• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.3
• /
• pp.1791-1795
• /
• 2013

Aims and Background: Prostate cancer is one of the most common malignant tumors in the male reproductive system, which causes the second most cancer deaths of males, and control of angiogenesis in prostate lesions is of obvious importance. This study assessed the effect of apogossypolone (ApoG2) on proliferation and apoptosis of human umbilical vein endothelial cells (HUVECs). Subjects and Methods: HUVECs were treated with different concentrations of ApoG2. The survival rate of HUVECs were determined by MTT assay. Utrastructural changes of HUVECs were assessed with transmission electron microscopy. Apoptosis in HUVECs was analyzed by flow cytometry and cell migration by Boyden chamber assay. Matrigel assays were used to quantify the development of tube-like networks. Results: ApoG2 significantly inhibited HUVEC growth even at 24 h (P<0.05). The inhibitory effect of ApoG2 is more obvious as the concentration and the culture time increased (P<0.05). These results indicate that ApoG2 inhibits the proliferation of HUVECs in a time- and concentration-dependent manner with increase of the apoptosis rate. Besides, ApoG2 reduced the formation of total pseudotubule length and network branches of HUVECs. Conclusions: The results suggest that ApoG2 inhibits angiogenesis of HUVECs by growth inhibition and apoptosis induction.

• Korean Institute of Interior Design Journal
• /
• no.32
• /
• pp.28-35
• /
• 2002

After 18th century in Korea, a tendency of the traditional folk houses shows not only the typical types but also the cultural areas in terms of each regional part. The existing folk houses are selected in order to compare the characteristic of the plans with those of the central region in Korea. Moreover this region has been a collided zone of culture and military from the old period of the Three Kingdoms, because the district of Che-chun is located between the southern part and the central one. So its culture and housing plan showed as unique forms, so-called the Culture of Frontier and Composite. Consequently the purposes of this study are to grasp the characteristic of those plans and to compare the plan types with ones of the central region. For the attainment of the above goal, this investigated study is prosecuted by means of the existing 6-folk houses in Che-chun city.

• Journal of Microbiology and Biotechnology
• /
• v.22 no.10
• /
• pp.1343-1349
• /
• 2012

Most of the Helicobacter pylori strains containing the cag pathogenicity island (PAI) have been associated with more severe gastric disease in infected humans. The cag PAI is composed of 27 proteins, and some of the components are required for CagA translocation into host cells as well as induction of proinflammatory cytokines, such as interleukin-8 (IL-8); however, the exact function of most of the components remains unknown or poorly characterized. In this study, we demonstrated that CagT (HP0532), which is an essential structural component of the cag PAI apparatus, plays an important role in the translocation of CagA into host epithelial cells. In addition to being located on the bacterial surface, CagT is also partially localized in the inner membrane, where it acts as a chaperone-like protein and promotes CagA translocation. However, CagT secretion was not detected by immunoprecipitation analysis of cell culture supernatants. Meanwhile, CagT was related to the introduction of IL-8 of the host cell. These results suggest that CagT is expressed on both the inner and outer bacterial membranes, where it serves as a unique type IV secretion system component that is involved in CagA secretion and cag PAI apparatus assembly.

• Strategy21
• /
• s.42
• /
• pp.293-317
• /
• 2017

A series of immoral conducts are repeatedly occurring by some commanders and high-ranking officers in the ROK navy. They are seriously compromising not only harmony and solidarity of the organization, but also pride and morale of members of the service. They seem to be results of the fragile ethical background of the service as well as of failures in military education and training on ethics. This paper sees backgrounds of weak ethical foundations of the navy as follows: the enduring legacies of cultural factors, such as the toxic military culture of the Japanese colonization, dark side of mariners' traditions, the sea-aversive Confucian culture, and unique characteristics in any small organization or society, etc... This paper also suggests the current ethnic systems of the navy are primarily based on responsive measures against misdeeds, rather than fundamental prescriptions for immoral behaviors, in the absence of ethical instrument for warriors. The paper also emphasizes the importance of developing character-based leadership, founded on, above all, respects for human integrity and strong sense of honor. Moreover, the importance of accountability in charging the command, as advocated by the US navy, is also stressed in order to establish a more robust ethic ground within the navy. Based on these analyses, the author proposes that in order to become a stronger and healthier fighting force, the navy needs to make continuous command efforts and organizational innovations to improve ethic principle and moral standard of the service, to strengthen ethics of naval leaders by a robust system of ethical education and training programs, and ultimately to solidify a navy culture in which moral passions and energies are spreading over.

• Journal of Digital Convergence
• /
• v.14 no.7
• /
• pp.397-402
• /
• 2016

This study discusses on the city-culture contents convergence design strategy which can be linked to the identity of the city through applying the graffiti on old-town of Dongducheon. First, the background and cultural asset of Dongducheon were researched. Second, the places revealing the identities were investigated. Third, the interviews with the college students in the city were performed. As the result, we found that using graffiti gains positive reaction as the reinforcement factor for the city identification. The exotic image made up by US military presence is evaluated as an important factor for the city identification. The Rock Festival is a representative cultural event derived by the cultural influence from the US military and is one of the crucial elements for the city identification. In this study, graffiti was proposed as the visual expression which can be harmonized with this culture and be reinforced for the city identity. Results of the study concludes with the strategy for the application of graffiti with the expectation for the improvement of city image of Dongducheon through the change of identity, urban regeneration, and making of pollution-free culture.

• The Journal of the Convergence on Culture Technology
• /
• v.8 no.3
• /
• pp.253-257
• /
• 2022

The Azerbaijani Armed Forces(AAF) that carried out a drone blitzkrieg for a short time defeated the Armed Forces of Armenia in 2020. As a result, the AAF proved that drones aren't supplementary means, but major ones in combat. Simultaneously, the AAF demonstrated that middle powers can shortly implement the revolution in military affairs(RMA) if the organizational culture for deep change are backed up. Especially, the AAF's RMA is full of suggestions to the Repulic of Korea Army(ROKA) because the ROKA wants to prepare the dronbot combat system for the future. After this, the ROKA is able to visualize how to perform the korean style drone blitzkrieg achieving a intact victory if its comabt system and structure are developed at the same time.

• The Journal of the Convergence on Culture Technology
• /
• v.10 no.4
• /
• pp.457-465
• /
• 2024

In the 21st century, the global security environment has undergone rapid changes, presenting South Korea with complex security dilemmas. This study aims to explore a new national security strategy for South Korea through the implementation of 'Positive Peace.' Based on Johan Galtung's concept of 'Positive Peace,' the study proposes a comprehensive approach to build sustainable peace by redesigning the peace process on the Korean Peninsula, establishing a multilateral security cooperation framework in Northeast Asia, expanding global peace contributions, promoting domestic social integration, and spreading a culture of peace. To realize these goals, the study discusses the need to redefine the role of the military, reallocate defense budgets, introduce the concept of a peace dividend, promote the peaceful use of science and technology, and legislate for the realization of the right to peace. The implementation of a 'Positive Peace' strategy aims to transform South Korea into a leading nation in peace, contributing to the peace and stability of the Korean Peninsula, Northeast Asia, and the global community.

• Journal of the Korea Institute of Military Science and Technology
• /
• v.14 no.4
• /
• pp.710-718
• /
• 2011

Edema factor(EF) is a portion of anthrax toxin which produces edema when combined with protective antigen. This paper describes about technique for cloning, expression, purification and activity test of EF. Using the E. coli expression system, we could make recombinant EF protein although it's origin is Bacillus anthracis. And also we could culture massively and purify highly pure protein. Finally we confirm a enzyme activity of purified EF to increase intracellular cAMP level. Through establishing this technique, it can be possible to research about EF in depth and apply to expression and purification of many other protein in biology.

• Journal of the military operations research society of Korea
• /
• v.22 no.1
• /
• pp.43-66
• /
• 1996

Many recent changes in medical area such as expansion of medical insurance, high expectation of people for medical service and the competition with foreign country open new area of medical service and hospital managements. Domestic medical personal have been doing their best for better medical service and more efficient hospital management. In other words, they are focusing on the renovation of organization culture, the reform of organization and operation process and building information systems. It has been more than 10 years since the first computer system was introduced in the domestic medical area. We have been trying to build more advance and more friendly computer systems. Recent advances of information technology could make this possible. In this paper, I introduce the system design of Integrated Hospital Information System include core technology, components of the system and important factors to be considered.

• Proceedings of the Korea Society of Costume Conference
• /
• 2003.10a
• /
• pp.77-77
• /
• 2003

If we look closely to the power shift of the powerful countries historically. during the 16th century Spain's power came from gold, colony trade, the mercenary force, close relation with the thrown, 17th century Netherlands owes their power to trade, capital market, the marines, 18th century France owes it to population, agriculture, public administration, and the army. Also, England had their industry, political unity, finance and trust, the marines, liberalistic principles, a geographical merit of being an island which can be defended well and the 20th century America has their cosmopolitan culture, supernational communication, the capacity of the economy, science technology, military strength, alliances, liberalism international formation. But in the 21st century culture and art will prevail over the information age where technology and knowledge was the key, and it is predicted that this will be the source of power for a strong country. Rolfe Yesson, the head of The Copenhagen Research Center for future studies said, "Information age has ended and in the future Dream Society will arrive which focuses on making distinctions by delivering dreams and emotions to consumers". As cyberspace gradually substitutes reality, cyberspace has become more than an information search engine and has become a place where people fulfill their desires and exchange culture. And as a medium for diffusing culture, the importance of the digital dress-up avatar is predicted to increase gradually.gradually.