• International Journal of Fuzzy Logic and Intelligent Systems
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• v.8 no.1
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• pp.61-67
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• 2008

This paper introduces the multi-vehicle routing problem(MRP) which is different from the traveling sales problem(TSP), and presents the ant system(AS) applied to the MRP. The proposed MRP is a distributive model of TSP since many vehicles are used, not just one salesman in TSP and even some constraints exist. In the AS, a set of cooperating agents called vehicles cooperate to find good solutions to the MRP. To make the proposed MRP extended more, Tokyo city model(TCM) is proposed. The goal in TCM is to find a set of routes that minimizes the total traveling time such that each vehicle can reach its destination as soon as possible. The results show that the AS can effectively find a set of routes minimizing the total traveling time even though the TCM has some constraints.

• Journal of the Korean Society of Food Science and Nutrition
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• v.38 no.1
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• pp.62-69
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• 2009

Maillard reaction products (MRPs) were produced from aqueous solution of various sugars with defatted hydrolyzed soybean protein (DFHSP) with different temperatures and pressures. Physicochemical properties of MRPs were investigated; also, DPPH and hydroxyl radical scavenging activity and sensory properties were evaluated. MRPs from ribose and DFHSP had the highest reactivity with larger pH reduce, higher browning index increase and higher antioxidant activity than other MRPs from other sugars. The antioxidant activities were increased with increasing temperatures and pressures of reaction. The highest antioxidant activity and sensory preference were obtained from MRPs with ribose at $140^{\circ}C$ with 2.8 kg/$cm^2$ for 30 mins.

• Journal of the Korea Society of Computer and Information
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• v.4 no.1
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• pp.54-61
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• 1999

The MRP, OPT and JIT systems have the respective limitations to become the suitable production management systems of the future. Therefore it is highly requested to develop an integrated production management system by the hybridization of those production systems. Accordingly, this study has focused its hybrid model using MRP, JIT and OPT. There has been many efforts in comparing and analyzing the usefulness and the limitations of those production systems and applying the usefulness to the maximum which improving and supplementing the weakpoints of respective systems. In this respect, this study develop the hybrid simulation model, and this hybrid model are evaluated and compared with MRP(Push system) and JIT(Pull system) by using a simulation.

• Animal cells and systems
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• v.2 no.4
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• pp.529-538
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• 1998

In order to analyze the intracellu1ar localization of specific RNA components of ribonucleoproteins (RNP) in Xenopus oocytes, a modified protocol of whole-mount in situ Hybridization is presented in this paper, Mitochondria specific 12S rRNA probe was used to detect the amplification and distribution of mitochondria in various stages of the oocyte life cycle, and the results were found to be consistent with previously known distribution of mitochondria. The results with other specific probes (U1 and U3 small nuclear RNAs, and 5S RNA) also indicate that this procedure is generally effective in localizing RNAs in RNP complexes even inside organelles. In addition, the RNA component of RNase MRP, the RNP with endoribo-nuclease activity, localize to the nucleus in various stages of the oocyte life cycle. Some of MRP RNA, however, were found to be localized to the special population of mitochondria near the nucleus, especially in the active stage of mitochondrial amplification. It suggests dual localization of RNase MRP in the nucleus and mitochondria, which is consistent with the proposed roles of RNase MRP in mitochondrial DNA replication and in rRNA processing in the nucleolus.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.6
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• pp.481-492
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• 2020

The present study aimed to examine the effect of allyl isothiocyanate (AITC) on chronic obstructive pulmonary disease and to investigate whether upregulation of multidrug resistance-associated protein 1 (MRP1) associated with the activation of the PARK7 (DJ-1)/nuclear factor erythroid 2-related factor 2 (Nrf2) axis. Lung function indexes and histopathological changes in mice were assessed by lung function detection and H&E staining. The expression levels of Nrf2, MRP1, heme oxygenase-1 (HO-1), and DJ-1 were determined by immunohistochemistry, Western blotting and reverse transcription-quantitative polymerase chain reaction. Next, the expression of DJ-1 in human bronchial epithelial (16HBE) cells was silenced by siRNA, and the effect of DJ-1 expression level on cigarette smoke extract (CSE)-stimulated protein degradation and AITC-induced protein expression was examined. The expression of DJ-1, Nrf2, HO-1, and MRP1 was significantly decreased in the wild type model group, while the expression of each protein was significantly increased after administration of AITC. Silencing the expression of DJ-1 in 16HBE cells accelerated CSE-induced protein degradation, and significantly attenuated the AITC-induced mRNA and protein expression of Nrf2 and MRP1. The present study describes a novel mechanism by which AITC induces MRP1 expression by protecting against CS/CSE-mediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis.

• Korean Management Science Review
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• v.5 no.2
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• pp.6-15
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• 1988

이 글에서는 다음의 내용을 다루었다. 1. MRP란 무엇인가 2. 어떻게 도입할 것인가 3. 무엇을 개발할 것인가 4. 어떻게 운영할 것인가 5. 한국형 MRP의 오늘과 내일

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3521-3526
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• 2013

Objective: The current study explored the expression of KAI1/CD82 and MRP1/CD9 and its significance in laryngeal squamous cell carcinoma (LSCC). Methods: The expression levels of KAI1/CD82 and MRP1/CD9 in 100 LSCC tissue specimens, as well as in 30 para-LSCC non-carcinomatous tissue specimens randomly taken from the patients, were assessed using the quantitative polymerase chain reaction (Q-PCR) and immunohistochemistry and correlations with pathological parameters of LSCC and their influence on survival function were analyzed. Results: KAI1/CD82 and MRP1/CD9 showed basically consistent changes in both mRNA and protein expression. Their expression in the 30 LSCC specimens was significantly lower compared with that in the corresponding non-carcinous tissues (P < 0.01 or 0.05), notably correlating with TNM stage, differentiation degree, clinical stage, and lymphatic metastasis (P < 0.01 or 0.05), but not gender, age, and LSCC growth sites (P > 0.05). The median survival of patients with positive KAI1/CD82 and MRP1/CD9 protein expression was longer than that of patients with negative protein expression (P < 0.01 or 0.05). KAI1/CD82 protein expression negatively correlated with MRP1/CD9 protein expression in LSCC (${\chi}^2$= 31.25, P < 0.01). Conclusion: KAI1/CD82 and MRP1/CD9 may jointly participate in the development of LSCC. They may serve as the markers for judging the infiltration, metastasis, and prognosis of LSCC.

• Journal of the Korea Safety Management & Science
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• v.3 no.1
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• pp.93-105
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• 2001

Many production management systems for increasing productivity, minimizing inventory, keeping due dates and maximizing use of resources have been proposed, and GT, MRP and JIT are frequently used among these systems. The three systems have merits and demerits through comparing with each other. Because each system has mutual dependence, a hybrid production system Is necessary for using their merits maximally. In this study, a hybrid production system is designed by combining GT, MRP and JIT, which is suitable in the domestic production system and it is presented as followings. -. Basic research works for G7, MRP and JIT. -. Comparison and analysis are carried out for each system.- . The hybrid production system is designed. -. The hybrid production system is developed.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.5 no.1
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• pp.113-122
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• 1985

Although PERT/CPM has been used for over twenty years as a technique for scheduling in a variety of industries and various extention to the basic model have been improved the realism of considering resource constraints, none of these techniqueis have integrated resource acquistion load times and inventory records into scheduling technique. This paper is to designed to over-come basic shortcoming of previous CPM into incorperate with MRP technique.

• Asia pacific journal of information systems
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• v.2 no.1
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• pp.57-76
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• 1992

Material Requirement Planning(MRP) has been the most widely implemented large scale production management system in the manufacturing industry. Computerization of MRP systems involves, in general, Bill Of Material(BOM) explosion algolithms which usually takes heavy computation time. In order to improve the effectiveness of the MRP systems, we propose to build a logical BOM database in advance, which reflects the Join operations for the BOM explosion. It reduces the response time for the BOM indented explosion. It reduces the MRP processing time. It also increased main memory utilization.