Journal of Korean Medical Science

Korean Acad Medical Sciences (대한의학회)
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Pregnancy Rates and Outcomes of HIV-Infected Women in Korea

  • Choi, Heun (Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine) ;
  • Kim, Moo Hyun (Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine) ;
  • Lee, Se Ju (Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine) ;
  • Kim, Eun Jin (Department of Infectious Diseases, Ajou University School of Medicine) ;
  • Lee, Woonji (Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine) ;
  • Jeong, Wooyong (Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine) ;
  • Jung, In Young (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Ahn, Jin Young (Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine) ;
  • Jeong, Su Jin (Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine) ;
  • Ku, Nam Su (Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine) ;
  • Baek, Ji Hyeon (Department of Internal Medicine, Inha University School of Medicine) ;
  • Choi, Young Hwa (Department of Infectious Diseases, Ajou University School of Medicine) ;
  • Kim, Hyo Youl (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Kim, June Myung (Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine) ;
  • Choi, Jun Yong (Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine)
  • Received : 2018.04.09
  • Accepted : 2018.08.16
  • Published : 2018.11.19
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Abstract

Background: Antepartum, intrapartum, and postpartum preventive measures with antiretroviral drugs, appropriate delivery methods, and discouraging breastfeeding significantly decrease the risk of mother-to-child transmission of human immunodeficiency virus (HIV) infection. Herein, we investigated the pregnancy outcomes in HIV-infected Korean women. Methods: We retrospectively reviewed medical records of childbearing-age HIV-infected women between January 2005 and June 2017 at four tertiary care hospitals in Korea. Results: Among a total of 95 HIV infected women of child-bearing age with 587.61 years of follow-up duration, 15 HIV-infected women experienced 21 pregnancies and delivered 16 infants. The pregnancy rate was 3.57 per 100 patient-years. Among the 21 pregnancies, five ended with an induced abortion, and 16 with childbirth including two preterm deliveries at 24 and 35 weeks of gestation, respectively. The two preterm infants had low birth weight and one of them died 10 days after delivery due to respiratory failure. Among the 14 full-term infants, one infant was small for gestational age. There were no HIV-infected infants. Conclusion: The pregnancy rate of HIV-infected women in Korea is lower than that of the general population. Although several adverse pregnancy outcomes were observed, mother-to-child transmission of HIV infection was successfully prevented with effective preventive measures.

Keywords

Acknowledgement

Supported by : Ministry of Science, ICT, and Future Planning of Korea, Ministry of Health & Welfare, Yonsei University College of Medicine, National Research Foundation of Korea (NRF)

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