• Asian-Australasian Journal of Animal Sciences
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• 제22권1호
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• pp.124-130
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• 2009

Estimating genetic interaction effects in animal genomics would be one of the most challenging studies because the phenotypic variation for economically important traits might be largely explained by interaction effects among multiple nucleotide sequence variants under various environmental exposures. Genetic improvement of economic animals would be expected by understanding multi-locus genetic interaction effects associated with economic traits. Most analyses in animal breeding and genetics, however, have excluded the possibility of genetic interaction effects in their analytical models. This review discusses a historical estimation of the genetic interaction and difficulties in analyzing the interaction effects. Furthermore, two recently developed methods for assessing genetic interactions are introduced to animal genomics. One is the restricted partition method, as a nonparametric grouping-based approach, that iteratively utilizes grouping of genotypes with the smallest difference into a new group, and the other is the Bayesian method that draws inferences about the genetic interaction effects based on their marginal posterior distributions and attains the marginalization of the joint posterior distribution through Gibbs sampling as a Markov chain Monte Carlo. Further developing appropriate and efficient methods for assessing genetic interactions would be urgent to achieve accurate understanding of genetic architecture for complex traits of economic animals.

• 한국환경보건학회지
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• 제37권1호
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• pp.1-11
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• 2011

Recent advances in Geographic Information Systems and spatial statistical and analytical methods, along with the availability of spatially referenced health and environmental data, have created unique opportunities to investigate spatial associations between environment exposures and health outcomes at multiple spatial scales and resolutions. However, the increased use of spatial data also faces challenges, one of which is to ensure certainty and accuracy of locational data that meets the needs of a study. This article critically reviews the use of spatially referenced data in epidemiologic studies, focusing on the issue of locational uncertainty generated from the process of geocoding health and environmental data. Primarily, major issues involving the use of spatially referenced data are addressed, including completeness and positional accuracy, potential source of bias and exposure misclassification, and implications for epidemiologic studies. The need for critical assessment and caution in designing and conducting spatial epidemiology studies is briefly discussed.

• 한국환경과학회지
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• 제21권11호
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• pp.1339-1348
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• 2012

The versatile aerosol concentration enrichment system (VACES) have proven useful for providing elevated levels of atmospheric aerosol to human and animal exposures. In this study, we describe a VACES and tests conducted to both optimize the enhancement factor (EF) and characterize how it depends on experiment conditions. Particle number concentrations were measured from upstream and downstream of the system by scanning mobility particle sizer (SMPS) with a long differential mobility analyzer (DMA) in combination with a condensation particle counter (CPC). SMPS was used for to determine VACES particle EF. Particle EF tends to increase for higher the saturator temperature ($T_{Sat}$) and lower the condenser temperature ($T_{Con}$). $T_{Con}$ higher than $0^{\circ}C$ and $T_{Sat}$ lower than $50^{\circ}C$ was the best to obtain the most increase in particle concentration. Correlation analysis of EF with factor variables of $T_{Sat}$ and $T_{Con}$ resulted in correlation 0.662 and 0.416, respectively. With all five predictor variables included in a multiple regression model, the EF had a liner correlation with $R^2=0.643$.

• Preventive Nutrition and Food Science
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• 제22권1호
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• pp.1-8
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• 2017

About 20 chemical elements are nutritionally essential for humans with defined molecular functions. Several essential and nonessential biometals are either functional nutrients with antidiabetic actions or can be diabetogenic. A key question remains whether changes in the metabolism of biometals and biominerals are a consequence of diabetes or are involved in its etiology. Exploration of the roles of zinc (Zn) in this regard is most revealing because 80 years of scientific discoveries link zinc and diabetes. In pancreatic ${\beta}$- and ${\alpha}$-cells, zinc has specific functions in the biochemistry of insulin and glucagon. When zinc ions are secreted during vesicular exocytosis, they have autocrine, paracrine, and endocrine roles. The membrane protein ZnT8 transports zinc ions into the insulin and glucagon granules. ZnT8 has a risk allele that predisposes the majority of humans to developing diabetes. In target tissues, increased availability of zinc enhances the insulin response by inhibiting protein tyrosine phosphatase 1B, which controls the phosphorylation state of the insulin receptor and hence downstream signalling. Inherited diseases of zinc metabolism, environmental exposures that interfere with the control of cellular zinc homeostasis, and nutritional or conditioned zinc deficiency influence the pathobiochemistry of diabetes. Accepting the view that zinc is one of the many factors in multiple gene-environment interactions that cause the functional demise of ${\beta}$-cells generates an immense potential for treating and perhaps preventing diabetes. Personalized nutrition, bioactive food, and pharmaceuticals targeting the control of cellular zinc in precision medicine are among the possible interventions.

• 환경정책연구
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• 제12권3호
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• pp.49-71
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• 2013

독성, 환경 노출 및 인체에 대한 위해성 유해성 등 안전성에 대한 문제점을 가지고 있는 나노물질의 확인 및 안전성 확보의 요구가 점차 높아지고 있다. 나노물질은 화학물질로 이용될 뿐만 아니라 소비자가 이용하는 제품으로 범 분야에 걸쳐 활용되기 때문에, 보다 효과적인 나노물질의 안전관리 제도화를 위해서는 각국의 정책사례를 규제 강도별, 나노 적용분야별, 규제대상 종류별로 구분하여 정책 동향을 파악하는 것이 중요하다. 나노물질의 잠재적 위험성을 최소화시키기 위해서는 사전예방원칙을 적용한 제도의 구축 또한 필요하다. 더불어 국내 실정에 적합한 정책 수립을 목표로 하고, 국제 흐름에 선제적, 능동적으로 대응할 수 있는 방안도 함께 고려해야 한다.

• 한국직업건강간호학회지
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• 제29권1호
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• pp.58-68
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• 2020

Purpose: Workers with chronic health problems find it difficult to maintain their work because of socioeconomic difficulties. The purpose of this study was to evaluate the relationships between physical, ergonomic, and mental health hazards in the workplace and chronic health problems of Korean workers. Methods: A total of 28,807 wage workers participated in the study and were selected using the Fifth Korean Working Conditions Survey (2017). Multiple logistic regression analysis was used to determine the associations between physical, ergonomic, and mental health hazards and chronic health problems. Results: Of the participants, 1,220 (4.23%) had chronic health problems. Even after adjusting the general characteristics, vibration, noise, high temperature, low temperature, dust, chemical and cigarette smoke, fatigue and painful posture, dragging or pushing or moving of heavy objects, repetitive hand or arm movements, working with a computer or smartphone, use of internet or e-mail, and anxiety situations increased the risk of chronic health problems. Conclusion: The study reaffirms that exposure of physical, ergonomic, and mental health hazards in the workplace significantly increases the risk of chronic health problems.

• 한국환경보건학회지
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• 제34권3호
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• pp.183-187
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• 2008

Indoor air quality can be affected by indoor sources, ventilation, decay, and outdoor levels. Various indoor and out-door combustion sources produce nitrogen dioxide ($NO_2$), which is a by-product of high temperature fossil fuel combustion. Especially, the presence of gas ranges and smoking have been identified as major factors contributing to indoor $NO_2$ exposures. In this study, we compared an industrial complex area with a country area by assessing the personal exposure to $NO_2$with measurements of indoor and outdoor $NO_2$ levels in residences and by house characteristics and questionnaire. Personal exposure concentrations were significantly correlated with indoor $NO_2$ concentrations of residences in both the industrial complex area and the country area with correlation coefficients of 0.561 and 0.664, respectively, compared to outdoors. Multiple regression analysis, indicated that indoor $NO_2$ levels in residences were only affected by outdoor levels (p = 0.000) in spite of higher indoor sources such as smoking. Therefore, it is suggested that outdoor air quality as well as indoor air quality should be considered in the reduction of the personal exposure to air pollutants.

• 한국직업건강간호학회지
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• 제24권2호
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• pp.67-75
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• 2015

Purpose: The objective of the present study was to evaluate the effects of occupational exposure to low dose organic solvents on the prevalence of cardiovascular risk factors. Methods: Study design was retrospective cohort study subjected on 191 exposures and 118 controls working in a petrochemical manufacture company. The eight indicators related to CVD risk were followed up for five years from 2008 to 2012. The risk level was compared during the follow up years and subject's characteristics, and the change of risk level were analyzed with repeated measures ANOVA and multiple logistic regression analysis. Results: At the start year 2008, the rate over cutoff value (ROCV) of BS (p<.001) and mean systolic BP (p=.017) were higher in organic solvent exposure group and the others showed no difference. And by the subject's characteristics, odds ratio of the ROCV of BS were higher in organic solvent exposure group and work shift group as 2.51 and 3.07. Comparing the results in 2012 to those of 2008, cardiovascular disease risk in organic solvent exposure group was about 1.5 times higher than that of in the control group. Conclusion: Gradual increase in the CVD risk was identified in organic solvent exposure group. However, the risk might be influenced by shift work and bad behaviors rather than organic solvent exposure.

• Journal of the Korean Data and Information Science Society
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• 제23권3호
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• pp.467-474
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• 2012

인간의 질병과 가축의 경제적인 특성은 하나의 유전자가 아닌 여러 유전자의 상호작용의 영향을 더 많이 받는다고 알려져 있다. 본 논문에서는 유전적인 효과만을 밝혀내기 위해 선형회귀모형을 활용하여 환경적인 요인을 보정하고, 최근 한우의 맛과 육질에 영향을 준다고 밝혀진 단일염기다형성 5개 (Oh 등, 2011)를 이용해 한우의 경제형질에 영향을 주는 우수 유전자 조합을 선별하고 우수 유전자형을 밝힌다. 이때, 많은 유전자들 중에서 우수한 유전자를 찾기 위한 비모수적인 방법인 다중인자 차원 축소 방법을 이용하여 단일 유전자의 효과보다 상호작용의 효과가 한우의 경제형질에 더 많은 영향을 준다는 사실을 확인하였다.

• Safety and Health at Work
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• 제12권2호
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• pp.230-237
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• 2021

Background: Noise-induced hearing loss is a well-known occupational disease that affects many fish harvesters from many fisheries worldwide, whose risk factor is prolonged exposure to hazardous noise levels. To date, academic research activities and regulatory bodies have not provided any comparative analysis among the existing methods to assess noise exposure levels of fish harvesters. This paper provides a comparison of four relevant assessment methods of noise exposure, examining the results of a measurement campaign performed onboard small fishing vessels from Newfoundland and Labrador. Methods: We traveled onboard 11 vessels engaged in multiple fisheries from Newfoundland and Labrador and performed extensive noise exposure surveys using the simplified International Maritime Organization method, the full-day measurement method, and the two methods provided by ISO 9612:2009, the task-based method and job-based method (JBM). Results: The results showed that the four methods yield similar values when the noise components are dominated by the engine and auxiliaries (steady-state sources); when noise components are dominated by the fishing gear, task-based method and the simplified International Maritime Organization method estimates are less accurate than JBM, using full-day measurements as baseline. Conclusion: The JBM better assesses noise exposure in small-scale fisheries, where noise exposure has significant variance and uncertainties on the exposure levels are higher.