• Korean Journal of Psychosomatic Medicine
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• v.25 no.2
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• pp.176-184
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• 2017

Objectives : Middle aged women with depression often experience hot flush symptoms. It is still unclear about the association between depression and hot flush symptoms. Therefore, we investigated hormonal profile, functional somatic symptoms, coping styles and attitude for menopause between depressed women with hot flush and those without hot flush. Methods : This study included 33 depressed patients with hot flush symptoms and 33 depressed patients without hot flush symptoms. Hot flush was confirmed through prospective daily symptom ratings for a week. Subjects' coping styles were assessed by the stress coping checklist. Somatic symptoms were assessed by the Patient Health Questionnaire-15(PHQ-15). Sex hormonal levels were assayed by a radioimmunoassay. The Brief World Health Organization Quality of Life Assessment Instrument(WHOQOL-BREF) was used to evaluate quality of life. Results : In coping style, depressed women with hot flush symptoms used less 'problem-centered coping'($13.15{\pm}3.17$) and 'search for social support'($11.83{\pm}2.84$) than those without hot flush symptoms($15.17{\pm}3.1$, p=0.028 ; $14.25{\pm}3.22$, p=0.009 ; respectively). Depressed women with hot flush symptoms showed more negative attitude toward post-menopause, but its statistical significance was marginally insufficient(p=0.059). We did not find any group differences in sex hormonal levels and somatic complaints assessed by the PHQ-15. The score of social relationship domain of WHOQOL-BREF was significantly lower in subjects with hot flush symptoms($8.62{\pm}2.04$) than subjects without hot flush symptoms($9.71{\pm}1.65$ ; p=0.044). Conclusions : Among middle aged women with depression, the manifestation of hot flush symptoms was associated with coping styles and attitude for menopausal transition. Hot flush symptoms in depressed women negatively influence quality of life, so clinicians actively perform therapeutic approach in case of depressed patients with hot flush symptoms. In case of depressed patients who present hot flushes, cognitive behavior therapy or stress management might be an effective treatment option in company with antidepressants or hormonal treatment. Later, longitudinal study will be needed to evaluate risk factor, cause and effect associated with hot flush and depression.

• Health Policy and Management
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• v.34 no.3
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• pp.309-318
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• 2024

Background: Sleep disorders in menopausal women can act as a factor that lowers the quality of life. This study aims to understand the effects of mental health, such as depression, generalized anxiety disorder, and stress, on sleep duration in menopausal women to contribute to the management of their mental health. Methods: Using data from the 2021 Korea National Health and Nutrition Examination Survey, we conducted a study on 549 naturally menopausal women aged 50-64 years. We applied frequency and weighted percentages, Rao-Scott chi-square tests, and logistic regression. Results: It was found that women with a university degree or higher had appropriate sleep duration (odds ratio [OR], 0.33; p=0.004). Women with mild depression were less likely to have appropriate sleep compared to those without depression (OR, 2.13; p=0.025). Additionally, women who experienced high levels of stress were less likely to have appropriate sleep compared to those with minimal stress (OR, 2.73; p=0.041). Conclusion: Depression and stress are related to sleep duration, and these mental health issues can lead to physiological problems due to their complex experiences. Therefore, individual attention and management of mental health are crucial, and it seems necessary to develop community-based treatment and prevention strategies.

• Journal of Digital Convergence
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• v.16 no.12
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• pp.467-475
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• 2018

The purpose of this study is to investigate the relationship andropause symptoms, stress, self-esteem and quality of life among middle-aged men. The data were collected from Jun to August 2017. The subjects were 40 to 60 year old males residing in Y city and 198 questionnaires were analyzed. A menopausal man's quality of life was significantly different according to final education, monthly income, exercise status, the scores of quality of life was negatively correlated with those of andropause symptoms and stress, but positively correlated with those of self-esteem. The result of adding six variables that have significantly different quality of life, factors influencing quality of life are self-esteem, stress, andropause symptoms, monthly income and analysis result, explaining 52.3% of the variance. Therefor, The results of this study through repeated research in the future, it will contribute to the development and application of a nursing arbitration program to improve the quality of life for men in menopause.

• Journal of the Korean Society of Food Culture
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• v.24 no.6
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• pp.588-596
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• 2009

To determine the relationships between soybean food intake, dietary isoflavone intake, and osteoporosis incidence, questionnaire surveys, bone mineral density measurements, and dietary surveys by food record were performed with 19 postmenopausal women ($57.6{\pm}7.3$ yrs of age) in Daejeon city. The subjects were divided into two groups: an 'osteoporosis group' (OG, n=10) and a 'normal group' (NG, n=9). Mean age, height, and body weight were similar between the two groups but BMI was higher in OG than in NG. Mean age at menarche was not different between the two groups. However, mean number of childbirths was greater in OG than in NG and mean total period of lactation was shorter in OG. Mean exercise time per week was similar between the two groups, and mean time of sunlight exposure tended to be shorter in OG. Mean daily intake of calcium was lower in OG whereas sodium intake was higher in OG. Mean daily intakes of total soybean food (OG: $203.8{\pm}84.6\;g/d$, NG: $285.0{\pm}146.3\;g/d$) and total dietary isoflavone (OG: $29.1{\pm}14.3\;mg/d$, NG: $38.3{\pm}23.1\;mg/d$) were not different between the two groups. However, greater intakes of soybean food and dietary isoflavone were associated with higher bone mineral density, respectively. The above results indicate that osteoporosis incidence tends to be influenced by BMI, maternal factors, dietary nutrient intakes, soybean food intakes, and dietary isoflavone intakes in postmenopausal women; although no significant differences in soybean food and dietary isoflavone intake were found between the two groups. This tendency implies that greater intakes of soybean food and dietary isoflavone lead to lower incidence of osteoporosis in postmenopausal women.

• Journal of Digital Convergence
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• v.16 no.5
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• pp.373-383
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• 2018

The purpose of this study was to identify menopausal resilience in middle-aged women. The data were collected from 227 middle-aged women who participated in friendship and religious activities in the Jeonbuk province. The data were collected through self-report questionnaires, which were constructed to Self-efficacy, family support, social support, menopausal adaptation, resilience. Data were analyzed using frequencies, means, $X^2$_Test, pearson's correlation coefficient and multiple regression with SPSS/WIN 23. Regular exercise(${\beta}=-.15$, p<.01), self-efficacy(${\beta}=.29$, p=<.001), social support(${\beta}=.29$, p=<.001), menopausal Adaptation(${\beta}=.17$, p<.01) were influencing factors and these variables showed an explanatory power of 35.3% (F=18.65, p<.001). Therefore, it is suggested that middle-aged women in menopause can plan to overcome the menopausal crisis positively through nursing interventions that include self-efficacy and social support.

• Journal of the Korean Applied Science and Technology
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• v.34 no.3
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• pp.427-435
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• 2017

To investigate whether genistein regulates menopause-induced obesity, it was studied the effects of genistein on anti-obesity effects in female ovariectomized (OVX) mice, an animal model of postmenopausal women. 7-week-old female mice (C57BL/6J) were randomly divided into three groups. All the animals received a high fat diet or a high fat diet supplemented with genistein for 8 weeks and variables and determinants of obesity were measured. The OVX mice had significantly higher body weight and adipose tissue mass than sham mice. However, genistein supplementation reduced body weight, adipose tissue mass, and adipocyte size of OVX mice. The OVX mice treated with genistein had significantly lower levels of serum triglycerides and total cholesterol than the vehicle-treated OVX mice. Lipid accumulation in liver was also markedly decreased by genistein in OVX mice. The results suggest that genistein can effectively prevent adiposity, adipocyte phertrophy, and llipid disorders caused by ovariectomy. Moreover, this study may contribute to the alleviation of metabolic syndrome, including obesity and hyerlipidemia in postmenopausal women.

• Journal of Digital Convergence
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• v.13 no.7
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• pp.423-429
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• 2015

The purpose of this research was to examine the effect of dance sports for twelve weeks on physical self-efficacy in post-menopausal depression obese women. A total 38 women participated in this study, and they were divided into three groups: mild-depression group(n=9), light-depression group(n=14) and control group(n=15). For the exercise program in this study, a dance sports program performed at an intensity of heart rate reserve 50~80%, 60 minutes of exercise time, and the frequency of 3 times a week. Physical self-efficacy for mild-depression group after 12-week dance sports program was significantly increased compared to before the exercise. Although light-depression group and control group didn't show significant increase in physical self-efficacy, dance sports is expected to act positively on mental stability, such as depression and hope used as an effective tool to improve the quality of life. Furthermore, we expect a convergence is achieved between the sports science and medical research sectors.

• Korean Journal of Clinical Pharmacy
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• v.20 no.2
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• pp.138-144
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• 2010

The results from eight randomized controlled studies demonstrate that venlafaxine is effective in the treatment of hot flashes with tolerable adverse effects. Based on the results of the above studies, venlafaxine can be recommended for the treatment of hot flashes. However, there are limitations in the above studies. The inclusion criteria of 5 studies reviewed in this paper was breast cancer patients, so it's hard to apply the results to the general population in clinical practice. Also 5 studies had less than 100 subjects included, and 18-week study was the longest one among studies reviewed in this paper. Therefore, large and long-term clinical studies with the general population should be conducted to use venlafaxine for the treatment of hot flashes in clinical practice.

• Korean Journal of Clinical Pharmacy
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• v.21 no.4
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• pp.376-382
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• 2011

The results from eight clinical studies demonstrate that citalopram and escitalopram could be an effective option in the treatment of hot flashes with tolerable adverse effects. However, there are limitations in the above studies. The inclusion criteria of 2 studies reviewed in this paper was breast cancer patients, so it's hard to apply the results to the general population in clinical practice. Also 4 studies had less than 50 subjects included, and the duration of study was 8 weeks or less in 7 studies reviewed in this paper. Moreover, only 4 studies were randomized, placebo-controlled trials (3 for citalopram and 1 for escitalopram). Therefore, further randomized, double-blind, placebo-controlled studies with the general population should be needed to use citalopram and escitalopram for the treatment of hot flashes in clinical practice.

• The Journal of Korean Medicine
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• v.45 no.1
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• pp.65-79
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• 2024

Objectives: The purpose of this study is to evaluate weight change and analyze adverse events in post-menopausal obese women with Gamitaeeumjowee-tang for weight loss. Methods: A retrospective chart review was conducted for medical records of 115 post-menopausal obese women (body mass index, BMI≥25 kg/m²) who were administered with Gamitaeeumjowee-tang for 12 weeks for the purpose of weight loss. Weight, skeletal muscle ratio and BMI changes were compared before and after the program. Adverse events were evaluated by causality, severity and system-organ classes. Results: A total of 115 patients were included in this study. The average total weight loss in post-menopausal women was 5.72±2.04kg(p<0.001) and the average weight loss rate was 8.06±2.70%(p<0.001). After the 12-week program, the body fat rate was significantly decreased(3.76±2.20%)(p<0.001) and the skeletal muscle ratio was significantly increased(2.07±1.24%)(p<0.001). There were no significant differences in weight loss, skeletal muscle ratio change and body fat rate change depending on the number of hospital visits. Insomnia was frequently reported throughout the period, and no serious adverse events were reported. Conclusions: This study showed the potential that weight management treatment with Gamitaeeumjowee-tang could be a good way to lose weight of post-menopausal obese women without serious adverse events. Continuous well designed clinical studies are needed.