• Biomolecules & Therapeutics
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• v.27 no.4
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• pp.349-356
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• 2019

Behavioral analysis in mice provided important contributions in helping understand and treat numerous neurobehavioral and neuropsychiatric disorders. The behavioral performance of animals and humans is widely different among individuals but the neurobehavioral mechanism of the innate difference is seldom investigated. Many neurologic conditions share comorbid symptoms that may have common pathophysiology and therapeutic strategy. The forced swim test (FST) has been commonly used to evaluate the "antidepressant" properties of drugs yet the individual difference analysis of this test was left scantly investigated along with the possible connection among other behavioral domains. This study conducted an FST-screening in outbred CD-1 male mice and segregated them into three groups: high performers (HP) or the active swimmers, middle performers (MP), and low performers (LP) or floaters. After which, a series of behavioral experiments were performed to measure their behavioral responses in the open field, elevated plus maze, Y maze, three-chamber social assay, novel object recognition, delay discounting task, and cliff avoidance reaction. The behavioral tests battery revealed that the three groups displayed seemingly correlated differences in locomotor activity and novel object recognition but not in other behaviors. This study suggests that the HP group in FST has higher locomotor activity and novelty-seeking tendencies compared to the other groups. These results may have important implications in creating behavior database in animal models that could be used for predicting interconnections of various behavioral domains, which eventually helps to understand the neurobiological mechanism controlling the behaviors in individual subjects.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.22 no.1
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• pp.57-65
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• 2012

People leave voicemails or record phone conversations in their daily cell phone use. Sometimes important voice data is deleted by the user accidently, or purposely to cover up criminal activity. In these cases, deleted voice data must be able to be recovered for forensics, since the voice data can be used as evidence in a criminal case. Because cell phones store data that is easily fragmented in flash memory, voice data recovery is very difficult. However, if there are identifiable patterns for the deleted voice data, we can recover a significant amount of it by researching images of it. There are several types of voice data, such as QCP, AMR, MP4, etc.. This study researches the data recovery solutions for EVRC codec and AMR codec in QCP file, Qualcumm's voice data format in cell phone.

• The korean journal of orthodontics
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• v.51 no.3
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• pp.179-188
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• 2021

Objective: To evaluate the overall treatment effects in terms of the amount of uprighting with changes in the sagittal and vertical positions of mandibular molars after applying an orthodontic miniplate with a nickel-titanium (NiTi) reverse curve arch wire (biocreative reverse curve [BRC] system). Methods: A total of 30 female patients (mean age, 25.99 ± 8.96 years) were treated with the BRC system (mean BRC time, 10.3 ± 4.07 months). An I-shaped C-tube miniplate (Jin Biomed) was placed at the labial aspect for the alveolar bone of the mandibular incisors. A 0.017 × 0.025-inch NiTi reverse curve arch wire was engaged at the C-tube mini-plate anteriorly and the first and second premolars and molars posteriorly in the mandibular arch. Pre- and post-BRC lateral cephalograms were analyzed. A paired t-test was used to analyze the treatment effects of BRC. Results: The mandibular second molars were intrusively uprighted successfully by the BRC system. Distal uprighting with a controlled vertical dimension was noted on the first molars when they remained engaged in the BRC and the distal ends of the arch wire were laid on the second molars. The mandibular first and second premolars showed a slight extrusion. The changes in the mandibular incisors were unremarkable, while the mandibular molar angulation improved significantly. The lower occlusal plane rotated counterclockwise (MP-LOP: 1.13° ± 2.60°). Conclusions: The BRC system can provide very effective molar uprighting without compromising the position of the mandibular anterior teeth.

• Nuclear Engineering and Technology
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• v.56 no.1
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• pp.195-206
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• 2024

Shenzhen Innovation Light source Facility (SILF) is a 3.0 GeV fourth generation diffraction limited synchrotron light source currently under construction in Shenzhen. The SILF storage ring is proposed to use two 500 MHz single cell superconducting radio frequency (SRF) cavities to provide 2.4 MV RF voltage. In this study, we examined the geometric structure of mature CESR superconducting cavities and adopted a beam-pipe-type extraction scheme for high-order modes (HOM). One of the objectives of SRF cavity design and optimization in this study is to reduce E_p/E_acc and B_p/E_acc as much as possible to reduce power loss and ensure stable operation of the cavity. To reduce the risk of beam instability and thermal breakdown, the HOM and Multipacting (MP) are simulated. Moreover, the mechanical properties of the cavity are analyzed, including frequency sensitivity from pressure of liquid helium (LHe), stress, tuning, Lorentz force detuning (LFD), the microphone effect, and buckling. By comprehensive design and optimization of 500 MHz single-cell SRF cavities, a superconducting cavity for SILF storage ring was developed. This paper will detailed present the design and simulation.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 2017.04a
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• pp.171-171
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• 2017

전산유체역학(CFD: Computational Fluid Dynamics)를 이용한 스마트팜 환경 내부의 정밀 제어 연구가 진행 중이다. 시계열 데이터의 난해한 동적 해석을 극복하기위해, 비선형 모델링 기법의 일종인 인공신경망을 이용하는 방안을 고려하였다. 선행 연구를 통하여 환경 데이터의 비선형 모델링을 위한 Tensorflow활용 방법이 하드웨어 가속 기능을 바탕으로 월등한 성능을 보임을 확인하였다. 그럼에도 오프라인 일괄(Offline batch)처리 방식의 한계가 있는 인공신경망 모델링 기법과 현장 보급이 불가능한 고성능 하드웨어 연산 장치에 대한 대안 마련이 필요하다고 판단되었다. CFD 해석을 위한 Solver로 SU2(http://su2.stanford.edu)를 이용하였다. 운영 체제 및 컴파일러는 1) Mac OS X Sierra 10.12.2 Apple LLVM version 8.0.0 (clang-800.0.38), 2) Windows 10 x64: Intel C++ Compiler version 16.0, update 2, 3) Linux (Ubuntu 16.04 x64): g++ 5.4.0, 4) Clustered Linux (Ubuntu 16.04 x32): MPICC 3.3.a2를 선정하였다. 4번째 개발환경인 병렬 시스템의 경우 하드웨어 가속는 OpenCL(https://www.khronos.org/opencl/) 엔진을 이용하고 저전력 ARM 프로세서의 일종인 옥타코어 Samsung Exynos5422 칩을 장착한 ODROID-XU4(Hardkernel, AnYang, Korea) SBC(Single Board Computer)를 32식 병렬 구성하였다. 분산 컴퓨팅을 위한 환경은 Gbit 로컬 네트워크 기반 NFS(Network File System)과 MPICH(http://www.mpich.org/)로 구성하였다. 공간 분해능을 계측 주기보다 작게 분할할 경우 발생하는 미지의 바운더리 정보를 정의하기 위하여 3차원 Kriging Spatial Interpolation Method를 실험적으로 적용하였다. 한편 병렬 시스템 구성이 불가능한 1,2,3번 환경의 경우 내부적으로 이미 존재하는 멀티코어를 활용하고자 OpenMP(http://www.openmp.org/) 라이브러리를 활용하였다. 64비트 병렬 8코어로 동작하는 1,2,3번 운영환경의 경우 32비트 병렬 128코어로 동작하는 환경에 비하여 근소하게 2배 내외로 연산 속도가 빨랐다. 실시간 CFD 수행을 위한 분산 컴퓨팅 기술이 프로세서의 속도 및 운영체제의 정보 분배 능력에 따라 결정된다고 판단할 수 있었다. 이를 검증하기 위하여 4번 개발환경에서 운영체제를 64비트로 개선하여 5번째 환경을 구성하여 검증하였다. 상반되는 결과로 64비트 72코어로 동작하는 분산 컴퓨팅 환경에서 단일 프로세서 기반 멀티 코어(1,2,3번) 환경보다 보다 2.5배 내외 연산속도 향상이 있었다. ARM 프로세서용 64비트 운영체제의 완성도가 낮은 시점에서 추후 성공적인 실시간 CFD 모델링을 위한 지속적인 검토가 필요하다.

• Journal of Korean Ophthalmic Optics Society
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• v.12 no.3
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• pp.19-25
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• 2007

It was studied how using soft contact lens multi-purpose solution (MPS), often used for medical treatment, effects the inhibition on cell growth, and how using the MPS demages eye cells, on rabbit eye's corneal epithelium and endothelium tissue. $ReNu^{(R)}$ (Baush & Lomb, USA), Opti-free $express^{(R)}$ (Alcon, USA), Free-sol $plus^{(R)}$ (Hanamedicon, Korea) were used as MPS. After culturing Clone 1-5C-4 cell lines (Human conjunctival cell lines), cell growth inhibition rate was measured by MIT assay. By making Hematoxylin and Eosin stain specimen, the morphology was observed by optical microscope. In the In vivo experiment, 9 white rabbit eyes (18 eyes) were classified into 3 groups. The experiment group is left eyes (9 eyes) of rabbit, and MPS were dropped; however the control group, the right eyes (9 eyes), were only used a saline solution without a preservatives. After the dropping within the period, the cornea surface of rabbit endothelium tissue was observed using scanning electron microscopy (SEM).

• Korean Journal of Food Science and Technology
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• v.13 no.2
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• pp.121-126
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• 1981

An adenine-guanine doubless and $\beta$-alanine requiring mutant, D-1550-40, which had been derived from Brevibacterium ammoniagenes ATCC 6872, produced a copious amount of xanthosine-5'-monophosphate (XMP). The optimum concentration of adenine and guanine for maximal accumulation of XMP was about 75 ml/l and 100 ml/l for growth. Concentrations higher than 100 mg/l of adenine and guanine inhibited cell growth and XMP accumulation strongly. The inhibition, however, could be recovered by adding $100{\mu}g$ of biotin per liter or 0.3% of casamino acids to the culture solution. High concentrations of phosphate and magnesium salts (1.0 to 1.5%(w/v) in media) were found to be indispensable for XMP accumulation, and the presence of manganese in the culture medium stimulated both growth of cells and accumulation of XMP leaving 5'-inosinic acid unaffected. The maximal accumulation of XMP reached to 60.5 mg/l after 4 days of fermentation which had been started with a medium containing 100 mg of adenine-guanine, 5 mg of $MnSO_4{\cdot}H_2O$ and $100{\mu}g$ of biotin per liter. The specific XMP synthesis(mg of XMP/mg of cells) was increased with the increase of the cell growth rate.

• Korean Journal of Poultry Science
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• v.20 no.4
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• pp.209-216
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• 1993

This study was conducted to classify Korean native chicken(KNC) and imported chicken by phenotypic performances and DNA fingerprinting. Two lines, KNC and White Leghorn(WL) , of chicken were maintained in the laboratory of Yeungnam University. Economic traits (body weight, sexual maturity, hen-day egg production, egg weight) and phenotypic characteristics (body-type, head, feather, shank) were checked. The DNA fingerprinting was analyzed for both breeds. The growth rate of the KNC was similar to WLS and sexual maturity of the KNC came later than WL. Hen-day egg production of the KNC was also slightly lower than the WL. The egg weight was about 10g lighter than WL. There was no difference in body weight of female KNC compared to the WL after 28 weeks. The study confirms difference between KNC and WL in DNA fingerprinting as well as its outlook. Thus, we suggest that these should be tested in nationwide districts about chickens known as the KNC using DNA fingerprinting. Then, the confirmed KNC populations should be maintained and used for the genetic improvement. Finally, only confirmed KNC should be in market which induce consumer to seek the KNC by its favorite.

• The Journal of the Acoustical Society of Korea
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• v.25 no.1
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• pp.21-29
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• 2006

In this Paper a split bandwidth wideband speech coder and its highband coding method are Proposed. The coder uses a split-band approach. where the wideband input speech signal is split into two equal frequency bands from 0-4kHz and 4-8kHz. The lowband and the highband are coded respectively by the 11.8kb/s G.729 Annex E and the proposed coding method. After the LPC analysis, the highband is divided by two modes according to the properties of signals. In stationary mode. the highband signals are compressed by the mixture excitation model; CELP algorithm and W (Matching Pursuit) algorithm. The others are coded by the only CELP algorithm. We compare the performance of the new wideband speech coder with that of G.722 48kbps SB-ADPCM and G.722.2 12.85kbps in a subjective method. The simulation results show that the Performance of the proposed wideband speech coder has better than that of 48kbps G.722 and no better than that of 12.85kbps G.722.2.

• The korean journal of orthodontics
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• v.28 no.4 s.69
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• pp.547-561
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• 1998

Obstructive sleep apnea (OSA) is a disorder characterized by repetitive episode of upper airway collapse during sleep. Recent studies showed that not only the anatomic factors but the physiologic factors of the upper airway also have effcts on the occurrence of apnea and that the genioglossus muscle also plays an important role in the maintenance of the upper airway. A variety of therapies were performed to treat OSA, and among them the use of mandibular repositioning appliances showed reasonable results. But there is still a lack of research on the structural and physiological mechanism upon the use of mandibular repositioning appliances. The author selected 26(male 17, female 9) OSA patients that came to the Yonsei University Dental Hospital, Department of Orthodontics, and 20 normal adults (male 10, female 10) and took cephalometric radiographs of them in a supine position before and after the placement of the mandibular repositioning appliance to see the structural changes of the upper airway and compare the therapeutic effects between the two groups. We also studied the waking genioglossus muscle activity in OSA patients and investigated the difference in the electromyogram of the genioglosssus muscle upon the change in body posture and the use of mandibular repositioning appliance. Following results were obtained. 1. Among the cephalometric measurements of the upper airway structure, the length of the soft palate, maximum thickness of the soft Palate and SPAS, MAS, VAL, H-H1, MP-H showed statistically significant differences between the normal and OSA groups, but the IAS and EAS showed no statistically significant differences between the two groups. 2. In both the normal and OSA groups, as the epiglottis moved forward on wearing the mandibular repositioning appliance, the epiglottis level of the upper airway increased and the maximum thickness of the soft palate changed and the hyoid bone also moved forward, but the IAS in both groups showed various results and the effect of the mandibular repositioning appliance on the structure of the upper airway was different in the two groups. 3. Upon changing the position, the electromyogram of the genioglossus muscle showed a increasing tendency but there was no statistically significant differences, and when the mandibular repositioning appliance were worn there was a statistically significant increase in the electromyogram of the genioglossus muscle in both the upright and supine positions. The mandibular repositioning appliances not only have an effect on the anatomical structure of the upper airway but also on the physiology of the upper airway. There are different responses to the use of mandibular repositioning appliance between the normal and OSA groups therefore it could be considered to have the different physiology of the upper airway between the two groups.