• BMB Reports
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• 제32권6호
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• pp.585-593
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• 1999

The water and methanol extracts of Artemisia argyi showed significant cytotoxicities against J774A.1 cells but not so much against normal leukocytes. The cytotoxicities were found to be dependent on the extract concentration and the incubation time. The concentration of water and methanol extracts inhibiting 50% of cell proliferation ($IC_{50}$) were estimated to be 44.2 mg/ml and 71.6 mg/ml, respectively. In the presence of Artemisia argyi water extract, total superoxide dismutase (CuZnSOD and MnSOD) activities of media, cytoplasmic and mitochondrial fractions of J774A.1 cells increased in accordance with cytotoxicity. MnSOD was found to be the main component of enhanced total SOD activities, particulary in the mitochondrial fraction. In contrast to SOD, catalase and glutathione peroxidase (GPx) were not found in any instance of the current investigation. In addition, substantial amount of $O_2^-$ appeared to be generated in the mitochondrial fraction under the influence of Artemisia argyi. All data put together, it is postulated that Artemisia argyi extracts seem to stimulate $O_2^-$ generation in mitochondria of J774A.1 cells with concomitant increases of SODs. Since $H_2O_2$, the reaction product of SOD on $O_2^-$, is known to be readily converted to very toxic $OH{\cdot}$ in the absence of catalase and/or GPx cooperation, toxicity derived from ROS such as $O_2^-$, $H_2O_2$, and $OH{\cdot}$ may be the main cause of necrosis and/or apoptosis of J774A.1 cells.

• 대한예방한의학회지
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• 제6권1호
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• pp.36-50
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• 2002

Health industry, a knowledge based high value-added industry, is being considered as a strategic area for the 21C and many advanced countries are making every endeavors for the promotion of health industry along with information technology, new materials, and mechatronics. Korean health industry, however, has been excluded from the governmental supports as well as bound by strict regulation so far, and there is a significant gap in technology compared with advanced countries. In 21C, technology is the main factor of national competitiveness and that is why the role of R&D institutes are so important in the high level of competition to cope with the technology protection policies of advanced countries. In this article, with Directory of Korean R&D Institutes published by Korea Industry Technology Association, I reviewed the trends of R&D institute of health industry. Main findings of the research can be summarized as follows. The portion of health industry R&D institute is 3.6% of total R&D institute but the amount of R&D investment is over than 5% This means health industry are knowledge based and R&D intensified industry, meanwhile the variations of same industry R&D institutes of health industry is huge in R&D investments and other activities. Regional distributions of health industry institutes show some kind of different patterns in each industry areas. Medical devices and Medical informatics's preference of metropolitan region are distinguished with other industry areas. Many of the institutes are located in same site of it's company rather than operating separate building for R&D specific uses. It is better for transforming ideas to products and close cooperation of research body with product lines, but it is a handicap for networking and communicating with other research institutions too. It takes 18.4yrs for bearing R&D institute on the average. For a long times 'copy products' or 'me too products' policies were easy way to maintain business entities. But recently, it is recognized that research activities are essential component of sustaining it's own business firms. This means technology itself is leading power of corporation itself in the high level of competition.

• 대한한의학방제학회지
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• 제25권3호
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• pp.413-427
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• 2017

Objectives : This report describes 75 studies related to the use of Zingiberis siccatum Rhizoma mainly blended from Dongeuibogam. Methods : The 75 Prescriptions of Consumptive part in DonguiBogam analysed frequency of basic prescriptions, symptoms of prescriptions and the pathology. Results : Prescriptions that Zingiberis siccatum Rhizoma was taken as a monarch drug are utilized for 25 therapeutic purposes, for example, cold disease, stool disease, cough disease. In particular, 16.0% of prescriptions appear in the chapter of cold. Prescriptions that utilize Zingiberis siccatum Rhizoma as the main component are used in the treatment of cold, stool and cough disease. Zingiberis siccatum Rhizoma is used in pathogenic factors such as weakness cold and cold strength and used in pathology related to the spleen and stomach system. The dosage of Zingiberis siccatum Rhizoma is 5pun(about 1.88g) to 4nyang(about 150.4g), however 1don(about 3.75g) has been taken the most for clinical application. Ijungtang is the most useful base prescriptions which use the Zingiberis siccatum Rhizoma as the main ingredient. Conclusions : As a result of Study on Analysis all Prescriptions of Zingiberis siccatum Rhizoma in DonguiBogam. We can understand more about basic prescriptions, symptoms of prescriptions and the pathology that are using for Zingiberis siccatum Rhizoma.

• 자원환경지질
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• 제30권5호
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• pp.443-450
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• 1997

The main purpose of this study is to investigate mineralogical and chemical changes during natural weathering, and assess the mobility of major and trace elements. Yongwol power plant utilize anthracite coal which is mainly composed of illite, kaolinite, pyrophyllite and quartz in mineralogy. Coal and coal-derived fly ash samples were sampled by the electrostatic precipitator in Yongwol coal-fired power plant in Korea. Short term weathered fly ash were also collected in ash disposal mound, and two profile soil samples were taken from an ash near the power plant. Amorphous materials are the main component of the fly ash, and mullite, quartz, magnetite and heamatite are present in all coal-derived fly ash. In chemistry, Si and Al are the most abundant elements of the total content. The ash samples were fractionated into upper $90{\mu}m$ and under $45{\mu}m$ size. Finer particles show higher concentrations in metal contents including Co, Cr, Cu, Ni, V, Zn and Pb. Concentration of Zn and Pb are nearly 4 times higher concentration in the finer particles. For the profile samples, the concentrations of $SiO_2$, $Na_2O$, MgO and $K_2O$ generally show increasing trends with depth, whereas those of $Fe_2O_3$ and $TiO_2$ appear to decrease with depth. Content of MnO does not show any specific depth trend. For the trace elements, Co, Cu, Ni and V show increasing concentrations with depth.

• Journal of Pharmaceutical Investigation
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• 제1권1호
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• pp.90-100
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• 1971

It is well known that the commonly used granular enzymic digestives are easy to diminish it's potency through preparation and custody. We made an experinent to know the proper way of manufacturing and keeping the granules without a loss of potency by $L_8$ orthogonal Tables. The factors, we considered, decomposition of enzyme activity through manufacturing are (1) sufficiency of granules drying (2) with or without sodium bicarbonate $(NaHCO_3)$ in gramules (3) separate wet granulation of enzyme and the rest of the component or mix together (4) kind of packing materials (Polycello or quartet silner paper) Besides we counted (5) humidity (6) temperature as block factors. Then we tested the potency of each sample by intervals of. a week, 2 weeks and we foretelled the potency of after one year by the life test. From the experimental results, main factor of activity loss is preserving humidity. Therefor the sufficiency of packing is became a main problem and the granules have to be made by separate wet granulation to inhibit it's decomposition. Temperature is the factor that accelerates loss of activity by humidity but does not so much by itself mixing enzyme toge therwith $NaHCO_3$ is not became a matter so far as it is dried.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2011년도 제37회 추계학술대회논문집
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• pp.344-347
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• 2011

본 논문은 한국형 기동헬기(수리온)에 탑재되는 T700/701K 터보 샤프트 엔진의 인증과정에 대해서 기술한다. T700/701K 엔진은 군용 헬기엔진으로 널리 사용되고 있는 GE사의 T700-701C/D엔진을 후방 구동형으로 개조 개발한 엔진이다. 주요 개발 내용은 크게 엔진 장착 요구조건에 의한 후방 구동형 개조, 동력터빈 성능 향상 및 엔진 운전 신뢰성 향상을 위한 2채널 FADEC 시스템 적용 등이다. 따라서 T700/701K 엔진이 수리온에 장착되어 비행을 하기 위해서 엔진 개발규격서의 요구도를 검증하여 정부의 인증을 받아야 한다. 개조 개발에 따른 영향성을 고려하여 성능을 포함한 엔진 주요 요구도는 해석과 시험을 통하여, 그리고 T700-701C/D 엔진과 동일한 부품 및 모듈에 대한 요구도는 유사성(Similarity) 해석을 통하여 검증을 수행 중이며, 2012년 상반기에 군용항공기 감항인증 절차에 따라서 인증이 될 예정이다.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2007년도 추계 종합학술대회 논문집
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• pp.457-461
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• 2007

레이저 슬라이드 마킹 시스템은 기존의 수작업으로 수행하던 작업 공정을 대체할 수 있으므로 병원의 임상병리과 등 관련 전문가들이 적극적으로 도입을 검토하고 있다. 현재 국내 병원에서는 IT기술의 발달로 각종 진단 결과의 처리에서 병원 내의 물류에 이르기까지 다양한 분야에서 전산화가 이루어지고 있다. 이에 따라 각종 검사 업무를 담당하고 있는 임상병리 부서에서도 검사 장비의 전산화, 자동화의 노력이 진행되고 있으며, 검사 업무의 핵심장비인 레이저 슬라이드 마킹 시스템을 도입하여 사용하려는 수요가 증가하고 있다. 레이저 슬라이드 마킹 시스템의 국내 시장규모는 2008년 2억5천만원이고, 2012년 17억5천만원으로 예상된다. 레이저 슬라이드 마킹 시스템은 2005년도에 국내에 처음으로 도입되었고, 제품수명 주기상 도입기에 해당하며, 향후 성장 가능성이 매우 높을 것으로 전망된다.

• Journal of Nutrition and Health
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• 제53권5호
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• pp.445-451
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• 2020

Purpose: Breastfeeding is the optimal method for feeding a newborn. But insufficient breast milk is the major reason why mothers give up breastfeeding. Herbal galactagogues have been used increasingly to treat postpartum hypogalactia. This study examined the effect of an herbal tea containing Chrysanthemum indicum, as the main ingredient, on milk production in lactating rats. Methods: The herbal tea contained C. indicum (27%), Foeniculum vulgare Mill (21%), Pimpinella anisum (18.2%), Carum carvi (16.1%), Urtica dioica (14.7%), and Gardenia jasminoides (3%). Sixteen lactating Sprague-Dawley (SD) rats were divided randomly into 2 groups, the normal control group (NC; n = 8), and the galactagogue herbal tea group (GHT; n = 8) for 7 days. Lactating rats were administered the decoction of an herbal galactagogue mixture by oral gavage or the same amount of distilled water and milk production was assessed by measuring the pups' weights during the suckling period. The blood concentrations of prolactin, cortisol, oxytocin levels and mammary gland tissues were examined to assess the effects of the galactagogue. Results: Milk production was 9.2% higher in the GHT group given the herbal tea than in the NC group and the difference was statistically significant. The cortisol level in the GHT group was 17.2% higher than the NC group. The herbal tea containing C. indicum increased the size of the alveoli epithelium cells and the mammary lobe. Conclusion: The present study revealed the potential of herbal tea containing C. indicum to enhance milk production in postpartum SD rats.

• International Journal of Naval Architecture and Ocean Engineering
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• 제9권3호
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• pp.315-325
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• 2017

The design dimension may not be satisfactory at the final stage due to the welding during the assembly stage, leading to cutting or adding the components in large structure constructions. The productivity is depend on accuracy of the welding quality especially at assembly stage. Therefore, it is of utmost importance to decide the component dimension during each assembly stage considering the above situations during the designing stage by exactly predicting welding deformation before the welding is done. Further, if the system that predicts whether welding deformation is equipped, it is possible to take measures to reduce deformation through FE analysis, helping in saving time for correcting work by arresting the parts which are prone to having welding deformation. For the FE analysis to predict the deformation of a large steel structure, calculation time, modeling, constraints in each assembly stage and critical welding length have to be considered. In case of fillet welding deformation, around 300 mm is sufficient as a critical welding length of the specimen as proposed by the existing researches. However, the critical length in case of butt welding is around 1000 mm, which is far longer than that suggested in the existing researches. For the external constraint, which occurs as the geometry of structure is changed according to the assembly stage, constraint factor is drawn from the elastic FE analysis and test results, and the magnitude of equivalent force according to constraint is decided. The comparison study for the elastic FE analysis result and measurement for the large steel structure based on the above results reveals that the analysis results are in the range of 80-118% against measurement values, both matching each other well. Further, the deformation of fillet welding in the main plate among the total block occupies 66-89%, making welding deformation in the main plate far larger than the welding deformation in the longitudinal and transverse girders.

• Journal of Forest and Environmental Science
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• 제34권2호
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• pp.101-107
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• 2018

We identified the main impacts, drivers, and restoration projects for Atlantic Forest in Northwest of the Rio Grande do Sul State, Brazil. The objective was to analyze the quantity, distribution, and causes of the environmental crimes in 2000-2014. To verify differences between degraded and restored areas, we performed a t-test; ANOVA for the municipalities with more quantity of crimes, simple linear regression analysis for the relationship between sizes of degraded areas and quantity of seedlings planted, and Principal Component Analysis (PCA) for environmental damages categories and population of the municipalities. The main environmental damages found were deforestation outside permanent preservation area (20%) and those related to Permanent Preservation Area (37%). Environmental crimes in these areas fall into two categories: native and exotic vegetation removal (17%), and impediment to natural regeneration (20%). The average size of the degraded areas was $5,359{\pm}526m^2$, while for restored areas was $3,337{\pm}255m^2$. The sizes of the degraded fragments were similar among the five municipalities with the higher number of environmental crimes (ANOVA: p>0.05, F=1.24; df=241). The number of seedlings planted was positively related to the sizes of the degraded fragments (p<0.001, $R^2=0.53$). Segregation between the less and the most populous municipalities was found with the PCA analysis along PC1 (51.7%), while PC2 represented 19.2% of the total variation. The most populous municipalities showed the highest number of environmental crimes, and the majority of degraded areas were recovered by planting native seedlings. Atlantic Forest fragments need to be recognized and preserved as an ecosystem with a unique ecological function by the population and public administration.