• Journal of Chest Surgery
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• v.47 no.2
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• pp.117-123
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• 2014

Background: Implanted venous access devices or permanent central venous access systems (PCVASs) are routinely used in oncologic patients. Complications can occur during the implantation or use of such devices. We describe such complications of the PCVAS and their management. Methods: Our retrospective study included 1,460 cases in which PCVAS was implanted in the 11 years between January 2002 and January 2013, including 810 women and 650 men with an average age of 45.2 years. We used polyurethane or silicone catheters. The site of insertion and the surgical or percutaneous procedure were selected on the basis of clinical data and disease information. The subclavian and cephalic veins were our most common sites of insertion. Results: About 1,100 cases (75%) underwent surgery by training surgeons and 360 patients by expert surgeons. Perioperative incidents occurred in 33% and 12% of these patients, respectively. Incidents (28%) included technical difficulties (n=64), a subcutaneous hematoma (n=37), pneumothoraces (n=15), and an intrapleural catheter (n=1). Complications in the short and medium term were present in 14.2% of the cases. Distortion and rupture of the catheter (n=5) were noted in the costoclavicular area (pinch-off syndrome). There were 5 cases of catheter migration into the jugular vein (n=1), superior vena cava (n=1), and heart cavities (n=3). No patient died of PCVAS insertion or complication. Conclusion: PCVAS complications should be diagnosed early and treated with probable removal of this material for preventing any life-threatening outcome associated with complicated PVCAS.

• Journal of the Korean Operations Research and Management Science Society
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• v.39 no.2
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• pp.111-130
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• 2014

For the key factors determining victory of combat, many works have been focusing on qualitative analyses in the past. As military training paradigm changes along with technology developments, demands for scientific analysis to prepare future military strength increase regarding military training results, and big data analysis has opened such possibility. We analyze the data from KCTC (Korea Combat Training Center) training to investigate the factors affected victory in offensive operations. In this context, we develop a way to measure the victory and the factors related to it from existing studies and military doctrines. We first identify Independent variables that affect offensive operations through variable selection and propose a mathematical model to explain combat victory by performing multiple regression analysis. We also verify our results with battalion-level live training data as well as previous studies on victory factors in the military doctrines.

• Journal of the Korean association of regional geographers
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• v.21 no.1
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• pp.176-191
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• 2015

Military Geography is a literature studying the application of geographical elements to military behaviour. The elements of military geography including topography greatly influences on building military art and theory. The military art applied on korean pennisula from the period of ancient three countries(Koguryeo, Shilla, Paekche) has been developed maintaining consistent stream reflecting topographic features. Despite the close relationship between building of military art and military geography's elements, the study for korean military geography has been depressed and the discourses of literature has been insufficient. But, in the western study of military geography, the study vitalization efforts studying military peace keeping and humanitarism activity are ongoing. Based on the current trend of western study and the analysis of existing korean study, this treatise proposes three plans to improve the study and education of korean military geography. The key contents of plans are comprised with the improvement of education curriculum, the construction of council between relevant organism, and the installation of subdivision in relevant geographical society. The possibility shaping up the identity of korean military geography as a common literature can be increased by enhancing the study toward peace and humanitarism and specifying the method for development as noted on this study.

• Journal of the Korea Institute of Military Science and Technology
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• v.17 no.2
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• pp.275-281
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• 2014

Although self-propelled artilleries are mobile equipment, they need their own covered-positions for survival against preemptive strikes. The most important military requirement is enough protective capacity against blast pressure caused by explosion. This paper aims to assess the protective capacity of the newly-placed concrete box-type artillery positions using accurate structural geometric models as well as soil-structure interaction analysis. The commercial program is used to model the structural geometry of the positions. In order to describe the correct wave propagation in the backfill along with soil-structure interaction, used parameters in shock equation of state are selected based on the related studies as well as theories and then their final results are verified with the ones calculated with empirical equations in the US Unified Facility Criteria. In sum, it could be concluded that the protective capacity of the newly-built positions satisfies the protective structural requirement.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.11
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• pp.4637-4642
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• 2014

Background: Hypoxia-inducible factor $1{\alpha}$ (HIF-$1{\alpha}$) plays an important role in regulating cell survival and angiogenesis, which are critical for tumor growth and metastasis. Genetic variations of HIF1A have been shown to influence the susceptibility to many kinds of human tumors. Increased expression of HIF-$1{\alpha}$ has also been demonstrated to be involved in tumor progression. However, the prognostic value of single nucleotide polymorphisms (SNPs) inthe HIF1A gene remains to be determined in most cancer types, including colorectal cancer (CRC). In this study, we sought to investigate the predictive role of HIF1A SNPs in prognosis of CRC patients and efficacy of chemotherapy. Materials and Methods: We genotyped two functional SNPs in HIF1A gene using the Sequenom iPLEX genotyping system and then assessed their associations with clinicopathological parameters and clinical outcomes of 697 CRC patients receiving radical surgery using Cox logistic regression model and Kaplan Meier curves. Results: Generally, no significant association was found between these 2 SNPs and clinical outcomes of CRC. In stratified analysis of subgroup without adjuvant chemotherapy, patients carrying CT/TT genotypes of rs2057482 exhibited a borderline significant association with better overall survival when compared with those carrying CC genotype [Hazard ratio (HR), 0.47; 95% confidence interval (95% CI): 0.29-0.76; P < 0.01]. Moreover, significant protective effects on CRC outcomes conferred by adjuvant chemotherapy were exclusively observed in patients carrying CC genotype of rs2057482 and in those carrying AC/CC genotype of rs2301113. Conclusions: Genetic variations in HIF1A gene may modulate the efficacy of adjuvant chemotherapy after surgery in CRC patients.

• Journal of the Korea Institute of Military Science and Technology
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• v.25 no.3
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• pp.267-274
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• 2022

The Republic of Korea has a close cooperative relationship with NATO, of which the United States is a member. NATO is encouraged to follow UHF coalition waveforms for military air operations(SATURN) as defined in STANAG 4372. SATURN is a high-speed frequency hopping waveform with enhanced anti-jamming and security functions. Plans to improve the performance of existing military aircraft with air to ground radios to which SATURN function is applied. IFF case analysis and MRT evaluation plan were established to present an efficient test and evaluation plan for air to ground radios.

• Journal of National Security and Military Science
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• s.9
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• pp.283-311
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• 2011

The Republic of Korea, ranked as the 5th military power according to the size of its ground troops, discharges more than 200,000 manpower to the society annually; more than 13,000 of them are officers. The re-employment rate of discharged military personnels, who experience early retirement of 5 to 15 years compared to general public officers, is very low, only amounting to 53.2%. On the other hand, major developed countries exhibit great national scale of effort to take responsibility in helping the settlement of the soldiers who have dedicated their career for their countries. The re-employment rate amounts to 94%. Fully acknowledging such disparity, this paper examines various policies on discharged members support of developed countries, and aims to suggest developmental model on employment support designed for discharged members in the Republic of Korea.

• Biomolecules & Therapeutics
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• v.24 no.3
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• pp.291-297
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• 2016

Cytisine (CYT), a partial agonist of ${\alpha}4{\beta}2-nicotinic$ receptors, has been used for antidepressant efficacy in several tests. Nicotinic receptors have been shown to be closely associated with depression. However, little is known about the effects of CYT on the depression. In the present study, a mouse model of depression, the unpredictable chronic mild stress (UCMS), was used to evaluate the activities of CYT. UCMS caused significant depression-like behaviors, as shown by the decrease of total distances in open field test, and the prolonged duration of immobility in tail suspension test and forced swimming test. Treatment with CYT for two weeks notably relieved the depression-like behaviors in the UCMS mice. Next, proteins related to depressive disorder in the brain region of hippocampus and amygdala were analyzed to elucidate the underlying mechanisms of CYT. CYT significantly reversed the decreases of 5-HT1A, BDNF, and mTOR levels in the hippocampus and amygdala. These results imply that CYT may act as a potential anti-depressant in the animals under chronic stress.

• Molecules and Cells
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• v.38 no.11
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• pp.959-965
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• 2015

Inducible and reversible gene silencing in desired types of cells is instrumental for deciphering gene functions using cultured cells or in vivo models. However, efficient conditional gene knockdown systems remain to be established. Here, we report the generation of an inducible expression system for short hairpin RNA (shRNA) targeted to PTEN, a well-documented dual-specificity phosphatase involved in tumor suppression and ontogenesis. Upon induction by doxycycline (DOX), the reverse tetracycline transcriptional activator (rtTA) switched on the concomitant expression of GFP and a miR-30 precursor, the subsequent processing of which released the embedded PTEN-targeted shRNA. The efficacy and reversibility of PTEN knockdown by this construct was validated in normal and neoplastic cells, in which PTEN deficiency resulted in accelerated cell proliferation, suppressed apoptosis, and increased invasiveness. Transgenic mice harboring the conditional shRNA-expression cassette were obtained; GFP expression and concurrent PTEN silencing were observed upon ectopic expression of rtTA and induction with Dox. Therefore, this study provides novel tools for the precise dissection of PTEN functions and the generation of PTEN loss of function models in specific subsets of cells during carcinogenesis and ontogenesis.

• Physical Therapy Rehabilitation Science
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• v.10 no.2
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• pp.217-224
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• 2021

Objective: This study is about the physical therapy facilities and environmental and service satisfaction of patients visiting in the front military hospitals and divisions. Design: Survey study Methods: Prior to this survey, 28 users of the front division and military hospital were surveyed in advance to verify the survey through reliability analysis. For this survey, 1,300 questionnaires were distributed to seven frontline divisions and three military hospitals, of which 578 military hospitals and 479 divisions were collected. Among them, 1,042 pieces of data were used for the analysis, excluding 15 questionnaires that exceeded the research period of the division. Analysis methods used Cronbach-α and multiple regression for mean comparison analysis, factor analysis for validation, and reliability verification to verify differences between groups. Results: As a result of the satisfaction analysis, the division's stage satisfaction was higher than that of military hospitals, and as a result of analyzing the satisfaction items by sector, accessibility, re-visit doctors, and professionalism accounted for a large portion in the field of physical therapy services. As a result of a regression analysis, the factors that affect the satisfaction of physical therapy had the greatest impact on facility and environmental satisfaction, and expertise in physical therapy services. Conclusions: In the future, it will be necessary to improve the comfort of the physical therapy room and the expertise of physical therapy in order to improve the satisfaction level of physical therapy at military medical facilities.