• 대한한방내과학회지
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• 제40권1호
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• pp.1-12
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• 2019

Objective: To investigate the effect of Alpiniae oxyphyllae fructus (AOF) on the alleviation of musculoskeletal disorders caused by aging, we conducted experiments on osteoporosis and muscle atrophy. Methods: The experimental group was classified into a control group, aging-elicited (AE) group and AOF group. The control group comprised 8-week-old Institute of Cancer Research (ICR) mice. The AE and AOF groups were ICR mice at 50 weeks of age. For the AE group, 10 mL of distilled water was administered once a day for 180 days without any treatment. An AOF extract (0.54 g/kg) was dissolved in distilled water and administered to the mice in the AOF group once a day for 180 days. Results: In the experiment on the alleviation of osteoporosis, the distribution of glucosaminoglycan in the bone matrix of the femoral bone was increased in the AOF group; moreover, the osteocalcin (OCN) positive reaction was increased and 8-OHdG positivity was decreased. In addition, AOF positively decreased RANKL, positively increased OPG, and positively decreased MMP-3. Muscle fiber loss in the endomysium following muscle degeneration of the quadriceps was reduced more in the AOF group compared with the AE group, and caspase-3 positive responses were also decreased. In addition, the 8-OHdG and p-lkB positivity in the AOF group decreased compared with the AE group, and the Myo-D positivity increased. Conclusion: We found that increasing bone formation alleviates osteoporosis, and that reducing bone loss alleviates muscle atrophy by reducing muscle loss and increasing muscle development.

• Imaging Science in Dentistry
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• 제41권4호
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• pp.151-153
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• 2011

Purpose : The purpose of this study was to obtain the description of the mandibular bone quality of male and female patients between 40-60 years old and their differences based on mandibular cortical bone thickness measured using Mental Index (MI). Materials and Methods : Forty digital panoramic radiographs, which consisted of twenty male and twenty female patients, 40-60 years old, were observed. Mandibular cortical bone thickness was measured using MI on both sides of the mandible. The average MI score of two groups were then assessed using t-sample independent test. Results : There were significant differences of mandibular bone quality based on mandibular cortical bone thickness measurement using MI between male and female patients (p<0.05). Conclusion : Mandibular bone quality based on cortical bone thickness measurement using MI of male and female patients indicated a significant difference.

• 대한정형외과학회지
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• 제56권6호
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• pp.491-497
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• 2021

목적: 단순 방사선상 척추 추체의 골 음영이 감소된, 즉 골다공증이 의심된 남성에서 골밀도 검사를 통해 골다공증(또는 골감소증)의 유병률을 알아보고자 하였다. 대상 및 방법: 정형외과 진료를 받은 남성 중 척추의 단순 방사선상 골다공증이 의심되었던 98명(이하 의심군)에서 실제 유병률을 확인하기 위해 이중에너지 X-선 흡수계측법 골밀도 검사를 실시하였고, 그 결과를 대조군 168명, 골다공증성 골절로 치료받은 환자군 113명(이하 골절군)과 비교하였다. 각 군마다 세계보건기구(World Health Organization, WHO) 방법(요추 평균 및 대퇴골 경부 골밀도 중 최하값)과, Hansen 방법(요추 1-4번 골밀도 중 최저값)의 두 가지 방법으로 골밀도 값의 평균, 표준편차를 비교하였고, 각 군별 골다공증, 골감소증의 유병률에 대해 확인하였다. 결과: 각 군별 골밀도 값의 평균(±표준편차) 통계 조사 결과, 의심군이 -1.4 (±1.2), 대조군이 -0.8 (±1.1), 골절군이 -2.4 (±1.0)으로 통계적으로 유의한 결과를 나타냈다. 각 군별 골다공증의 유병률을 WHO 방법(요추 평균 및 대퇴골 경부 골밀도 중 최하값)으로 비교한 결과 의심군 17.3%, 대조군 8.3%, 골절군의 45.1%에서 골다공증이 진단되었고, 의심군의 40.8%에서 골감소증이 관찰되었다. Hansen 방법(요추 1-4번 골밀도 중 최저값)으로는 의심군 30.6%, 대조군 17.9%, 골절군 62.0%가 골다공증으로 진단되었다. 결론: 요추 단순 영상에서 골음영이 감소된 것으로 의심되어 골밀도 검사로 확인한 남성 환자들 중 17.4%에서 골다공증이, 40.8%에서 골감소증이 진단되었다. 대조군 또한 전체의 8%에서 골다공증이 확인되었다. 이러한 결과는 남성에서도 골다공증의 존재 가능성이 적지 않음을 일깨워 주는 것으로, 특히 단순 영상에서 골다공증이 의심될 경우 골밀도 검사를 통한 확인이 필요함을 말해 준다.

• 한국콘텐츠학회논문지
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• 제12권12호
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• pp.335-344
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• 2012

우리나라는 급격한 경제성장과 의료기술의 발달로 고령화 사회가 되면서 골다공증 발병이 증가하고 있다. 또한 서구화된 식생활로 암질환이 증가하였고 항암치료과 방사선 치료 등으로 인해 골다공증이 발생하게 된다. 골다공증은 골밀도의 감소로 인한 것으로 대퇴근위부의 형태학적 구조 변화와도 밀접한 관계를 가지고 있으며, 대퇴 근위부의 형태학적 구조 변화는 고관절 골절의 위험을 나타내는 요인이다. 본 연구는 T-score변화에 따라 정상, 골감소증, 골다공증으로 분류하여 각 군별로 대퇴 근위부의 형태학적 변화를 관찰하고 상관관계를 분석하였다. 조사대상은 부산지역의 D종합병원의 남녀 350명을 대상으로 연령, 성별, T-score변화로 질환을 구분하여 분석하였다. 결과는 연령, 성별에 따라 골다공증의 발병빈도는 유의한 차이를 보였고, T-score변화에 따른 질환 분류와 대퇴근위부 형태학적 특성의 7가지 파라미터로서 Cortical ratio calcar, Cortical ratio shaft, Hip/shaft Angle, Strength index, Section modulus, CSMI, CSA는 유의한 차이를 보였으며 골다공증과 높은 상관관계가 있었다. 그러므로 연구 결과는 T-score변화에 따른 대퇴근위부의 형태학적 변화를 상관관계 분석함으로써 골다공증을 진단하는데 대퇴 근위부의 형태학적 변화가 지표로서 활용가능하리라 사료되며, 향후에 대퇴근위부의 형태학적 파라미터가 골다공증 진단의 정확성을 높이고 예측인자로서 임상활용이 가능하리라 판단된다.

• 문화기술의 융합
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• 제6권3호
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• pp.457-462
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• 2020

골다공증은 주로 노인에서 나타나는 질병으로써 뼈 질량 및 조직의 구조적 악화에 따라 골절의 위험을 증가시킨다. 본 연구의 목적은 영양소 성분과 골다공증과의 연관성을 파악하고, 영양소 성분을 기반으로 골다공증을 예측하는 모델을 생성 및 평가하는 것이다. 실험방법으로 binary logistic regression을 이용하여 연관성분석을 수행하였고, naive Bayes 알고리즘과 variable subset selection 메소드를 이용하여 예측 모델을 생성하였다. 단일 변수들에 대한 분석결과는 남성에서 식품섭취량과 비타민 B2가 골다공증을 예측하는데 가장 높은 the area under the receiver operating characteristic curve (AUC)값을 나타내었다. 여성에서는 단일불포화지방산이 가장 높은 AUC값을 나타내었다. 여성 골다공증 예측모델에서는 Correlation based feature subset 및 wrapper 기반 feature subset 메소드를 이용하여 생성된 모델이 0.662의 AUC 값을 얻었다. 남성에서 전체변수를 이용한 모델은 0.626의 AUC를 얻었고, 그외 남성 모델들에서는 민감도와 1-특이도에서 예측 성능이 매우 낮았다. 이러한 연구결과는 향후 골다공증 치료 및 예방을 위한 기반정보로 활용할수 있을 것으로 기대된다.

• Journal of Nutrition and Health
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• 제21권5호
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• pp.333-347
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• 1988

The purpose of the present study was to investigate the relationship between nutrient status, and bone mineral state which influenced by aging process. The subjects were 196 people over 65 years old(male 72, female124). The present dietary intake was estimated by the 24-hr, recall method, and individual dietary history concerning consumption of meat, fish and dairy products was obtained by questionaires. The syndrome of senility including seniliy was evaluated according to "Cornell Medical Index". The five subjects who showed 'Good' grade in bone senility, and five subjects who showed 'Risk' and 'Danger' grade were selected and their spine and femur bone density was measured by "Dual Photon Absorptiometry". The bone density measurement showed that the subjects with 'Good' grade in bone senility had bone density above that of normal person, and their nutrient status were satisfactory, whereas the subjects with 'Risk' and 'Danger' grade in bone senility had severe osteoporotic pattern, and their nutrient status were very poor. The food consumption score showed that the subject with higher intake of meat rather than milk had good grade in bone senility (p<0.05). Therefore, past meats consumption can be considered to be a significant factor in the present bone status. The nutrient intakes appeared to be significant factors in bone status in male, whereas there was little effect of nutrients intakes in female. Therefore, the risk of osteoporosis can increase as syndrome of bone senility and nutrient intakes were worse, and its is possible to evaluate bone status and predict osteoporosis simply from informations concerning syndrome of bone senility and nutrient intakes in old population over 65.

• Natural Product Sciences
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• 제6권4호
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• pp.155-160
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• 2000

Testosterone deficiency increased bone resorption, giving rise to osteoporosis. Testosterone deficiency also increased lipid peroxidation and free radical formation. Free radicals have been shown to be toxic to osteoblasts as well as to activate osteoclasts. In this study, the effects of giving an antioxidant, i.e. vitamin E-rich extract from palm oil on bone mineral density and calcium content was studied. Palm vitamin E prevented the loss in bone mineral density due to orchidectomy, seen in the whole femur, proximal amd midshaft regions, as well as L4 vertebra. Similar observations were seen in bone calcium content of the L5 vertebra. Giving palm olein also prevented the loss in bone mineral density in the femoral midshaft and L4 vertebra; and bone calcium content in the L5 vertebra. In conclusion, vitamin E-rich extract from palm oil was effective in preventing the loss in bone mineral density and calcium content of orchidectomized male rats. This action is probably due to its role as an antioxidant.

• 한국보건간호학회지
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• 제29권2호
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• pp.177-189
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• 2015

Purpose: The purpose of this study was to investigate bone mineral density (BMD) and risk factors related to osteopenia in community people. Methods: The subjects consisted of 145 community people. The variables of osteoporosis knowledge and preventive health promoting behavior were measured using questionnaires. BMD and BMI (body mass index) were measured. Dietary nutrients intake related to osteoporosis was measured using 24hours recall. Data analysis was performed using the SPSS 18.0 program, using mean, standard deviation, ${\chi}^2-test$, t-test, and logistic regression. Results: Eighty six people (59.3%) had an osteopenia. According to normal group and osteopenia group, there was significant difference in gender (${\chi}^2=6.72$, p=.010) and smoking (${\chi}^2=5.18$, p=.023). Predictors of osteopenia group were male (OR=2.65, CI=1.03-8.98), BMI(OR=0.86, CI=0.72-0.96). Conclusion: Health care providers must consider factors that affect osteopenia such as gender, BMI. These results suggest the need to instruct nursing activities and interventions which are beneficial for prevention of osteoporosis.

• Korean Journal of Radiology
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• 제20권6호
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• pp.916-930
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• 2019

Objective: To investigate the relationships of T₂^*-corrected 6-echo Dixon volumetric interpolated breath-hold examination (VIBE) imaging-based fat fraction (FF) and R₂^* values with bone mineral density (BMD); determine their associations with sex, age, and menopause; and evaluate the diagnostic performance of the FF and R₂^* for predicting osteopenia and osteoporosis. Materials and Methods: This study included 153 subjects who had undergone magnetic resonance (MR) imaging, including MR spectroscopy (MRS) and T₂^*-corrected 6-echo Dixon VIBE imaging. The FF and R₂^* were measured at the L4 vertebra. The male and female groups were divided into two subgroups according to age or menopause. Lin's concordance and Pearson's correlation coefficients, Bland-Altman 95% limits of agreement, and the area under the curve (AUC) were calculated. Results: The correlation between the spectroscopic and 6-echo Dixon VIBE imaging-based FF values was statistically significant for both readers (p_c = 0.940 [reader 1], 0.908 [reader 2]; both p < 0.001). A small measurement bias was observed for the MRS-based FF for both readers (mean difference = -0.3% [reader 1], 0.1% [reader 2]). We found a moderate negative correlation between BMD and the FF (r = -0.411 [reader 1], -0.436 [reader 2]; both p <0.001) with younger men and premenopausal women showing higher correlations. R₂^* and BMD were more significantly correlated in women than in men, and the highest correlation was observed in postmenopausal women (r = 0.626 [reader 1], 0.644 [reader 2]; both p < 0.001). For predicting osteopenia and osteoporosis, the FF had a higher AUC in men and R₂^* had a higher AUC in women. The AUC for predicting osteoporosis was highest with a combination of the FF and R₂^* in postmenopausal women (AUC = 0.872 [reader 1], 0.867 [reader 2]; both p < 0.001). Conclusion: The FF and R₂^* measured using T₂^*-corrected 6-echo Dixon VIBE imaging can serve as predictors of osteopenia and osteoporosis. R₂^* might be useful for predicting osteoporosis, especially in postmenopausal women.

• 치과방사선
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• 제13권1호
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• pp.87-96
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• 1983

Radiographic measurements on the width of mandibular cortical plate and the lamina dura and on the root length were done in 42 patients who were in long-term Dilantin medication. Osteoporosis and root abnormalities were also investigated. The obtained results were as follows: 1. The number of male patients was greater than that of female patients. 2. The width of mandibular cortical plate was thinner in patient group than in control group. 3. There was no significant change in the width of lamina dura between the patient group and control group. 4. The root length of patient group was generally shorter than that of control group. 5. There were evidences of generalized mandibular osteoporosis and alteration in mandibular canal wall in 8 patients. (19%) 6. In Dilantin induced osteomalacia, the radiographic changes of mandibular canal wall and mandibular cortical plate were prominent, but that of lamina dura was not significant.