• Biomolecules & Therapeutics
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• v.20 no.3
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• pp.313-319
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• 2012

In recent years, inhibition of HDACs has emerged as a potential strategy to reverse aberrant epigenetic changes associated with cancer, and several classes of HDAC inhibitors have been found to have potent and specific anticancer activities in preclinical studies. But their precise mechanism of action has not been elucidated. In this study, a novel synthetic inhibitor of HDAC, 3-(4-dimethylamino phenyl)-N-hydroxy-2-propenamide [IN-2001] was examined for its antitumor activity and the underlying molecular mechanisms of any such activity on human breast cancer cell lines. IN-2001 effectively inhibited cellular HDAC activity ($IC_{50}$ = 0.585 nM) inMDA-MB-231 human breast cancer cells. IN-2001 caused a significant dose-dependent inhibition of cell proliferation in estrogen receptor (ER) negative MDA-MB-231human breast cancer cells. Cell cycle analysis revealed that the growth inhibitory effects of IN-2001 might be attributed to cell cycle arrest at $G_0/G_1$ and/or $G_2$/Mphase and subsequent apoptosis in human breast cancer cells. These events are accompanied by modulating several cell cycle and apoptosis regulatory genes such as CDK inhibitors $p21^{WAF1}$ and $p27^{KIP1}$ cyclin D1, and other tumor suppressor genes such as cyclin D2. Collectively, IN-2001 inhibited cell proliferation and induced apoptosis in human breast cancer cells and these findings may provide new therapeutic approaches, combination of antiestrogen together with a HDAC inhibitor, in the hormonal therapy-resistant ER-negative breast cancers. In summary, our data suggest that this histone deacetylase inhibitor, IN-2001, is a novel promising therapeutic agent with potent antitumor effects against human breast cancers.

• Korean Journal of Food Science and Technology
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• v.54 no.1
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• pp.1-7
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• 2022

Riboflavin (Rb), in the presence of methionine (Met) under light, generates superoxide radicals that can reduce nitro blue tetrazolium (NBT) to its corresponding formazan. The Rb-Met/NBT system has been used to measure the superoxide dismutase (SOD)-like activities of various antioxidants. However, the reaction mechanisms have not been clearly defined, and the assay conditions are not consistent. In this study, the effects of different photosensitizers and amino acids on NBT reduction in different solvents were investigated. NBT reduction in the Rb-Met/NBT system was more pronounced in phosphate-buffered saline, compared to distilled water or Tris (pH 7.5); histidine (His) instead of Met also led to considerable Rb-induced NBT reduction. Among the photosensitizers, methylene blue with His caused potent NBT reduction in Tris. Rb-induced NBT reduction combined with Met or His was quantitatively inhibited by SOD or gallic acid, but did not affect MB-induced reduction sensitively.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.8
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• pp.125-136
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• 2009

This paper presents a high-speed low-complexity two-bit level pipelined Viterbi decoder architecture for MB-OFDM UWB systems. As the add-compare-select unit (ACSU) is the main bottleneck of the Viterbi decoder, this paper proposes a novel two-bit level pipelined MSB-first ACSU, which is based on 2-step look-ahead techniques to reduce the critical path. The proposed ACSU architecture requires approximately 12% fewer gate counts and 9% faster speed than the conventional MSB-first ACSU. The proposed Viterbi decoder was implemented with $0.18-{\mu}m$ CMOS standard cell technology and a supply voltage of 1.8V. It operates at a clock frequency of 870 MHZ and has a throughput of 1.74 Gb/s.

• Electrical & Electronic Materials
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• v.10 no.10
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• pp.1041-1047
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• 1997

In this paper the dielectric properties of (0.8-x)Pb(Mb$_{1}$3//Nb/2/3)O$_3$/BaTiO$_3$-CaZrO$_3$(x=0.1, 0.15, 0.2, 0.25) ceramics were investigated. Specimens were prepared by the conventional mixed oxide method and sintering temperature and time were 1000~115$0^{\circ}C$ 2hr, respectively. The structural and dielectric properties with variation of sintering temperature and composition were investigated. All the specimens sintered at 115$0^{\circ}C$ for 2hr showed the highest value of 1043. With increasing the contents of CZ and frequency dielectric constant was decreased and which was decreased with increasing temperature from 3$0^{\circ}C$ to 15$0^{\circ}C$.

• Proceedings of the IEEK Conference
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• 2004.06a
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• pp.293-296
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• 2004

This paper proposes an architecture of channel estimation for multi-band OFDM UWB systems presented to IEEE 802.15.3a by Multi-band OFDM alliance(MBOA). The multi-band OFDM (MB-OFDM) systems should have channel estimation for compensation of signal distortion by multi-band channel. The moving-averaging estimation algorithm and multi-band equalization architecture for MB-OFDM UWB systems proposed in this paper was verified by the simulation. Simulation results show that MB-OFDM system with the proposed architecture have the performance improved by about 3.4 dB compared to system with no channel estimation in 0.1$\pi$ phase-rotated channel.

• IEMEK Journal of Embedded Systems and Applications
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• v.2 no.1
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• pp.66-75
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• 2007

In this paper, we have propose a preamble structure and synchronization/channel estimation method for UWB-MIMO which has 960Mbps transmit rate. The proposed structure is a compatible preamble structure for synchronization/channel estimation used by MIMO in MB-OFDM(Multi-Band OFDM) systems that are one of the standard systems of MBOA. The system is compatible with MB-OFDM using the proposed preamble structure. In this paper, we argue the problem in receiver part used by MIMO technique. And we simulate the proposed preamble for using synchronization/channel estimation. The simulation result shows the same performance compared with single receiver antenna.

• Journal of information and communication convergence engineering
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• v.8 no.6
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• pp.687-689
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• 2010

In this paper, the equalization for frequency slope of path loss in Multi-Band(MB) OFDM UWB is proposed. The path loss of a signal is proportionate to the square of the signal's frequency. So, the received signal amplitudes of OFDM subcarrier can be different up to 3dB when MB-OFDM occupies bandwidth over 1.5GHz. The differences of subcarrier-amplitudes make an effective of 0.3 bit reduction of soft decision bits of viterbi decoder, and when the effective of 0.3 bit reduction can cause 0.5dB SNR degradation. This paper proposes two modem architectures which compensate for the degraded subcarrier by multiplying the reciprocal of degraded values in analog or digital domain. It is shown that, for the proposed architecture applied to MB-OFDM UWB, the performance improvements up to 0.5dB can be obtained over the conventional uncompensated receiver architecture.

• Speech Sciences
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• v.10 no.1
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• pp.85-94
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• 2003

In this paper an algorithm to reduce the size of Text-to-Speech database is proposed. The algorithm is based on the characteristics of Korean phonemic units. From the initial database, a reduced phoneme unit set is induced by articulatory similarity of concatenating phonemes. Speech data is read by one female announcer for 1000 phonetically balanced sentences. All the recorded speech is then segmented by phoneticians. Total size of the original speech data is about 640 MB including laryngograph signal. To synthesize wave, RE-PSOLA (Residual-Excited Pitch Synchronous Overlap and Add Method) was used. The voice quality of synthesized speech was compared with original speech in terms of spectrographic informations and objective tests. The quality of the synthesized speech is not much degraded when the size of synthesis DB was reduced from 320 MB to 82 MB.

• Journal of Korean Society for Quality Management
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• v.35 no.1
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• pp.73-80
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• 2007

The learning, which is a view extended from and replaces the concept of continuous improvement, has become the very core concept in Malcolm Baldrige National Quality Award. The most potent one among 11 core values in MBNQA Model is 'organizational and personal learning'. Learning also plays a critical role to get the good scores for 6 categories except results category among 7 categories of MBNQA Model. But the concept of learning often has been overlooked by the people who are interested in the MB award or TQM. This paper reviews and analyzes the concept of learning in the MB criteria since it first appears in 1993 to enlighten the importance of learning.

• Korean Journal of Organic Agriculture
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• v.19 no.spc
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• pp.165-168
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• 2011

An organic apple (Malus ${\times}$ domestics Borkh.) orchard was established to study the interaction effects of ground cover management systems (GMS) and nutrient sources (NS) on soil and tree nutrient status and tree growth. Trees received one of four GMS: 1) green compost (GC), 2) wood chips (WC), 3) shredded paper (SP), and 4) mow-and-blow (MB). Across all GMS, one of three NS was applied: A) a commercial organic fertilizer (CF), B) poultry litter (PL), and C) control (NF). Overall, GMS had greater effects on the variables than did NS. GC mulch supplied greater nutrients, followed by WC, SP, and MB mulches. SP trees had lower foliar [N] in the first two years than the GC and WC trees. GC-and WC-treated trees had larger trunk cross sectional area than the SP and MB trees.