• Proceedings of the KOSOMBE Conference
• /
• v.1998 no.11
• /
• pp.203-204
• /
• 1998

ECG analysis is main techniques for diagnosing heart disease. In recent, some studies have been performed about detection of QT interval. But, it's difficult to detect QT interval because T wave is evasive. In this paper, we have detected peak point and end point of T wave and calculated QT interval. And the result has been compared with the other algorithm after detection of QT interval.

• BMB Reports
• /
• v.28 no.6
• /
• pp.546-551
• /
• 1995

The conformation studies of myelin P2 protein and two of its major peptides were carried out using circular dichroism and fluorescence spectroscopy in water and in lipid environments. Significant conformational changes occur when the protein or peptides were bound to gangliosides. Similar effects were also found in trifluoroethanol solutions. The conformational features of P2 protein and its major peptides were discussed in relation to the environmental changes and the disease-inducing effects.

• Research in Plant Disease
• /
• v.28 no.3
• /
• pp.113-121
• /
• 2022

Rice blast is a major plant disease that occurs worldwide and significantly reduces rice yields. Rice blast disease occurs periodically in Korea, causing significant socio-economic damage due to the unique status of rice as a major staple crop. A disease outbreak prediction system is required for preventing rice blast disease. Epidemiological investigations of disease outbreaks can aid in decision-making for plant disease management. Currently, plant disease prediction and epidemiological investigations are mainly based on quantitatively measurable, structured data such as crop growth and damage, weather, and other environmental factors. On the other hand, text data related to the occurrence of plant diseases are accumulated along with the structured data. However, epidemiological investigations using these unstructured data have not been conducted. The useful information extracted using unstructured data can be used for more effective plant disease management. This study analyzed news articles related to the rice blast disease through text mining to investigate the years and provinces where rice blast disease occurred most in Korea. Moreover, the average temperature, total precipitation, sunshine hours, and supplied rice varieties in the regions were also analyzed. Through these data, it was estimated that the primary causes of the nationwide outbreak in 2020 and the major outbreak in Jeonbuk region in 2021 were meteorological factors. These results obtained through text mining can be combined with deep learning technology to be used as a tool to investigate the epidemiology of rice blast disease in the future.

• Research in Plant Disease
• /
• v.8 no.3
• /
• pp.189-192
• /
• 2002

Mummy disease has been observed for a long time in the button mushroom, Agaricus bisporus farms in Korea, and severe mummy disease occurred on “Shinryung” mushroom, A. blazei recently. Typical symptoms of mummy disease were observed on the mushroom-cultivation beds infected ; tilted caps of mushrooms, browning and lignified internal tissue of stipe, overdevelopment of mycelium around the base of the stipe, and mummified mushrooms. Electron micrographs prepared from internal tissue of stripe of the diseased mushrooms showed that many bacterial cells present inside hyphal cells of the diseased mushroom, which is one of the characteristics of mummy disease reported previously, Survey in Buyo, Chungnam showed that mummy disease occurred at 55% and 83% frequency on bottom mushroom (brown strain) and “Shinryung” mushroom cultivation during year 2000. It indicates that mummy disease is one of the major diseases for the mushrooms cultivation.

• The Journal of the Institute of Internet, Broadcasting and Communication
• /
• v.19 no.6
• /
• pp.145-152
• /
• 2019

Parkinson's disease(PD) is one of the three major senile diseases and the incidence rate is increasing worldwide as the population ages. And as the disease progresses, time and economic costs increase, so it is important to understand the progress of the disease and to diagnose it early In this paper, we propose a method for pre-screening Parkinson's disease using a smartphone. The contents of the developed application are composed of tapping, tremor, spiral drawing, and gait based on Part III of the Unified Parkinson's Disease Rating Scale. This can be used to quantitatively diagnose Bradykinesia, Tremor and Postural Instability, which are known as motility symptoms of Parkinson's disease, and to monitor the progress of symptoms. This method is expected to be useful for the diagnosis and treatment of Parkinson's disease.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.19 no.3 s.31
• /
• pp.171-179
• /
• 2006

Objective : The purpose of this study is to investigate outpatients of ophthalmologic disease who had visited to Hospital of Oriental Medicine. Method : We analyzed statistics study in 590 patients, who had visited to the Dept. of dermatology, ophthalmology & otorhinolayngology Hospital of Oriental Medicine Dongeui University from January, 1998 to July , 2006. Result : The results were as follows. 1. Distributions of sex : male 45.42%, female 54.58%. 2. The age distributions of patients showed highest in 51-60 years, followed by 41-50 years, 61-70 years in order. 3. The yearly distributions of patients showed highest in 2004, followed by 2005, 2002 in order. The seasonal distributions of patients showed highest in summer, followed by spring, winter, autumn in order. The monthly distributions of patients showed highest in August, followed by June, March in order. 4. The frequency of chief complaint showed highest in visual disorder, followed by dry eye, blepharospasm, squint in arch order. Visual disorder and dry eye were the most common ophthalmologic disease, irrespective of age. 5. The Distribution of past history showed highest in ophthalmologic disease, followed by circulatory disease, digestive disease in order. The Distribution of ophthalmologic diseases showed highest in retinal disease, followed by lens-induced ocular disease, disease of the optic nerve in order. 6. The number of times in treatment : 1-20 times(84.07%), 21-40 times(7.97%). 7. In the treatment method, a major portion of treatment methods was acupuncture & herbal medicine treatment, followed by acupuncture, consulting, herbal medicine treatment in order.

• Health Policy and Management
• /
• v.31 no.1
• /
• pp.65-73
• /
• 2021

Background: With the recent aging of the population, the transition to a disease structure centered on chronic diseases is accelerating. Moreover, the socio-economic gap and the polarization of the health gap between regions further increase the burden of disease on the country. Accordingly, this study calculated the disease cost of hypertension, diabetes, and hyperlipidemia, which are the three major chronic diseases, to establish an effective health promotion policy strategy for each region, and analyzed the gap in disease cost within the region to determine health determinants at the individual as well as the regional level. Methods: This study utilized data from the 2015 sample cohort of the National Health Insurance Service and calculated the disease cost of patients (diabetes: I10-I15, hypertension: E10-E14, hyperlipidemia: E78) based on the main diagnosis. Results: Based on our analysis, the case of medical use in cities and provinces was higher than in metropolitan cities, with relatively small medical use in Seoul and Gangwon-do. In terms of the disease cost, the cost of chronic diseases in Seoul and Jeju was the highest, but the difference in disease cost between patients in each region was the largest in Seoul and Gangwon-do. Conclusion: The results of this study provide meaningful data for implementing efficient health promotion policies by analyzing the differences in disease cost and identifying health determinants in different regions. Furthermore, in Korea, where socioeconomic differences are clearly revealed, it can be used as a basis for preparing a strategic plan, from a long-term perspective, to improve the health of patients with chronic diseases in the future.

• Korean Journal of Clinical Laboratory Science
• /
• v.44 no.1
• /
• pp.7-16
• /
• 2012

The Korean GDP per capita doubled during the last 10 years. As the GDP increases, Korean health behaviors such as, eating, drinking, smoking, and exercise habits changed as well. Compared to the remarkably advanced diagnostic technologies and therapeutics during the last decade, the leading causes of death in Korea scarcely changed. Among the leading causes of death, cerebrovascular disease, heart disease, diabetes, liver disease and hypertension are closely related to health behaviors. Using the database of medical check-up between 2001 and 2010, the authors performed a longitudinal study for the prevalence rates and the trends of major chronic adult diseases among the 2,721 workers along with their health behavior. Among the diagnostic test items, fasting blood sugar, cholesterol and BMI levels showed steady increase and these three test items all showed linear trends (p<0.001). The average blood sugar and cholesterol levels were near worrying levels. Moreover, the average BMI of males was found to be at the overweight level, intimating the possibility reaching thee Obese Class I level soon if there are no aggressive counter measures. Fasting blood sugar and cholesterol levels were higher in a drinking group as compared to a non-drinking group, and the BMI levels were also higher in the drinking group and the smoking group as compared to the non-drinking and the non-smoking group (p<0.001). Finally, the authors believe that the fasting blood sugar, cholesterol and BMI levels should be designated as target monitoring test items in the medical check-up for Korean employees.

• The Journal of Internal Korean Medicine
• /
• v.26 no.4
• /
• pp.836-843
• /
• 2005

Objective : Liver cirrhosis is a disease of the liver in which normal cells are replated by scar tissue. Chronic liver disease and liver cirrhosis are the foutth ranked causes of death in Korea. However, clinical data on liver cirrhosis is not accumulated in oriental medicine. Therefore, clinical characteristics of 33 liver patients admitted to Hana Oriental Hospital from May 2004 to May 2005 were studied. Methods : Clinical characteristics of liver cirrhosis, such sex, age, causes, Child-Pugh class, chief complain, abdomen ultrasonography, disease duration, past history, blood test and urinalysis were reviewed. Results : The results of this study were as follows: 1 The distribution of sex and age in our study is similar to already reported statistics. 2. Hepatitis B and alcohol are the major factors to cause the liver cirrhosis. Diabetes and hypertention contribute more to cause than they have in previous histories. 3. Major symptoms are following: fatigue 87.9%, ascites 84.8%, jaundice 78.8%, leg edema 72.7%, dyspepsia 45.5%. 4. Most liver cirrhosis patients have pancytopenia. Standard Deviation accentuates the big differences between total bilirubin and serum amonia. 5. In urinalysis, Urobilinogen 19 patients (57.6%), bilirubin 12 patients (36.4%), blood 15 patients (45.5%) are positive. 11 cases of 15 in blood positive results scored $3{\sim}4+$. Contusions : In oriental medicine, it will be necessary to research and develop oriental medical therapies for liver disease including liver cirrhosis.

• Proceedings of the Korea Society of Poultry Science Conference
• /
• 2006.11a
• /
• pp.7-16
• /
• 2006

Poultry products including meat and eggs constitute a major protein source in the American diet and disease - causing pathogens represent major challenges to the poultry industry. More than 95 % of pathogens enter the host through the mucosal surfaces of the respiratory, digestive and reproductive tracts and over the past few decades, the two main mechanisms used to control diseases have been the use of vaccines and antibiotics. However, in the poultry industry, there are mounting concerns over the ability of current vaccines to adequately protect against emerging hyper - virulent strains of pathogens and a lack of suitable, cost effective adjuvants. Thorough investigation of the immunogenetic responses involved in host-pathogen interactions will lead to the development of new and effective strategies for improving poultry health, food safety and the economic viability of the US poultry industry. In this paper, I describe the development of immunogenomic and proteomic tools to fundamentally determine and characterize the immunological mechanisms of the avian host to economically significant mucosal pathogens such as Eimeria. Recent completion of poultry genome sequencing and the development of several tissue-specific cDNA libraries in chickens are facilitating the rapid application of functional immunogenomics in the poultry disease research. Furthermore, research involving functional genomics, immunology and bioinformatics is providing novel insights into the processes of disease and immunity to microbial pathogens at mucosal surfaces. In this presentation, a new strategy of global gene expression using avian macrophage (AMM) to characterize the multiple pathways related to the variable immune responses of the host to Eimeria is described. This functional immunogenomics approach will increase current understanding of how mucosal immunity to infectious agents operates, and how it may be enhanced to enable the rational development of new and effective strategies against coccidiosis and other mucosal pathogens.