the expected discrepancy: in fitting a first order model fearing quadratic terms as bias where there are more than two correlated responses. Kim and Draper(1994) discussed about choosing a design for straight line fits to two correlated responses The general case with r responses is examined here and the result is applied to a specific case to help understandings.

• 한국데이터정보과학회:학술대회논문집
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• 2005.04a
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• pp.1-6
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• 2005

In this paper we propose how to simultaneously optimize multiple responses for robust design when data are collected from a combined array. The proposed method is based on the quadratic loss function. An example is illustrated to show the proposed method.

• The Korean Journal of Physiology and Pharmacology
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• v.11 no.5
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• pp.221-226
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• 2007

Melittin-induced tonic pain model is characterized by local inflammation, edema, spontaneous flinchings, and sustained mechanical hypersensitivity. These nociceptive responses are mediated through selective activation of capsaicin-sensitive primary afferent fibers by melittin. The present study was undertaken to elucidate the role of peripheral 5-hydroxytryptamine(5-HT) receptors in the melittin-induced nociceptive responses. Changes in mechanical threshold, flinching behaviors and paw thickness were measured in rat intraplantarly injected with melittin($40{\mu}g/paw$) alone or treated together with melittin and 5-HT receptor antagonists. WAY-100635($100{\mu}g\;&\;200{\mu}g/paw$), isamoltane hemifumarate($100{\mu}g\;&\;200{\mu}g/paw$), methysergide maleate($60{\mu}g,\;120{\mu}g\;&\;200{\mu}g/paw$) and ICS-205,930($100{\mu}g\;&\;200{\mu}g/paw$) were intraplantarly injected 20 min before melittin injection. All 5-HT receptor antagonists tested in this experiment significantly attenuated the ability of melittin to reduce mechanical threshold and to induce flinching behaviors. 5-HT receptor antagonists, except ICS-205,930, had mild inhibitory effect on melittin-induced edema. These experimental findings suggest that multiple peripheral 5-HT receptors are involved in the melittin-induced nociceptive responses.