• Journal of Families and Better Life
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• v.28 no.5
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• pp.1-12
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• 2010

This study investigates the mediation effects of affection-rejection parenting in the relationships between reports by mothers in regards to marital conflicts and the behavior and emotional control of preschoolers. The participants were 311 preschoolers and their mothers. A total of 311 preschoolers attended kindergartens or day care centers in Daegu or Gyeongbuk Province. The collected data were analyzed by Pearson's correlation, single and hierarchical multiple regressions, using SPSS Win 15.0. The results are as follows. (1) Mothers' marital conflicts exerted indirect effects on preschoolers' behavioral control mediated by affection parenting. (2) Mothers' marital conflicts exerted indirect effects on preschoolers' behavioral control mediated by rejection parenting. (3) Mothers' marital conflicts partly exerted indirect effects on preschoolers' emotional control mediated by affection parenting. (4) Mothers' marital conflicts partly exerted indirect effects on preschoolers' emotional control mediated by rejection parenting.

• The Korean Journal of Physiology and Pharmacology
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• v.19 no.6
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• pp.523-531
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• 2015

Serotonin [5-hydroxytryptamine (5-HT)] regulates synaptic plasticity in the visual cortex. Although the effects of 5-HT on plasticity showed huge diversity depending on the ages of animals and species, it has been unclear how 5-HT can show such diverse effects. In the rat visual cortex, 5-HT suppressed long-term potentiation (LTP) at 5 weeks but enhanced LTP at 8 weeks. We speculated that this difference may originate from differential regulation of neurotransmission by 5-HT between the age groups. Thus, we investigated the effects of 5-HT on apha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-, ${\gamma}$-aminobutyric acid receptor type A (GABAAR)-, and N-methyl-D-aspartic acid receptor (NMDAR)-mediated neurotransmissions and their involvement in the differential regulation of plasticity between 5 and 8 weeks. AMPAR-mediated currents were not affected by 5-HT at both 5 and 8 weeks. GABAAR-mediated currents were enhanced by 5-HT at both age groups. However, 5-HT enhanced NMDAR-mediated currents only at 8 weeks. The enhancement of NMDAR-mediated currents appeared to be mediated by the enhanced function of GluN2B subunit-containing NMDAR. The enhanced GABAAR- and NMDAR-mediated neurotransmissions were responsible for the suppression of LTP at 5 weeks and the facilitation of LTP at 8 weeks, respectively. These results indicate that the effects of 5-HT on neurotransmission change with development, and the changes may underlie the differential regulation of synaptic plasticity between different age groups. Thus, the developmental changes in 5-HT function should be carefully considered while investigating the 5-HT-mediated metaplastic control of the cortical network.

• Korean Journal of Childcare and Education
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• v.14 no.1
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• pp.249-268
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• 2018

Objective: The purpose of this study was to examine the effects of preschooler's temperament on peer play activity, focusing on the mediation of mothers' social interaction parenting behaviors Methods: 1695 mothers of preschoolers completed questionnaires on children's temperament and peer play behaviors, and mothers' parenting behaviors. Data were analyzed by regression analyses by SPSS 18.0. Results: First, preschoolers' sociability exerted positive effects on good peer play behaviors(play interaction) and negative effects on the bad peer play behaviors (disruption, disconnection) and both were partially mediated by mothers' social interaction parenting behaviors. Second, preschoolers' emotionality exerted negative effects on good peer play behaviors and positive effects on the bad peer play behaviors and both were partially mediated by mothers' social interaction parenting behaviors. Preschoolers' activity exerted positive effects on good peer play behaviors and negative effects on the bad peer play behaviors and both were partially mediated by mothers' social interaction parenting behaviors. Conclusion/Implications: These findings provide preliminary evidence that mothers' social interaction parenting behavior partially mediate the effects of preschoolers' temperament on peer play behaviors. Implications for the use of intervention targeting specific temperament have been discussed.

• Human Ecology Research
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• v.62 no.2
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• pp.337-349
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• 2024

The aim of this study was to explore the mediating effects of adult attachment and marital satisfaction on the relationship between childhood maternal attachment and parenting behavior. A total of 372 mothers of preschoolers completed questionnaires on childhood maternal attachment, adult attachment, marital satisfaction, and parenting behavior. Adult attachment was analyzed by distinguishing between attachment anxiety and attachment avoidance. Parenting behavior was categorized into positive and negative behaviors. For the main analyses, Preacher and Hayes's PROCESS macro program was used to examine serial mediating effects. The results revealed that attachment anxiety mediated the effects of mothers' childhood attachment experiences on both positive and negative parenting behavior. However, attachment avoidance only mediated the effects on positive parenting behavior. Marital satisfaction mediated the effects of mothers' childhood attachment experiences on both positive and negative parenting behavior. Notably, the sequential mediating effects of attachment anxiety and marital satisfaction were not significant for either positive or negative parenting behavior. By contrast, the sequential mediating effects of attachment avoidance and marital satisfaction were significant for both positive and negative parenting behavior. These findings elucidate the predictive factors for parenting behavior within a process model framework, providing valuable insights for parental education and counseling aimed at enhancing mothers' parenting practices.

• Archives of Pharmacal Research
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• v.22 no.1
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• pp.35-43
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• 1999

Overstimulation of both kainate (KA) and N-methyl-D-aspartate (NMDA) receptors has been reported to induce excitatoxicity which can be characterized by neuronal damage and formation of reactive oxygen free radicals. Neuroprotective effect of melatonin against KA-induced excitotoxicity have been documented in vitro and in vivo. It is, however, not clear whether melationin is also neuroportective against excitotoxicity mediated by NMDA receptors. In the present work, we tested the in vivo protective effects of striatally infused melatonin against the oxidative stress and neuronal damage induced by the injection of KA and NMDA receptors into the rat striatum. Melatonin implants consisting of 22-gauge stainless-steel cannule with melatonin fused inside the tip were placed bilaterally in the rat brain one week prior to intrastriatal injection of glutamate receptor subtype agonists. Melatonin showed protective effects against the elevation of lipid peroxidation induced by either KA or NMDA and recovered Cu, Zn-superoxide dismutase activities reduced by both KA and NMDA into the control level. Melatonin also clearly blocked both KA- and NMDA-receptor mediated neuronal damage assessed by the determination of choline acetyltransferase activity in striatal monogenages and by microscopic observation of rat brain section stained with cresyl violet. The protective effects of melatonin are comparable to those of DNQX and MK801 which are the KA- and NMDA-receptor antagonist, respectively. It is suggested that melatonin could protect against striatal oxidative damages mediated by glutamate receptors, both non-NMDA and NMDA receptors.

• Molecules and Cells
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• v.39 no.3
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• pp.186-194
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• 2016

Epidemiological evidence suggests that bone is especially sensitive to oxidative stress, causing bone loss in the elderly. Previous studies indicated that human amnion-derived mesenchymal stem cells (HAMSCs), obtained from human amniotic membranes, exerted osteoprotective effects in vivo. However, the potential of HAMSCs as seed cells against oxidative stress-mediated dysfunction is unknown. In this study, we systemically investigated their antioxidative and osteogenic effects in vitro. Here, we demonstrated that HAMSCs significantly promoted the proliferation and osteoblastic differentiation of $H_2O_2$-induced human bone marrow mesenchymal stem cells (HBMSCs), and down-regulated the reactive oxygen species (ROS) level. Further, our results suggest that activation of the ERK1/2 MAPK signal transduction pathway is essential for both HAMSCs-mediated osteogenic and protective effects against oxidative stress-induced dysfunction in HBMSCs. U0126, a highly selective inhibitor of extracellular ERK1/2 MAPK signaling, significantly suppressed the antioxidative and osteogenic effects in HAMSCs. In conclusion, by modulating HBMSCs, HAMSCs show a strong potential in treating oxidative stress- mediated bone deficiency.

• BMB Reports
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• v.43 no.10
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• pp.683-687
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• 2010

Previous studies have shown that one of the primary causes of increased iron content in the brain may be the release of excess iron from intracellular iron storage molecules such as ferritin. Free iron generates ROS that cause oxidative cell damage. Carnosine and related compounds such as endogenous histidine dipetides have antioxidant activities. We have investigated the protective effects of carnosine and homocarnosine against oxidative damage of DNA induced by reaction of ferritin with $H_2O_2$. The results show that carnosine and homocarnosine prevented ferritin/$H_2O_2$-mediated DNA strand breakage. These compounds effectively inhibited ferritin/$H_2O_2$-mediated hydroxyl radical generation and decreased the mutagenicity of DNA induced by the ferritin/$H_2O_2$ reaction. Our results suggest that carnosine and related compounds might have antioxidant effects on DNA under pathophysiological conditions leading to degenerative damage such as neurodegenerative disorders.

• Korean Journal of Child Studies
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• v.28 no.4
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• pp.113-126
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• 2007

This study explored mediating effects of the maternal emotional expressiveness between maternal behavioral inhibition/behavioral activation system and children's emotional intelligence. subjects were 138 4- to 5-year-old preschoolers (92 boys, 46 girls) and their mothers. The maternal behavioral inhibition/behavioral activation system was measured by BIS/BAS(Behavioral Inhibition System/Behavioral Activation System, Carver & White, 1994), maternal emotional expressiveness was measured by the Self-Expressiveness in the Family Questionnaire (Halberstadt, 1995), and children's emotional intelligence was measured by the Emotional Intelligence Questionnaire (Lee, 1998). Data were analyzed by descriptive statistics and multiple regression analysis. Results were that maternal positive expressiveness mediated the effects of maternal BIS on children's self-understanding and maternal negative expressiveness mediated the effects of maternal BAS on children's self-regulation.

• Journal of Food Hygiene and Safety
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• v.11 no.4
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• pp.235-241
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• 1996

The rhamnan sulfate extracted from green algae seaweed, Monostroma nitidum was characterized as activity in vitro culture assay with macrophages from mice. Rhamnan sulfate indicated that F-4-3 fraction enhanced glucose consumption, as well as the production of nitrogen dioxide and tumor necrosis factor(TNF). F-4-3 fraction was also augmented IL-1 secretion from those macrophages. Effects of the pretreatment of peritoneal macrophages with rhamnan sulfate F-4-3 fraction and several polysaccharides as relative standard on the production of H2O2 induced with unopsonized zymosan A were examined. Pretreatment with polysaccharides inhibited the zymosan A mediated H2O2 production by macrophages. The phorbol myristate acetate (PMA) mediated H2O2 production was not affected by the pretreament. These result suggested that pretreatment of rhamnan sulfate interfered with the interaction of macrophages zymosan A. Rhamnan sulfate inhibited zymosan A mediated production of H**O** by macrophages and F-4-3 Fraction was also activator of macrophages.

• The Korean Journal of Pharmacology
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• v.32 no.2
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• pp.169-175
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• 1996

The reactivity of the sulfhydryl (thiol) group of homocysteine has been associated with an Increased risk of atherosclerosis, thrombosis and stroke. Thiols also react with nitric oxide (NO, an endothelium-derived relaxing factor (EDRF) ), forming S-nitrosothiols that have been reported to have potent vasodilatory and antiplatelet effects and been expected to decrease adverse vascular effects of homocysteine. The present study was aimed to Investigate whether the S-nitrosation of homocysteine modulates the neurotoxic effects of homocysteine. An 18 hour-exposure of cultured rat cortical neurons to homocysteine ( >1 mM) resulted in a significant neuronal cell death. At comparable concentrations ( <10 mM), however, S-nitrosohomocysteine did not induce neuronal cell death. Furthermore, S-nitrosohomocysteirle partially blocked NMDA-mediated neurotoxicity. S-nitrosohomocysteine also decreased NMDA-mediated increases in intracellular calcium concentration. The present data indicate that in brain nitric oxide produced from neuronal and nonneuronal cells can modulate the potential, adverse properties of homocysteine.