• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1783-1789
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• 2014

Background: The EMSY gene encodes a BRCA2-binding partner protein that represses the DNA repair function of BRCA2 in non-hereditary breast cancer. Although amplification of EMSY gene has been proposed to have prognostic value in breast cancer, no data have been available concerning EMSY tissue expression patterns and its associations with clinicopathological features. Materials and Methods: In the current study, we examined the expression and localization pattern of EMSY protein by immunohistochemistry and assessed its prognostic value in a well-characterized series of 116 unselected breast carcinomas with a mean follow up of 47 months using tissue microarray technique. Results: Immunohistochemical expression of EMSY protein was detected in 76% of primary breast tumors, localized in nuclear (18%), cytoplasmic (35%) or both cytoplasmic and nuclear sites (23%). Univariate analysis revealed a significant positive association between EMSY expression and lymph node metastasis (p value=0.045) and larger tumor size (p value=0.027), as well as a non-significant relation with increased risk of recurrence (p value=0.088), whereas no association with patients' survival (log rank test, p value=0.482), tumor grade or type was observed. Conclusions: Herein, we demonstrated for the first time the immunostaining pattern of EMSY protein in breast tumors. Our data imply that EMSY protein may have impact on clinicipathological parameters and could be considered as a potential target for breast cancer treatment.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1585-1588
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• 2014

Background: Data regarding childhood and adolescent non Hodgkin lymphomas in Iran are limited. The aim of this study was to assess the epidemiological and histomorphological features and survival of affected patients in our center. Materials and Methods: The clinicopathologic features and outcome of 44 children and adolescents with non Hodgkin lymphoma diagnosed during 2004-2012, were investigated retrospectively. The influence of potential prognostic parameters in overall survival was investigated by log-rank test and Cox regression analysis. Results: The mean age at presentation was $13.8{\pm}6.16$ years with a male predilection (M: F=3:1). Malignant lymphoma, not otherwise specified, diffuse large cell lymphoma and Burkitt lymphoma were the three most common histological types observed. The tumors were 36.4% intermediate grade, 27.3% high grade and 34.1% belonged to the malignant lymphoma not otherwise specified group. Immunohistochemistry findings were available in 39 cases. Out of these cases 33 (84.6%) had B cell lineage, 4 (10.25%) T cell lineage and 2 (5.12%) of the cases belonged to miscellaneous group. 3 year and 5 year survivals were 48% and 30% respectively and median survival was 36 months (95%CI=21.7-50.3 months). Overall survival in patients with high grade tumors was 19.5 months, in the intermediate group,79 months, and for malignant lymphomas not otherwise specified it was 33.6 months (p value=0.000). Conclusions: The survival rate for children and adolescents with non Hodgkin lymphomas at our center during 2004-2012 was at a low level.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제37권1호
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• pp.15-20
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• 2011

Introduction: The characteristics of oral tongue squamous cell carcinomas (SCC) and the treatment results were reviewed to determine the appropriate treatment strategies. Materials and Methods: The medical records of 140 patients diagnosed and treated for oral tongue SCC at Yonsei University Health System from January 1995 to December 2004 were reviewed. For statistic analysis, the survival rate was determined using the Kaplan-Meier method with SPSS version 12.0, and the difference in survival rates was evaluated using a log-rank test. Results: The mean age of the patients with oral tongue SCC patients was 55 (19-85 years old). According to the T, N and pathologic stage, the patients were distributed from a higher to a lower incidence of cases, as follows: T2 (46.4%), T1 (37.9%), T4 (8.5%), and T3 (7.1%); N0 (65%), N1 (20.7%), N2 (13.6%), and N3 (0.7%); and stage I (31.4%), stage II(25.7%), stage IV (22.2%), and stage III (20.7%). Local and regional recurrence and distant metastasis was present in 13.6%, 5% and 4.2% of patients, respectively. The five-year survival rate was 72.2%, and the prognostic factors for oral tongue SCC included neck metastasis, pathologic stage of the disease, cell differentiation, treatment modality, neck dissection as part of the treatment plan, and neck node recurrence. Discussion: It is suggested that ipsilateral neck dissection or bilateral neck dissection should be selected as a treatment of tongue SCC patients with advanced stage.

• The Journal of Korean Physical Therapy
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• 제17권3호
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• pp.297-310
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• 2005

Open kinetic chain exercise has lost favour in rehabilitation after cruciate ligament reconstruction due to concerns that this exercise is harmful to the graft and will be less effective in improving function. Therefore rehabilitation has focused over the past decade on closed kinetic chain exercise. Open kinetic chain and closed kinetic chain exercises were compared for their effects on proprioception, muscle strength and knee instability in the early period of cruciate ligament reconstruction rehabilitation. The study subjects were 14 patients in 28weeks from cruciate reconstruction surgery(11 male, 3 female; mean age = 44.36 years). Closed kinetic chain exercise group used ball, balance pad and air cushion, to perform weightbearing exercises and the open kinetic chain exercise group used elastic rope and N-K table, to perform non-weightbearing exercises. Between tests, subjects trained 5 times per week for 2 weeks. Statistical analysis was by Wilcoxon signed rank test and Mann Whitney U test. In result, this study shows that both open and closed kinetic chain exercise programs lead to an improved muscle strength and Lysholm score. But there was no improvement in proprioception at both exercises. Closed versus open kinetic chain exercise in early period of rehabilitation after cruciate ligament reconstruction surgery do not differ in their effects on knee proprioception, muscle strength and instability. But the effect of closed kinetic chain exercises was showed more improvement than open kinetic chain exercises between pre-post exercises. Therefore further study is required to assess effect of both groups in more long period.

• Journal of Oral Medicine and Pain
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• 제41권1호
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• pp.1-6
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• 2016

Purpose: To investigate the efficacy of pregabalin for patients with primary burning mouth syndrome (BMS) who are unresponsive to topical clonazepam therapy. Methods: By searching the clinical electronic records from the Department of Oral Medicine, Pusan National University Dental Hospital from 2012 to 2014, a retrospective analysis was performed on patients with primary BMS who were treated with topical clonazepam therapy during this period. Of the patients who were unresponsive to this therapy, 19 patients who were subsequently treated with pregabalin were included in the study. A pain assessment was performed using the 11-point numerical rating scale at first visit, following topical clonazepam therapy, and again after pregabalin therapy. The treatment outcomes were statistically analyzed using the Wilcoxon signed rank test. Results: Following additional pregabalin administration, the mean pain score was slightly reduced. A total of 7 patients reported a marked response (>50% pain reduction), and 3 patients reported a slight reduction in pain. Pain reduction following pregabalin therapy was statistically significant (p<0.05). Conclusions: Pregabalin has a slight therapeutic effect on patients with primary BMS. Therefore, we recommend pregabalin as an alternative drug for BMS patients who are unresponsive to topical clonazepam therapy.

• 대한가정학회지
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• 제20권4호
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• pp.143-153
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• 1982

The objectives of this study were as follows: 1) To describe the group of selected disabled homemakers in terms of demographic and medical variables related to organizational activities in the home and family participation in household activities. 2) To identify those demograhpic and medical variables that were related to organizational activities in the home and family participation in household activities. 3) To identify relationship between organizational activities in the home and family participation in household activities. Questionnaires were given to the selected disabled homemakers living in Seoul. The sample was small(N=35) and it was not random; therefore generalizations could not be made to the population as a whole. Data were analyzed by mean, Kruskal-Wallis one-way analysis of variance by ranks, and Spearman rank correlation coefficients. Homemaker's organizational activities were measured by 16 items about physical and mental activities from Mumaw's Organizational Activities Index. Family participation in household activities was measured by 8 items about how often family members participated in two areas of household activities: house chores and extra-activities. The results were as follows: 1) The homemaker's higher organizational activities scores were associated with younger homemaker, higher the level of education, small households, and higher the economic status. The homemaker without children performed better organizational household activities. The homemaker with shorter the duration of disability performed better organizational activities. The homemaker who needed crutches for mobility performed better organizational household activities. 2) The homemaker who was younger, higher the level of education, with smaller households, and lower the economic level was helped by husband. Husband helped better the homemaker with shorter the duration of disability in household activities. 3) Factors affecting children's participation in disabled homemaker's house chores and extra-activities were the age of homemaker and the marital status. The homemaker was single and older, the children were more helpful. 4) Task standardization score was the highest among the factors of homemaker's organizational activities and families with a disabled homemaker participated more extensively than families with abled homemaker. 5) Significant intercorrelation was found between the dependent variables.

• 한국조경학회지
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• 제34권5호
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• pp.39-51
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• 2006

This study was carried out to provide guidance to environmental policy makers when deciding which assessment fields (biotic, abiotic, qualitative, functional) should have priority for ecological preservation and to develop an objective and scientific methodology by introducing the engineering concept of the fuzzy integral. The grant of weights was used the eigenvalues calculated by factor analysis, and the converted values of indicators were obtained in multiplying the arithmetic values and eigenvalues. The results of the appropriateness and reliability of assessment fields were examined over 0.6, and the results showed that the design of questionnaire presented no great problems. When the fuzzy integral was calculated to determine the rankings at ${\lambda}$=1, 2, 3, 4, 5, respectively, they were 0.646, 0.630, 0.943, 1.423, and 1.167 for the biotic field, 1.298, 1.400, 0.901, 0.580, and 1.456 for the abiotic field, 0.714, 0.674, 0.346, 0.674, and 1.610 in the qualitative field and 1.000, 0.973, 0.943, 1.024, and 1.008 in the functional field. The sensitivity to ${\lambda}$ value showed that ${\lambda}=4$ was the most suitable. In comparison with ${\lambda}=0$ (the arithmetic mean), the range of change was narrow. Because the range for ${\lambda}=4$ was narrower than my other values, ${\lambda}=4$ was sure to be available in ranking-decision. The fuzzy integral is expected to be a method for analyzing and filtering human thoughts. In the future, in order to overcome linguistic uncertainty and subjectivity, other fuzzy integral models including Sugeno's method, AHP, and so forth should be used.

• 한방안이비인후피부과학회지
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• 제17권2호
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• pp.87-93
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• 2004

Objective: We would like to find out the correlation between acne distribution in the jaw and the emmeniopathy. Methods: The clinical studies were made on 43 cases of acne vulgaris who visited to Department of Dermatology, Dongguk University Gangnam Oriental Medical Hospital during from August, 2002 to July, 2004. We divided the patients into two groups. A group had the emmeniopathy. B group didn't have the emmeniopathy. In the acne grade and the number of acne, we investigated the difference between A and B group statistically. We used the statical methods of student's t-test on the number of acne and wilcoxon rank sum test on acne grade. Results: The mean age was 25.8${\pm}$4.80 in A group and 27.6${\pm}$5.68 in B group. There were painful menstruation, quality of thickness, menstrual cycle disorder, menstrual amount disorder, dark purple color, premenstrual acne in A group with the emmeniopathy. The acne grade was 1.69${\pm}$1.28 in A group, 1.43${\pm}$1.28 in B group. The number of acne was 3.66${\pm}$3.15 in A group, 4.36${\pm}$4.07 in B group. P-value was 0.52 in acne grade and 0.25 in the number of acne. We investigated no difference between A and B group statistically on acne grade and the number of acne. Conclusions: We needed the further study about the factor which affect on acne distribution and emmeniopathy.

• 근관절건강학회지
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• 제3권1호
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• pp.23-36
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• 1996

This study was undertaken to evaluate the effect of long-term(6 Month) aquatic exercise through home nursing care demonstration on body weight, body fat, pain, muscle strength, self-efficacy and quality of life. Twenty-one women with rheumatoid arthritis were enrolled in the study. The sample was restricted to women in order to increase homogeneity. All patients were stable medication regimens in rheumatism center. The data was collected from October, 1994 to November, 1995. The data were analyzed Mean, Standard Deviation, $x^2$ Test, Mann-Whitney U-Wilcoxon Rank Sum W Test, Wilcoxon Matched-pairs signed-ranks test using SPSS $pc^+$ program. The results of this study were as follows : 1. There was no significant difference between the control and the experimental group on body weight. 2. There was no significant difference between the control and the experimental group on body fat. 3. There was no significant difference between the control and the experimental group on pain(RAI). 4. There was no significant difference between the control and the experimental group on muscle strength. 5. There was no significant difference between the control and the experimental group on quality of life. But in the experimental group, finding from additional analysis showed significant difference in the score of quality of life between pre and post experiment. 6. There was no significant difference between the control and the experimental group on self-efficacy. The findings in this study were not support the positive effect of long-term aquatic exercise in women with rheumatoid arthritis. A further study is necessary to determine the pure effect of aquatic exercise except the effect of home nursing care.

• Journal of Korea Trade
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• 제25권5호
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• pp.110-128
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• 2021

Purpose - The essential purpose of this study is to analyze the possibility of substitution of an individual job resulting from technological development represented by the 4th Industrial Resolution, considering the different effects of digital transformation on the labor market. Design/methodology - In order to estimate the substitution probability, this study used two data sets which the job characteristics data for individual occupations provided by KEIS and the information on occupational status of substitution provided by Frey and Osborne(2013). In total, 665 occupations were considered in this study. Of these, 80 occupations had data with labels of substitution status. The primary goal of estimation was to predict the degree of substitution for 607 of 665 occupations (excluding 58 with markers). It utilized three methods a principal component analysis, an unsupervised learning methodology of machine learning, and Ridge and Lasso from supervised learning methodology. After extracting significant variables based on the three methods, this study carried out logistics regression to estimate the probability of substitution for each occupation. Findings - The probability of substitution for other occupational groups did not significantly vary across individual models, and the rank order of the probabilities across occupational groups were similar across models. The mean of three methods of substitution probability was analyzed to be 45.3%. The highest value was obtained using the PCA method, and the lowest value was derived from the LASSO method. The average substitution probability of the trading industry was 45.1%, very similar to the overall average. Originality/value - This study has a significance in that it estimates the job substitution probability using various machine learning methods. The results of substitution probability estimation were compared by industry sector. In addition, This study attempts to compare between trade business and industry sector.