• Childhood Kidney Diseases
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• 제7권1호
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• pp.96-102
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• 2003

저자들은 methymalonic acidemia로 진단된 체중 2.4 kg의 생후 5일된 여아에서 지속적 정정맥 투석 여과법(CVVHDF)을 이용하여 혈역학적 불안정 상태나 특별한 후유증 없이 체내 암모니아를 효과적으로 제거하였기에 보고하는 바이다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권4호
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• pp.1049-1065
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• 2023

Recently, with the development of IoT, AI, and mobile terminals, medical information platforms are expanding. The medical information platform can determine a patient's emergency situation, and medical staff can easily access patient information through a mobile terminal. However, in the existing platform, emergency situation decision is delayed, and faster and stronger authentication is required in emergency situations. Therefore, we propose an edge computing-based medical information platform for automatic authentication using patient situations. We design an edge computing-based medical information platform architecture capable of rapid transmission of biometric data of IoT and quick emergency situation decision, and implement the platform data flow in emergency situations. Relying on this platform, we propose the automatic authentication using patient situations. The automatic authentication protects patient information through patient-centered authentication by using the patient's situation as an authentication factor, and enables quick authentication by automatically proceeding with mobile terminal authentication after user authentication in emergencies without user intervention. We compared the proposed platform with existing platforms to show that it can make quick and stable emergency decisions. In addition, comparing the automatic authentication with existing authentication showed that it is fast and protects medical information centered on patient situations in emergency situations.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2021년도 춘계학술발표대회
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• pp.454-456
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• 2021

본 논문은 웹의 발달로 인하여 의료 서비스들이 기존의 Client-Server 방식의 제품에서 Web 방식의 제품으로 변경되고 있는 현대 흐름에서 인공지능 어플리케이션 또한 Web 으로 서비스 하기 위한 방법과 구현된 요로결석 AI 어플리케이션에 대해 기술한다. 이를 구현하기 위해 Python 기반의 Flask 라는 마이크로 웹 프레임워크를 사용하여 DICOM 핸들링, Pre-Processing, Mask 를 생성하고 Predict 결과를 Model Serving 을 통하여 Urinary Stone Segmentation Model 이 서비스되는 인공지능 웹 어플리케이션 동작 방식과 수행 결과를 보인다.

• Korean Journal of Radiology
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• 제24권3호
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• pp.259-270
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• 2023

Objective: It is unknown whether artificial intelligence-based computer-aided detection (AI-CAD) can enhance the accuracy of chest radiograph (CR) interpretation in real-world clinical practice. We aimed to compare the accuracy of CR interpretation assisted by AI-CAD to that of conventional interpretation in patients who presented to the emergency department (ED) with acute respiratory symptoms using a pragmatic randomized controlled trial. Materials and Methods: Patients who underwent CRs for acute respiratory symptoms at the ED of a tertiary referral institution were randomly assigned to intervention group (with assistance from an AI-CAD for CR interpretation) or control group (without AI assistance). Using a commercial AI-CAD system (Lunit INSIGHT CXR, version 2.0.2.0; Lunit Inc.). Other clinical practices were consistent with standard procedures. Sensitivity and false-positive rates of CR interpretation by duty trainee radiologists for identifying acute thoracic diseases were the primary and secondary outcomes, respectively. The reference standards for acute thoracic disease were established based on a review of the patient's medical record at least 30 days after the ED visit. Results: We randomly assigned 3576 participants to either the intervention group (1761 participants; mean age ± standard deviation, 65 ± 17 years; 978 males; acute thoracic disease in 472 participants) or the control group (1815 participants; 64 ± 17 years; 988 males; acute thoracic disease in 491 participants). The sensitivity (67.2% [317/472] in the intervention group vs. 66.0% [324/491] in the control group; odds ratio, 1.02 [95% confidence interval, 0.70-1.49]; P = 0.917) and false-positive rate (19.3% [249/1289] vs. 18.5% [245/1324]; odds ratio, 1.00 [95% confidence interval, 0.79-1.26]; P = 0.985) of CR interpretation by duty radiologists were not associated with the use of AI-CAD. Conclusion: AI-CAD did not improve the sensitivity and false-positive rate of CR interpretation for diagnosing acute thoracic disease in patients with acute respiratory symptoms who presented to the ED.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2022년도 제66차 하계학술대회논문집 30권2호
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• pp.31-34
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• 2022

본 논문에서는 손목 부착형 웨어러블(Wearable) RGB 카메라를 통해 취득한 손 이미지에 최적화된 손 자세 추정모델과 학습방법을 제안한다. 최근 의료분야에서 활발하게 인공지능이 사용되고 있으며 그 중 이미지 인식을 중심으로 하는 진단 분야[1]가 괄목할만한 성과를 보인다. 본 연구에서는 웨어러블 카메라를 통해 얻은 손 자세를 활용하여 질병 진단에 적용할 계획이다. 또한, 본 연구수행을 통해 질병진단에 필요한 데이터 측정비용 절감 및 개인 맞춤형 진단서비스를 제공할 것으로 기대된다.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2023년도 추계학술발표대회
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• pp.904-905
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• 2023

본 논문에서는 의료 영상 생성을 위한 Med-StyleGAN2를 제안한다. 생성적 적대 신경망은 이미지 생성에는 효과적이지만, 의료 영상 생성에는 한계점을 가지고 있다. 따라서 본 연구에서는 의료 영상 생성에 특화된 StyleGAN 기반 학습 모델을 제안한다. 이는 다양한 의료 영상 어플리케이션에 활용할 수 있으며, 생성된 의료 영상에 대한 정량적, 정성적 평가를 수행함으로써 의료 영상 생성 분야의 발전 가능성에 대해 연구한다.

• Clinical and Experimental Pediatrics
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• 제61권1호
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• pp.30-34
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• 2018

Congenital pulmonary airway malformation (CPAM), previously known as congenital cystic adenomatoid malformation, is a rare developmental lung abnormality associated with rhabdomyosarcoma, pleuropulmonary blastoma, and mucinous adenocarcinoma of the lung. We report an unusual case of a 10-day-old male newborn with a left lower lobe pulmonary cyst who underwent lobectomy, which revealed type II CPAM complicated by multifocal mucinous adenocarcinoma. KRAS sequencing revealed a somatic mutation in Codon12 ($GGT{\rightarrow}GAT$), suggesting the development of a mucinous adenocarcinoma in the background of mucinous metaplasia. Mucinous adenocarcinoma is the most common lung tumor associated with CPAM, but it generally occurs in older children and adults. Further, all cases in the literature are of type I CPAM. This case in a neonate indicates that malignant transformation can occur very early in type II CPAM.

• 대한의용생체공학회:의공학회지
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• 제42권6호
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• pp.277-286
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• 2021

The global market size of AI based SaMD for medical image in 2023 will be anticipated to reach around 620 billion won (518 million dollars). In order for Korean manufacturers to efficiently obtain CE marking for marketing in the EU countries, the paper is to introduce the recommendation and suggestion of how to reclassify SaMD based on classification rules of MDR because, after introducing the Regulation EU 2017/745, classification rules are quite modified and newly added compared to the Directive 93/42/EEC. In addition, the paper is to provide several rules of MDR that may be applicable to decide the classification of SaMD. Lastly, the paper is to examine and demonstrate various secondary data supported by qualitative data because the paper focuses on the suggestion and recommendation with a public trust on the basis of various secondary data conducted by the analysis of field data. In conclusion, the paper found that the previous classification of SaMD followed by the rule of MDD should be reclassified based on the Regulation EU 2017/745. Therefore, the suggestion and recommendation are useful for Korean manufacturers to comprehend the classification of SaMD for marketing in the EU countries.

• Journal of Radiation Protection and Research
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• 제47권3호
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• pp.111-133
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• 2022

The exciting advancement related to the "modeling of digital human" in terms of a computational phantom for radiation dose calculations has to do with the latest hype related to deep learning. The advent of deep learning or artificial intelligence (AI) technology involving convolutional neural networks has brought an unprecedented level of innovation to the field of organ segmentation. In addition, graphics processing units (GPUs) are utilized as boosters for both real-time Monte Carlo simulations and AI-based image segmentation applications. These advancements provide the feasibility of creating three-dimensional (3D) geometric details of the human anatomy from tomographic imaging and performing Monte Carlo radiation transport simulations using increasingly fast and inexpensive computers. This review first introduces the history of three types of computational human phantoms: stylized medical internal radiation dosimetry (MIRD) phantoms, voxelized tomographic phantoms, and boundary representation (BREP) deformable phantoms. Then, the development of a person-specific phantom is demonstrated by introducing AI-based organ autosegmentation technology. Next, a new development in GPU-based Monte Carlo radiation dose calculations is introduced. Examples of applying computational phantoms and a new Monte Carlo code named ARCHER (Accelerated Radiation-transport Computations in Heterogeneous EnviRonments) to problems in radiation protection, imaging, and radiotherapy are presented from research projects performed by students at the Rensselaer Polytechnic Institute (RPI) and University of Science and Technology of China (USTC). Finally, this review discusses challenges and future research opportunities. We found that, owing to the latest computer hardware and AI technology, computational human body models are moving closer to real human anatomy structures for accurate radiation dose calculations.

• 대한영상의학회지
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• 제83권4호
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• pp.759-770
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• 2022

인공지능의 연구 개발 및 활용에서 윤리의 중요성이 의료분야뿐 아니라 전 사회적으로 점차 널리 인식되고 있다. 이 종설은 영상의학 영상데이터를 인공지능 연구에 활용할 때 개인정보의 보호 및 데이터에 대한 권리 측면에서 윤리적으로 고려할 사항들에 대해서 국내 독자들에게 실용적인 정보를 제공하고자 한다. 따라서 이 글에 담긴 내용은 많은 부분이 관련된 국내 법과 정부 제도에 바탕을 두고 있다. 인공지능의 연구 개발 및 활용에서 개인정보 보호는 매우 중요한 윤리적 원칙이며 연구 데이터의 적절한 가명처리는 개인정보 보호를 위한 핵심 방법이다. 아울러 인공지능 연구 개발에 의료 데이터를 상업적 이해관계를 최소화하며 윤리적으로 공유할 필요성도 부각되고 있다. 연구 데이터 공유는 개인정보 유출의 위험을 증가시키므로 개인정보 보호에 더욱 주의가 필요하다.