• Bulletin of the Korean Chemical Society
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• v.22 no.1
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• pp.17-18
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• 2001

• Journal of Aquaculture
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• v.19 no.1
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• pp.33-39
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• 2006

Anticoagulant activities of a fermented edible brown alga, Laminaria ochotensis was investigated. L. ochotensis was fermented with 15% sugar (w/v) at $25^{\circ}C$ for 10 weeks. Anticoagulant activity was measured from the supernatant of algal mixture at biweekly intervals up to $10^{th}$ week by activated partial thromboplastin (APTT), prothrombin time (PT) and thrombin time (TT) assay using citrated human plasma. Sample having high APTT activity $(6^{th}\;week)$ was filtered, ethanol precipitated and freeze-dried. The polysaccharide compound having anticoagulant activity was purified by DEAE ion exchange chromatography followed by Sepharose-4B gel filtration chromatography. Anticoagulant activity, polysaccharide concentration, and heparin like activity were determined for the collected fractions by APTT, $phenol-H_2SO_4$, and glycosaminoglycan assay, respectively. The anticoagulant activity assay showed that the activity was increased up to $6^{th}$ week, and decreased thereafter. The concentration of our purified compound was $31.0{\mu}g/ml$ and showed higher APTT activity than commercial heparin. At the same concentration of $31.0{\mu}g/ml$, the heparin showed 186.5 sec activity while our purified compound showed an activity of 386 sec. Single spot on agarose gel electrophoresis showed that the compound was purified and polyacrylamide gel electrophoresis (PAGE) results revealed that the molecular mass of the purified polysaccharide compound was between 60 and 500 kDa. Therapeutic interest of the algal polysaccharide as an anticoagulant has recently been in highlighted. This purified anticoagulant compound from fermented L. ochotensis can be used as a model for anticoagulant agent or could be developed as an anticoagulant agent. This study can be extended to identify the structure and chemical composition of the purified polysaccharide, and to establish a relationship between structure and the function of the identified anticoagulant compounds.

• Journal of Communications and Networks
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• v.12 no.5
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• pp.411-432
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• 2010

We consider three different secure broadcasting scenarios: i) Broadcast channels with common and confidential messages (BCC), ii) multi-receiver wiretap channels with public and confidential messages, and iii) compound wiretap channels. The BCC is a broadcast channel with two users, where in addition to the common message sent to both users, a private message, which needs to be kept hidden as much as possible from the other user, is sent to each user. In this model, each user treats the other user as an eavesdropper. The multi-receiver wiretap channel is a broadcast channel with two legitimate users and an external eavesdropper, where the transmitter sends a pair of public and confidential messages to each legitimate user. Although there is no secrecy concern about the public messages, the confidential messages need to be kept perfectly secret from the eavesdropper. The compound wiretap channel is a compound broadcast channel with a group of legitimate users and a group of eavesdroppers. In this model, the transmitter sends a common confidential message to the legitimate users, and this confidential message needs to be kept perfectly secret from all eavesdroppers. In this paper, we provide a survey of the existing information-theoretic results for these three forms of secure broadcasting problems, with a closer look at the Gaussian multiple-input multiple-output (MIMO) channel models. We also present the existing results for the more general discrete memoryless channel models, as they are often the first step in obtaining the capacity results for the corresponding Gaussian MIMO channel models.

• YAKHAK HOEJI
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• v.54 no.4
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• pp.300-308
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• 2010

Adrenoceptor has been considered to be an important target in psychiatric disorders. Based on x-ray structures of bovine rhodopsin, we established homology model of ${\alpha}_{2c}$-adrenoceptor (ADA2C_rat) and then analyzed docking from binding model of receptor-ligand complex with high-active compound No.29 in tricyclic isoxazole analogues (1-30). We observed that the N (1.907 $\AA$) and O (1.712 $\AA$) atoms of isoxazole ring on the docked ligand (No.29) formed H-bonding interaction with O-H of Ser5.32 and carmeron phenyl ring centroid of tricyclic isoxazole formed $\pi-\pi$ interaction at 3.342 $\AA$ distance with phenyl ring centroid of Phe6.52. According to predictions of blood-brain distribution (logBB) through penetration of blood-brain barrie (BBB) and polar surface area (PSA) of the ligands, the high-active compound No.29 has values of logBB=-0.203, PSA=67.50, respectively. These results suggest that the high-active compound No.29 is a novel anti-depressant with the characteristics such as dopamine and serotonin.

• Journal of Korean Society for Atmospheric Environment
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• v.20 no.3
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• pp.331-343
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• 2004

The results of individual PAH source profiles that can be applied to receptor model are as follows. The sum of 16 PAH concentrations was 391.41 ng/S㎥ in a tunnel. Phenanthrene was the most abundant compound among 16 PAH, and then pyrene, fluoranthene, anthracene, and naphthalene can be seen in elevated contents. 11,056.61 ng/S㎥ of 16 PAH concentrations in BC oil boiler was two times higher than 6,582.57 ng/S㎥) of those in LNG boiler. Naphthalene was the most abundant compound in both facilities. Phenanthrene, anthracene, and acenaphthylene were the second dominant compound group in order from both facilities. BC oil boiler had relatively high concentration of pyrene compared to LNG boiler that had high concentration of fluorene and did not detect pyrene. The sum of 16 PAH concentrations emitted from MSW incinerators after APCD (air pollution control device) was three times higher than those from MSW incinerators before APCD. However, the concentrations of more than 4-ring PAH compounds (e.g., benzo (a)anthracene) before APCD were higher than those after APCD. This fact implies that PAHs generated by combustion process are eliminated in APCD and they are continuously produced in stack or atmosphere by PAHs precursors.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.7
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• pp.3016-3021
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• 2011

While there is ample information on the investment plans about Korea's selected new growth businesses, it is hard to find any analysis on the valuation of the projects. In this paper, I intend to do a valuation for the three particular technologies, which are solar cell, automotive battery, and bio-pharmaceutical, based on compound option model so that the valuation can capture not only the expected net cash flow but also the value originated from the flexibility of the decision maker. In addition, the real option pricing theory is reviewed and its practical limitations are thoroughly investigated.

• Proceedings of the Safety Management and Science Conference
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• 2010.11a
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• pp.551-557
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• 2010

The research proposes the hypergeometric, binomial and Poisson yield models for defective and defect. The paper also presents the hypothesis test, confidence interval and control charts for DPU(Defect Per Unit) and DPO(Defect Per Opportunity). Especially the study considers the analysis of compound Poisson yield models using various DOU density distributions.

• Natural Product Sciences
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• v.6 no.2
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• pp.53-55
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• 2000

In the course of continous work for the discovery of anti-thrombotic constituents from tubers of Gastrodia elata, citric acid 1,5-dimethyl ester was isolated from ethylacetate soluble fraction prepared from the methanol extract. The structure of the compound was determined by the spectroscopic data. The anti-thrombotic effect of this compound was observed with prolonging the bleeding time in thrombin-induced thrombosis model of mice.

• Journal of Korea Water Resources Association
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• v.43 no.6
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• pp.517-524
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• 2010

In this study, the 1D apparent shear stress model for vegetated compound open-channel flows was suggested. To consider the effect of momentum exchange between main channel and floodplain, the eddy viscosity concept was used in the present model. The interfacial eddy viscosity in the interface of main channel and floodplain was determined from the 3D Reynolds stress model. The evaluated interfacial eddy viscosity appears to be good agreement with those proposed previously. To investigate the effect of interfacial eddy viscosity, sensitive analysis was carried out. the computed backwater profiles are nearly identical with respect to the value of the interfacial eddy viscosity. However, the discharge conveyed by the floodplain changes is proportional to the interfacial eddy viscosity. Finally, the changes of the interfacial eddy viscosity due to the vegetation density and vegetation height were examined. The computed results of interfacial eddy viscosity are in proportion to the vegetation density and vegetation height, and the interfacial eddy viscosity has a range of $(2-5)\;{\times}\;10^{-4}$.

• The Korea Journal of Herbology
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• v.28 no.4
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• pp.71-76
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• 2013

Objectives : The biological activities and compound contents of herbal medicine vary depending on manufacturing processes. In this study, we compared anti-inflammatory effects and compound contents of three kinds of multi-herbal extract HT008 produced by different manufacturing processes in order to determine chemical and biological equivalence. Methods : HT008 was produced by three different manufacturing methods: 1. Freeze dried extract of Eleutherococcus senticosus, Scutellaria baicalensis and Angelica sinensis (HT008 FD), 2. Spray dried extract of E. senticosus and S. baicalensis combined with reflux extract of A. sinensis (HT008 SD), 3. Spray dried extract of E. senticosus and S. baicalensis combined with supercritial fluid extract of A. sinensis (HT008 SF). Anti-inflammatory effects were evaluated using acetic acid induced pain model and ${\lambda}$-carageenan induced paw edema model. Compound contents were evaluated by HPLC quantitative analysis of standard compounds of HT008, eleutheroside E, baicalin, z-ligustilide. Results : HT008 FD, HT008 SD and HT008 SF significantly decreased acetic acid induced pain index and ${\lambda}$-carrageenan induced paw edema volume compared with that of control group. There was no significant difference in efficacy among the HT008 FD, HT008 SD and HT008 SF. Standard compound contents of HT008 FD, HT008 SD and HT008 SF were quantified within the range of Korean pharmacopoeia or other research. Conclusions : Three different manufacturing methods of multi-herbal extracts have been developed without noticeable difference in the efficacy or compound contents. The results might be used to establish manufacturing process and industrialization of herbal extracts.