• Korean Journal of Clinical Pharmacy
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• v.9 no.1
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• pp.66-70
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• 1999

The effect of circadian rhythm on cyclosporine pharmacokinetics was studied in rabbits after oral administration of 10 mg/kg dose of cyclosporine at 10:00 a.m. and 10:00 p.m. The blood concentration data were subjected to simultaneous computer nonlinear least squares regression analysis using a 1-compartment pharmacokinetic model. The blood concentrations of cyclosporine at 10:00 a. m. were increased significantly during 2-6 hr compared to those at 10:00 p.m. The area under the blood concentration-time curve (AUC) and peak concentration $(C_{max})$ of cyclosporine at 10:00 a.m. were increased significantly compared to those at 10:00 p.m. The mean total body clearance (CL) of cyclosporine at 10:00 a.m. were decreased significantly compared to those at 10:00 p.m. It is reasonable to consider individual circadian rhythm for effective dosage regimen of cyclosporine in therapeutics.

• Journal of Aerospace System Engineering
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• v.15 no.2
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• pp.16-25
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• 2021

Reliability of fatigue strength on Aircraft Composites(GFRP) Structures was assessed in this paper. Fatigue strength of GFRP was used through the existing fatigue test data with Monte Carlo method. The S_a-N_f curve of composites fatigue strength was assumed as normal distribution and reliability was analyzed using SSIT model. Fatigue stress was designed IAW ASTM F3114-15 with special safety factor of S_sf=1.2~2.0. Reliability was calculated by analytic method and FORM. Sensitivity for the effect of mean and standard deviation of fatigue strength as well as fatigue stability was evaluated. This result can be usefully applied to reliability and fatigue design for composite structures of light weight aircraft.

• Smart Structures and Systems
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• v.29 no.4
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• pp.549-560
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• 2022

The optimum damping and tuning frequency ratio of the tuned mass damper-inerter (TMDI) for the base-isolated structure is obtained using the numerical searching technique under stationary white-noise and filtered white-noise earthquake excitation. The minimization of the isolated structure's mean-square relative displacement and absolute acceleration, as well as the maximization of the energy dissipation index, were chosen as the criteria for optimality. Using a curve-fitting technique, explicit formulae for TMDI damping and tuning frequency for white-noise excitation are then derived. The proposed empirical expressions for TMDI parameters are found to have a negligible error, making them useful for the effective design of base-isolated structures. The effectiveness of TMDI and its optimum parameters are influenced by the soil condition and isolation frequency, according to the comparison made of the optimized parameters and response with different soil profiles. The effectiveness of an optimally designed TMDI in controlling the displacement and acceleration response of the flexible isolated structure under real and pulse-type earthquakes is also observed and found to be increased as the inertance mass ratio increases.

• Bulletin of the Korean Mathematical Society
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• v.60 no.5
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• pp.1299-1320
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• 2023

In the present paper, firstly we obtain the general expression of the canal hypersurfaces that are formed as the envelope of a family of pseudo hyperspheres, pseudo hyperbolic hyperspheres and null hyper-cones whose centers lie on a non-null curve with non-null Frenet vector fields in E⁴₁ and give their some geometric invariants such as unit normal vector fields, Gaussian curvatures, mean curvatures and principal curvatures. Also, we give some results about their flatness and minimality conditions and Weingarten canal hypersurfaces. Also, we obtain these characterizations for tubular hypersurfaces in E⁴₁ by taking constant radius function and finally, we construct some examples and visualize them with the aid of Mathematica.

• Honam Mathematical Journal
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• v.45 no.2
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• pp.231-247
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• 2023

In this study, we mean that timelike q-helices are curves whose q-frame fields make a constant angle with a non-zero fixed axis. We present the necessary and sufficient conditions for timelike curves via the q-frame to be q-helices in Lorentz-Minkowski 3-space. Then we find some results of the relations between q-helices and Darboux q-helices. Furthermore, we portray Darboux q-helices as special curves whose Darboux vector makes a constant angle with a non-zero fixed axis by choosing the curve as one of the types of q-helices, and also the general case.

• Annual Conference of KIPS
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• 2021.05a
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• pp.323-325
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• 2021

In this article, we have improved the prediction of hypertension detection using the feature selection method for the Korean national health data named by the KNHANES database. The study identified a variety of risk factors associated with chronic hypertension. The paper is divided into two modules. The first of these is a data pre-processing step that uses a factor analysis (FA) based feature selection method from the dataset. The next module applies a predictive analysis step to detect and predict hypertension risk prediction. In this study, we compare the mean standard error (MSE), F1-score, and area under the ROC curve (AUC) for each classification model. The test results show that the proposed FIFA-OE-NB algorithm has an MSE, F1-score, and AUC outcomes 0.259, 0.460, and 64.70%, respectively. These results demonstrate that the proposed FIFA-OE method outperforms other models for hypertension risk predictions.

• Journal of the Korean Society of Radiology
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• v.12 no.6
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• pp.755-762
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• 2018

The purpose of this study was to compare the FA(faractional anisotropy) and ADC(apparent diffusion coefficient) values, which were derived from diffusion tensor imaging in breast cancer patients. The diffusion gradient used in this study was derived from quantitative diffusion indices using 20 directions(b-value, 0 and $1,000s/mm^2$). Quantitative analysis was analyzed using Pearson's correction and qualitative analysis using for correction coefficients. As a result, $FA_{min}$, $FA_{mean}$ and $FA_{max}$ were $0.098{\pm}0.065$, $0.302{\pm}0.142$ and $0.634{\pm}0.236$, respectively(p > 0.05). The $ADC_{min}$, $ADC_{mean}$ and $ADC_{max}$ were $0.741{\pm}0.403$, $1.095{\pm}0.394$ and $1.530{\pm}0.447$, respectively(p > 0.05). The $FA_{min}$, $FA_{mean}$, and $FA_{max}$ mean values were $0.132{\pm}0.050$, $0.418{\pm}0.094$, and $0.770{\pm}0.164$ for Category 6 and Kinetic Curve Pattern III, respectively. $ADC_{min}$, $ADC_{mean}$, and $ADC_{max}$ were $0.753{\pm}0.189$, $1.120{\pm}0.236$, and $1.615{\pm}0.372$, respectively. Quantitative analysis showed negative correlation between $ADC_{mean}-FA_{mean}$ and $ADC_{max}-FA_{max}$(p = 0.001, 0.003). The qalitative analysis showed ADC 0.628(p = 0.001), FA 0.620(p = 0.001) in the internal evaluations, ADC 0.677(p = 0.001), FA 0.695(p = 0.001) in external evaluations. In conclusion, based on the morphological examination, time to signal intensity graph is the form of wash-out(pattern III) in the dynamic contrast enhance examination, As a result, the $ADC_{mean}$ $1.120{\pm}0.236$ and $FA_{mean}$ values were $0.032{\pm}0.142$ with a negative correlation (Y=1.44-1.12X). Therefore, If we understand the shape of time to signal intensity graph and the relationship between ADC and FA, It will be a criterion for distinguishing malignant diseases in breast cancer.

• Clinical and Experimental Pediatrics
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• v.57 no.10
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• pp.451-456
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• 2014

Purpose: We evaluated serum procalcitonin (PCT) as a diagnostic marker of neonatal sepsis, and compared PCT levels with C-reactive protein (CRP) levels. Methods: We retrospectively reviewed the medical records of 269 neonates with a suspected infection, admitted to Wonkwang University School of Medicine & Hospital between January 2011 and December 2012, for whom PCT and CRP values had been obtained. Neonates were categorized into 4 groups according to infection severity. CRP and PCT values were analyzed and compared, and their effectiveness as diagnostic markers was determined by using receiver operating characteristic (ROC) curve analysis. We also calculated the sensitivity, specificity, and positive, and negative predictive values. Results: The mean PCT and CRP concentrations were respectively $56.27{\pm}81.89$ and $71.14{\pm}37.17mg/L$ in the "confirmed sepsis" group; $15.64{\pm}32.64$ and $39.23{\pm}41.41mg/L$ in the "suspected sepsis" group; $9.49{\pm}4.30$ and $0.97{\pm}1.16mg/L$ in the "mild infection" group; and $0.21{\pm}0.12$ and $0.72{\pm}0.7mg/L$ in the control group. High concentrations indicated greater severity of infection (P<0.001). Five of 18 patients with confirmed sepsis had low PCT levels (<1.0 mg/L) despite high CRP levels. In the ROC analysis, the area under the curve was 0.951 for CRP and 0.803 for PCT. The cutoff concentrations of 0.5 mg/L for PCT and 1.0 mg/L for CRP were optimal for diagnosing neonatal sepsis (sensitivity, 88.29% vs. 100%; specificity, 58.17% vs. 85.66%; positive predictive value, 13.2% vs. 33.3%; negative predictive value, 98.6% vs. 100%, respectively). Conclusion: PCT is a highly effective early diagnostic marker of neonatal infection. However, it may not be as reliable as CRP.

• Journal of the Korean Society of Clothing and Textiles
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• v.20 no.6
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• pp.1116-1124
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• 1996

The factors to presume the shapes of bending and draping were examined in this study, by applying the similar phenomenon and theory of analysis. The findings were as followings: 1. The value of deflection angle (f) of deflection curve were almost consistent with those of K number and the shapes of deflection curve were congruent, under the condition of that the values of EI/w are almost similar and the lengths of samples are consistent. 2. The values of drape area, drape coefficient, mean of deflection angle, and $\pi$ number were consistently estimated and the shapes of drape were almost the same, under the condition of that the values of EI/w are similar and the diameter of samples are consistent. 3. In using the samples with different values of EI/w, scale factor, kl, was obtained from the formula, the shapes of bending of the referent samples and compsactive smaples was geometrically similar, which the lengths of samples were 1,1'and were satisfied with the formula, hi: L'11, and their $\pi$ number were also consistent. 4. In applying the samples with different values of Rllw, scale factor (kl) was obtained and then, when semidiameter of samples was adjusted to be satisfied with the formula, k1=L/L, the shapes of draping of referent samples and comparative samples were geometrically similar. Furthermore, their $\pi$ number was also consistent. 5. The shares of bending and draping could be changed in terms of three factors such as the lengths of samples, bending ridigity, and weigths per unit area. $\pi$ number was obtained from theory of similar phenomenon, which was index to presume shapes of bending and the shapes of draping getting from the three factors.

• Korean Journal of Environment and Ecology
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• v.25 no.6
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• pp.861-866
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• 2011

Using skeletochronology in the Daejung-eup, Jeju, we determined the age structure of Kaloula borealis. The study was performed during the breed season in June 2009. We measured the snout-vent length(SVL) and body weigth(BW) and analyzed the age structure of 38 male and 58 female frogs. The mean value of SVL is $43.69{\pm}3.44mm$ in males and $46.32{\pm}4.23mm$ in females. The age at first reproduction was estimated to be 2 years of age in males and 3 years in females. The oldest males and females were 8 and 10 years of age, respectively. Therefore, the longevity in this species was estimated to be more than 8 years for males and 10 years for females. So, females live longer than males. Also, this difference between the male and the female in age structure was significant. We estimated the growth curve for Kaloula borealis using von Bertalanffy growth model. The growth coefficient (K) was 0.56 in male and 0.41 in female. The asymptotic size was 46.41 mm in male and 50.22 mm in female.