• Nutrition Research and Practice
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• v.12 no.3
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• pp.191-198
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• 2018

BACKGROUD/OBJECTIVES: Neuroinflammation plays critical role in neurodegenerative disorders, such as Alzheimer's disease (AD). We investigated the effect of three licorice varieties, Glycyrhiza uralensis, G. glabra, and Shinwongam (SW) on a mouse model of inflammation-induced memory and cognitive deficit. MATERIALS/METHODS: C57BL/6 mice were injected with lipopolysaccharide (LPS; 2.5 mg/kg, intraperitoneally) and orally administrated G. uralensis, G. glabra, and SW extract (150 mg/kg/day). SW, a new species of licorice in Korea, was combined with G. uralensis and G. glabra. Behavioral tests, including the T-maze, novel object recognition and Morris water maze, were carried out to assess learning and memory. In addition, the expressions of inflammation-related proteins in brain tissue were measured by western blotting. RESULTS: There was a significant decrease in spatial and objective recognition memory in LPS-induced cognitive impairment group, as measured by the T-maze and novel object recognition test; however, the administration of licorice ameliorated these deficits. In addition, licorice-treated groups exhibited improved learning and memory ability in the Morris water maze. Furthermore, LPS-injected mice had up-regulated pro-inflammatory proteins, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2, interleukin-6, via activation of toll like receptor 4 (TLR4) and nuclear factor-kappa B ($NF{\kappa}B$) pathways in the brain. However, these were attenuated by following administration of the three licorice varieties. Interestingly, the SW-administered group showed greater inhibition of iNOS and TLR4 when compared with the other licorice varieties. Furthermore, there was a significant increase in the expression of brain-derived neurotrophic factor (BDNF) in the brain of LPS-induced cognitively impaired mice that were administered licorice, with the greatest effect following SW treatment. CONCLUSIONS: The three licorice varieties ameliorated the inflammation-induced cognitive dysfunction by down-regulating inflammatory proteins and up-regulating BDNF. These results suggest that licorice, in particular SW, could be potential therapeutic agents against cognitive impairment.

• Journal of Life Science
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• v.26 no.7
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• pp.812-818
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• 2016

The aim of this study was to investigate the anti-amnesic effect of Stachys sieboldii MIQ. according to the mixing ratio of calcium on scopolamine-induced learning and memory impairment, in vivo. At the end of the adaptation period, SD rats were divided into a normal group (N), a control group (C: scopolamine), a positive control group (PC: scopolamine + tacrine), and a sample group (S: scopolamine + Stachys sieboldii MIQ., 1CS: scopolamine + low calcium-mixed Stachys sieboldii MIQ., 5CS: scopolamine + high calcium-mixed Stachys sieboldii MIQ.), and were tested with learning and memory tests. The C and CS groups were found to have a decreased scopolamine-induced memory deficit in the Y-maze and water maze tests. Brain tissue analysis showed that the CS group decreased acetylcholinesterase (AChE) activity and increased acetylcholine (Ach) content, both of which are indicative of neuronal cell activity. From a light microscopy study, the nucleus of neurons in the hippocampus of the brain was more shrunken or condensed in the C group compared to the CS group. In the CS group, the damage to the neurons in the hippocampus of the brain was suppressed. These results suggest that Stachys sieboldii MIQ. according to the mixing ratio of calcium provides a significant anti-amnesic effect against scopolamine-induced cholinergic system deficits and cognitive impairment.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.21 no.3
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• pp.17-27
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• 2010

This study aimed to identify the problems of college students in reading the literature and on the basis of the identified problems, to suggest the approaches to solve the problems. To this end, time required for reading passages, reading patterns, understanding, memory and reading habits and attitudes were analyzed with the freshmen in A university. In accordance with the analysis results, 58% of subjects was good and 42% was not sufficient on the basis of the averages in Scholastic Aptitude Test. Second, 77% of subjects had the good patterns but 23% showed certain problems in reading patterns. Third, 69% and 67% of subjects illustrated good results in the analysis on understanding and memory, respectively. However, 31% and 33% were evaluated as being on the general level or requiring efforts in the analysis on understanding and memory, respectively. Next, according to the analysis on reading habits and attitudes, 77% had no problems but 23% required improvement. For solving the problems identified through the analysis, it is recommended to develop the scientific and standardized evaluation tools for evaluating the reading ability of college students. Second, it is necessary to evaluate the reading ability, habit and attitude during the screening process for admission or after admission. Finally, it is required to operate the Fundamental Academic Ability Learning Center(tentative name) to improve the ability of students who show the insufficient results in evaluation.

• Journal of Mechanical Science and Technology
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• v.20 no.1
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• pp.110-124
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• 2006

The multi scale wavelet-Galerkin method implemented in an adaptive manner has an advantage of obtaining accurate solutions with a substantially reduced number of interpolation points. The method is becoming popular, but its numerical efficiency still needs improvement. The objectives of this investigation are to present a new numerical scheme to improve the performance of the multi scale adaptive wavelet-Galerkin method and to give detailed implementation procedure. Specifically, the subdomain technique suitable for multiscale methods is developed and implemented. When the standard wavelet-Galerkin method is implemented without domain subdivision, the interaction between very long scale wavelets and very short scale wavelets leads to a poorly-sparse system matrix, which considerably worsens numerical efficiency for large-sized problems. The performance of the developed strategy is checked in terms of numerical costs such as the CPU time and memory size. Since the detailed implementation procedure including preprocessing and stiffness matrix construction is given, researchers having experiences in standard finite element implementation may be able to extend the multi scale method further or utilize some features of the multiscale method in their own applications.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.11
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• pp.2080-2085
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• 2008

KEPCO's AMR (Automatic Meter Reading) is a system that performs the real-time inspection and management of the 15-minute load profile of electric power consumption through a wired and/or wireless network such as CDMA. It has been utilized widely for real-time collection and data analysis. So far, KEPCO has focused on establishing wireless networks using CDMA and collecting data in real time but failed to consider sufficiently performances that can improve the quality of the original data required in terms of data utilization as well as establish the summary information. In this paper, we are going to show the functions that improve data quality by recording the final renewal time of any erroneous data and maintaining such data lists to use them in the rebuilding of summary information. The goals are to reduce any load applied mainly on the DBMS (Database Management System) of AMR, to enable the real-time performance of establishment in the summary information, and to obtain high-quality inspection data. The performance evaluation result has revealed a 10-fold improvement compared to the traditional disk-based DBMS system when the summary information is established.

• The Journal of Korean Association of Computer Education
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• v.8 no.5
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• pp.17-30
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• 2005

The education has changed from the memory education for knowledge to the creativity education. Education of computer has attached importance to teach the creativity. But it till now developed materials are short improvement of the creativity. Especially studies of computer program education are no more than studies of education for genius. Hereupon I developed the teaching material for elementary students with computer program elements by matters in daily life. It has 20 subject in program elements, the aim is improvement of the creativity. After I taught students with developed teaching material, prove the creativity of students has improved.

• IEMEK Journal of Embedded Systems and Applications
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• v.13 no.5
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• pp.225-234
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• 2018

Control flow errors are caused by the vulnerability of memory and result in system failure. Signature-based control flow monitoring is a representative method for alleviating the problem. The method commonly consists of two routines; one routine is signature update and the other is signature verification. However, in the existing signature-based control flow monitoring, monitoring target application is tightly combined with the monitoring code, and the operation of monitoring in a single thread is the basic model. This makes the signature-based monitoring method difficult to expect performance improvement that can be taken in multi-thread and multi-core environments. In this paper, we propose a new signature-based control flow monitoring model that separates signature update and signature verification in thread level. The signature update is combined with application thread and signature verification runs on a separate monitor thread. In the proposed model, the application thread and the monitor thread are separated from each other, so that we can expect a performance improvement that can be taken in a multi-core and multi-thread environment.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2004.04b
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• pp.13-17
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• 2004

The PZT thin films are well-known material that has been widely studied for ferroelectric random access memory (FRAM). We etched the PZT thin films by $CF_4/(Cl_2+Ar)$ plasma and investigated improvement in etching damage by $O_2$ annealing. PZT thin films were etched for 1 min in an ICP using a gas mixture of $Cl_2$(80%)/Ar (20%) with 30% $CF_4$ addition. The etching conditions were fixed at a substrate temperature of $30^{\circ}C$, an rf power of 700 W, a dc-bias voltage of -200 V and a chamber pressure of 2 Pa. To improve the ferroelectric properties of PZT thin films after etching, the samples were annealed for 10 min at various temperatures in $O_2$ atmosphere. After $O_2$ annealing, the remanent polarization, fatigue, and the leakage current were gradually recovered to the characteristics of the as-deposited film, according as the temperature increased.

• Journal of the Korea Society for Simulation
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• v.9 no.4
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• pp.51-58
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• 2000

The control of the data retention time is a main issue for realizing future high density dynamic random access memory. The novel junction process scheme in sub-micron DRAM cell with STI(Shallow Trench Isolation) has been investigated to improve the tail component in the retention time distribution which is of great importance in DRAM characteristics. In this' paper, we propose the new implantation scheme by gate-related ion beam shadowing effect and buffer-enhanced ${\Delta}Rp$ (projected standard deviation) increase using buffered N-implantation with tilt and 4X(4 times)-rotation that is designed on the basis of the local-field-enhancement model of the tail component. We report an excellent tail improvement of the retention time distribution attributed to the reduction of electric field across the cell junction due to the redistribution of N-concentration which is Intentionally caused by ion Beam Shadowing and Buffering Effect using tilt implantation with 4X-rotation. And also, we suggest the least requirements for adoption of this new implantation scheme and the method to optimize the key parameters such as tilt angle, rotation number, Rp compensation and Nd/Na ratio. We used MEDICI Simulator to confirm the junction device characteristics. And measured the refresh time using the ADVAN Probe tester.

• IEIE Transactions on Smart Processing and Computing
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• v.3 no.3
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• pp.110-117
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• 2014

This paper reports a depth-adaptive sharpness adjustment algorithm for stereoscopic perception improvement, and presents its field-programmable gate array (FPGA) implementation results. The first step of the proposed algorithm was to estimate the depth information of an input stereo video on a block basis. Second, the objects in the input video were segmented according to their depths. Third, the sharpness of the foreground objects was enhanced and that of the background was maintained or weakened. This paper proposes a new sharpness enhancement algorithm to suppress visually annoying artifacts, such as jagging and halos. The simulation results show that the proposed algorithm can improve stereoscopic perception without intentional depth adjustments. In addition, the hardware architecture of the proposed algorithm was designed and implemented on a general-purpose FPGA board. Real-time processing for full high-definition stereo videos was accomplished using 30,278 look-up tables, 24,553 registers, and 1,794,297 bits of memory at an operating frequency of 200MHz.