Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)
- Volume 19 Issue 5
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- Pages.1311-1316
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- 2005
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- 1738-7698(pISSN)
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- 2288-2529(eISSN)
Enhanced Vasorelaxation of Banhabackchulchunma-Tang and Involved Mechanism
반하백출천마탕(半夏白朮天麻湯)의 조성에 따른 혈관이완활성과 기전
- Lee Heon-Jae (Department of Physiology, College of oriental Medicine, Dongguk University) ;
- Seong You-Jin (Department of Physiology, College of oriental Medicine, Dongguk University) ;
- Kim Sang-Dae (Department of Physiology, College of oriental Medicine, Dongguk University) ;
- Moon Kook-Jin (Department of Physiology, College of oriental Medicine, Dongguk University) ;
- Kim Jeong-Bong (Department of Physiology, College of oriental Medicine, Dongguk University) ;
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Kim Gil-Wheon
(Department of Physiology, College of oriental Medicine, Dongguk University) ;
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Shin Heung-Mook
(Department of Physiology, College of oriental Medicine, Dongguk University)
- 이헌재 (동국대학교 한의과대학 생리학교실) ;
- 성유진 (동국대학교 한의과대학 생리학교실) ;
- 김상대 (동국대학교 한의과대학 생리학교실) ;
- 문국진 (동국대학교 한의과대학 생리학교실) ;
- 김종봉 (동국대학교 한의과대학 생리학교실) ;
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김길훤
(동국대학교 한의과대학 생리학교실) ;
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신흥묵
(동국대학교 한의과대학 생리학교실)
- Published : 2005.10.01
Abstract
This study was designed to potentiate the vasodilation effect of Banhabackchulchunma-Tang(BCT) prescription by change of mixture. Six different BCT compositions were made according to mixture of herbs. The vascular relaxation effects of 6 different BCT compositions were examined on phenylephrine(PE)-precontracted rat thoracic aorta. The BCT-1 composition exerted significant relaxation on phenylephrine- or KCI- contracted rat thoracic aorta. Its elaxation was endothelium- independent in both PE- and KCl-induced contraction. Treatment of glibenclamide or tetraethylammonium(TEA) did not affect the relaxation of BCT-1. Vasorelaxation efficacy of BCT-1 was also not influenced by low (25mM) or high (50mM, 80mM) KCl-induced contraction. Furthermore, the contraction by increasing
Keywords
- Banhabackchulma-tang-1 (BCT-1 );
- Endothelium-independent relaxation;
- $Ca^{2+}$ influx;
- $Ca^{2+}$ channel