• Molecules and Cells
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• v.25 no.3
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• pp.452-456
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• 2008

The interactions between monocytes and extracellular matrix proteins have been implicated in atherosclerosis pathophysiology. In the present study we evaluated monocyte attachment and migration through oxidized and non-oxidized collagen IV. Monocyte attachment was tested on microwells coated with either native or oxidized collagen IV. Monocyte migration through collagen IV was examined on transwells. Monocytes derived from patients with diabetes mellitus showed an increased ability to attach and migrate through collagen IV as compared to those derived from healthy volunteers. Moreover, control monocytes attached to oxidized collagen at a higher degree, while they migrated through oxidized collagen at a lower degree, as compared to the native protein. Our results also showed the involvement of the alpha2 integrin subunit in the above phenomena suggesting a modified interaction between monocytes and collagen IV in diabetes mellitus.

• Journal of Microbiology and Biotechnology
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• v.25 no.10
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• pp.1734-1741
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• 2015

Few research had investigated the secretion of phospholipase and aspartyl proteinase from Candida spp. causing infection in females with type 2 diabetes mellitus. This research aimed to investigate the prevalence of vulvovaginal candidiasis (VVC) in diabetic versus non-diabetic women and compare the ability of identified Candida isolates to secrete phospholipases and aspartyl proteinases with characterization of their genetic profile. The study included 80 females with type 2 diabetes mellitus and 100 non-diabetic females within the child-bearing period. Candida strains were isolated and identified by conventional microbiological methods and by API Candida. The isolates were screened for their extracellular phospholipase and proteinase activities by culturing them on egg yolk and bovine serum albumin media, respectively. Detection of aspartyl proteinase genes (SAP1 to SAP8) and phospholipase genes (PLB1, PLB2) were performed by multiplex polymerase chain reaction. Our results indicated that vaginal candidiasis was significantly higher among the diabetic group versus nondiabetic group (50% versus 20%, respectively) (p = 0.004). C. albicans was the most prevalent species followed by C. glabrata in both groups. No significant association between diabetes mellitus and phospholipase activities was detected (p = 0.262), whereas high significant proteinase activities exhibited by Candida isolated from diabetic females were found (82.5%) (p = 0.000). Non-significant associations between any of the tested proteinase or phospholipase genes and diabetes mellitus were detected (p > 0.05). In conclusion, it is noticed that the incidence of C. glabrata causing VVC is increased. The higher prevalence of vaginal candidiasis among diabetics could be related to the increased aspartyl proteinase production in this group of patients.

• Korean Journal of Health Education and Promotion
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• v.30 no.4
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• pp.111-123
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• 2013

Objectives: This study aimed to share with experiences of a demonstration program based on a community for prevention and management of hypertension and diabetes mellitus, and to supply the evidence of accessible strategies within the community through the public-private partnershipin the near future. Methods: This study case was "the program of registration and management of hypertension and diabetes mellitus patients" which was conducted in Hogncheon-gun in Gangwon-province, 2012. Results: The infrastructure of this center was constructed with the public-private sector partnership according to the basic model of demonstration program since November, 2012. So, the total registered rate of hypertension and diabetes mellitus patients were 26.6% in comparison with suspected patients (to the result of 2011 Korea National Health and Nutrition Examination Survey), 37.8% in comparison with the real number of outpatient (to the claims data of 2011 Branch Honcheon-gun, National Health Insurance Corporation), and 107.8% in comparison with the project goal, sequentially. To the patients who were not treated for 30 and 60 days among the registered patients, a recall service was conducted. Through this intervention, it was monitored that this program has enhanced the consecutive treatment rate of the registered patients. Conclusions: To improve the continuous management of hypertension and diabetes mellitus patients, we are gotten to know that the community need the joint participation and mutual cooperation with public-private sector partnership.

• Research in Community and Public Health Nursing
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• v.8 no.1
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• pp.102-115
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• 1997

The purpose of this study was to determine an effect of the health camp program on self-efficacy, sick-role behavioral compliance and glucose metabolism in juvenile diabetes mellitus patients. The quasi -experimental study was designed using a nonequivalent control group pre-posttest design with the framework of Bandura's self-efficacy theory. Forty-two juvenile diabetes mellitus patients participating in this study were selected from outpatients. Of these, twenty-one were assigned to the experimental group and twenty-one to the control group. The period of data collection was from August 8 to December 9 in 1994. The health camp program for the experimental group was carried out over 6 days and the control group did not participate in the program. Collection data was analyzed by means of chi - square test, t - test, ANCOVA, Pearson correlation with SPSS /PC+. The result were summarized as follows: 1. The health camp program was effective in in-creasing the scores of self-efficacy for juven-ile diabetes mellitus patients. 2. The health camp program was effective in increasing the scores of sick - role behavioral compliance for juvenile diabetes mellitus patients. 3. The health camp program was not effective in decreasing the levels of glucose metabolism. 4. The more self-efficacy increased, the more sick - role behavioral compliance increased. 5. Boys showed the higher self-efficacy than girls and the group with diabetes patients whose family members are also patients, showed the higher self-efficacy and sick-role behavioral compliance than the group without diabetic patient among the family members. Thus, it can be concluded that the health camp program was a useful health intervention for juvenile diabetes mellitus patients.

• The Journal of Korean Medicine
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• v.25 no.3
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• pp.169-179
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• 2004

Objectives : The purpose of this study is to research trends in the study of diabetes mellitus and to establish the future direction for its study. Methods : We reviewed oriental medicine papers published in the last twenty-three years(1980-2002). Results : 1. We researched 94 papers in 14 journals and the patterns of study were as follows: experimental studies were 53 (56.3%), reviewed studies were 20 (21.2%), clinical studies were 12 (12.7%) and case reports were 9 (9.8%). 2. The experimental studies (53) were divided into papers on efficiency testing of herbal medications (40) and acupuncture & moxibustion (13). 3. The reviewed studies showed that research has been carried out in the fields of cause, pathogenesis, principles for treating disease, acupuncture and moxibustion, herbal medication, exercise, and relation of sasang (사상) to diabetes mellitus. 4. The clinical studies showed that the research was carried out in the fields of follow up surveys for herbal medication efficiency testing, the relativity of diabetes mellitus to other diseases and sasang (사상). 5. In consequence of researching the case reports, there was no common prescription used meaningfully. Conclusions : We need more studies of diabetes mellitus by reaching for specific therapy.

• Journal of Korean Academic Society of Home Health Care Nursing
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• v.19 no.1
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• pp.74-82
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• 2012

Purpose: The aim of this study is to evaluate the effects of community based chronic disease management program for managing hypertension and diabetes mellitus. Method: The subjects of this study were 1,000 clients, who participated in a city community based chronic disease management program. The data were collected by a phone survey directly, and selected from DB of community based chronic disease management program, indirectly. The data were analyzed by the STATA program, using descriptive statistics, t-test, and Multiple regression analysis. Results: The mean score of knowledge of hypertension was 4.33 and diabetes mellitus was 2.52. The affecting factors of knowledge of hypertension were the clinic visiting point and blood sugar. However, the affecting factors of knowledge of diabetes mellitus was core lab point, diastolic blood pressure, and blood sugar. Conclusion: the results of this study showed that knowledge of hypertension increased with higher level of education, and younger ages, while knowledge of diabetes mellitus increased with higher level education, more core lab point, younger ages, and in males. Therefore, to control the chronic diseases more effectively in a community, it is important to develop a more systematic education and self- managing programs, using collaboration of health centers and local clinics.

• Journal of Haehwa Medicine
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• v.29 no.2
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• pp.22-29
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• 2020

Objectives: This study aims to investigate the effects of diabetes mellitus care mixture (DCM) on blood glucose and lipid metabolism in type 2 diabetic mellitus mice. DCM consisted of lagerstroemia speciose, allium hookeri, momordica charantia, amaranthus tricolor, and boesenbergia rotunda, which have been proven to have antidiabetic properties. Methods: In this study, we researched the effects of DCM in type 2 diabetic mellitus mice. C57BLKS/J mouse groups had no treatment, db/db mouse randomly assigned to 2 groups, and treated with distilled water and DCM (200 mg/kg/day). Blood glucose levels and body weight were checked every week. After 4 weeks of treatment, liver function indicators (AST, ALT, and LDH) and lipid metabolites (triglyceride, total cholesterol, LDL-cholesterol, HDL-cholesterol) were measured with a biochemistry analyzer. Diabetic factors (insulin, resistin, and leptin) were measured with ELISA. Results: DCM was decreased blood glucose, diabetic factors, liver function indicators, triglyceride, total cholesterol, and LDL-cholesterol significantly. Also, HDL-cholesterol was significantly increased in DCM group. The bodyweight of DCM group decreased but, no significant difference with the control group. DCM may have the potential to improved diabetes mellitus by regulating blood glucose levels and diabetic factors. Also protecting from diabetic complications by adjusting liver function indicators and lipid metabolites. Conclusions: These results suggest that DCM to be used as an oriental medicine for diabetes, the results of clinical trials are needed.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.4
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• pp.1125-1132
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• 2003

A Study was researched in oder to classify the clinical symptoms of the diabetes mellitus according of the Sasang constitution that is used to treat and manage the diabetics. We collected 98 patients with diabetes who were diagnosed Sasang constitution at department of Sasang constitutional Medicine in Dongeui Oriental Hospital during 1 year from August. 2000 to July. 2002. and then we investigated and analyzed the clinical symptoms of the diabetics according of the Sasang constitution, and 98 patient was examinated. We investigated the clinical symptoms of the diabetes according of the Sasang constitution to find relationship between the symptoms and the Sasang constitutions. The result of it, we found that it is different between the symptoms according of the Sasang constitution in first symptoms of the diabetes mellitus, weight, appetite, urine and drinking water. Therefore we have found that it is possibility to classify the clinical symptoms of the diabetes mellitus patients according of the Sasang constitution.

• Child Health Nursing Research
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• v.25 no.2
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• pp.234-243
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• 2019

Purpose: The purpose of this study was to investigate associations between self-management and diabetes knowledge, diabetes-related attitudes, family support, and self-efficacy in adolescents with type 1 diabetes mellitus based on the information-motivation-behavior skills model. Methods: Data collection was conducted between March 18 and September 30, 2018. Patients (N=87) aged 12 to 19 years were recruited from the outpatient clinic of S children's hospital and an online community for patient with type 1 diabetes mellitus. Data were analyzed using descriptive statistics, the independent t-test, one-way ANOVA, Pearsons correlation, and hierarchical multiple linear regression with SPSS IBM 23.0, with the two-tailed level of significance set at 0.05. Results: The mean score of self-management in adolescents with type 1 diabetes mellitus was $61.23{\pm}10.00$ out of 80. The regression analysis showed that self-efficacy and family support significantly explained 56.9% of the variance in self-management (F=21.38, p<.001). Self-efficacy (${\beta}=.504$, p<.001) and family support (${\beta}=.188$, p<.001) were significant predictors of self-management. Conclusion: It is necessary to develop individual interventions to improve self-efficacy and family support for adolescents with type 1 diabetes mellitus to help them enhance their self-management.

• Tissue Engineering and Regenerative Medicine
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• v.15 no.6
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• pp.699-709
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• 2018

BACKGROUND: Diabetes mellitus is a major health concern in current scenario which has been found to affect people of almost all ages. The disease has huge impact on global health; therefore, alternate methods apart from insulin injection are being explored to cure diabetes. Therefore, this review mainly focuses on the current status and therapeutic potential of stem cells mainly mesenchymal stem cells (MSCs) for Type 1 diabetes mellitus in preclinical animal models as well as humans. METHODS: Current treatment for Type 1 diabetes mellitus mainly includes use of insulin which has its own limitations and also the underlying mechanism of diseases is still not explored. Therefore, alternate methods to cure diabetes are being explored. Stem cells are being investigated as an alternative therapy for treatment of various diseases including diabetes. Few preclinical studies have also been conducted using undifferentiated MSCs as well as in vitro MSCs differentiated into ${\beta}$ islet cells. RESULTS: These stem cell transplant studies have highlighted the benefits of MSCs, which have shown promising results. Few human trials using stem cells have also affirmed the potential of these cells in alleviating the symptoms. CONCLUSION: Stem cell transplantation may prove to be a safe and effective treatment for patients with Type 1 diabetes mellitus.