• 한국임상약학회지
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• 제22권3호
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• pp.228-233
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• 2012

Purpose: The purpose of this study was to elucidate the effect of dissolved oxygen in alcohol to blood pressure of healthy persons. Methods: Subjects (n=30) were randomized in a double blind crossover study to receive 120 mL, 240 mL, 360 mL of alcohol (Korean spirit, 19.59 v/v%, dissolved oxygen is 8 ppm and 20 ppm). Blood alcohol concentration (BAC) and blood pressure were measured applying Lion SD-400 Alcolmeter$^{(R)}$ Breathalyser and Tensoval duo control. Pharmacokinetic parameters ($C_{max}$, $T_{max}$, $AUC_{last}$, $K_{el}$, $V_d$, Clearance) were calculated using Winnonlin$^{(R)}$ program. The difference of parameters and values were analysed by student t-test using Microsoft$^{(R)}$ Excel program. Results: The $AUC_{last}$ values of 8 ppm group and 20 ppm group in 240 ml administration were $6.15{\pm}2.60cg{\cdot}min/ml$, $5.33{\pm}1.84cg{\cdot}min/ml$ (p<0.05) and those in 360 mL were $11.93{\pm}5.70cg{\cdot}min/ml$, $10.33{\pm}4.60cg{\cdot}min/ml$ (p < 0.01), respectively. Thus, the $AUC_{last}$ was significantly decreased. On the other hands, there was a significant change in systolic blood pressure (SBP) after alcohol administration. All measured value after 360 mL of alcohol administration was significantly decreased (p < 0.01). Conclusions: The dissolved oxygen in alcoholic beverage has no effect on blood pressures but the alcohol administration has an effect on blood pressure. Thus, SBP can be used as a biomarker of alcohol administration and utilized in PK/PD modeling of alcohol.

• 콘크리트학회논문집
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• 제28권1호
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• pp.23-31
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• 2016

수축 균열의 저감 대책으로서 팽창재를 적용한 콘크리트의 모델화에 관한 연구로서 선행하여 구축한 모델을 바탕으로 팽창재에 의한 콘크리트의 수축저감 및 균열억제 효과에 대한 매크로 예측 수법을 제안하고 타당성을 검증했다. 또한, 모델의 적용을 실부재로 확장해, 실부재에 발생하는 변형을 예측하는 한편, 실부재에 발생하는 응력을 예측하여, 기존의 방법에 따른 결과와 비교 검토함으로서 본 연구에서 제안하는 모델의 타당성을 검증했다. 본 연구로부터 실시한 팽창재를 혼입한 콘크리트에 대한 이론적인 모델의 검토로부터 팽창콘크리트의 실구조물 레벨로의 검토와 함께 수축저감 및 균열억제 효과에 대한 매크로 예측수법의 제안은 향후, 팽창콘크리트의 적용 및 실용화에 있어, 실증적인 데이터를 제공할 수 있다고 생각한다.

• 한국의류산업학회지
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• 제18권4호
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• pp.457-467
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• 2016

This study aimed to develop functional underwear for elderly women in their sixties in terms of good fit, wear comfort and body temperature regulation. To satisfy elderly women's physical and metabolical needs, an automatic temperature control system via PCM treatment was applied. Underwear pattern was produced by producing body surface replica, which was derived from 3D body parametric model. Differential ratios of outline length and area between 3D surface and 2D plane were 1.4% and 0.5%, respectively. The reduction rate was determined as 10% through the expert's evaluation. PCM treated fabric showed higher Q-max, meaning that it can facilitate the thermal transition in hot situation. Moreover, it also showed higher insulation to preserve heat and keep warm microclimate in a cold weather. Heat distribution measurements on various body parts revealed that the temperature after PCM treatment was significantly higher. The clothing pressure after 10% pattern reduction showed higher before reduction, at the same time, even lower than the comfort clothing pressure range of $5{\sim}10gf/cm^2$, implying that experimental garment of this research is acceptable in terms of clothing pressure. Evaluation results on the comfort to move in various motions proved that adequate clothing pressure improved the wear comfort in various motions.

• 컴퓨터교육학회논문지
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• 제14권1호
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• pp.23-33
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• 2011

본 연구는 사이버 폭력에 영향을 미치는 변인들 간의 구조관계를 규명하기 위해 진행되었다. 문헌연구를 토대로 조절의지, 사회적 정체성, 규범의식을 사이버 폭력에 영향을 미치는 변인으로 설정하고, 인터넷의 주요한 속성인 익명성이 이러한 변인들과 사이버폭력 행위에 미치는 영향을 분석하였다. 모델의 검증은 AMOS 6.0을 통해 분석하였으며, 모델적합도는 ${\chi}^2$값, RMSEA, CFI, NNFI를 통해 평가하였다. 분석결과, 정체성, 규범의식은 사이버 폭력에 직접적인 원인으로 나타났다. 익명상황은 사이버 폭력과 직접적으로 영향관계는 없었으나 정체성과 규범의식에 영향을 미침으로 사이버 폭력에 간접적으로 영향을 미치는 것으로 나타났다. 즉, 익명상황은 정체성을 왜곡시키고 규범의식을 떨어뜨리는 원인이며, 이로 인해 사이버 폭력 행위가 유발되는 것으로 예측되었다.

• 대한디지털의료영상학회논문지
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• 제11권2호
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• pp.85-92
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• 2009

This study, "The study about performance evaluations of mobile cover for X-ray's diffusion and distribution in mobile radiation" is based on the rules of mobile defense apparatus for radiation producer in 2006. To use the mobile cover for X-ray for diagnosis has been compulsory in common wards except operation rooms, emergency rooms and intensive care units. we have confirmed the effect in arbitrary shielding material after Qualitiy Control was carried out for accuracy in an experiment of mobile photographing equipment. The performance evaluation was conducted with the fabrics of selenium, 0.2 mmPb, 0.1 mmPb and aluminiums. Considering the result, we choosed 0.1 mmPb and attached cover to mobile photographing equipment. We have finished making the cover after drew up the draft to attach cover to mobile photographing equipment through the modeling and the structural analysis. the process of the study is that we assembled the manufactured structures and carried out the practical experiment to take the photograph after attaching the fabric of 0.1 mmPb to mobile photographing equipment. It is need of additional thesises hereafter that we compare the result between the part to improve for safety besides convenience in photographic experiment about clinical radiation and the effect of covering the diffusion in condition attached the cover.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2000년도 제15차 학술회의논문집
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• pp.395-395
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• 2000

Optimization of existing processes becomes more important than the past as environmental problems and concerns about energy savings stand out. When we can model a process mathematically, we can easily optimize it by using the model as constraints. However, modeling is very difficult for most chemical processes as they include numerous units together with their correlation and we can hardly obtain parameters. Therefore, optimization that is based on the process models is, in turn, hard to perform. Especially, f3r unknown processes, such as bioprocess or microelectronics materials process, optimization using mathematical model (first principle model) is nearly impossible, as we cannot understand the inside mechanism. Consequently, we propose a few optimization method using empirical model evolutionarily instead of mathematical model. In this method, firstly, designing experiments is executed fur removing unecessary experiments. D-optimal DOE is the most developed one among DOEs. It calculates design points so as to minimize the parameters variances of empirical model. Experiments must be performed in order to see the causation between input variables and output variables as only correlation structure can be detected in historical data. And then, using data generated by experiments, empirical model, i.e. response surface is built by PLS or MLR. Now, as process model is constructed, it is used as objective function for optimization. As the optimum point is a local one. above procedures are repeated while moving to a new experiment region fur finding the global optimum point. As a result of application to the pulp digester benchmark model, kappa number that is an indication fur impurity contents decreased to very low value, 3.0394 from 29.7091. From the result, we can see that the proposed methodology has sufficient good performance fur optimization, and is also applicable to real processes.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1998년도 추계학술대회
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• pp.249-250
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• 1998

In this study, we modeled moving-actuator type Total Artificial Heart (TAH) with cardiovascular system as a form of electric circuit. The bronchial circulation, important for the imbalance between the left cardiac output and the right one, was considered and added to the model. In the model, the relations of hemodynamic variables, just as blood pressures, volumes, or flow rates of each part of body, can be expressed as simultaneous first order ordinary differential equations. To solve the equations by the numerical analysis, Runge-Kutta forth order approximation method was adopted. The simulation software (SimTAH), implemented in C++ as a window-based application program, was developed to display the hemodynamic variables and to receive control inputs from users. SimTAH was evaluated by comparison of the simulation results with the results of mock-circulation tests, in vitro.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2006년도 춘계학술대회 논문집
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• pp.321-322
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• 2006

In many manufacturing processes such as web formation, manufacturing of paper and nonwoven, fabric weaving, etc., planar sheets are transported and at the same time appropriate tension is imposed. The input material rolled up on beams is fed by unwinding the beam and the processed is then taken up on beams by winding it. While processed, the planar sheets are thrown under the processing load of impulse form, which causes irregular thickness of the processed sheet. To improve the quality of the product, a dynamic model is needed and the dynamic characteristics is to be analyzed by simulation. This study shows that density variation dynamics of the in-process-sheet in the machine direction can be described at each moment of disturbing impacts in forms of difference equations, while the impacts and tension, the time-dependency of the material properties were taken into account. Simulation showed the most serious variation of the density occurred in the process starting phase. The starting velocity curve with step form showed the least variation of the density. As the time order of the function of the starting velocity cure becomes higher, the density variation gets greater.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2013년도 추계학술대회
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• pp.737-740
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• 2013

오래 전부터 홈 네트워크 컴퓨팅을 위하여 많은 스마트 홈 생활기기의 개발과 함께 지능형 개인화 서비스 연구가 진행되어왔다. 그러나 실제 일상생활에서는 이미 구매한 생활기기의 긴 수명주기 때문에 건축물 신축 시 스마트 생활기기 및 관련 시스템이 설치되지 않으면 사용자는 홈네트워킹을 위한 지능형 개인화 서비스를 이용하는데 어려움이 있다. 따라서 기존(legacy) 생활기기를 사용하면서 지능형 개인화 서비스를 이용하기위해 가전기기에 부착시킬 수 있는 인에이블러(enabler)를 사용한다. 다양한 센서가 내장되어 있는 인에이블러는 각 센서로부터 취득한 데이터들을 사물웹 게이트 웨이로 전달하며 게이트웨이는 사용자의 간섭 없이 입력받은 정보를 통하여 사용자의 상황을 명확하게 파악하여 필요한 서비스를 제공한다. 이에 본 논문에서는 인에이블러의 센서를 활용하여 사용자의 다양한 상황을 자동으로 추론하여 실시간으로 적합한 서비스를 제공할 수 있는 상황인지 온톨로지 모델을 제시한다.

• Journal of Ginseng Research
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• 제39권4호
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• pp.406-413
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• 2015

Background: Pathogenesis-related 10 (PR-10) proteins are small, cytosolic proteins with a similar three-dimensional structure. Crystal structures for several PR-10 homologs have similar overall folding patterns, with an unusually large internal cavity that is a binding site for biologically important molecules. Although structural information on PR-10 proteins is substantial, understanding of their biological function remains limited. Here, we showed that one of the PgPR-10 homologs, PgPR-10.3, shares binding properties with flavonoids, kinetin, emodin, deoxycholic acid, and ginsenoside Re (1 of the steroid glycosides). Methods: Gene expression patterns of PgPR-10.3 were analyzed by quantitative real-time PCR. The three-dimensional structure of PgPR-10 proteins was visualized by homology modeling, and docking to retrieve biologically active molecules was performed using AutoDock4 program. Results: Transcript levels of PgPR-10.3 expressed in leaves, stems, and roots of 3-wk-old ginseng plantlets were on average 86-fold lower than those of PgPR-10.2. In mature 2-yr-old ginseng plants, the mRNA of PgPR-10.3 is restricted to leaves. Ginsenoside Re production is especially prominent in leaves of Panax ginseng Meyer, and the binding property of PgPR-10.3 with ginsenoside Re suggests that this protein has an important role in the control of secondary metabolism. Conclusion: Although ginseng PR-10.3 gene is expressed in all organs of 3-wk-old plantlets, its expression is restricted to leaves in mature 2-yr-old ginseng plants. The putative binding property of PgPR-10.3 with Re is intriguing. Further verification of binding affinity with other biologically important molecules in the large hydrophobic cavity of PgPR-10.3 may provide an insight into the biological features of PR-10 proteins.