Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Decreased HDL-Dependent Paraoxonase and Arylesterase Enzyme Activity May Indicate a Worse Prognosis in Multiple Myeloma

  • Ellidag, Hamit Yasar (Central Laboratories of Antalya Education and Research Hospital of Ministry of Health) ;
  • Aydin, Ozgur (Maternaty and Children's Hospital) ;
  • Eren, Esin (Turkey Department of Biochemistry, Ataturk Hospital) ;
  • Yilmaz, Necat (Central Laboratories of Antalya Education and Research Hospital of Ministry of Health) ;
  • Ergin, Merve (Ankara Ataturk Education and Research Hospital)
  • Published : 2014.12.18
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Multiple myeloma (MM) is a haematological cancer characterized by clonal proliferation of plasma cells.The aim of this study was to investigate the activity of serum paraoxonase-1 (PON1) and arylesterase (ARE) in multiple myeloma with and without free light chain excretion(FLCe-MM and NFLCe-MM); as well as to investigate possible alterations in oxidative stress parameters. Materials and Methods: Total thiol (T.thl), oxidative stress index (OSI), total oxidant status (TOS) and total antioxidant status (TAS) were examined in addition to the PON1 and ARE enzyme activities in twenty one FLCe-MM and nineteen NFLCe-MM subjects. Routine parameters like lipid panel, serum total protein, albumin, creatinine, blood urea nitrogen (BUN), uric acid and hemoglobin levels were compared with the oxidative stress markers. Results: Serum total protein, BUN, creatinin, and uric acid levels were significantly higher (p=0.04, p=0.001, p=0.001 and p=0.0022, respectively), while hemoglobin and albumin levels were significantly lower in FLCe-MM patients (p=0.009 and p=0.04,respectively). PON1 and ARE activities were significantly lower in patients with FLCe-MM compared to those with NFLCe-MM (p=0.001 and p=0.008, respectively). Conclusions: Depending on our results of prognostic markers of MM such as age, hemoglobin, albumin, and creatinine we feel confident to presume FLCe-MM as a subgroup with a worse prognosis. A decrease in PON1 and ARE activities may contribute to the prognosis and may be used as a prognostic tool in MM.

Keywords

References

  1. Aviram M, Rosenblat M, Bisgaier CL, et al (1998). Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. J Clin Invest, 101, 1581-90. https://doi.org/10.1172/JCI1649
  2. Ayub A, Mackness MI, Arrol S, et al (1999). Serum paraoxonase after myocardial infarction. Arterioscler Thromb Vasc Biol, 19, 330-5. https://doi.org/10.1161/01.ATV.19.2.330
  3. Basnayake K, Ying WZ, Wang PX, Sanders PW (2010). Immunoglobulin light chains activate tubular epithelial cells through redox signaling. J Am Soc Nephrol, 21, 1165-73. https://doi.org/10.1681/ASN.2009101089
  4. Batuman V, Dreisbach AW, Cyran J (1990). Light-chain binding sites on renal brush-border membranes. Am J Physiol, 258, 1259-65.
  5. Batuman V, Verroust PJ, Navar GL, et al (1998). Myeloma light chains are ligands for cubilin (gp280). Am J Physiol, 275, 246-54.
  6. Blade J, Teresa CM, Fernandez de LC, Rosinol L (2010). Multiple myeloma, (symposium article). Annals of Oncology, 21, 313-9.
  7. Dimopoulos MA, Kastritis E, Rosinol L, Blade J, Ludwig H (2008). Pathogenesis and treatment of renal failure in multiple myeloma. Leukemia, 22, 1485-93. https://doi.org/10.1038/leu.2008.131
  8. Durie BG, Salmon SE (1975). A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer, 36, 842-54. https://doi.org/10.1002/1097-0142(197509)36:3<842::AID-CNCR2820360303>3.0.CO;2-U
  9. Eckerson HW, Wyte MC, La Du BN (1983). The human serum paraoxonase/arylesterase polymorphism. Am J Hum Genet, 35, 1126-38.
  10. Ellidag HY, Bulbuller N, Eren E, et al (2013). Ischemia-modified albumin: could it be a new oxidative stress biomarker for colorectal carcinoma? Gut Liver, 7, 675-80. https://doi.org/10.5009/gnl.2013.7.6.675
  11. Ellidag HY, Eren E, Aydin O, et al (2013). Ischemia modified albumin levels and oxidative stress in patients with bladder cancer. Asian Pac J Cancer Prev,14, 2759-63. https://doi.org/10.7314/APJCP.2013.14.5.2759
  12. Ellman GL (1959). Tissue sulfhydryl groups. Arch Biochem Biophys, 82, 70-7. https://doi.org/10.1016/0003-9861(59)90090-6
  13. Erel O (2004). A novel automated direct measurement method for total antioxidant capacity using a new generationmore stable ABTS radical cation. Clin Biochem, 37, 277-85. https://doi.org/10.1016/j.clinbiochem.2003.11.015
  14. Erel O (2005). A new automated colorimetric method for measuring total oxidant status. Clin Biochem, 38, 1103-11. https://doi.org/10.1016/j.clinbiochem.2005.08.008
  15. Gan KN, Smolen A, Eckerson HW, La Du BN. Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities. Drug Metab Dispos, 19, 100-6.
  16. Geldmacher-von Mallinckrodt M, Diepgen TL, Duhme C, Hommel G (1983). A study of the polymorphism and ethnic distribution differences of human serum paraoxonase. Am J Phys Anthropol, 62, 235-41. https://doi.org/10.1002/ajpa.1330620302
  17. Greipp PR, San Miguel J, Durie BG, et al (2005). International staging system for multiple myeloma. J Clin Oncol, 23, 3412-20. https://doi.org/10.1200/JCO.2005.04.242
  18. Haagen L, Brock A (1992). A new automated method for phenotyping arylesterase (E.C.3.1.1.2.) based upon inhibition of enzymatic hydrolisis of 4-nitrophenyl acetate. Eur J Clin Chem Clin Biochem, 30, 391-5.
  19. Harma M, Harma M, Erel O (2003). Increased oxidative stress in patients with hydatidiform mole. Swiss MedWkly, 133, 563-6.
  20. Hu ML (1994). Measurement of protein thiol groups and glutathione in plasma, Methods Enzymol, 233, 380-5. https://doi.org/10.1016/S0076-6879(94)33044-1
  21. Jarad G, Miner JH (2009). Update on the glomerular filtration barrier. Curr Opin Nephrol Hypertens, 18, 226-32. https://doi.org/10.1097/MNH.0b013e3283296044
  22. Kyle RA, Therneau TM, Rajkumar SV, et al (2006). Prevalence of monoclonal gammopathy of undetermined significance. N Engl J Med, 354, 1362-69. https://doi.org/10.1056/NEJMoa054494
  23. Levey AS, Bosch JP, Lewis JB,et al (1999). A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. modification of diet in renal disease study group. Ann Intl Med, 130, 461-70. https://doi.org/10.7326/0003-4819-130-6-199903160-00002
  24. Li M, Hering-Smith KS, Simon EE, Batuman V (2008). Myeloma light chains induce epithelial-mesenchymal transition in human renal proximal tubule epithelial cells. Nephrol Dial Transplant, 23, 860-70.
  25. Lippi G, Montagnana M, Franchini M, Favaloro EJ, Targher G (2008). The paradoxical relationship between serum uric acid and cardiovascular disease. Clinica Chimica Acta, 3, 921-7.
  26. Mackness MI, Harty D, Bhatnagar D, et al (1991). Serum paraoxonase activity in familial hypercholesterolaemia and insulin-dependent diabetes mellitus. Atherosclerosis, 86, 193-9. https://doi.org/10.1016/0021-9150(91)90215-O
  27. Morigi M, Macconi D, Zoja C, et al (2002). Protein overload induced NF-${\kappa}B$ activation in proximal tubular cells requires HO through a PKC-dependent pathway. J Am Soc Nephrol, 13, 1179-89.
  28. Netea MG, Kullberg BJ, Blok WL, Netea RT, van der Meer JW (1997). The role of hyperuricemia in the increased cytokine production after lipopolysaccharide challenge in neutropenic mice. Blood, 89, 577-82.
  29. Sanders PW, Herrera GA, Chen A, Booker BB, Galla JH (1988). Differential nephrotoxicity of low molecular weight proteins including Bence Jones proteins in the perfused rat nephron in vivo. J Clin Invest, 82, 2086-96. https://doi.org/10.1172/JCI113830
  30. Sengul S, Zwizinski C, Batuman V (2003). Role of MAPK pathways in light chain induced cytokine production in human proximal tubule cells. Am J Physiol Renal Physiol, 284, 1245-54. https://doi.org/10.1152/ajprenal.00350.2002
  31. Sharma A, Tripathi M, Satyam A, Kumar L (2009). Study of antioxidant levels in patients with multiple myeloma. Leuk Lymphoma, 50, 809-15. https://doi.org/10.1080/10428190902802323
  32. Shi Y, Evans JE, Rock KL (2003). Molecular identification of a danger signal that alerts the immune system to dying cells. Nature, 425, 516-21. https://doi.org/10.1038/nature01991
  33. Strazzullo P, Puig JG (2007). Uric acid and oxidative stress: relative impact on cardiovascular risk? Nutr Metab Cardiovasc Dis, 17, 409-14. https://doi.org/10.1016/j.numecd.2007.02.011
  34. Stringer S, Basnayake K, Hutchison C, Cockwell P (2011). Recent advances in the pathogenesis and management of cast nephropathy (myeloma kidney), review article. Bone Marrow Res, 2011, 493697.
  35. von Meyenfeldt M (2005). Cancer-associated malnutrition: an introduction. Eur J Oncol Nurs, 9, 35-8. https://doi.org/10.1016/j.ejon.2005.09.001
  36. Wlodek L (2002). Beneficial and harmful effects of thiols. Pol J Pharmacol, 54, 215-23.
  37. Yilmaz N (2012). Relationship between paraoxonase and homocystein: crossroads of oxidative disease. Arch Med Sci, 8, 138-53.

Cited by

  1. A comparative study of the effects of endurance and resistance exercise training on PON1 and lipid profile levels in obese men vol.11, pp.3, 2015, https://doi.org/10.1007/s11332-015-0232-2
  2. Paraoxonase 1 (PON1) Q192R Gene Polymorphism and Cancer Risk: A Meta-Analysis Based on 30 Publications vol.16, pp.10, 2015, https://doi.org/10.7314/APJCP.2015.16.10.4457
  3. Assessment of serum thiol/disulfide homeostasis in multiple myeloma patients by a new method vol.22, pp.6, 2017, https://doi.org/10.1080/13510002.2016.1180100
  4. Copper and zinc in stage I multiple myeloma: relation with ceruloplasmin, lipid peroxidation, and superoxide dismutase activity vol.0, pp.0, 2018, https://doi.org/10.1515/hmbci-2018-0055