• Asian Pacific Journal of Cancer Prevention
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• v.15 no.9
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• pp.3973-3980
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• 2014

Prostate adenocarcinoma is one of the leading causes of cancer related mortality in men but still limited knowledge is available about its associated functional SNPs including rs1042522 (Pro72Arg). The present study was undertaken to explore the association of this SNP with susceptibility to prostate adenocarcinoma along with its structural and functional impacts in the Pakistani population in a case-control study. Three-dimensional structure of human TP53 with Pro72Arg polymorphism was predicted through homology modeling, refined and validated for detailed structure-based assessment. We also carried out a HuGE review of the previous available data for this polymorphism. Different genetic models were used to evaluate the genotypes association with the increased risk of PCa (Allelic contrast: OR=0.0.34, 95%CI 0.24-0.50, p=0.000; GG vs CC: OR=0.17, 95%CI 0.08-0.38, p=0.000; Homozygous: OR=0.08, 95%CI 0.04-0.15, p=0.000; GC vs CC: OR=2.14, 95%CI 1.01-4.51, p=0.046; Recessive model: OR=0.10, 95%CI 0.05-0.18, p=0.000; Log Additive: OR=3.54, 95%CI 2.13-5.89, p=0.000) except the Dominant model (OR=0.77, 95%CI 0.39-1.52, p=0.46). Structure and functional analysis revealed that the SNP in the proline rich domain is responsible for interaction with HRMT1L2 and WWOX. In conclusion, it was observed that the Arg coding G allele is highly associated with increased risk of prostate adenocarcinoma in the Pakistani population (p=0.000).

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.1
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• pp.137-147
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• 2013

It is essential to understand the hydraulic characteristics of rivers for increasing flood-control capacity and operating hydraulic structures efficiently. Multi-dimensional models can be the proper measures to obtain the detailed information on the hydraulic characteristics of rivers. But huge amount of data and time-consuming work have been the obstacle for applying multi-dimensional models. In this study, simulation technique with multi-dimensional model(EFDC), coupled with COSFIM and FLDWAV, has been developed and applied to the real river system for verification. Developed technique can offers spatial and grid unit information as well as line and section unit information from 1-D modeling. It is considered that the coupling simulation technique can provide useful hydraulic information for river management and treatment.

• Advances in aircraft and spacecraft science
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• v.3 no.4
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• pp.427-445
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• 2016

Star sensors are the attitude estimation sensors of the satellite orbiting in its path. It gives information to the control station on the earth about where the satellite is heading towards. It captures the images of a predetermined reference star. By comparing this image with that of the one captured from the earth, exact position of the satellite is determined. In the process of imaging, stray lights are eliminated from reaching the optic lens by the mechanical enclosures of the star sensors called Baffles. Research in space domain in the last few years is mainly focused on increased payload capacity and reduction in launch cost. In this paper, a star sensor baffle made of Aluminium is considered for the study. In order to minimize the component weight, material wastage and to improve the structural performance, an alternate material to Aluminium is investigated. Carbon Fiber Reinforced Polymer is found to be a better substitute in this regard. Design optimisation studies are carried out by adopting suitable design modifications like implementing an additional L-shaped flange, Upward flange projections, downward flange projections etc. A better configuration of the baffle, satisfying the design requirements and achieving manufacturing feasibility is attained. Geometrical modeling of the baffle is done by using UNIGRAPHICS-Nx7.5(R). Structural behavior of the baffle is analysed by FE analysis such as normal mode analysis, linear static analysis, and linear buckling analysis using MSC/PATRAN(R), MSC-NASTRAN(R) as the solver to validate the stiffness, strength and stability requirements respectively. Effect of the layup sequence and the fiber orientation angle of the composite layup on the stiffness are also studied.

• International Commerce and Information Review
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• v.17 no.3
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• pp.29-57
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• 2015

The purpose of this study is to find the factors of Social Network Games of continuous game flow and addiction. This study analyzes the significant factors of the addiction of SNGs from three categories. It also seeks to find out what relation between continuous game flow and addiction in SNGs. The model consists of three categories (SNG characteristic, User characteristic, and Environmental characteristic). The research model was conducted through the structural equation modeling(SEM) approach, and tested using 374 questionnaires. The results indicated that SNG characteristic(accessibility, enjoyment, feedback), User characteristic(self-control), Environmental characteristic(social interaction, subjective norm) have a positive effect on continuous game flow. The findings also that continuous game flow plays a moderation role that affects addiction. Finally, we discussed the research results and offered relevant suggestions for schools, firms, and future studies

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.3D
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• pp.259-267
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• 2012

The development of construction automation systems is proposed as a potent solution to the difficulties encountered by the construction industry and the preparation for the rapidly changing construction environment. A research concerning an intelligent excavation system has taken place since 2006. The intelligent excavation system has several functions for environment sensing, 3D site modeling, work planning, work path generation, unmaned control, and information management. This paper presents a space information model and a work path simulator for work planning and work path generation which is one of key technologies required to apply the earthwork system to the real world. A data structure for an earthwork site is suggested. It overcomes the limitations of previous data structures such as Quadtree and Octree. The work path simulator can generate an effective work path with considering information on work environment, equipment and operator's heuristic. The work path generated by the simulator is compared with that suggested by human operators.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.14 no.10
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• pp.2223-2229
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• 2010

The integrity monitoring of anomalous GPS signal have been researched because of the degradation of GPS satellite performance. It is known that anomalous GPS signal can occur by failure of GPS satellite, sudden increase of ionosphere delay error, SA, wrong modeling for navigation parameters from control segment, and an electromagnetic wave interference, etc. In case of GPS anomaly by satellites can arise from carrier frequency, code and navigation message. In this paper, the scenarios with navigation message errors were made by using GPS simulator, and the influences of GPS navigation message error to receiver were analysed. The anomalies of preamble, bits related TOW count message, subframe ID in HOW, bits related satellite healthy, and the other navigation message errors were described and simulated. Also, the number of satellites, DOP and pseudorange are analyzed to know how the anomalous signal can affect on GPS receiver.

• The Journal of the Korea Contents Association
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• v.20 no.9
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• pp.558-576
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• 2020

The purpose of the research was to verify the mediating effect of social support and cognitive emotional regulation strategy when office worker's emotional expressive ambivalence influences on interpersonal stress. A survey was conducted with 422 office workers from August to September of 2018. SPSS, AMOS and Mplus were used for descriptive statistics, correlation analysis, verification of structural equation modeling and mediated effect. There was a partial mediating effect in emotional expressive ambivalence of self-defense model, a complete mediating effect in relational emotional expressive ambivalence model. In both self-defense and relational emotional expressive ambivalence model, double mediation effect of passing through support and cognitive emotional regulation strategy in the relationship between emotional expressive ambivalence and interpersonal stress was significant. This study sought ways to reduce interpersonal stress by increasing the level of perception of social support and using adaptive cognitive emotional control strategies for office workers.

• Informatization Policy
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• v.22 no.3
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• pp.36-46
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• 2015

This study verified theoretical model to explain adolescents' addictive use of smartphone. I used the data of 679 middle and high school students among 2013 internet addiction survey of National Information Society Agency(NIA). This study utilized structural equation modeling analysis to compare a suggestive model and alternative model. According to the final model, higher the satisfaction of family relationship, the addictive use of smartphone and emotional problems of adolescents were reduced. And, higher the addictive use of smartphone, higher the emotional problems of adolescents. Also, family relationship affects emotional problems via addictive use of smartphone. While, in the alternative model, path from amount of smartphone use to addictive use of smartphone was not significant. Results of this study suggest that family relationship variable may play an antecedent factor of addictive use of smartphone and emotional problems of adolescents and control of smartphone use is important to keeping a mental health of adolescents.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.23 no.12
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• pp.1096-1102
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• 2013

The useful practical land shall be reserved when an artificial land covers the railway and road. However, the problem is that since the artificial land places directly on the top of noise sources likely on the railway and road there will arise the weak points, noise and vibration. On this study based on creating the artificial land on the top of a railway vehicle base and placing a tenement on that land, it was comprehended the noise influence from the railway car through the simulation. In order to secure the input value for the simulation, at first measured the noise condition of the railway station building and the railway vehicle base. The output value for the railway station building (place A) was around (53.6~57.6) dB(A), the equivalent continuous sound level for an hour, and for the railway station building (place B) it was around (63.7~68.9) dB. The maximum outdoor noise of the tenement on the artificial land was measured as 64.1 dB(A) under the fixed condition on the simulation modeling. The built purpose of placing the artificial land to prevent the noise influence from the railway met the expectation to be less influenced on the tenement. Rather, because of placing the artificial land the noise level on the lower space could be increased so there requires having a noise control.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.24 no.10 s.181
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• pp.2552-2559
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• 2000

Most of ferrous b.c.c weld materials have martensitic transformation during rapid cooling after welding. It is well known that volume expansion due to the phase transformation could influence on the relaxation of welding residual stress. To apply this effect practically, it is necessary to establish a numerical model which is able to estimate the effect of phase transformation on residual stress relaxation quantitatively. For this purpose, the analysis is carried out in two regions, i.e., heating and cooling, because the variation of material properties following a phase transformation in cooling is different in comparison with the case in heating, even at the same temperature. The variation of material properties following phase transformation is considered by the adjustment of specific heat and thermal expansion coefficient, and the distribution of residual stress in analysis is compared with that of experiment by previous study. In this study, simplified numerical procedures considering phase transformation, which based on a commercial finite element package was established through comparing with the experimental data of residual stress distribution by other researcher. To consider the phase transformation effect on residual stress relaxation, the transition of mechanical and thermal property such as thermal expansion coefficient and specific heat capacity was found by try and error method in this analysis. In addition to, since the transformation temperature changes by the kind and control of alloying elements, the steel with many kinds of transformation temperature were selected and the effect of transformation on stress releasement was investigated by the numerical procedures considering phase transformation.