• Biomolecules & Therapeutics
• /
• v.28 no.4
• /
• pp.361-369
• /
• 2020

Tofacitinib, a Janus kinase inhibitor, was developed for the treatment of rheumatoid arthritis. Recently, it has been associated with an increased change in arthritis development in patients with diabetes. Herein, we evaluated the pharmacokinetics of tofacitinib after intravenous (10 mg/kg) and oral (20 mg/kg) administration to rats with streptozotocin-induced diabetes mellitus and control rats. Following intravenous administration of tofacitinib to rats with streptozotocin-induced diabetes mellitus, area under the plasma concentration-time curve from time zero to infinity of tofacitinib was significantly smaller (33.6%) than that of control rats. This might be due to the faster hepatic intrinsic clearance (112%) caused by an increase in the hepatic cytochrome P450 (CYP) 3A1(23) and the faster hepatic blood flow rate in rats with streptozotocin-induced diabetes mellitus than in control rats. Following oral administration, area under the plasma concentration-time curve from time zero to infinity of tofacitinib was also significantly smaller (55.5%) in rats with streptozotocin-induced diabetes mellitus than that in control rats. This might be due to decreased absorption caused by the higher expression of P-glycoprotein and the faster intestinal metabolism caused by the higher expression of intestinal CYP3A1(23), which resulted in the decreased bioavailability of tofacitinib (33.0%) in rats with streptozotocin-induced diabetes mellitus. In summary, our findings indicate that diabetes mellitus affects the absorption and metabolism of tofacitinib, causing faster metabolism and decreased intestinal absorption in rats with streptozotocin-induced diabetes mellitus.

• The Journal of Korean Medicine
• /
• v.19 no.2
• /
• pp.137-152
• /
• 1998

Acute complications of diabetes mellitus were diminished after Banting and Best discovered insulin. But chronic complications of diabetes mellitus have been increased. The main complications of diabetes mellitus are diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, diabetic foot lesion and macrovascular complication. These complications can result in renal failure, loss of sight, cerebral infarction and myocardial infarction. So it is very difficult to treat the complications of diabetes mellitus. In oriental medicine, the transformations(傳變症) of Sogal(消渴) are edema, carbuncle, loss of sight and so on. The comparative study between the trcmsformations(傳變症) of SogaI(消渴) and the complications of diabetes mellitus has come to the following conclusions. 1. In oriental medicine, diabetic retinopathy was expessed as loss of sight and the treament of diabetic retinopathy should be started at an early stage, to prevent vitreous hemorrhage and traction retinal detachment. 2. In oriental medicine. diabetic nephropathy was expressed as edema and the treatment should be started at an early stage of renal injury when the protein comes from urine.3. Symmetrical distal polyneuropathy is the main part of diabetic neuropathy and it was expressed as weakness of the lower limbs and pain of joints in the symptoms of Haso(下消). In Oriental medicine, acupuncture and herb medicine which effect is SopungHwalHyul can treat polyneuropathy. 4. Chief macrovascular complications are coronary artery disease and cerebrovascular disease, The cause of macrovascular complication is atherosclerosis. So the method of treating atherosclerosis should be studied in oriental medicine. 5. Diabetic foot were expressed as carbuncle and its main causes are decreasing perfusion of fool, diabetic neuropathy and infection. So these causes should be studied in oriental medicine. 6. The complications of diabetes mellitus afe very similar to the transfonnatiuns of Sogal(消渴).The control of blood glucose is indispensable to prevent and delay the complication of diabetes mellitus.

• Journal of Pharmacopuncture
• /
• v.11 no.4
• /
• pp.65-77
• /
• 2008

Objective The purpose of this study was to analyze the directions of Korean Medicine treatment of diabetes mellitus. Methods We reviewed the 52 studies about diabetes mellitus which had been published from 2000 to 2007. We selected those studies from the search engine of the web site of five journals. Those were the Journal of Korean Oriental Medical Society, Korean Journal of Oriental Physiology & Pathology, the Journal of Korean Acupuncture & Moxibustion Society, Korean Journal of Oriental Internal Medicine and the Journal of Korean Pharmacopuncture Institute. Results 1. The types of diabetes mellitus model in studies were the model used Alloxan(2cases), the model used Streptozotocin(41cases), NOD mice(1case), ob/ob mice(1case), db/db mice(5cases) and rats fed highfat diet(2cases). 2. The types of method in studies were pharmacopuncture(8cases), herbal medcine(47case) and both pharmacopuncture and herbal medcine(3cases). the types of materials in studies were single herb(24cases), multiple herbs(32cases) and both single and multiple herbs(4cases). 3. The types of evaluation criteria in studies were glucose, pancreas, liver, kidney, serum lipid, oxidative stress, nervous system, vascular system and immunity. Conclusions There have been reported many studies of diabetes mellitus in Korean Medicine. It requires to study further types of diabetes mellitus, kinds of herbs and complications of diabetes mellitus for Korean Medicine treatment of diabetes mellitus was covered the ground.

• Preventive Nutrition and Food Science
• /
• v.12 no.3
• /
• pp.154-159
• /
• 2007

This study was conducted to find obesity, biochemical indices and nutrient intakes in type Ⅱ diabetes mellitus with hypertension in Gwangju area. Subjects were divided into two groups based on the status of hypertension. Duration of 139 normotensive type Ⅱ diabetes mellitus was $49.8{\pm}80.2$ months while that of hypertensive type Ⅱ diabetes was $79.7{\pm}95.5$ months. Anthropometric measurement revealed that subjects in both groups were in overweight determined by BMI, though there was no significant difference between two groups. Contrastingly, obesity rate and subscapular fat distribution were a good predictor to identify hypertensive group due to the significant differences between two groups, regardless of sex. Hypertensive type Ⅱ diabetes mellitus is significantly associated with more elevated cholesterol and fasting blood glucose level. Triglyceride level in the hypertensive female was prominent. Significant gender differences were shown in energy, carbohydrate, protein, Ca, Zn, vitamin $B_{6}$ and cholesterol intakes. Nutrient intakes of female normotensive group were higher than those of female hypertensive group except for riboflavin. However, different pattern on nutrient intakes in male was noted. Thus, sex is a great determinant to influence nutrient intakes in subject. Effective nutrition education program targeting type Ⅱ diabetes mellitus, especially hypertensive type Ⅱ diabetes mellitus should be developed and implemented to control blood glucose and lipidemia. It might be suggested to consider the importance different approaches of nutrition education program to both genders.

• The Journal of Internal Korean Medicine
• /
• v.25 no.3
• /
• pp.684-689
• /
• 2004

One of the serious long-tenn complications of diabetes mellitus is the diabetic foot lesion. Diabetic foot lesions are a major cause of morbidity, mortality, disability in patients with diabetes and frequent cause of lower-extremity amputations. The treatment of diabetic foot lesions is based on the strict control of diabetes mellitus. A patient with diabetic foot lesions was treated with Cheunhwasangamibang and improvement was seen. Results in this case support a role for Cheunhwasangamibang in controlling diabetes mellitus, and are here reported to encourage further study.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.21 no.6
• /
• pp.1601-1610
• /
• 2007

The purpose of this study was to determine whether a pulse analyzer was useful 1) to characterize the variables of pulse wave of diabetes mellitus group, compared with those of healthy subjects, and 2) to determine Sasang Constitution in diabetes mellitus group and healthy subjects. 1. The sum of pulse pressure (energy) and the ratio of systolic period area (As%), called pulse pressure-related variables, were higher in diabetes mellitus group than healthy group, while the height of dicrotic wave (h5) and the ratio of height of dicrotic wave to height of percussion wave (h5/h1), correlated with arterial compliance, were lower in diabetes mellitus group than healthy group. 2. Taeumin of diabetes mellitus group showed higher pressure-related variables than that of healthy group. 3. Soumin of diabetes mellitus group had shorter the time to dicrotic wave (t5) than that of healthy group. 4. Soyangin of diabetes mellitus group showed higher heart rates and lower values in pulse wave time-related variables, including time to dicrotic wave(t5), time to incisura (t4), total time minus time to incisura (t-t4), total time (t), width of percussion wave (w), and the ratio of width of percussion wave to total time (w/t), than that of healthy group. 5. Contact pressure (CP), sum of pulse pressure (energy), height of pre-incisura (h2), height of incisura (h4), width of percussion wave (w), time to incisura (t4), time to percussion wave (t1), variance of total time (Vt), variance of height of percussion wave(Vp) and the ratio of height of incisura to height of percussion wave (h4/h1) were used to develop the rules of Sasang Constitution Classification with about seventy five percents accuracy. These suggested that the pulse analyzer was useful to evaluate the risk degree of diabetes mellitus and to determine Sasang Constitution among either diabetes mellitus group or healthy group.

• Journal of the Korean Dietetic Association
• /
• v.23 no.1
• /
• pp.54-63
• /
• 2017

Anemia, defined as a reduction in the hemoglobin concentration of blood, is common in diabetes mellitus (DM) patients, can be potentially caused by diabetes complications such as nephropathy. Recent research suggests that diabetes mellitus (DM) itself may be a major risk factor of anemia. However, there are few Korean studies on the relationship between diabetes mellitus (DM) and anemia. This study was performed to investigate the association between anemia and diabetes mellitus (DM) in Korean adults. A total of 10,151 Korean adults over aged 19 years (4,422 male, 5,729 female) were selected from the participants of the Korean National Health and Nutrition Examination Survey VI (KNHANES VI). Korean adults with anemia had a higher prevalence of diabetes mellitus (DM) than the normal adults (11.4% vs. 30.4% in male, 8.8% vs. 9.4% in female). The unadjusted odds ratio (OR) for anemia was greater in adults with DM than in normal male (OR=3.28; 95% CI: 2.27~4.73). After adjusting for other risk factors including age, education, family income, smoking, drinking, and menstrual status, anemia and diabetes were not associated (OR=1.33; 95% CI: 0.84~2.09). Similarly, there was no association between anemia and diabetes in female. In conclusion, this study shows that the prevalence of anemia is similar in diabetic and non-diabetic Korean adults after adjusting for multiple risk factors. Further research is required to elucidate the mechanism of anemia caused as a consequence of diabetes mellitus (DM).

• Korean Journal of Community Nutrition
• /
• v.14 no.6
• /
• pp.734-745
• /
• 2009

Diabetes mellitus is the prevalent disease among older adults. The purpose of this study was to implement and evaluate the nutrition education program for diabetes mellitus patients aged 60 and over. The one group pretest and posttest design was employed to evaluate the program effectiveness. Nutrition education program for diabetes mellitus patients was carried out at the public healthy center in Guri city. The 38 out of 63 patients completed education program. They received four sessions of group education during four weeks. Nutrition education materials (booklet, leaflet) for older adults were provided to participants. Data about blood glucose, blood pressure, nutrition and diabetes mellitus knowledge, dietary behavior, dietary intake by 24-hour recalls were collected before and after nutrition education to evaluate the program effectiveness. All data were statistically analyzed using SAS package (ver.8.2) and significant difference was evaluated by $X^2$-test, paired t-test and Wilcoxon signed rank test. Study results showed that blood pressure and blood glucose were slightly decreased after nutrition education but they did not reach statistical significance. There were positive changes in nutrition knowledge and dietary behavior. The total score of nutrition and diabetes knowledge increased significantly (p < 0.001), and the total score of dietary behavior was improved (p < 0.05) after nutrition education. Dietary intakes of most of nutrients examined were not significantly different between pre- and post-test. Based on study results, it appears that nutrition education program for the aged diabetes mellitus patients might effectively increase nutrition knowledge, dietary behavior and diet quality. This nutrition education program can be used at the public health centers or senior centers for the management of diabetes mellitus for older adults.

• The Journal of Internal Korean Medicine
• /
• v.38 no.4
• /
• pp.509-519
• /
• 2017

Objectives: This study describes how two patients diagnosed with type-II diabetes mellitus were successfully treated using herbal medicine. Methods: The patients were given Yuldahanso-tang to reduce the effects of Taeumin's dry-febrile symptom. Results: Type-II diabetes mellitus symptoms experienced by patients with Taeumin's dry-febrile symptom included thirst, fatigue, weight loss, and numbness in the hands and feet. After administering Yuldahanso-tang, all numerical levels for blood sugar, glycated hemoglobin (HbA1c), glycosuria, and proteinuria recovered to within normal levels. Conclusions: Treatment of patients with Taeumin's dry-febrile symptom and type-II diabetes mellitus with Yuldahanso-tang was effective, and this new evidence supports the use of herbal medicine for treating such patients.

• Journal of Nutrition and Health
• /
• v.32 no.4
• /
• pp.401-406
• /
• 1999

The purpose of this study was to identify some anthropometric characteristics related to the incidence of diabetes mellitus in Korea. The subjects were 165 male and female patients aged 30 to 70 years who had been diagnosed with diabetes mellitus for less than five year, recruied from eight different hospitals in Seoul, Korea. Weight, height, waist circumference, hip circumference and triceps skinfold thickness were measured. Weight before diagnosis of diabetes was also surveyed. The body mass index(BMI) of diabetic patients before diabetic diagnosis was significantly higher than that of reference values. Fifty percent of patients had BMI values greater than 25kg/$m^2$, and female patients were somewhat fatter than male patients. Since many subjects were overweight before diagnosis, obestty could be regarded as a risk factor for the incidence of diabetes mellitus. However, waist-hip ratios(WHR) fell within the normal range, so WHR may not be regarded as an important risk factor for NIDDM in Korea. This study suggests that the risk factors of onset of diabetes in Western populations may not be applicable to the Korea population. More study is needed to clarify the risk factors of Korean diabetes.