• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.25 no.4
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• pp.295-300
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• 2016

In the design of passive and active boring bars, the structural dimensions and shape of the vibration control boring bar are modified depending on the diameter and depth of the workpiece, which changes the dynamic behavior. Thus, the natural frequency, effective mass, and stiffness for the main structure of a tube-type boring bar need to be reset for each vibration control case. However, commercial finite element method (FEM) software and experimental modal analysis are mostly used at present despite being too time-consuming. To overcome the weaknesses of the two methods currently used for vibration control, we realized a graphical user interface (GUI) program for the modal analysis of a modified tube-type damping structure. The analysis results with the GUI program were compared to those with commercial FEM software in order to confirm the effectiveness of the former.

• Bulletin of the Korean Chemical Society
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• v.34 no.1
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• pp.35-41
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• 2013

Metabolic analysis of CR6 interacting factor 1 (Crif1) deficient mouse embryonic fibroblasts with impaired oxidative phosphorylation has been carried out using LC-MS/MS and GC-MS methods. Metabolic profiles of the Crif1 deficient cells were comprehensively obtained for the first time. Loss of oxidative phosphorylation functions in mitochondria resulted in cancer-like metabolic reprogramming with consumption of majority of glucose carbon from up-regulated glycolysis to produce lactate, suppressed utilization of glucose carbon in the TCA cycle, increased amounts of amino acids. The changes in metabolic profile of the Crif1 deficient cells are most probably a consequence of metabolic reprogramming to meet the needs of energy balance and anabolic precursors in compensation for the loss of major oxidative phosphorylation functions.

• Bulletin of the Korean Chemical Society
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• v.34 no.5
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• pp.1401-1406
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• 2013

This study tested the feasibility of observing H/D exchange of intact protein by top-down electron capture dissociation (ECD) mass spectrometry for the investigation of protein structure. Ubiquitin is selected as a model system. Local structural information was obtained from the deuteration levels of c and $z^{\cdot}$ ions generated from ECD. Our results showed that ${\alpha}$-helix region has the lowest deuteration level and the C-terminal fraction containing a highly mobile tail has the highest deuteration level, which correlates well with previous X-Ray and HDX/NMR analyses. We studied site-specific H/D exchange kinetics by monitoring H/D exchange rate of several structural motives of ubiquitin. Two hydrogen bonded ${\beta}$-strands showed similar HDX rates. However, the outer ${\beta}$-strand always has higher deuteration level than the inner ${\beta}$-strand. The HDX rate of the turn structure (residues 8-11) is lower than that of ${\beta}$-strands (residues 1-7 and residues 12-17) it connects. Although isotopic distribution gets broader after H/D exchange which results in a limited number of backbone cleavage sites detected, our results demonstrate that this method can provide valuable detailed structural information of proteins. This approach should also be suitable for the structural investigation of other unknown proteins, protein conformational changes, as well as protein-protein interactions and dynamics.

• The Korean Journal of Rehabilitation Nursing
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• v.14 no.2
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• pp.129-135
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• 2011

Purpose: This study was done to examine the effects of Tai Chi exercise program on BMI, positive and negative psychiatric symptoms in patient with schizophrenia. Methods: The participants were patient with schizophrenia in S psychiatric hospital in D city. Twenty five patients were assigned to experimental group, and 26 patients were assigned to control group. Data were collected from May 9, to July 8, 2011. The Tai Chi exercise program was conducted with a duration of 60 minutes, 2 times a week for 8 weeks (a total 8 times). Measures were BMI, positive and negative psychiatric symptoms. Data were analyzed using descriptive statistics, chi-square test and t-test with SPSS/WIN 19.0 version. Result: The experimental group received Tai Chi exercise program had a significant changes in BMI, positive and negative psychiatric symptoms. Conclusion: The results of this study indicate that Tai Chi exercise program is an effective intervention program to improve the BMI, positive and negative psychiatric symptoms of patients with schizophrenia.

• Journal of The Korean Astronomical Society
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• v.33 no.2
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• pp.81-88
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• 2000

The international ultraviolet explorer (IUE) spectra of a low dispersion $\~6{\AA}$, have been investigated for two Seyfert 1 galaxies, Mrk 335 and NGC 4051, well known for the line variability. The electron densities of broad line region (BLR) of these variable Seyfert 1 galaxies have been derived, which showed a non-linear abrupt variation from $10^8$ to $10^{10} cm-3$ within a month. We also found the excitation (or temperature) changes in the Mrk 335 BLR from the IUE broad line profiles analysis, but no such evidence in the NGC 4051. The large amount of mass inflow activity through the bar or spiral structure of host galaxies, may trigger the density change in BLR and emission line variability for both objects. Mass of the giant black holes appear to be order of $10^7\;M_{\bigodot}$ for both variable Seyfert l's.

• Journal of Korean Medicine for Obesity Research
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• v.5 no.1
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• pp.21-29
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• 2005

Objectives : This study was carried out to evaluate the difference of body mass index(BMI) distribution and the difference of effect of weight reduction program among Sasang constitution. Methods : Sasang constitution was differentiated by QSCC II of 875 cases. Body composition was analysed by bioelectrical impedance analysis(Inbody 3.0, Biospace, Seoul, Korea) in before and after treatment to evaluate the effect among Sasang constitution. The weight reduction program including very low calorie diet, electrical acupuncture and herbal medicine was treated to all cases equally during 1 month. Results and Conclusions : The group of Taeum was more obese and less reducted in body fat mass and % body fat in tools of percent rates of the changes than other type of Sasang constitution. In conclusion, the group of Taeum is more easy to become obese and more difficult to treat obesity

• Environmental Engineering Research
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• v.23 no.3
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• pp.309-315
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• 2018

Chlortetracycline (CTC) is one of the most important compounds in antibiotic production, and its distribution has been widely investigated due to health and ecological concerns. This study presents systematic approach to optimize the high-performance liquid chromatography-tandem mass spectrometry for analyzing CTC in a multiple reaction monitoring mode ($479{\rightarrow}462m/z$). One-factor-at-a-time (OFAT) test with response surface analysis (RSA) was used as optimization strategy. In OFAT tests, the fragmentor voltage, collision energy, and ratio of acetonitrile in the mobile phase were selected as major factors for RSA. The experimental conditions were determined using a composite in cube design (CCD) to maximize the peak area. As a result, the partial cubic model precisely predicted the peak area response with high statistical significance. In the model, the (solvent composition) and (collision $energy^2$) terms were statistically significant at the 0.1 ${\alpha}$-level, while the two-way interactions of the independent variables were negligible. By analyzing the model equation, the optimum conditions were derived as 114.9 V, 15.7 eV, and 70.9% for the fragmentor voltage, collision energy, and solvent composition, respectively. The RSA, coupled with the CCD, offered a comprehensive understanding of the peak area that responds to changes in experimental conditions.

• ALGAE
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• v.28 no.2
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• pp.131-147
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• 2013

Major progress has been made in the past decade towards understanding of the biosynthesis of red carotenoid astaxanthin and its roles in stress response while exploiting microalgae-based astaxanthin as a potent antioxidant for human health and as a coloring agent for aquaculture applications. In this review, astaxanthin-producing green microalgae are briefly summarized with Haematococcus pluvialis and Chlorella zofingiensis recognized to be the most popular astaxanthin-producers. Two distinct pathways for astaxanthin synthesis along with associated cellular, physiological, and biochemical changes are elucidated using H. pluvialis and C. zofingiensis as the model systems. Interactions between astaxanthin biosynthesis and photosynthesis, fatty acid biosynthesis and enzymatic defense systems are described in the context of multiple lines of defense mechanisms working in concert against photooxidative stress. Major pros and cons of mass cultivation of H. pluvialis and C. zofingiensis in phototrophic, heterotrophic, and mixotrophic culture modes are analyzed. Recent progress in genetic engineering of plants and microalgae for astaxanthin production is presented. Future advancement in microalgal astaxanthin research will depend largely on genome sequencing of H. pluvialis and C. zofingiensis and genetic toolbox development. Continuous effort along the heterotrophic-phototrophic culture mode could lead to major expansion of the microalgal astaxanthin industry.

• Archives of Reconstructive Microsurgery
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• v.26 no.1
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• pp.23-25
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• 2017

The malignant peripheral nerve sheath tumor (MPNST) originates from neurofibromatosis type 1 (NF1). Because NF1 patients have many accompaniments with growth of additional masses, they usually overlook potential malignant changes in their masses. Our patient had two growing mass near the left elbow for several months; however, she ignored these masses until 7 days prior to writing this article, at which time they began bleeding. Traditionally, sarcoma including MPNST treatment consisted of amputation of the involved extremity. However, treatment now consists of surgical resection with adjuvant therapy. Therefore, we conducted resection of the mass and subsequent coverage with a local advancement flap. We believe that the most effective treatment for MPNST is early diagnosis and fast surgery, coupled with notification that there is always potential for malignant change in NF1 patient's masses.

• Nutrition Research and Practice
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• v.2 no.4
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• pp.259-268
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• 2008

Children's food behaviors have been expressed in a various ways because of recent changes in their family environment. Thus, this study was performed to investigate in-depth qualitative research on the mother's perception on children's food behaviors by focused group interview. This study was designed in four steps of planning, collection of participants, process, and analysis. Participants for the focus group interview were recruited and sampled from households with elementary school students in the Seoul and Gyeonggido areas. Groups were divided by total income and education expense levels. 1) High income household: It is better to improve currently existing web sites for nutrition education. 2) Mid income household: Easy, practical, and inexpensive off-line cooking class/nutrition education classes for mothers are needed. Nutrition programs for children should be developed through mass media and be promoted in the broadcasting circle. 3) Low income household: Motivation is required for mothers' educatior and the serious nutritional problems of children should be informed through mass media and home correspondence from school. And interesting educational materials should be developed for children to read whenever they want.