Isolation and Anti-thrombotic Activity of Citric acid 1,5-dimethyl ester from Gastrodia elata

  • Pyo, Mi-Kyung (Natural Products Research Institute, Seoul National University) ;
  • Park, Kyung-Mi (Natural Products Research Institute, Seoul National University) ;
  • YunChoi, Hye-Sook (Natural Products Research Institute, Seoul National University)
  • Published : 2000.06.01

Abstract

In the course of continous work for the discovery of anti-thrombotic constituents from tubers of Gastrodia elata, citric acid 1,5-dimethyl ester was isolated from ethylacetate soluble fraction prepared from the methanol extract. The structure of the compound was determined by the spectroscopic data. The anti-thrombotic effect of this compound was observed with prolonging the bleeding time in thrombin-induced thrombosis model of mice.

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