• Title/Summary/Keyword: Mobile-Immobile

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The Antidepressant Effects of Cirsium japonicum in ICR Mice (ICR생쥐에서 엉겅퀴 잎 추출물의 항우울 효과)

  • Park, Hyung-Keun;Yoon, Seo-Young;Choi, Jong-Hyun;Ko, Hong-Sook;Suh, Yeon-Won;Lee, Yong-Soo;Kim, Gun-Hee;Chung, Mi-Sook;Cheong, Jae-Hoon
    • YAKHAK HOEJI
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    • v.50 no.6
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    • pp.429-435
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    • 2006
  • The antidepressant effects of Cirsium japonicum compositae was investigated using open field test and forced swimming test. Total extract of Cirsium japonicum (CJ) was orally administered at dose of 20, 100, 300, 500 mg/kg bodyweight. Supplementation of CJ increased dose-dependently movement, rearing frequency and total turn angle in the center area of open field in mice. Treatment of Cirsium japonicum's extract (300 mg/kg, CJ) decreased immobile duration and increased mobile and strong mobile duration significantly; and it is comparable to that of imipramine and fluoxetine. These results indicate that CJ has antidepressant effect. Treatment of CJ did not induced any impairment in motor coordination and myorelaxation. These results indicate that the constituents or its complex of Cirsium japonicum could be a candidate of new antidepressant drug.

Estimation of Pesticide Leaching Potential Using GUS, RF and AF Index in Cheju Citrus Orchard Soils (제주도 감귤원 토양에서 GUS, RF, AF 지수를 이용한 농약의 용탈잠재성 평가)

  • Oh, Sang-Sil;Moon, Doo-Khil;Chung, Jong-Bae;Hyun, Hae-Nam
    • Korean Journal of Environmental Agriculture
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    • v.21 no.1
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    • pp.7-16
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    • 2002
  • Contamination of groundwater by agrochemicals used in the regional-scale Is now a major environmental problem, and this is especially true for Cheju island where virtually all potable water is from groundwater. The objective of this study was to assess leaching potential of eight pesticides in soils of citrus orchards using groundwater ubiquity score (GUS), retardation factor (RF) and attenuation factor (AF). Considering GUS estimated in 30 citrus orchard soils, metribuzin and metolachlor were classified as leacher, alachlor in volcanic ash soils and linuron in non-volcanic soils were classified as leacher, but chlorothalonil and chlorpyrifos were classified as non-leacher. For RF values, metribuzin was classified to be mobile in soils of low organic carbon, metolachlor and alachlor were classified to be moderately immobile in most soils, but linuron, diuron, diniconazole, chlorothalonil and chlorpyrifos were all classified to be very immobile. For AF values, diniconazole, chlorothalonil, and chlorpyrifos were classified to be very unlikely leachable in all of the soils, metribuzin was classified to be likely leachable, and metolahclor, alachlor, linuron and diuron were classified to be leachable only in non-volcanic soils. Although there were some variations in the relative potential of teachability of pesticides estimated with the three different indices, the ranking was essentially determined on the base of the intrinsic properties of the chemicals and environmental properties. Among the eight pesticides, metribuzin, metolachlor, and alachlor, which have high water solubility and low $K_{oc}$ values, have a significant leaching potential especially in non-volcanic ash soils of low organic carbon. But diniconazole, chlorothalonil, and chlorpyrifos, which have low water solubility and high $K_{oc}$ values, were classified to be very immobile in all of the soils. Therefore, to lower the possibility of pesticide contamination of the groundwater in Cheju island, those pesticides which have high water solubility and low $K_{oc}$ values should be used with care in soils of low organic carbon including non-volcanic ash soils.

Study of Rainfall-Runoff Variation by Grid Size and Critical Area (격자크기와 임계면적에 따른 홍수유출특성 변화)

  • Ahn, Seung-Seop;Lee, Jeung-Seok;Jung, Do-Joon;Han, Ho-Chul
    • Journal of Environmental Science International
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    • v.16 no.4
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    • pp.523-532
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    • 2007
  • This study utilized the 1/25,000 topographic map of the upper area from the Geum-ho watermark located at the middle of Geum-ho river from the National Geographic Information Institute. For the analysis, first, the influence of the size of critical area to the hydro topographic factors was examined changing grid size to $10m{\times}10m,\;30m{\times}30m\;and\;50m{\times}50m$, and the critical area for the formation of a river to $0.01km^2{\sim}0.50km^2$. It is known from the examination result of watershed morphology according to the grid size that the smaller grid size, the better resolution and accuracy. And it is found, from the analysis result of the degree of the river according to the minimum critical area for each grid size, that the grid size does not affect on the degree of the river, and the number of rivers with 2nd and higher degree does not show remarkable difference while there is big difference in the number of 1st degree rivers. From the results above, it is thought that the critical area of $0.15km^2{\sim}0.20km^2$ is appropriate for formation of a river being irrelevant to the grid size in extraction of hydro topographic parameters that are used in the runoff analysis model using topographic maps. Therefore, the GIUH model applied analysis results by use of the river level difference law proposed in this study for the explanation on the outflow response-changing characters according to the decision of a critical value of a minimum level difference river, showed that, since an ogival occurrence time and an ogival flow volume are very significant in a flood occurrence in case of not undertow facilities, the researcher could obtain a good result for the forecast of river outflow when considering a convenient application of the model and an easy acquisition of data, so it's judged that this model is proper as an algorism for the decision of a critical value of a river basin.

A Study on the Men's Fashion Trend through the Statistical Analysis (통계적 분석을 통한 남성 패션 트렌드 연구)

  • Kim, Yoon-Kyoung;Lee, Kyoung-Hee
    • Journal of the Korean Society of Clothing and Textiles
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    • v.31 no.6 s.165
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    • pp.837-847
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    • 2007
  • 1,098 pieces of photographs($1995{\sim}2002$) of men's suit style have been classified according to fashion images in order to examine features and change aspects with statistical analysis. The findings of examining features of the trend by year with test of homogeneity, correspondence analysis, biplots, correlation analysis and regression analysis are as follows: (a) there are significant differences on fashion images as the trend by yew with test of homogeneity, (b) there are remarkable differences on the fashion trend by year with correspondence analysis and biplots. (c) There are significant correlations for appearance among fashion images by its frequency through correlation analysis, and (d) it is assumed that fashion images are going to be gradually outstanding according to regression analysis.

Study on the channel of bipolar plate for PEM fuel cell (고분자 전해질 연료전지용 바이폴라 플레이트의 유로 연구)

  • Ahn Bum Jong;Ko Jae-Churl;Jo Young-Do
    • Journal of the Korean Institute of Gas
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    • v.8 no.2 s.23
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    • pp.15-27
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    • 2004
  • The purpose of this paper is to improve the performance of Polymer electrolyte fuel cell(PEMFC) by studying the channel dimension of bipolar plates using commercial CFD program 'Fluent'. Simulations are done ranging from 0.5 to 3.0mm for different size in order to find the channel size which shoves the highst hydrogen consumption. The results showed that the smaller channel width, land width, channel depth, the higher hydrogen consumption in anode. When channel width is increased, the pressure drop in channel is decreased because total channel length Is decreased, and when land width is increased, the net hydrogen consumption is decreased because hydrogen is diffused under the land width. It is also found that the influence of hydrogen consumption is larger at different channel width than it at different land width. The change of hydrogen consumption with different channel depth isn't as large as it with different channel width, but channel depth has to be small as can as it does because it has influence on the volume of bipolar plates. however the hydrogen utilization among the channel sizes more than 1.0mm which can be machined in reality is the most at channel width 1.0, land width 1.0, channel depth 0.5mm and considered as optimum channel size. The fuel cell combined with 2cm${\times}$2cm diagonal or serpentine type flow field and MEA(Membrane Electrode Assembly) is tested using 100W PEMFC test station to confirm that the channel size studied in simulation. The results showed that diagonal and serpentine flow field have similarly high OCV and current density of diagonal (low field is higher($2-40mA/m^2$) than that of serpentine flow field under 0.6 voltage, but the current density of serpentine type has higher performance($5-10mA/m^2$) than that of diagonal flow field under 0.7-0.8 voltage.

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A Study for impact absorption function of midsole in Cushioned Marathon Shoes (충격흡수용 마라톤화(Cushioned Shoes) 개발을 위한 중창·하지의 충격흡수기능 연구 -마라톤화 연구의 과거 & 현재를 중심으로-)

  • Park, Seung-Bum;Seo, Kuk-Woong;Kim, Yong-Jae
    • Korean Journal of Applied Biomechanics
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    • v.12 no.1
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    • pp.89-114
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    • 2002
  • The purpose of this study was to analyze impact absorption function of midsole in cushioned marathon shoes. The foot is made up of a complex interaction of bones, ligaments, and muscles. These structures help the foot alternate between being a mobile, flexible adaptor and a stable rigid lever. The foot is broken down into two functional parts, the forefoot and the rearfoot. Cushioned marathon shoes for high arches have generous cushioning for efficient and high-mileage runners. Cushioned marathon shoes are made for feet that have high arches or no excessive motion and don't roll inward or roll outward. This condition is known as underpronation. Especially, Cushioned marathon shoes are designed to reduce shock and generally have the softest (or most cushioned) midsoles and the least medial support. They are usually built on a semicurved or curved last to encourage foot motion, which is helpful for underpronators (who have rigid, immobile feet). Cushioning marathon shoes recommended for the high-arched runner, whose foot may roll outward (supinate) rather than the natural slight inward roll, or whose feet may be relatively rigid. Cushioning shoes emphasize flexibility and usually are built on a curved or semicurved last to encourage a normal motion of the foot. Cushioning shoes usually offer no medial (inner foot) support. Cushioned marathon shoes have the single-density midsole, which is stable and relatively firm for a cushioned shoe, stays the same. But the forefoot is more rounded, and the rearfoot now includes a new and supportive rearfoot cradle. A foam midsole, perhaps with layers of different densities, to provide cushioning and shock absorption. EVA (ethylene vinyl acetate) and PU (polyurethane), the materials from which these foams usually are made. EVA is slightly softer than PU. EVA and PU may be layered together in a shoe, or a shoe may have more than one density of EVA.

Anxiolytic and Antidepressant Activities of Ginsenoside Rb1

  • Choi, Jong-Hyun;Yoon, Seo-Young;Choi, Eun-Joo;Ryu, Yim-Seon;Ko, Hong-Sook;Yim, Dong-Sool;Her, Youl;Lee, Yong-Soo;Song, Mi-Ryoung;Cheong, Jae-Hoon
    • Biomolecules & Therapeutics
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    • v.15 no.1
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    • pp.27-33
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    • 2007
  • The psychopharmacological profile of ginsenosides has not yet been confirmed systematically although various neuropharmacological activities associated with them have been investigated. In the present study, the psychological activities of Rb1 were investigated to evaluate whether it can be used in treatment or prevention of psychological disorders. Rb1 was intravenously injected at doses of O.2,2,5 and 10 mg/kg. The effects of Rb1 on the $Cl^-$ ion influx were investigated using IMR-32 human neuroblastoma cells. Moreover, locomotor activity, forced swimming activity, activity on rotating rod and activity in elevated plus-maze were tested in mice. Rb1 increased the $Cl^-$ influx into the intracell region in a dose-dependent manner. Rb1 did not cause change in behavior in total open field when locomotor activity was tested, however it increased activities, especially, such as rearing frequency in center area. Administration of Rb1 at 0.2 mg/kg significantly reduced activities on rotating rod however administration at high dosages had no effect on them. Rb1 administration decreased animal immobile time in a water chamber in a dose dependent manner, and increased the strong mobile time of animals. In conclusion, the present results demonstrate that Rb1 contributes to the psychopharmacological effects of ginseng and may be used in treatment or prevention of psychological disorders such as anxiety or depression.

The Tax Structure of Welfare States - Recommendations for Universal Welfare States - (복지국가의 조세체계와 함의 - 보편적 복지국가 친화적인 조세구조는 있는 것일까 -)

  • Yoon, Hong-Sik
    • Korean Journal of Social Welfare
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    • v.63 no.4
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    • pp.277-299
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    • 2011
  • The current study analyzed the tax structure in the welfare states. The appropriate tax structure of universal welfare state should be based on expanding all taxes, rather than choosing between direct and indirect, progressive and regressive, or mobile and immobile tax. The revenue for the universal welfare payment should be raised by levying tax on all people provided that the welfare payment is made available to all people. The analysis led to classification of tax structure into the high tax European model and the low tax English and East Asian model. The high tax European model was further classified into the balance tax model and the high social security model. The low tax English and East Asian model was classified into the low social security model and the high property tax model. Based on the results, the study maintained that the universal welfare states need not only to expand welfare resources but to develop tax system that corresponds to the universal welfare system.

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Comparison of the Antidepressant Activity of Cirsii herbal Extracts Collected from 5 Different Regions of Korea Determining the Optimal Herbal Preparation (원료 생약 추출물의 최적화를 위한 한국 5개 지역에서 채집된 대계 추출물들의 항우울 효과 비교)

  • Lee, Hye Lim;dela Pena, June Bryan I.;Yoon, Seo Young;Kim, Seong Mok;Hong, Eunyoung;Lee, Yong Soo;Jang, Miran;Kim, Gun-Hee;Cheong, Jae Hoon
    • YAKHAK HOEJI
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    • v.56 no.6
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    • pp.401-406
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    • 2012
  • Previously, we identified that Cirsium japonicum (CJ) extract posses antidepressant properties. In order to look for the optimal hebal preparation, CJ extracts collected from Koheung, Yesan, Cheju, Pyungchang and Pocheon were compared. The psychopharmacological activities of each extract were investigated using the open field test, the rota-rod test and the forced swimming test. Effect of each extract on $Cl^-$ influx in neuroblastoma cells were also identified. All of the extracts were orally administered at dosages of 50, 100, 200, 400 mg/kg of body weight. Supplementation of CJ did not significantly alter psychomotor behaviors such as movement, rearing frequency and total turn angle on the open field. Supplementation of CJ's extract from Pyungchang (100 mg/kg, p.o.), Cheju (200 and 400 mg/kg p.o.) and Yesan (100 and 200 mg/kg, p.o.) significantly decreased immobile duration and increased mobile duration in the forced swimming test. All of extracts have no influence on NE uptake in HEK-293 cells, but increased $Cl^-$ influx in neuroblastoma cell. The extract from Yesan demonstrated the most potent effect on $Cl^-$ influx. These results indicate that CJ's extracts from Pyungchang, Cheju and Yesan may alleviate depression, and the extract from Yesan may be the most effective preparation.

Church Education in the COVID-19 Era (포스트 코로나 시대의 교회교육)

  • Yu, Jae Deog
    • Journal of Christian Education in Korea
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    • v.63
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    • pp.13-37
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    • 2020
  • The World Health Organisation(WHO), paying attention to the spread and fatality of the coronavirus(COVID-19), which first occurred in Wuhan, China, declared a global emergency. Although many countries implement strict measures to slow down the spread, WHO officially declared a pandemic. COVID-19 has sparked fears of an impending economic crisis and recession. Due to the economic crisis caused by social distancing, self-isolation and travel restrictions, the collapse of the world economic system centered on free trade and the decline of globalization are mentioned. Political leadership that has not responded properly to the pandemic is challenged, and nearly all of society is rapidly changing to a non-contact and immobile culture. COVID-19 has seriously affected all levels of the education system, from preschool to tertiary education. The so-called old concept of deschooling is realizing in the field of education through digital media paradoxically. Church education is facing a serious crisis as well. Churches are seeking now a new normal that includes theological reflection on the pandemic, online worship, education, and non-face-to-face ministry to overcome the worst unexpected crisis. In the post-corona era, church education must actively seek alternatives in response to rapidly changing surrounding conditions and reconstruct educational philosophy(theology) that focuses on Christian values. In addition, it is necessary to start operating a mobile(or online) church school that combines offline and online. It is necessary to introduce 'Blended Learning' method that combines non-face-to-face and face-to-face learning, and by combining church school and homeschooling, churches and families need to share the responsibility of education in faith.