• 대한치과의사협회지
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• 제48권6호
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• pp.436-442
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• 2010

Objective: Transmission of S. mutans, a major dental caries pathogen, occurs mainly during the first 2.5 years of age. Children appear to acquire S. mutans mostly from their mothers, but few studies have investigated preventive effect of xylitol to S. mutans transmission from mother to child. The aim of this study was to perform a follow-up evaluation the preventive effect of xylitol chewing gum of the S. mutans of children's oral cavities, which included the characteristics of vertical transmission from mother to child. Methods: The mothers voluntarily participating in a women's oral health prevention program were divided into two groups (a control and a xylitol group). The subjects were 20 mother-child pairs, who were monitored for 30 months. Xylitol chewing gum group had consumed 2 gum pellets, 3 times a day for 24 months, and then they were followed until 30 months. At baseline, 24 and 30 months whole stimulated saliva samples were collected from the mothers. Children were also recruited from 6 months to 30 months after birth and were collected their dental plaque samples. After isolation and identification, the analysis of the colony count, transmission electron microscopy and real-time RT-PCR were performed to analyze the characteristics of S. mutans. Results: The S. mutans counts decreased steadily in the xylitol group at 24 months, but increased at 30 months. The similar results were showed at their children. While the glucan synthesis was decreased at xylitol group both mother and child. The expression of gtfB, gtfD and ftf were significantly reduced in the xylitol group both mother and child (p<0.05). Conclusions: These findings indicate that chewing xylitol gum over a long period may decrease the expression of the genes associated virulence and reduced the glucan synthesis of S. mutans, which can result the preventing the mother-to-child transmission of S. mutans.

• 대한가정학회지
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• 제30권4호
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• pp.219-230
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• 1992

The purpose of this study is to investigate the intergenerational transmission of the family violence. The focus of the study is on the effect of the parental violent behavior on the child's aggression. For this purpose, 266 6th grade children in Seoul are classified into the two groups according to their aggression rated by their teachers. The results are as follow: 1. There are social class differences in the level of the child's aggression, experience of parent-to-child violence and parental marital violence. 2. Experiencing parent-to-child violence and parental marital violence greately affected the level of the child's aggression. The effects are greater for the children who observed parental marital violence than who experienced child violence. 3. Father-to-mother violence rather than mother-to-father violence affected the level of the child's aggression, especially for the boys.

• Clinical and Experimental Pediatrics
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• 제57권3호
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• pp.117-124
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• 2014

Purpose: Administration of antiretroviral drugs to mothers and infants significantly decreases mother-to-child human immunodeficiency virus (HIV) transmission; cesarean sections and discouraging breastfeeding further decreases this risk. The present study confirmed the HIV status of babies born to mothers infected with HIV and describes the characteristics of babies and mothers who received preventive treatment. Methods: This study retrospectively analyzed medical records of nine infants and their mothers positive for HIV who gave birth at Korea University Ansan Hospital, between June 1, 2003, and May 31, 2013. Maternal parameters, including HIV diagnosis date, CD4+ count, and HIV ribonucleic acid (RNA) copy number, were analyzed. Infant growth and development, HIV RNA copy number, and HIV antigen/antibody test results were analyzed. Results: Eight HIV-positive mothers delivered nine babies; all the infants received antiretroviral therapy. Three (37.5%) and five mothers (62.5%) were administered single- and multidrug therapy, respectively. Intravenous zidovudine was administered to four infants (50%) at birth. Breastfeeding was discouraged for all the infants. All the infants were negative for HIV, although two were lost to follow-up. Third trimester maternal viral copy numbers were less than 1,000 copies/mL with a median CD4+ count of $325{\mu}L$ ($92-729{\mu}L$). Among the nine infants, two were preterm (22.2%) and three had low birth weights (33.3%). Conclusion: This study concludes that prophylactic antiretroviral therapy, scheduled cesarean section, and prohibition of breastfeeding considerably decrease mother-to-child HIV transmission. Because the number of infants infected via mother-to-child transmission may be increasing, studies in additional regions using more variables are necessary.

• 대한가정학회지
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• 제44권6호
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• pp.141-153
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• 2006

This study examined the intergenerational transmission of family violence. The main focus of this study was on the effect of an experience of childhood violence and the witnessing of interparental violence on the future spouse and child violence. Two hundred and forty-two married couples and 50 married couples with indicted husbands and their wives were surveyed. The results showed that Husbands who had experienced childhood violence from their father and witnessed their father's violence towards their mother tended to inflict more physical violence on their wives than those who did not experience such events. Wives who witnessed violence between both parents' tended to receive more physical violence from their husbands than those who did not witness such events. In addition, wives who did not experience childhood violence but at the same time witnessed interparental violence tended to receive more physical violence from their husbands than those who did not witness such events. Husbands who experienced childhood violence from their mother and both parents and husbands who witnessed their father's violence toward their mother tended to be more violent towards their children than those who did not experience such events. Wives who experienced childhood violence from their mother and father and wives who witnessed violence between both parents tended to be more violent towards their children than those who did not experience such events. These results partially support that the transmission of family violence across generations and show the differential effects of gender and the violent parent's gender on family violence.

• 아동학회지
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• 제20권1호
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• pp.147-164
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• 1999

The purpose of this study was to investigate (1) intergenerational transmission from mother's internal working model of relationships formed in her childhood and infant's attachment patterns and (2) the associations among maternal working models, maternal sensitivity, and infant attachment patterns. The subjects were twenty 12- to 20-month-old infants and their mothers. The Adult Attachment Interview (1996) was used to assess mother's internal work model of relationships. Interviews were audio-recorded and transcribed verbatim. Each dyad was videotaped in the modified Ainsworth Strange Situation(1978) and filmed for 3 minutes in the Questionaire Situation of Smith and Pederson (1988). Mothers were classified as autonomous(F), dismissing(Ds), preoccupied(E), or unresolved/disorganized(Ud). Infants were classified as secure(B), insecure-avoidant(A), or insecure-resistant(C). Exact A/B/C/D and Ds/F/E/Ud agreement was observed in 55% of the dyads. Maternal sensitivity was related to infant attachment patterns but not to maternal working models.

• 한국환경보건학회:학술대회논문집
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• 한국환경보건학회 2004년도 International Conference Current Challenges and Advances in Environmental Health
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• pp.95-95
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• 2004

• 대한소아치과학회지
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• 제38권1호
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• pp.9-16
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• 2011

최근 우리와 다른 민족 또는 다른 문화적 배경을 가진 사람들이 포함된 다문화가정이 증가하였고 그들에 대한 사회적 관심이 증가하고 있으나, 우리는 아직 이들의 구강상태에 대한 기초적인 자료도 없는 실정이다. 본 연구는 부모가 모두 한국인인 가정과 다문화 가정에서, 어머니와 어린이의 구강 상태를 검사하고, polymerase chain reaction(PCR)을 이용하여 치아우식증의 주요 원인균인 Streptococcus mutans의 serotype 분포와 전이에 대한 실험을 통해 다음과 같은 결과를 얻었다. 1) 한국인 가정에서는, serotype c는 95%, serotype e, f, k는 10%의 비율로 나타났으며, 다문화가정을 대상으로 하였을 때에는 serotype c는 68.8%, serotype e는 31.25%, serotype f는 43.75%, serotype k는 18.8%의 비율로 나타났다. 2) 어머니와 어린이 둘 다 serotype이 확인된 경우, 92.86%에서 어머니와 어린이가 하나 이상의 같은 serotype을 포함하는 것으로 나타났다. 3) 한 가지 serotype만 나타난 경우보다 두 종류 이상의 serotype이 확인된 경우에서 평균 S. mutans level이 높게 나왔으나 통계적으로 유의한 차이는 없었다(p>0.05). 4) 우식 위험이 높다고 볼 수 있는 S. mutans level 2를 기준으로 비교하였을 때, 각 그룹 간에 우식 위험도는 통계적으로 유의한 차이가 없었다(p>0.05). 5) 그룹에 따른 serotype의 수, 우식 이환율, S. mutans level 간에는 유의한 상관관계가 없었다(p>0.05).

• 아동학회지
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• 제27권6호
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• pp.69-79
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• 2006

This study investigated intergenerational transmission from mother's attachment representation to infant's attachment pattern and the associations between maternal attachment representation and their childhood experiences. Subjects were forty 12- to 15-month-old infants and their mothers. The Adult Attachment Interview (Main & Goldwyn, 1984) was used to assess mother's attachment representation. The Strange Situation (Ainsworth, 1978) was used to classify infant's attachment relationship. Mothers were classified as autonomous (F), dismissing (Ds), preoccupied (E), or unresolved/disorganized (Ud). Infants were classified as secure (B), insecure-avoidant (A), insecure-resistant (C), or insecure-disorganized (D). Exact A/B/C/D and Ds/F/E/Ud agreement was observed in 30 of 40 dyads(75%). Maternal childhood experiences were related to maternal attachment representation.

• Journal of Korean Medical Science
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• 제33권47호
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• pp.296.1-296.7
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• 2018

Background: Antepartum, intrapartum, and postpartum preventive measures with antiretroviral drugs, appropriate delivery methods, and discouraging breastfeeding significantly decrease the risk of mother-to-child transmission of human immunodeficiency virus (HIV) infection. Herein, we investigated the pregnancy outcomes in HIV-infected Korean women. Methods: We retrospectively reviewed medical records of childbearing-age HIV-infected women between January 2005 and June 2017 at four tertiary care hospitals in Korea. Results: Among a total of 95 HIV infected women of child-bearing age with 587.61 years of follow-up duration, 15 HIV-infected women experienced 21 pregnancies and delivered 16 infants. The pregnancy rate was 3.57 per 100 patient-years. Among the 21 pregnancies, five ended with an induced abortion, and 16 with childbirth including two preterm deliveries at 24 and 35 weeks of gestation, respectively. The two preterm infants had low birth weight and one of them died 10 days after delivery due to respiratory failure. Among the 14 full-term infants, one infant was small for gestational age. There were no HIV-infected infants. Conclusion: The pregnancy rate of HIV-infected women in Korea is lower than that of the general population. Although several adverse pregnancy outcomes were observed, mother-to-child transmission of HIV infection was successfully prevented with effective preventive measures.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제32권1호
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• pp.28-34
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• 2021

Objectives: This study aimed to examine the effect of maternal adverse childhood experiences (ACEs) on the attention-deficit/hyperactivity disorder (ADHD) symptoms in the offspring and to examine the mediating role of antepartum health risk on the intergenerational transmission of maternal ACEs. Methods: The participants consisted of 461 mother-child dyads. Mothers completed the ACEs questionnaire and Diagnostic Predictive Scales. Multivariate logistic regression analysis was used to estimate the risk of ADHD symptoms in the offspring of mothers with ACEs and the mediating effect of antepartum health risks by path analysis. Results: In all, 35.4% (n=163) had at least one maternal ACE, and 11.1% (n=51) had three or more. Compared to the non-ADHD symptom group, the group of offspring with ADHD symptoms showed a significant association with maternal ACE score (p<0.001) and antepartum health risks (p<0.001). Multivariate analysis further showed a significant association between the sum of maternal ACEs [odds ratio (OR)=1.264, 95% confidence interval (CI)= 1.060-1.516, p=0.009], antepartum health risks (OR=1.236, 95% CI=1.036-1.475, p=0.019), and ADHD symptoms in the offspring. In the mediation model in which the mother's ACE score affected the offspring's ADHD symptoms, partial mediation through antepartum health risks was found to be significant (B=0.041, 95% CI=0.011-0.124). Conclusion: Maternal ACEs are significantly related to the incidence of ADHD symptoms in the offspring and antepartum health risks exert an indirect effect. These findings suggest that maternal ACEs have a negative impact on the offspring's brain development through intergenerational transmission, resulting in neurodevelopmental disorders such as ADHD.