• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.4
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• pp.177-183
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• 2020

The Hippo-YAP signaling pathway is critical for cell proliferation, survival, and self-renewal in both Drosophila and mammals. Disorder of Hippo-YAP pathway leads to tumor development, progression and poor prognosis in various cancers. YAP/TAZ are the key downstream effectors of the Hippo pathway and they can be inhibited through LATS1/2, core kinases in the Hippo pathway, mediated phosphorylation. In this study, we investigated the effect of Angelica gigas Nakai extract (AGNE) on Hippo-YAP/TAZ pathway. First, ANGE induced YAP/TAZ phosphorylation and dissociation of the YAP/TAZ-TEAD transcription complex. By qRT-PCR, we found that ANGE inhibits the expression of YAP/TAZ-TEAD target gene, CTGF and CYR61. In addition, the transcriptional activity of YAP/TAZ was not suppressed significantly in LATS1/2 double-knockout (DKO) cells by ANGE compared to LATS1/2 wild-type (WT) cells, which means AGNE inhibits YAP/TAZ signaling through direct action on LATS1/2. Further, it was confirmed that AGNE-induced activation of LATS1/2 inhibited the migration potential of the vector-expressing cells by suppressing YAP/TAZ activity. The reduced migration potential was restored in active YAP-TEAD expressing cells. Taken together, the results of this study indicate that ANGE downregulates YAP/TAZ signaling in cells through the activation of LATS1/2.

• Clinical and Experimental Pediatrics
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• v.45 no.4
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• pp.498-504
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• 2002

Purpose : The purpose of this study was to evaluate the perioperative myocardial damage in pediatric congenital heart disease with the cardiac specific protein of cardiac troponin I(cTpn-I). Methods : All 25 pediatric patients who were diagnosed with tetralogy of Fallot or double outlet right ventricle were classified as group A(acyanotic, $SaO_2$ >90%), group B(mildly cyanotic, $SaO_2$ >80-90%) and group C(moderately cyanotic, $SaO_2$ <80%). The control group D was consisted of 10 patients with ventricular septal defects who were operated in the same period. We measured preoperative hemoglobin, preoperative and postoperative(24 and 72 hour) arterial oxygen saturation, cTpn-I and creatine kinase(CK-MB). Results : Total 25 patients were subdivided into 6 of group A, 12 of group B and 7 of group C. The concentrations of preoperative cTpn-I were $0.23{\pm}0.12ng/mL$ in group A, $0.25{\pm}00.12 ng/mL$ in group B, $0.26{\pm}0.13ng/mL$ in group C. And the concentrations of cTpn-I in postoperative 24 hour were $10.04{\pm}5.28ng/mL$ in group A, $12.50{\pm}6.86ng/mL$ in group B, $12.55{\pm}9.90ng/mL$ in group C. Which revealed cTpn-I in group C was higher than that of the another less cyanotic groups. In addition, the concentration of cTpn-I of group C in postoperative 72 hour was higher than any other groups. The concentration of cTpn-I in postoperative 72 hour was statistically correlated with that in postoperative 24 hour and preoperative arterial oxygen saturation(P=0.001). Conclusion : Preoperative chronic cyanosis can influence on the postoperative concentration of cTpn-I in pediatric cardiac patients, which means impairment on the postoperative myocardial recovery.

• Bulletin of the Korean Chemical Society
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• v.34 no.3
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• pp.827-830
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• 2013

Investigation of an organic extract of the fruits Schisandra wilsoniana led to the isolation of two new highly oxygenated nortriterpenoids, named schilancidilactones V-W (1-2). Their structures were elucidated by spectroscopic evidence. Compounds 1-2 feature a double bond between C-7 and C-8 compared with related known nortriterpenoids isolated from the genus Schisandra. Compounds 1 and 2 were tested for their anti-HIV-1 activities and cytotoxicity. The results revealed that compounds 1 and 2 showed moderate anti-HIV-1 activities with $EC_{50}$ 3.05 and 2.87 ${\mu}g/mL$, respectively, and compound 1 showed high cytotoxicity against KB and MDA-MB-231 cell with $IC_{50}$ values of 3.18 and 5.22 ${\mu}M$, respectively.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.5
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• pp.1311-1316
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• 2005

This study was designed to potentiate the vasodilation effect of Banhabackchulchunma-Tang(BCT) prescription by change of mixture. Six different BCT compositions were made according to mixture of herbs. The vascular relaxation effects of 6 different BCT compositions were examined on phenylephrine(PE)-precontracted rat thoracic aorta. The BCT-1 composition exerted significant relaxation on phenylephrine- or KCI- contracted rat thoracic aorta. Its elaxation was endothelium- independent in both PE- and KCl-induced contraction. Treatment of glibenclamide or tetraethylammonium(TEA) did not affect the relaxation of BCT-1. Vasorelaxation efficacy of BCT-1 was also not influenced by low (25mM) or high (50mM, 80mM) KCl-induced contraction. Furthermore, the contraction by increasing $Ca^{2+}$ concentrations (0.3-10.0mM) to a $Ca^{2+}$-free high K+ (60mM) was significantly reduced by pretreatment with BCT-1 In addition, the relaxant effects were not inhibited by pretreatment of rat aorta with L-NAME, MB, indomethacin and atropine. These results confirm that BCT-1 may exerts its vasodilation effect by endothelium-independent manner. According to the above results, we suggest that the relaxation effect of BCT-1 is endothelium-independent and is related with block of $Ca^{2+}$ influx via $Ca^{2+}$ channel.

• Journal of Chest Surgery
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• v.36 no.7
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• pp.483-488
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• 2003

There are still debates in the literature on the relative benefits of blood cardioplegia and crystalloid cardioplegia in pediatric cardiac surgery. We performed a clinical trial to compare the myocardial protective effect between HTK solution and blood cardioplegic solution in congenital heart surgery. Material and Method: 15 patients who underwent HTK solution cardioplegia (group 1) and 15 patients who underwent blood cardioplegia(group 2) were included in this study. Preoperative and postoperative serial serum cardiac enzyme levels (troponin I, CK-MB, LDH) were measured in all patients. Clinical data were analyzed and compared between the two groups. Result: There were no differences in age and body weight between the two groups. Operative diagnosis included ventricular septal defect (VSD, n＝4), atrial septal defect (ASD, n＝1), tetralogy of Fallot (TOF, n＝4), and other complex heart diseases (n＝6) in group 1, VSD (n＝7), ASD (n＝5), and TOF (n＝3) in group 2. Cardiopulmonary bypass times were 99.1$\pm$48.1 minutes in group 1, and 69.3$\pm$27.3 minutes in group 2 (p＝0,02). Aortic clamping times were 52.1$\pm$23.6 minutes in group 1, and 37.9$\pm$20.5 minutes in group 2 (p＝0.07). There was no mortality and spontaneous defibrillation was possible in all patients. No differences were observed in the serial enzyme levels between the two groups. There were no differences in the duration of inotropic support and ventilator time between the two groups. Conclusion: HTK solution provided comparable myocardial protection compared with blood cardioplegic solution. A single high dose of HTK solution may be safely and conveniently used for an extended periods as well in congenital heart surgery.

• Proceedings of the Korean Information Science Society Conference
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• 2005.11a
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• pp.391-393
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• 2005

최근 유비쿼터스 네트워크 환경을 구축하기 위해 많은 무선 통신 기술들이 등장하였다. 그 중 무선랜 기술은 쉬운 설치와 저렴한 비용 덕에 폭발적인 보급이 이루어 겼다. IEEE 802.11 표준을 기반으로 만들어진 무선랜은 여러 개의 전송속도를 지원한다. 대표적으로 802.11b는 1, 2, 5.5, 11MbPs의 4가지 전송속도를 지원한다. 낮은 전송속도로 전송을 하면 패킷 전송시간은 증가하지만 비트 에러율은 감소된다. 각각의 전송속도에 따라 다른 패킷 전송 성공률을 갖게 된다. 한 무선랜 AP에 연결된 노드들은 각자 자신의 처리율을 최대화할 수 있는 전송속도를 결정하여 사용하게 된다. 이러한 상황은 전체 시스템 성능에는 문제를 발생시킬 수 있다. 본 논문에서는 각자의 전송속도를 각자가 결정하는 것이 전체 시스템 성능에 문제를 발생시키는 경우를 보이고, 그것을 해결하기 위해 AP가 각 노드의 전송속도를 결정하는 기법을 제안한다. 나아가 무선랜에서의 문제점인 Performance Anomaly 현상을 해결하고, [3]에서 언급된 Inefficient Equilibria 현상도 막아본다.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.17 no.1
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• pp.23-29
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• 2007

Pitch-coated anatase $TiO_2$ typed was prepared by $CCl_4$ solvent mixing method with different mixing ratios. Since the carbon layers derived from pitch on the $TiO_2$ particles were porous, the pitch-coated $TiO_2$ sample series showed a good adsorptivity and photo decomposition activity. The BET surface area for the carbon layer in the sample increases to increasing with pitch contents. The SEM results present to the characterization of porous texture on the pitch-coated $TiO_2$ sample and pitch distributions on the surfaces for all the materials used. From XRD data a weak and broad carbon peak of graphene with pristine anatase peaks were observed in the X-ray diffraction patterns for the pitch-coated $TiO_2$. The EDX spectra show the presence of C, O and S with strong Ti peaks. Most of these samples are richer in carbon and major Ti metal than any other elements. Finally, the excellent photocatalytic activity of pitch-coated $TiO_2$ with slope relationship between relative concentration of MB ($c/c_o$) and t could be attributed to the homogeneous coated pitch on the external surface by $CCl_4$ solvent method.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.2
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• pp.610-630
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• 2020

A large number of people suffered from traffic accidents each year, so people pay more attention to traffic safety. However, the traditional methods use laser sensors to calculate the vehicle distance at a very high cost. In this paper, we propose a method based on deep learning to calculate the vehicle distance with a monocular camera. Our method is inexpensive and quite convenient to deploy on the mobile platforms. This paper makes two contributions. First, based on Light-Head RCNN, we propose a new vehicle detection framework called Light-Car Detection which can be used on the mobile platforms. Second, the planar homography of projective geometry is used to calculate the distance between the camera and the vehicles ahead. The results show that our detection system achieves 13FPS detection speed and 60.0% mAP on the Adreno 530 GPU of Samsung Galaxy S7, while only requires 7.1MB of storage space. Compared with the methods existed, the proposed method achieves a better performance.

• ETRI Journal
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• v.39 no.4
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• pp.582-591
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• 2017

To address the wire complexity problem in large-scale globally asynchronous, locally synchronous systems, a current-mode ternary encoding scheme was devised for a two-phase asynchronous protocol. However, for data transmission through a very long wire, few studies have been conducted on reducing the long propagation delay in current-mode circuits. Hence, this paper proposes a current steering logic (CSL) that is able to minimize the long delay for the devised current-mode ternary encoding scheme. The CSL creates pulse signals that charge or discharge the output signal in advance for a short period of time, and as a result, helps prevent a slack in the current signals. The encoder and decoder circuits employing the CSL are implemented using $0.25-{\mu}m$ CMOS technology. The results of an HSPICE simulation show that the normal and optimal mode operations of the CSL achieve a delay reduction of 11.8% and 28.1%, respectively, when compared to the original scheme for a 10-mm wire. They also reduce the power-delay product by 9.6% and 22.5%, respectively, at a data rate of 100 Mb/s for the same wire length.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2003.10a
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• pp.336-339
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• 2003

A digital data logging system has been developed for the purpose of a compact offline Ocean Bottom Seismometer(OBS). The Digital Data Logger(DDL) consists of A/D system, Micom with storage memory and firmware managing data files. The A/D system acquires data of 16bit/4ch with sampling rate of 250Hz per channel. The Micom, a micro controller board with T33521 processor of 8051 class, was equipped with 8 flash memories of 128MB for data storage capacity of 1GB. The firmware stores the acquiring data in form of binary files. The DDL was designated to be compact and light and to consume low energy as possible. The DDL is to interface with PC through USB(Universal Serial Bus). The performance of the DDL has been validated through tests with respect to a 3-axis seismometer.