• Journal of Korean Society of Industrial and Systems Engineering
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• v.42 no.4
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• pp.61-68
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• 2019

Currently many companies are interested in reduction of the carbon emissions associated with their supply chain activities such as transportation and operations. Operational decisions, such as modifications in order quantities could an effective way in reducing carbon emissions in the supply chain. Cap-and-trade regulation, sometimes called emissions trading, is a market-based tool to limit greenhouse gas emissions. Under cap-and-trade regulation, emission credits are allocated to the firms and the firms trades emissions under cap-and-trade schemes. In this paper, we propose a single-manufacturer single-buyer two-echelon supply chain problem under the cap-and-trade mechanism incorporating the carbon emissions caused by transportation and warehousing activities where a single manufacturer produces a family of items in order to deliver a family of items to a single buyer at a fixed interval of time for effective implementation of Just-In-Time (JIT) Purchasing. An integrated multi-product lot-splitting model of facilitating multiple shipments in small lots between buyer and manufacturer is developed in a JIT Purchasing environment. Also, an iterative heuristic algorithm is developed to derive the common order interval, the number of intervals for each product and the number of shipments between the buyer and the manufacturer during the common interval. A numerical example is given to illustrate the savings in reduction of total cost and carbon emissions by the inventory model incorporating cap-and-trade mechanism compared to the classical inventory model. The proposed inventory model could be useful for the practical solution of two-echelon supply chain inventory problem under cap-and-trade mechanism.

• Journal of Microbiology and Biotechnology
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• v.26 no.12
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• pp.2184-2191
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• 2016

The time-consuming and high-cost preparation of soluble peptide-major histocompatibility complexes (pMHC) currently limits their wide uses in monitoring antigen-specific T cells. The single-chain trimer (SCT) of peptide-${\beta}2m$-MHC class I heavy chain was developed as an alternative strategy, but its gene fusion is hindered in many cases owing to the incompatibility between the multiple restriction enzymes and the restriction endonuclease sites of plasmid vectors. In this study, overlap extension PCR and one-step cloning were adopted to overcome this restriction. The SCT gene of the $OVA_{257-264}$ peptide-$(GS_4)_3-{\beta}2m-(GS_4)_4-H-2K^b$ heavy chain was constructed and inserted into plasmid pET28a by overlap extension PCR and one-step cloning, without the requirement of restriction enzymes. The SCT protein was expressed in Escherichia coli, and then purified and refolded. The resulting $H-2K^b/OVA_{257-264}$ complex showed the correct structural conformation and capability to bind with $OVA_{257-264}$-specific T-cell receptor. The overlap extension PCR and one-step cloning ensure the construction of single-chain MHC class I molecules associated with random epitopes, and will facilitate the preparation of soluble pMHC multimers.

• Journal of Communications and Networks
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• v.17 no.2
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• pp.184-197
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• 2015

This paper builds on a recent method, chain routing with even energy consumption (CREEC), for designing a wireless sensor network with chain topology and for scheduling the communication to ensure even average energy consumption in the network. In here a new suboptimal design is proposed and compared with the CREEC design. The chain topology in CREEC is reconfigured after each group of n converge-casts with the goal of making the energy consumption along the new paths between the nodes in the chain as even as possible. The new method described in this paper designs a single near-optimal Hamiltonian circuit, used to obtain multiple chains having only the terminal nodes different at different converge-casts. The advantage of the new scheme is that for the whole life of the network most of the communication takes place between same pairs of nodes, therefore keeping topology reconfigurations at a minimum. The optimal scheduling of the communication between the network and base station in order to maximize network lifetime, given the chosen minimum length circuit, becomes a simple linear programming problem which needs to be solved only once, at the initialization stage. The maximum lifetime obtained when using any combination of chains is shown to be upper bounded by the solution of a suitable linear programming problem. The upper bounds show that the proposed method provides near-optimal solutions for several wireless sensor network parameter sets.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.9847-9851
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• 2014

Background: Multiple myeloma (MM) is a haematological cancer characterized by clonal proliferation of plasma cells.The aim of this study was to investigate the activity of serum paraoxonase-1 (PON1) and arylesterase (ARE) in multiple myeloma with and without free light chain excretion(FLCe-MM and NFLCe-MM); as well as to investigate possible alterations in oxidative stress parameters. Materials and Methods: Total thiol (T.thl), oxidative stress index (OSI), total oxidant status (TOS) and total antioxidant status (TAS) were examined in addition to the PON1 and ARE enzyme activities in twenty one FLCe-MM and nineteen NFLCe-MM subjects. Routine parameters like lipid panel, serum total protein, albumin, creatinine, blood urea nitrogen (BUN), uric acid and hemoglobin levels were compared with the oxidative stress markers. Results: Serum total protein, BUN, creatinin, and uric acid levels were significantly higher (p=0.04, p=0.001, p=0.001 and p=0.0022, respectively), while hemoglobin and albumin levels were significantly lower in FLCe-MM patients (p=0.009 and p=0.04,respectively). PON1 and ARE activities were significantly lower in patients with FLCe-MM compared to those with NFLCe-MM (p=0.001 and p=0.008, respectively). Conclusions: Depending on our results of prognostic markers of MM such as age, hemoglobin, albumin, and creatinine we feel confident to presume FLCe-MM as a subgroup with a worse prognosis. A decrease in PON1 and ARE activities may contribute to the prognosis and may be used as a prognostic tool in MM.

• Journal of the Korean Institute of Intelligent Systems
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• v.25 no.2
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• pp.186-190
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• 2015

Intelligent vehicle plans motion and navigate itself based on the surrounding environment perception. Hence, the precise environment recognition is an essential part of self-driving vehicle. There exist many vulnerable road users (e.g. vehicle, pedestrians) on vehicular driving environment, the vehicle must percept all the dynamic obstacles accurately for safety. In this paper, we propose an multiple vehicle tracking algorithm using microwave radar. Our proposed system includes various special features. First, exceptional radar measurement model for vehicle, concentrated on the corner, is described by mixture density network (MDN), and applied to particle filter weighting. Also, to conquer the curse of dimensionality of particle filter and estimate the time-varying number of multi-target states, reversible jump markov chain monte carlo (RJMCMC) is used to sampling step of the proposed algorithm. The robustness of the proposed algorithm is demonstrated through several computer simulations.

• Korean Journal of Microbiology
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• v.47 no.4
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• pp.328-334
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• 2011

Leucine zipper motif consists of multiple periodic leucine residues, which forms amphipathic alpha helix. The hydrophobic nature of leucine zipper motif can dimerize proteins which contain this motif. Leucine zipper motif addition at C-terminus of single-chain Fv (ScFv) antibody induces its dimerization. Since the dimeric ScFv antibody contains two antigen binding sites (bivalency) like Y-shaped complete antibody, it could increase avidity. As a result, it could show higher antigen binding activity than monomeric ScFv antibodies. Based on this concept, monomeric chicken 8C3 ScFv antibody previously developed from chicken hybridoma was dimerized by the addition of leucine zipper motif at C-terminus of ScFv antibody. The dimeric 8C3 ScFv antibody specifically reacted with Eimerian sporozoite which causes Avian Coccidiosis. As expected, dimeric 8C3 ScFv antibody showed 3-folds higher antigen binding activity than monomer due to increased avidity. In addition, protien yields of dimer expression were 2-folds higher than monomer.

• Bulletin of the Korean Chemical Society
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• v.35 no.9
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• pp.2679-2683
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• 2014

Mechanisms underlying the impacts of interactions between carbon nanoparticles (CNPs) and ionic liquids (ILs) on the physicochemical behavior of CNPs need to be more full worked out. This manuscript describes a theoretical investigation at multiple levels on the interactions of fullerene $C_{60}$ with 21 imidazolium-based ILs of varying alkyl side chain lengths and anionic types and their impacts on $C_{60}$ dispersion behavior. Results show that ${\pi}$-cation interaction contributed to mechanism of the $C_{60}$-IL interaction more than ${\pi}$-anion interaction. The calculated interaction energy ($E_{INT}$) indicates that $C_{60}$ can form stable complex with each IL molecule. Moreover, the direction of charge transfer occurred from IL to $C_{60}$ during the $C_{60}$-IL interaction. Quantitative models were developed to evaluate the self-diffusion coefficient of $C_{60}$ ($D_{fullerene}$) in bulk ILs. Three interpretative molecular descriptors (heat of formation, $E_{INT}$, and charge) that describe the $C_{60}$-IL interactions and the alkyl side chain length were found to be determinants affecting $D_{fullerene}$.

• Journal of Broadcast Engineering
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• v.25 no.2
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• pp.192-199
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• 2020

Recently, the utilization of the object tracking algorithm based on the deep learning model is increasing. A system for tracking multiple objects in an image is typically composed of a chain form of an object detection algorithm and an object tracking algorithm. However, chain-type systems composed of several modules require a high performance computing environment and have limitations in their application to actual applications. In this paper, we propose a method that enables real-time operation in low-performance computing environment by adjusting the computational process of object detection module in the object detection-tracking chain type system.

• Journal of Intelligence and Information Systems
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• v.9 no.1
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• pp.109-123
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• 2003

The relationship between suppliers and customers is treated importantly not only in the traditional business-to-business (BtoB) commerce but also in today's Internet environments. On the one hand, most of Internet-based BtoB commerce services like customer-centric e-procurement, supplier-centric e-sales or intermediary-centric e-marketplace focus mainly on the selection of partners according to bidding, auction, etc. This point may result in the problem of overlooking the relationships between suppliers and customers. To overcome this problem in this paper, an intelligent agents-based supply chain operation architecture is proposed and appraised considering the relationship and its adaptation.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.17 no.4
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• pp.336-345
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• 1992

In this paper, the performance evaluation on the throughput and the delay between station under the interconnected LANs environments is studied. The connection is formed through bridges. Interconnected system is modelled as single-chain and multiple-chain closed queueing networks. For performance enaluation the iteration algorithm, which is based on the MVA(Mean Value Analysis)is proposed, Various system parameters, such as chain population interconnected communication link capacity, and service times of several queues, are used for the investigation of their influence of the station to station performance, Transport and MAC layers are mainly taken into consideration for the layer modeling. The analysis is shown as a graph by computer programming.