• Maxillofacial Plastic and Reconstructive Surgery
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• 제28권1호
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• pp.68-72
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• 2006

Mucoepidermoid carcinoma is one of the most common malignant salivary gland neoplasm. It occurs over a wide age range, and is most common in the parotid gland and usually appears as an asymptomatic swelling. Pain or facial nerve palsy may develop. Minor salivary gland tumors also typically appear as asymptomatic swellings, which are sometimes fluctuant and have blue or red color that can be mistaken clinically for a mucocele. Histopathologically the mucoepidermoid carcinoma is composed of a mixture of mucous-producing cells and squamous (epidermoid) cells. Low-grade tumors show prominent cyst formation, minimal cellular atypia, and relatively high proportion of mucous cells. Mucoepidermoid carcinoma of the minor salivary glands are treated usually by assured surgical excision. For low-grade neoplasm, only a modest margin of surrounding normal tissue may need to be removed, but high-grade or large tumors warrant wider resection. Postoperative radiation therapy also may be used for more aggressive tumors. Mucoepidermoid carcinoma of the oral minor salivary glands generally have a good prognosis, because they are mostly low-to intermediate grade tumors. We present a case of mucoepidermoid carcinoma managed with surgical enucleation and postoperative irradiation and a good clinical result with review of literatures.

• Applied Microscopy
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• 제42권4호
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• pp.186-193
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• 2012

The ultrastructure of the secretory granules of the submandibular gland was examined in the Korean spider shrew, Sorex caecutiens, lesser white-toothed shrew, Crocidura suaveolens and big white-toothed shrew, C. lasiura. The mucous and serous acinar granules of S. caecutiens with a border of the lucid corona differed from those of C. suaveolens and C. lasiurar with a dense lateral border. The mucous acinar granules of C. lasiura with several bands producing a variety of patterns in the matrix were similar to those of C. suaveolens. The serous acinar granules of C. lasiura had a homogenous pale center surrounded by minute dense specks or had an unusual substructure showing a geometric pattern according to the inclusions in the pale matrix of the granules. This is the first report of an unusual substructure showing a geometric pattern of the serous acinar granules of C. lasiura. The myelin-like body was observed in the granular duct cell of the three species of shrew. The myelin-like body of S. caecutiens with layers of unit membranes was different from that of C. suaveolens and C. lasiura with paired membranes. Therefore, the layers composing of the paired membranes of the myelin-like body might be one of the characteristics of Crocidura.

• 한국어류학회지
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• 제17권4호
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• pp.241-247
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• 2005

왕종개 Iksookimia longicorpa의 공기호흡에 관한 호흡체계를 조사하기 위해 표피 (epidermis)와 소화관 (intestinal tract)를 관찰하였다. 표피는 작은 점액세포 (mucous cell)와 곤봉세포 (club cell)로 이루어진 두 종류의 선세포 (gland cell)을 가진다. 점액세포는 대부분 acid sulfomucin으로 구성되었으나 곤봉상세포는 점액물질에 대한 어떠한 반응도 보이지 않았다. 기저층에는 작은 림파구를 포함하는 lymphocytes가 존재하며, 다량의 모세혈관이 기저층 바로 아래부분에 존해하고 있다. 장( intestinal tract)은 거의 일직선형태이며, 크게 장(intestine)과 직장(rectum)으로 구성된다. 이러한 장은 점액층 (mucosa), 점막하층 (laminal propria-submucosa), 근육층 (musculary), 장막 (serosa) 층으로 구성되었다. 이러한 장은 짧은 fold와 얇은 벽으로 구성되었으며, 점막층은 acid sulfomucin의 점액을 가지고 있다. 공기호흡하는 어류들의 변형된 공기호흡 기관의 특징들과 비교해 볼 때 왕종개는 하천의 가뭄으로 인해 용존산소가 부족할 경우 장에서는 이루어지지않고 표피에서만 공기를 흡입하는 것으로 생각된다.

• 한국어류학회지
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• 제11권2호
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• pp.109-116
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• 1999

한국산 미꾸리 Misgurnus anguillicaudatus의 피부 구조 및 조직화학적 특정을 조사하기 위해 등, 측면, 복부, 머리부분의 피부를 조사하였다. 미꾸리의 epidermis는 elongated mucous cell과 club cell의 2개의 gland로 구성되었으며 두께는 아주 두꺼웠다. mucous cell은 acid mucopolysaccharides의 물질을 분비하였으나 club cell은 mucopolysaccharides에 어떠한 반응도 보이지 않았다. 표피의 기저층은 림파구를 가지는 lymphocytic space가 발달하였으며 기저막과 상피세포사이에 배모양의 감각세포인 pit organ이 존재하였다. Dermis의 stratum laxum에는 acid mucopolysaccharides를 나타내는 부분(a definite area)이 존재하며, 이러한 물질은 비늘에도 분포하고 있다. 작은 비늘이 dermis속에 파 묻혀 있으나 머리부분에는 없다. 또한 많은 양의 모세혈관들이 기저막 바로 아래에 존재하였다. 피부의 이러한 특징들은 미꾸리가 공기를 이용하는 피부호흡과 밀접한 관계가 있다.

• Journal of Yeungnam Medical Science
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• 제38권2호
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• pp.169-174
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• 2021

Mucoepidermoid carcinoma (MEC) is the most common malignant neoplasm of the salivary gland, but primary thyroid MEC has rarely been reported and usually has a good prognosis. Herein, I report a case of thyroidal MEC with a poor prognosis in an 82-year-old woman with an anterior neck mass. Ultrasonography and computed tomography revealed a thyroid mass. The patient initially underwent fine-needle aspiration, was diagnosed with malignancy, and underwent a right lobectomy. On gross examination, a 4.0×3.6×2.6 cm-sized ill-defined, unencapsulated, and infiltrative tan to whitish mass with necrosis was identified. Microscopically, epidermoid tumor cell nests or solid sheets were identified. Mucous cells that were positive for periodic acid-Schiff and mucicarmine stains were also identified within epidermoid cell nests. Frequent mitosis and necrosis were observed. Immunohistochemical staining for p40 and p63 was positive, and that for thyroid transcription factor-1 and paired box gene 8 was focally positive. According to the Armed Forces Institute of Pathology grading system for salivary gland MEC, the current case was classified as high-grade MEC. After surgery, the patient suffered from dyspnea due to a remnant neck mass that compressed and obstructed the trachea; therefore, the patient refused further treatment. Thyroidal MECs are considered low-grade with a favorable prognosis, but there are several reported cases of thyroidal MEC with poor prognosis. The current case is a rare presentation of high-grade thyroidal MEC with a poor prognosis.

• 치과방사선
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• 제15권1호
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• pp.27-40
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• 1985

This study was undertaken to observe the histopathologic changes in salivary gland of the white rats when exposed to megavoltage fractionated dose of cobalt-60 irradiation and 78 female white rats, weighing approximately 180gm, were divided into control and 3 experimental groups. Irradiation on experimental groups was delivered by using 6000 curies MeV ALCYON cobalt-60 teletherapy unit with exposure rate 183 rads per minute, in source skin distance 80cm, 600 rads every 3 days. In experimental groups, Group Ⅰwas irradiated of total dose 1200 rads for a period of 6 days, Group Ⅱ was irradiated of total dose 2400 rads for a period of 12 days and Group Ⅲ was irradiated of total dose of 4800 rads for a period of 24 days. The animals were sacrificed serially at 3 hours, 6 hours, 10 hours, 1st day, 4th day, 7th day after each completion of irradiation exposure. At sacrifice, salivary glands were excised and examined microscopically and electromicroscopically. The results were as follows: 1. The acinar cells of parotid and submaxillary gland showed damage varied with dose, 1200 rads resulted in very mild injury while 4800 rads caused most extensive injury. 2. The acinar cells of parotid and submandibular gland showed similar ultrastructural alterations, appeared as pleomorphic nucleus, decreased numbers and pleomorphism of secretory granules, distention of rough endplasmic reticulum, expansion and pallor appearance of mitochondria, and hypertrophy of Golgi complex. 3. Parotid serous cells were the most sensitive components, displaying morphological alterations of radiation damage as early as 3 hours, followed by submandibular seromucinous cells and secretory tubular cells. 4. The mucous cells of sublingual gland, as well as the whole ductal lining cells of each salivary gland, displayed no significant alterations. No evidence of microvascular injury through whole experimental groups indicated that microvascular impairment does not contribute to early salivary gland injury.

• 대한소아치과학회지
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• 제27권2호
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• pp.216-221
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• 2000

점액낭종은 타액선의 분비도관이 외상, 타석, 반흔조직등에 의해 폐쇄되거나 파열되어 점액이 조직내로 유출 및 저류되어 발생하는 가성의 낭종으로, 이 중 하마종은 구강저에서 발생하는 점액낭종에 사용하는 용어이다. 염증에 이환되지 않았다면 대부분이 무통의 양상을 나타내며 심부에 위치할수록 정상색조를 띄게된다. 점액낭종의 치료는 주로 재발을 방지하기 위하여 인접소타액선을 포함한 완전절제를 시행하며, 병소의 크기가 큰 경우 부분절제를 시행하기도 한다. 하마종의 치료는 조대술과 완전절제술이 있으며, 조대술은 찾은 재발을 일으키는 단점이 있으나 치료가 성공적으로 시행되었을 경우, 환자에게 타액선이 제거되는 불편감을 덜 할 수 있다. 본 증례에서는 하순과 구강저에 발생한 점액낭종과 하마종을 완전절제술과 조대술로 치료하고 그 경과를 관찰한 바 술 후 재발이 관찰되지 않았고, 정상기능을 회복하였다 향후 치료부위의 재발여부에 대한 계속적인 관찰이 필요하리라 생각되며, 하마종의 치료시 조대술이 적절히 이용되었을 때 환아의 불필요한 타액선 절제를 피할 수 있다고 사료된다. 또한 점액낭종의 치료시, 병력과 임상적 특징을 바탕으로 한 정확한 감별진단과 적절한 치료법의 선택이 중요하다는 결론을 얻었다.

• 생명과학회지
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• 제8권5호
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• pp.509-519
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• 1998

발암물질인 NDMA 17m/kg을 경구 투여했을 때 흰쥐설 von Ebner선과 설 점액선의 glycoconjugates에 미치는 영향을 prelectin 조직화학법인 PAS반응, AB pH 2.5 염색법, AB pH 0.4 염색법, AB pH 2.5 -PAS 염색법, AF pH 1.7-AB pH 2.5 염색법 및 HID-AB pH 2.5 염색법으로 연구하였다. NDMA 투여군의 설 von Ebner선의 형태적인 주된 변화는 장액선포의 위축 및 파괴, 장액세포의 세포질 과립의 감소 및 소실, 세포질의 공포변성 그리고 도관상피세포의 점액화였으며 NDMA 투여후 12시간군부터 72시간군까지 현저하였다. NDMA 투여군의 설점액선의 주된 형태적 변화는 점액선포의 확장, 융합, 파괴 및 점액세포의 세포질의 과립 소실 및 공포변성, 도관상피의 점액화 등이었으며 NDMA 투여후 12시간군부터 72시간군까지 현저하였다. 설 von Ebner선의 neutral glycoconjugates가 대조군에 비해 NDMA 투여후 12시간군과 72시간군에서 현저히 감소되었으며 NDMA 투여후 96시간군후에 회복되는 경향을 나타내었다. 대조군에서 나타나지 않던 acidic glycoconju-gates가 NDMA 투여후 6시간군부터 48시간군, 그리고 120시간군에서 약간의 장액세포들에서 나타났다. 설 점액선의 neutral glycoconjugates와 acidic glycocon-jugates가 대조군에 비해 NDMA 투여후 3시간군, 24시간군, 48시간군에서 다같이 현저히 감소되었으며, 후자는 NDMA 투여후 72시간군에 아주 현저히 감소하였다. Aci-dic glycoconjugates중 sulfated glycoconjugates는 대조군에 비해 NDMA 투여후 감소하는 경향을 나타내며 NDMA 투여후 72시간군에 가장 현저한 감소를 나타내는데 비해 sialic glycoconjugates는 NDMA 투여후 3시간군, 12시간 군 및 48시간군에서 증가하는 경향을 나타내었다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제20권3호
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• pp.241-245
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• 1998

The plunging ranula or cervical ranula is amucous extravasation cyst of the sublingual gland. It is slightly common in females, shows no side preference, and is more prevalent in the second and third decades of life. It typically manifests as a painless, nonmobile swelling in the neck. The pathogenesis of plunging ranula is the discontinuities of the mylohyoid muscle in a position that would allow extravasation of sublingual gland mucin. The histologic appearance is characteristically of a cyst, devoid of epithelium or endothelium, with a vascular fibro-connective tissue wall containing some chronic inflammatory cells and macrophages stuffed with mucin. The correct diagnosis is essential for the most effective treatment, which is exicision of the sublingual gland. The plunging ranula must be differentiated clinically and histomorphologically from thyroglossal duct cyst, dermoid cyst, branchogenic cyst, lymphangioma, laryngocele, lipoma, hemangioma, cervial thymic cyst, cysts of the parathyroid or thyroid gland, lymphadenopathy, abscess, or tumor. We report a case and review the literatures, in our case, 23-year old man were diagnosis as plunging ranula after have been taken sialogam, MRI, etc. He underwent surgery via a cervical approach. The ranula reached the anterior neck by passing through a dehiscence in the mylohyoid muscle. A pseudocyst was extirpated. Although total sublingual gland excision was not performed, no recurrence was observed during 6 months follow-up periods.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제28권2호
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• pp.166-171
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• 2006

Mucoepidermoid carcinoma is a common salivary gland tumor. It comprised 8% of all salivary gland tumor and originated mainly in parotid gland. Central mucoepidermoid carcinoma is rare. It comprised $2{\sim}3%$ of all mucoepidermoid carcinoma, but it occurs in the mandible two or three times more frequently than in the maxilla. Central Mucoepidermoid carcinoma are frequently associated with an odontogenic cyst, such as dentigerous cyst, in which mucous goblet cell would have neoplastic transformation. In May 2002, a 25 year-old male visits in our clinic, presented with a progressive facial swelling after surgical tooth extraction of left mandibular third molar at 1999 in the army. After incisional biopsy, the lesion was confirmed as mucoepidermoid carcinoma so we performed tumor resection and reconstruction surgery of mandible.