• Title/Summary/Keyword: Mean value model

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Cardiovascular Responses and Nitric Oxide Production in Cerebral Ischemic Rats

  • Shinl, Chang-Yell;Lee, Nam-In;Je, Hyun-Dong;Kim, Jeong-Soo;Sung, Ji-Hyun;Kim, Dong-Seok;Lee, Doo-Won;Bae, Ki-Lyong;Sohn, Uy-Dong
    • Archives of Pharmacal Research
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    • v.25 no.5
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    • pp.697-703
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    • 2002
  • We investigated that the role of nitric oxide (NO) on ischemic rats in brain and heart. Ischemia was induced by both common carotid arteries (CCA) occlusion for 24h following reperfusion. Then tissue samples were removed and measured NOx. In brain, NOx was increased by about 40% vs. normal and it was significantly inhibited by aminoguanidine, selective iNOS inhibitor. This result showed that NOx concentration was increased by iNOS. We investigated the role of $Ca^{2+}$ during ischemia. Nimodipine, L-type calcium channel blocker, didn't inhibit the increases of NOx concentration during ischemia. It suggested that increased NOx was due to calcium-independent NOS. MK-801, which N-methyl-D-aspartate (NMDA) receptor antagonist, didn't significantly prevent the increases of NOx. In heart, ischemia caused NOx decrease and it is inconsistent with NOx increase in brain. Aminoguanidine and nimodipine didnt affect on NOx decrease. But MK-801 more lowered NOx concentration than those of ischemia control group. It seemed that $Ca^{2+}$ influx in heart partially occurred via NMDA receptor and inhibited by NMDA receptor antagonist. The mean arterial pressure (MAP) in ischemic rats after 24h of CCA occlusion was decreased when compared to normal value, whereas the heart rates (HR) was not different between two groups. Aminoguanidine or MK801 had no effect on MAP or HR, but nimodipine reduced MAP. There was no difference the effects of aminoguanidine, nimodipine, or MK-801, on MAP and HR between normal rats and ischemic rats. In summary, ischemic model caused an increase of NOx concentration, suggesting that this may be produced via iNOS, which is calcium independent in brain. However in heart, ischemia decreased NOx concentration and NMDA receptor was partially involved. The basal MAP was decreased in ischemic rats but HR was not different from normal control, suggesting that increased NOx in brain of ischemic rat may result in the hypotension.

An Analysis of the Effects of Consumer Characteristics and Consumer Trust on Purchase Intention of Environment-friendly Agricultural Products (소비자 특성과 소비자 신뢰가 친환경농산물의 구매의도에 미치는 영향 분석)

  • Kim, Mi-Song;Choi, Hyung-Kyu;Kim, Dong-Hwan
    • Journal of Distribution Science
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    • v.11 no.1
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    • pp.45-53
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    • 2013
  • Purpose - The environment-friendly agricultural product market in Korea sees continual high growth. Recently, the Korean government has been actively fostering environment-friendly agriculture as an engine of future growth. Korean people have increasingly become more health-conscious and interested in food safety issues. Many distribution and retailing companies have responded with various promotional activities. However, most of these are not strategic and appear to have unsatisfactory outcomes. The main purpose of this paper is to suggest effective marketing strategies for environment-friendly agricultural products. To achieve this aim, the study empirically investigates the effects of consumer characteristics and trust on the purchase intention of environment-friendly agricultural products. Research design, data, methodology - Based on the theory of planned behavior, and previous studies related to the purchase intention and consumption of environment-friendly agricultural products, we set up five study hypotheses. These related to the demographic characteristics of consumers, purchase intention, and behavior of the products. We then set up a study model and four study hypotheses relating to health consciousness, environmental consciousness, consumer trust level, purchase intention, and behavior of the products. The data were collected using a questionnaire given to consumers living in Seoul and southern Geonggi Province. The final sample size is 403 and mean age is 44.3. SPSS 15.0 for Windows and Amos 7.0 were used as statistical analysis tools. Meaningful results were derived using frequency analysis, correlation analysis, a t-test, and structural equation modeling. Results - Empirical results of this research are as follows. (1) First, it is shown that consumers consider such attributes as intimacy and health to be important when they buy environment-friendly agricultural products. (2) We also found that consumers recognize the value of environment-friendly agricultural products as high, but their trust level as low. (3) Consumer groups consisting of married couples, with higher education, higher income, and higher age are shown to have a higher intention of buying environment-friendly agricultural products than any other consumer group. (4) It is estimated that the level of consumer trust positively affects the purchase intention of environment-friendly agricultural products. The path coefficient (.138) between consumer trust and purchase intention is statistically significant at the α = .05 level. (5). It is also estimated that environmental consciousness positively affects purchase intention. The path coefficient (.245) between environmental consciousness and purchase intention is statistically significant at the α = 0.05 level. The standardized path coefficients of consumer trust and environmental consciousness with purchase intention are .556 and .288 respectively. Therefore, consumer trust affects purchase intention more than environmental consciousness. (6) Finally, purchase intention is estimated to positively affect purchase behavior. Conclusions - Based upon empirical results, this research suggests that marketers of environment-friendly agricultural products should focus more on increasing consumer trust levels, emphasizing the training and education of employees. The government also should pay attention to a standardized certification system for environment-friendly agricultural products. Marketers of environment-friendly agricultural products should consider the consumer groups of married couples, with higher education, higher income, and higher age as a major target segment.

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An Evaluation of Thermal Comfort on Urban Neighborhood Park for Improving Thermal Environment (도시근린공원의 열환경 개선을 위한 열쾌적성 평가)

  • Lim, Eun-Na;Lee, Woo-Sung;Choi, Chul-Hyun;Song, Bong-Geun;Jung, Sung-Gwan
    • Journal of the Korean Association of Geographic Information Studies
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    • v.16 no.4
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    • pp.153-170
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    • 2013
  • This study was conducted to analyze the thermal comfort in the urban neighborhood park and to obtain a plan for improvement of the thermal environment. First, in the result of the analysis of the distribution characteristics of the park's main thermal environment factors and differences among types of space, temperature, relative humidity, and wind speed did not show a clear difference spatially. However, the median radiant temperature showed great differences according to the openness of the space and the covering material. According to the evaluation of thermal comfort by types of space based on derived thermal environmental factors, the PMV value of the square was the highest at 4.39, the paths showed 2.58, greenery 1.90, and resting spaces 0.42. In the result of the PMV regression model established for the evaluation of the significance of these thermal environment factors that decide thermal comfort, it showed that the relative significance to the PMV was as follows in decreasing order: median radiant temperature(1.084), wind speed(-0.280), temperature(0.013), and relative humidity(-0.009). When conducting a scenario analysis on the areas with need for improvement in thermal environment, it was found that through reflectivity, color and the change in the physical properties of packing materials the thermal comfort felt by the body could be improved, and it is believed that through this the improvement plan can be established.

EVALUATION MODEL OF GROWTH AND DEVELOPMENT IN PEDIATRIC DENTISTRY (한국인 소아의 성장 발육 평가 자료 제작에 관한 연구)

  • Kim, Young-Jae;Lee, Shin-Jae;Kim, Jung-Wook;Jang, Ki-Taeg;Lee, Sang-Hoon;Hahn, Se-Hyun;Kim, Chong-Chul
    • Journal of the korean academy of Pediatric Dentistry
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    • v.33 no.2
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    • pp.173-180
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    • 2006
  • Knowledge of growth and development is essential for pediatric dentistry treating growing patients. The data from the pediatric growth curve being used today does not reflect the growth transition of modern times, nor does it match the age range required for dental purposes. The present study, therefore, aims to introduce the process of producing a growth curve and growth rate curve based on data which represents a more accurate description of the present situation. The original data used in this study were from the 5th nationwide survey, SIZE KOREA 2004 study carried out by the Technology and Standards Policy Division, Department of Technology and Standards Planning, Ministry of Commerce, Industry. and Energy. Processing and rearranging the produced data with variations divided into the three quartiles and the 1st, 5th, 95th and 99th percentiles were included to produce a growth observation chart according to sex, height and weight differences. In the same way, a growth rate curve based on the geometric mean value was produced. The resulting growth charts can be used as an index for growth and development, and used for better communication between the pediatric dentist, patients or their parents.

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Constitutive Characteristics of Decomposed Korean Granites(1) (구성식을 이용한 다짐화강토의 공학적 특성(1))

  • Kim, Yong-Jin;Lee, In-Mo;Lee, In-Geun
    • Geotechnical Engineering
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    • v.10 no.3
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    • pp.55-78
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    • 1994
  • Decomposed granite soil is a Granitic Gneiss, and it is a c Korean peninsula. It is known a changed significantly when it is aim of this study is to evaluat utility of the constitutive laws. Firstly, triaxial tests were pe sites prepared by the laborato scrutinized the characteristics results were analysed and the p evaluated. Finally, the predicted Even though the origins of slight difference in the angle of pression line( A) : both soils show In the effective mean normal uniqueness of the Normal Compr The relationships between the the decomposed granite soil tier OCR is larger than 2, the stress stress(MDS) or. even thous moved below the theoretical Ros was found to coincide with the (NC) soils, the pore pressure parameter, A,, increased up to 1.3. This phenomenon might be mainly due to the effect of the particle crushing during shearing, When the OCR value approaches 7, the negative pore pressure is developed in undrained tests and the dilatancy is observed in drained tests. The predicted and the observed behavior of drained tests showed relatively good fitting with the Cam-Clay model.

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Economic Evaluation of The Newly Developed Fish Meal Analog (BAIFA-M) (양어사료의 어분대체품 개발의 경제성 분석)

  • 김기수;배승철;최재영;김우경
    • The Journal of Fisheries Business Administration
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    • v.29 no.1
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    • pp.121-137
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    • 1998
  • This study was conducted to examine the economic evaluation of the newly developed fish meal analog (BAIFA-M) in Korean rockfish feed. A raw fish feed (MP) and two commercially formulated diets (EP) were employed to compare weight gain (WG), feed conversion ratio (FCR) and survival rate (SR) from the sea cage culture system. By using the economic model in the practical sea cage culture system, feed cost, production cost and gross profit per kg production, rate of profit to gross revenue (RPGR), and internal rate of return (IRR) were calculated based upon the results of the experiment and the information of the private aquaculture farm (Young Chang) in Tong young, Korean. IRR criteria is one of the popular economic feasibility analysis methods applicable far aquaculture industry. This is an economic evaluation method to compare the given interest rate or the discount rate with IRR which can be calculated by the difference between the present value of the benefit stream and of the cost stream. The benefits of using EP on WG, FCR, SR, and production cost will be emphasized in this study. Fish averaging 20$\pm$3.6g (Mean$\pm$SD) were randomly distributed in each small cage (6m$\times$6m) as groups of 2,000 fish. By using 3 large size cages (12m$\times$12m), 12 small cages were constructed, and only 9 small cages were employed for three replicates of each diet treatment. To compare with MP diet, two sinking EP diets were designed by our laboratory and produced by the local feed company who wanted to promote these EP diets for the mass cage culture of Korean rockfish in the future. Two EP diets contain white fish meal and/or BAIFA-M as the main animal protein sources : WFM diet, maximum 43% of white fish meal : BAIEA- M diet, 30% of white fish meal nab replaced by BAIFA- M from WFM diet. Results are summarized in Table 1. Fish fed MP diet showed significantly lower SR than does fish fed two EP diets(P<0.05). However, there Were no significant difference on FCR among fish fed three practical diets. Table 1. Average feed conversion ratio (FCR), accumulative average survival rate (SR) and economic evaluation data far three practical diets. As we expected, BAIFA-M diet is more economical than WFM diet as well as MP diet. Feed cost and production cost per kg production from BAIEA - M diet were lower than those from WFM and MP diets. Moreover, gross profit per Kg production, RPGR and IRR from BAIFA- M diet were higher than those from WFM and MP diets. This economic evaluation study clearly indicated that MP diet should be replaced by the commerical formulated EP diets as soon as possible in the near future because MP diet is not economical in the practical sea cage culture system.

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A Study on the Economic Efficiency of Capital Market (자본시장(資本市場)의 경제적(經濟的) 효율성(效率性)에 관한 연구(硏究))

  • Nam, Soo-Hyun
    • The Korean Journal of Financial Management
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    • v.2 no.1
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    • pp.55-75
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    • 1986
  • This article is to analyse the economic efficiency of capital market, which plays a role of resource allocation in terms of financial claims such as stock and bond. It provides various contributions to the welfare theoretical aspects of modern capital market theory. The key feature that distinguishes the theory described here from traditional welfare theory is the presence of uncertainty. Securities has time dimensions and the state and outcome of the future are really uncertain. This problem resulting from this uncertainty can be solved by complete market, but it has a weak power to explain real stock market. Capital Market is faced with the uncertainity because it is a kind of incomplete market. Individuals and firms in capital market made their consumption-investment decision by their own criteria, i. e. the maximization of expected utility form intertemporal consumption and the maximization of the market value of firm. We noted that allocative decisions that had to be made in the economy could be naturally subdivided into two groups. One set of decisions concerned the allocation of first-period resources among consumption $C_i$, investment in risky firms $I_j$, and riskless investment M. The other decisions concern the distribution among individuals of income available in the second period $Y_i(\theta)$. Corresponing to this grouping, the theoretical analysis of efficiency has also been dichotomized. The optimality of the distribution of output in the second period is distributive efficiency" and the optimality of the allocation of first-period resources is 'the efficiency of investment'. We have found in the distributive efficiency that the conditions for attainability is the same as the conditions for market optimality. The necessary and sufficient conditions for attainability or market optimality is that (1) all utility functions are such that -$\frac{{U_i}^'(Y_i)}{{U_i}^"(Y_i)}={\mu}_i+{\lambda}Y_i$-linear risk tolerance function where the coefficients ${\mu}_i$ and $\lambda$ are independent of $Y_i$, and (2) there are homogeneous expectations, i. e. ${\Large f}_i(\theta)={\Large f}(\theta)$ for every i. On the other hand, the efficiency of investment has disagreement about optimal investment level. The investment level for market rule will not generally lead to Pareto-optimal allocation of investment. This suboptimality is caused by (1)the difference of Diamond's decomposable production function and mean-variance valuation model and (2) the selection of exelusive investment or competitive investment. In conclusion, this article has made an analysis of conditions and processes of Pareto-optimal allocation of resources in capital marker and tried to connect with significant issues in modern finance.

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A Study on the Emission and Dispersion of Particulate Matter from a Cement Plant (한 시멘트공장의 분진발생과 대기확산에 관한 조사연구)

  • Chang, Man-Ik;Chung, Yong;Kwon, Sook-Pyo
    • Journal of Preventive Medicine and Public Health
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    • v.16 no.1
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    • pp.67-77
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    • 1983
  • To investigate the an air pollution by particulate matter and its dispersion, a cement plant produceing portland cement 600,000 ton/year and its vicinity were surveyed from Obtober, 1980 to April, 1983. The survey was mainly focused on main stack emmission rate of the cement plant and particle size distribution in the dust, dustfall and total suspended particulate concentration in the area by month and distance from the stack. The results of the study were as follows; 1. The main stack emission rate was surveyed before and after the spray tower was additionally installed to the original E.P bag filter. Before the spray tower installed, the main stack emission rate was higher ($0.64g/Nm^3$) than the emission standard of Korean Environmental Preservation Law's ($0.59g/Nm^3$, amended to $0.4g/Nm^3$ on April 1983), but after the spray tower was installed, its main stack emission rate was markedly decreased to the standard ($0.43g/Nm^3$). 2. $2{\sim}3{\mu}m$ of the particle size was the largest portion (20.8%) of the dust particulate from the main stack and 50% of the frequency distribution was $1.5{\mu}m$ of the size. Most particle size was below $10{\mu}m$. 3. The spray tower reduced the dustfall to $37.81{\sim}9.76\;ton/km^2/month$ while dustfall appeared at $45.29-15.45ton/km^2/month$, in the vicinity of plant before spray tower installed 4. Mean concentrations of total suspended particulate for 24 hours of the various stations were determined in $20.6-200.0{\mu}g/m^3$, 3 stations of tham were higher than the value of Harry and William's arthmetic average standard $130{\mu}g/m^3$. 5. Linear regression between dustfall [X] and total suspended particulate[Y] concentration was an equation, Y=4.024X+11.479.[r=0.91] 6. During the whole seasons in the opposite area 100m apart from the omission source the prevailing wind direction was with estimated more than $30ton/km^2/month$, and the concentration of total suspended particulate for 24 hours averaging time was more than $140{\mu}g/m^3$ in the same area and direction. 7. Assuming the wind direction were constant through the day dustfalls for a day were estimated at $13.40ton/km^2/day,\;10.79ton/km^2/day$ and $4.55ton/km^2/day$ at various distances of 100m, 500m and 1,500m from the emission source respectively. 8. In the simutalion of dustfall and suspended dust by area, Gaussian dispersion model modified by size distribution of particulate matter was not applicated since the emission of dust were from multi sources other them stack. From the above results, it could be applied that the dispersion of dust from the cement plant is estimated and regulated for the purpose of environmental protection.

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The Relationship between Physically Disability Persons Participation in Exercise, Heart Rate Variance, and Facial Expression Recognition (지체장애인의 운동참여와 심박변이도(HRV), 표정정서인식력과의 관계)

  • Kim, Dong hwan;Baek, Jae keun
    • 재활복지
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    • v.20 no.3
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    • pp.105-124
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    • 2016
  • The This study aims to verify the causal relationship among physically disability persons participation in exercise, heart rate variance, and facial expression recognition. To achieve such research goal, this study targeted 139 physically disability persons and as for sampling, purposive sampling method was applied. After visiting a sporting stadium and club facilities that sporting events were held and explaining the purpose of the research in detail, only with those who agreed to participate in the research, their heart rate variance and facial emotion awareness were measured. With the results of measurement, mean value, standard deviation, correlation analysis, and structural equating model were analyzed, and the results are as follows. The quantity of exercise positively affected sympathetic activity and parasympathetic activity of autonomic nervous system. Exercise history of physically disability persons was found to have a positive influence on LF/HF, and it had a negative influence on parasympathetic activity. Sympathetic activity of physically disability persons turned out to have a positive effect on the recognition of the emotion, happiness, while the quantity of exercise had a negative influence on the recognition of the emotion, sadness. These findings were discussed and how those mechanisms that are relevant to the autonomic nervous system, facial expression recognition of physical disability persons.

Diffusion Tensor-Derived Properties of Benign Oligemia, True "at Risk" Penumbra, and Infarct Core during the First Three Hours of Stroke Onset: A Rat Model

  • Chiu, Fang-Ying;Kuo, Duen-Pang;Chen, Yung-Chieh;Kao, Yu-Chieh;Chung, Hsiao-Wen;Chen, Cheng-Yu
    • Korean Journal of Radiology
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    • v.19 no.6
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    • pp.1161-1171
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    • 2018
  • Objective: The aim of this study was to investigate diffusion tensor (DT) imaging-derived properties of benign oligemia, true "at risk" penumbra (TP), and the infarct core (IC) during the first 3 hours of stroke onset. Materials and Methods: The study was approved by the local animal care and use committee. DT imaging data were obtained from 14 rats after permanent middle cerebral artery occlusion (pMCAO) using a 7T magnetic resonance scanner (Bruker) in room air. Relative cerebral blood flow and apparent diffusion coefficient (ADC) maps were generated to define oligemia, TP, IC, and normal tissue (NT) every 30 minutes up to 3 hours. Relative fractional anisotropy (rFA), pure anisotropy (rq), diffusion magnitude (rL), ADC (rADC), axial diffusivity (rAD), and radial diffusivity (rRD) values were derived by comparison with the contralateral normal brain. Results: The mean volume of oligemia was $24.7{\pm}14.1mm^3$, that of TP was $81.3{\pm}62.6mm^3$, and that of IC was $123.0{\pm}85.2mm^3$ at 30 minutes after pMCAO. rFA showed an initial paradoxical 10% increase in IC and TP, and declined afterward. The rq, rL, rADC, rAD, and rRD showed an initial discrepant decrease in IC (from -24% to -36%) as compared with TP (from -7% to -13%). Significant differences (p < 0.05) in metrics, except rFA, were found between tissue subtypes in the first 2.5 hours. The rq demonstrated the best overall performance in discriminating TP from IC (accuracy = 92.6%, area under curve = 0.93) and the optimal cutoff value was -33.90%. The metric values for oligemia and NT remained similar at all time points. Conclusion: Benign oligemia is small and remains microstructurally normal under pMCAO. TP and IC show a distinct evolution of DT-derived properties within the first 3 hours of stroke onset, and are thus potentially useful in predicting the fate of ischemic brain.