• Korean Journal of Otorhinolaryngology-Head and Neck Surgery
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• 제61권12호
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• pp.705-709
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• 2018

It is challenging to achieve sufficient hearing gain in patients with mixed hearing loss. In chronic middle ear diseases, conventional passive reconstructive surgeries often result in suboptimal hearing gain and additional hearing aids may have limitations due to insufficient sound amplification, occlusion effect, acoustic feedback, and skin irritation. Middle ear implantation (MEI) using Vibrant Soundbridge (VSB) is another option for auditory rehabilitation in mixed hearing loss as well as sensorineural hearing loss. The floating mass transducer of VSB can be placed on various middle ear structures either directly or using different types of couplers in order to deliver vibratory mechanical energy to the cochlea. We report a patient who presented with bilateral mixed hearing loss due to chronic otitis media and had limitations using conventional hearing aids in the worse hearing ear. The patient was successfully treated with MEI using the Bell coupler together with middle ear surgery in a single step.

• Genomics & Informatics
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• 제16권4호
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• pp.20.1-20.20
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• 2018

Genetic hearing loss crosses almost all the categories of hearing loss which includes the following: conductive, sensory, and neural; syndromic and nonsyndromic; congenital, progressive, and adult onset; high-frequency, low-frequency, or mixed frequency; mild or profound; and recessive, dominant, or sex-linked. Genes play a role in almost half of all cases of hearing loss but effective treatment options are very limited. Genetic hearing loss is considered to be extremely genetically heterogeneous. The advancements in genomics have been instrumental to the identification of more than 6,000 causative variants in more than 150 genes causing hearing loss. Identification of genes for hearing impairment provides an increased insight into the normal development and function of cells in the auditory system. These defective genes will ultimately be important therapeutic targets. However, the auditory system is extremely complex which requires tremendous advances in gene therapy including gene vectors, routes of administration, and therapeutic approaches. This review summarizes and discusses recent advances in elucidating the genomics of genetic hearing loss and technologies aimed at developing a gene therapy that may become a treatment option for in the near future.

• 한국전기전자재료학회논문지
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• 제22권8호
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• pp.704-713
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• 2009

As using recruitment phenomenon, SISI test and Bekesy audiometry are employed to differentially diagnose both the cochlear hearing loss and the retrocochlear hearing loss. The main purpose of this study is to find out the sensitivity and specificity of the SISI test within the scope of 1 KHz to 4 KHz in diagnosing various types of hearing losses. In this study, the Bekesy audiometry was conducted for Bekesy audiograms of certain groups according to Jerger's classification, which included persons with normal hearing and patients with hearing impairment. Subject persons of the SISI test were categorized into the several groups with normal hearing, mild hearing loss, moderate hearing loss, moderate-severe hearing loss and severe hearing loss, respectively. The sensitivity and specificity of certain groups were evaluated according to the SISI scores of 20 % below, 25 ${\sim}$ 65 %, and more than 70%. Also, the Bekesy audiometry is conducted on the several subject groups with normal hearing, mixed hearing loss, and sensori-neural hearing loss.

• 대한청각학회지
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• 제25권2호
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• pp.110-114
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• 2021

We report a case of hearing rehabilitation following combined cochlear implantation and ossiculoplasty. A 71-year-old patient visited the clinic for right-sided mixed hearing loss. We targeted neural and conductive components, performing two different operations simultaneously. At two months post-operative, the patient showed satisfactory results with respect to hearing threshold and speech comprehension. Our experience suggests that careful evaluation of patients and consideration of the diverse array of available treatment strategies can be used to provide personalized rehabilitation with maximal effectiveness. To the best of our knowledge, this is the first report to take such an integrated approach to treat hearing impairment and is thus likely to have clinical importance for otologists.

• Journal of Audiology & Otology
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• 제25권2호
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• pp.110-114
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• 2021

We report a case of hearing rehabilitation following combined cochlear implantation and ossiculoplasty. A 71-year-old patient visited the clinic for right-sided mixed hearing loss. We targeted neural and conductive components, performing two different operations simultaneously. At two months post-operative, the patient showed satisfactory results with respect to hearing threshold and speech comprehension. Our experience suggests that careful evaluation of patients and consideration of the diverse array of available treatment strategies can be used to provide personalized rehabilitation with maximal effectiveness. To the best of our knowledge, this is the first report to take such an integrated approach to treat hearing impairment and is thus likely to have clinical importance for otologists.

• 대한인간공학회지
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• 제15권1호
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• pp.79-90
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• 1996

A research project was conducted to assess the levels of noise exposed to "Noraebang" users and potential hazards to noise-induced hearing loss due to commercial Noraebang noise. A two-way, mixed-factors factorial design was employed for the experiment using independent variables of "noise source" (no- singer, 1-singer, and 2-singer conditions) and "music type" (Trot, Ballad, and Rock music) with 18 normal hearing subjects. Each singer group sang 5 popular songs of each music type in each signing condition, whereas background music was just played for the no-singer condition. For each music played/sung, equivalent continuous sound pressure levels and maximum sound pressure levels were measured for data analysis purposes. Pure-tone audiometry was applied for measuring subjects' hearing threshold levels before and after exposure to Noraebgang noise. The statistical analyses indicate that average continuous noise levels due to Noraebang leisure environment were very serious, especially when two people were singing (higher than 95 dBA). Furthermore, maximum noise levels often exceeded the OSHA's non-premissible 115 dBA level. Worse yet, hearing loss assessment implies that Noraebang facilities may pose a serious threat to noise-induced hearing loss, based on 6-8 dB loss at 125 Hz and 8 dB loss at 4000 Hz after about 1-hour Noraebang noise exposure.

• 대한두경부종양학회지
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• 제27권1호
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• pp.84-87
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• 2011

Branchio-otic syndrome(BOS) is a relatively uncommon genetic malformation associated with dysmorphogenesis of the first and second branchial arches and is characterized by branchial fistulae, congenital preauricular fistulae, and anomalies of the pinnae, external, middle, and inner ears, accompanied by hearing loss. Recently, we experienced a case of BOS in a 10 years old female patient and report this case with a review of literature. 10-year-old girl presented with hearing impairment, bilateral preauricular fistula and cervical fistula. The pure tone audiometry revealed that she had 60dB sensorineural hearing loss on right side and 90dB mixed hearing loss on left. Bilateral branchial fistula was found on the neck CT scan and bilateral ossicular and cochlear abnormality combined with enlarged internal auditory canal was noted on the temporal bone CT scan. To investigate the association with EYA1 gene, we performed DNA sequncing with peripheral white blood cell and found the point mutations on Exon 7, 12 and 16 of EYA1 gene. The preauricular fistula and branchial fistula was excised surgically and hearing aid was applied on her left side. There was no sign of fistula recurrence for seven years after the surgery.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1981년도 제15차 학술대회연제순서 및 초록
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• pp.39.1-39
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• 1981

이명은 청기질환의 중요한 증후로 청기질환의 조기 혹은 단독증상으로 존재할 때도 있으나 대부분의 경우에 있어서 난청을 수반하게 된다. 이명의 성립기전은 불분명하나 청기내 혹은 그 중추경로에의 이상자극에 의해 발생한다고 한다. 1978년 1월에서 1980년 12월까지 이명을 주소로 이대부속병원 이비인후과에 내원한 환자중 순음청력검사를 시행한 111명을 임상적 분석 및 고찰을 하였다. 1) 성별분포는 남자가 52.2%, 여자가 47.8%로 남자가 약간 많았고 연령은 21세에서 30세까지가 가장 많아 28.8%였다. 2) 발병기간은 1달에서 1년까지가 가장 많아 31.5%였다. 3) 이명만을 호소하였던 환자는 11명 (10.0%)였으며 대부분인 72%에서는 수반증상으로 난청을 호소하였다 4) 38.7%의 환자에서는 양측, 32.4%는 좌측, 28.9%는 우측의 이명을 호소하였다. 5) 고막소견은 48.0%에서는 정상고막소견을 보였으나 33.1%에서는 내함, 8.4%에서는 고막천공이 있었다. 6) 청력소실정도는 29.2%에서 정상이었고 22.7%에서는 중등고도의 청력소실이 있었다. 7) 청력상을 보면 33.1%에서 고음장애형이었고 수평형은 33.0%, 저음장애형은 11.9%였으며 $C_{5}$ dip은 11.0%에서 있었다. 8) 난청의 종류는 감각신경성난청이 가장 많아 46.9%, 혼합성난청이 33.1% 전도성난청이 20.1%였다.

• Journal of Audiology & Otology
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• 제25권3호
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• pp.146-151
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• 2021

Background and Objectives: The relationship between hearing aid (HA) use and improvement in cognitive function is not fully known. This study aimed to determine whether HAs could recover temporal resolution or hearing in noise functions. Materials and Methods: We designed a prospective study with two groups: HA users and controls. Patients older than 45 years, with a pure tone average threshold of worse than 40 dB and a speech discrimination score better than 60% in both ears were eligible. Central auditory processing tests and hearing in noise tests (HINTs) were evaluated at the beginning of the study and 1, 3, 6, and 12 months after the use of a monaural HA in the HA group compared to the control group. The changes in the evaluation parameters were statistically analyzed using the linear mixed model. Results: A total of 26 participants (13 in the HA and 13 in the control group) were included in this study. The frequency (p<0.01) and duration test (p=0.02) scores showed significant improvements in the HA group after 1 year, while the HINT scores showed no significant change. Conclusions: After using an HA for one year, patients performed better on temporal resolution tests. No improvement was documented with regard to hearing in noise.

• 대한청각학회지
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• 제25권3호
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• pp.146-151
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• 2021

Background and Objectives: The relationship between hearing aid (HA) use and improvement in cognitive function is not fully known. This study aimed to determine whether HAs could recover temporal resolution or hearing in noise functions. Materials and Methods: We designed a prospective study with two groups: HA users and controls. Patients older than 45 years, with a pure tone average threshold of worse than 40 dB and a speech discrimination score better than 60% in both ears were eligible. Central auditory processing tests and hearing in noise tests (HINTs) were evaluated at the beginning of the study and 1, 3, 6, and 12 months after the use of a monaural HA in the HA group compared to the control group. The changes in the evaluation parameters were statistically analyzed using the linear mixed model. Results: A total of 26 participants (13 in the HA and 13 in the control group) were included in this study. The frequency (p<0.01) and duration test (p=0.02) scores showed significant improvements in the HA group after 1 year, while the HINT scores showed no significant change. Conclusions: After using an HA for one year, patients performed better on temporal resolution tests. No improvement was documented with regard to hearing in noise.