• 제목/요약/키워드: MDS

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MDS 분석방법을 이용한 거실의 가구사용행태연구 (An Application of MDS(Multidimensional Scaling) Methods to the Study of Furniture Usage and Behavior in the Living Room)

  • 조성희
    • 한국주거학회논문집
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    • 제1권2호
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    • pp.1-11
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    • 1990
  • A study of domestic furniture arrangements may reveal the living style relevant to the room as conceived and coded by occupants and the effects of the physical environment on the structure of behavior settings. The purpose of this study was to investigate, through analizing the furniture usage and behavior as a non-reactive and activity oriented behavioral measures, the occupants` domestic habits as a living style using MDS. MDS(multidimensional scaling technique) is a statistical technique for creating a spatial representation of data. It Is a particularly appropriate technique for analizing qualitative data such as the furniture usage and behavior because it takes into account all of the relationships between items. For the MDS analysis, the furniture usage and behavior examined by housing types based on 114 households in Seoul. The result of spatial configuration by MDS has three dimensions : recogn;lion of room function, pattern of room organization, understanding of room meaning. The effect of housing types for dimensions is identical but configuration of furniture items is different.

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블록 암호에서 교환 계층의 MDS 코드 생성 확인 알고리즘 (MDS code Creation Confirmation Algorithms in Permutation Layer of a Block Cipher)

  • 박창수;조경연
    • 한국정보통신학회논문지
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    • 제7권7호
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    • pp.1462-1470
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    • 2003
  • 정보통신의 발달과 인터넷의 확산으로 인해 정보보안의 필요성이 증대되면서 다양한 암호알고리즘이 개발되어 활용되고 있다. 이와 더불어 암호 공격 기술도 발전하여서, 공격에 강한 알고리즘에 대한 연구가 활발하게 진행되고 있다. Substitution Permutation Networks(SPN)등의 블록 암호알고리즘에서 교환계층의 선형변환행렬이 Maximum Distance Separable(MDS) 코드를 생성하면 차분공격과 선형공격에 강한 특성을 보인다. 본 논문에서는 선형변환행렬이 MDS 코드를 생성하는가를 판단하는 새로운 알고리즘을 제안한다. 선행변환행렬의 입력코드는 GF(2$^n$)상의 원소들로 이들을 변수로 해석할 수 있다. 하나의 변수를 다른 변수들의 대수식으로 변환하고 대입하여 변수를 하나씩 소거한다. 변수가 하나이고 모든 계수가 ‘0’이 아니면 선형변환 행렬은 MDS 코드를 생성한다. 본 논문에서 제안한 알고리즘은 기존의 모든 정방부분행렬이 정칙인지를 판단하는 알고리즘과 비교하여 곱셈 및 역수 연산수를 많이 줄임으로서 수행 시간을 크게 감소 시켰다.

Revisiting Use of Growth Factors in Myelodysplastic Syndromes

  • Newman, Kam;Maness-Harris, Lori;El-Hemaidi, Ihab;Akhtari, Mojtaba
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권4호
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    • pp.1081-1091
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    • 2012
  • Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematologic neoplasms characterized by morphologic dysplasia, aberrant hematopoiesis and peripheral blood refractory cytopenias. MDS is recognized to be associated with an increased risk of symptomatic anemia, infectious complications and bleeding diathesis, as well as a risk of progression to acute myeloid leukemia, particularly in patients with a high IPSS score. The advent of use of hematopoietic growth factors such as granulocyte colony-stimulating factor (G-CSF) and recombinant erythropoietin (EPO) has improved symptoms in MDS patients in addition to some data that suggest there might be an improvement in survival. G-CSF is an effective therapeutic option in MDS patients, and it should be considered for the management of refractory symptomatic cytopenias. G-CSF and EPO in combination can improve outcomes in appropriate MDS patients such as those with lower-risk MDS and refractory anemia with ring sideroblasts (RARS). This article reviews use of growth factors for lower-risk MDS patients, and examines the data for G-CSF, EPO and thrombopietic growth factors (TPO) that are available or being developed as therapeutic modalities for this challenging disease.

Development of Molecular Diagnostic Innovation System in India: Role of Scientific Institutions

  • Singh, Nidhi
    • Asian Journal of Innovation and Policy
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    • 제11권1호
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    • pp.87-109
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    • 2022
  • The study attempts to examine the system-building activities of scientific institutions in developing the Molecular Diagnostic (MDs) Innovation System in India. Scientific Institutions are the precursor of any technological development with their capabilities in generating new ideas. MDs are advanced and accurate diagnostic technology with considerable scope to serve the diagnostic needs and requirements of the healthcare system. We adopted a System framework and analyzed the development of MDs in terms of the Technological Innovation System (TIS) functions, and the systematic challenges are assessed through the System Failure Framework (SFF). Based on the secondary and primary survey of prominent science base actors, the study finds that the role of government is crucial for facilitating technological development within a science base through the mobilization of resources. In India, the MDs technological development gained significant momentum over the last decade with the development of specialized human resources and dedicated research institutes. However, we do find that the innovative capabilities in attaining need-based TIS are sub-optimal owning to the specific diagnostic needs of highly burdened diseases in the society. The system analysis reveals that the TIS functions are underperforming because of the absence of a well-defined funding mechanism and goal-oriented targeted policy regime of the government. Since MDs have a transformative effect on the present healthcare system, we argue that the government has to address the system-based challenges and issues for developing a need-based technological innovation system for MDs in the country.

Scaling MDS for Preference Data Using Target Configuration

  • Hwang, S.Y.;Park, S.K.
    • Journal of the Korean Data and Information Science Society
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    • 제14권2호
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    • pp.237-245
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    • 2003
  • MDS(multi-dimensional scaling) for preference data is a graphical tool which usually figures out how consumers recognize, evaluate certain products. This article is mainly concerned with an optimal scaling for MDS when target configuration is available. Rotation of axis and SUR(seemingly unrelated regression) methods are employed to get a new configuration which is obtained as close to the target as we can. Methodologies developed here are also illustrated via a real data set.

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RUNX1 Mutations in the Leukemic Progression of Severe Congenital Neutropenia

  • Olofsen, Patricia A.;Touw, Ivo P.
    • Molecules and Cells
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    • 제43권2호
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    • pp.139-144
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    • 2020
  • Somatic RUNX1 mutations are found in approximately 10% of patients with de novo acute myeloid leukemia (AML), but are more common in secondary forms of myelodysplastic syndrome (MDS) or AML. Particularly, this applies to MDS/AML developing from certain types of leukemia-prone inherited bone marrow failure syndromes. How these RUNX1 mutations contribute to the pathobiology of secondary MDS/AML is still unknown. This mini-review focusses on the role of RUNX1 mutations as the most common secondary leukemogenic hit in MDS/AML evolving from severe congenital neutropenia (SCN).

모바일 데이터 서비스 사용량 증감에 영향을 미치는 요인들에 관한 연구: 이요인 이론(Two Factor Theory)을 바탕으로 (A Study for Factors Influencing the Usage Increase and Decrease of Mobile Data Service: Based on The Two Factor Theory)

  • 이상훈;김일경;이호근;박현지
    • Asia pacific journal of information systems
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    • 제17권2호
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    • pp.97-122
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    • 2007
  • Conventional networking and telecommunications infrastructure characterized by wires, fixed location, and inflexibility is giving way to mobile technologies. Numerous research reports point to the ultimate domination of wireless communication. With the increasing prevalence of advanced cell-phones, various mobile data services (hereafter MDS) are gaining popularity. Although cellular networks were originally introduced for voice communications, statistics indicate that data services are replacing the matured voice service as the growth engine for telecom service providers. For example, SK Telecom, the Korea's largest mobile service provider, reported that 25.6% of revenue and 28.5% of profit came from MDS in 2006 and the share is growing. Statistics also indicate that, in 2006, the average revenue per user (ARPU) for voice didn't change but MDS grew seven percents from the previous year, further highlighting its growth potential. MDS is defined "as an assortment of digital data services that can be accessed using a mobile device over a wide geographic area." A variety of MDS have been deployed, with a few reaching the status of killer applications. Many of them need to access the Internet through the cellular-phone infrastructure. In the past, when the cellular network didn't have acceptable bandwidth for data services, SMS (short messaging service) dominated MDS. Now, Internet-ready, next-generation cell-phones are driving rich digital data services into the fabric of everyday life, These include news on various topics, Internet search, mapping and location-based information, mobile banking and gaming, downloading (i.e., screen savers), multimedia streaming, and various communication services (i.e., email, short messaging, messenger, and chaffing). The huge economic stake MDS has on its stakeholders warrants focused research to understand associated dynamics behind its adoption. Lyytinen and Yoo(2002) pointed out the limitation of traditional adoption models in explaining the rapid diffusion of innovations such as P2P or mobile services. Also, despite the increasing popularity of MDS, unexpected drop in its usage is observed among some people. Intrigued by these observations, an exploratory study was conducted to examine decision factors of MDS usage. Data analysis revealed that the increase and decrease of MDS use was influenced by different forces. The findings of the exploratory study triggered our confirmatory research effort to validate the uni-directionality of studied factors in affecting MDS usage. This differs from extant studies of IS/IT adoption that are largely grounded on the assumption of bi-directionality of explanatory variables in determining the level of dependent variables (i.e., user satisfaction, service usage). The research goal is, therefore, to examine if increase and decrease in the usage of MDS are explained by two separate groups of variables pertaining to information quality and system quality. For this, we investigate following research questions: (1) Does the information quality of MDS increase service usage?; (2) Does the system quality of MDS decrease service usage?; and (3) Does user motivation for subscribing MDS moderate the effect information and system quality have on service usage? The research questions and subsequent analysis are grounded on the two factor theory pioneered by Hertzberg et al(1959). To answer the research questions, in the first, an exploratory study based on 378 survey responses was conducted to learn about important decision factors of MDS usage. It revealed discrepancy between the influencing forces of usage increase and those of usage decrease. Based on the findings from the exploratory study and the two-factor theory, we postulated information quality as the motivator and system quality as the de-motivator (or hygiene) of MDS. Then, a confirmative study was undertaken on their respective role in encouraging and discouraging the usage of mobile data service.

Inhibition of DNMT3B and PI3K/AKT/mTOR and ERK Pathways as a Novel Mechanism of Volasertib on Hypomethylating Agent-Resistant Cells

  • Eun-Ji Choi;Bon-Kwan Koo;Eun-Hye Hur;Ju Hyun Moon;Ji Yun Kim;Han-Seung Park;Yunsuk Choi;Kyoo-Hyung Lee;Jung-Hee Lee;Eun Kyung Choi;Je-Hwan Lee
    • Biomolecules & Therapeutics
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    • 제31권3호
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    • pp.319-329
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    • 2023
  • Resistance to hypomethylating agents (HMAs) in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) is a concerning problem. Polo-like kinase 1 (PLK1) is a key cell cycle modulator and is known to be associated with an activation of the PI3K pathway, which is related to the stabilization of DNA methyltransferase 1 (DNMT1), a target of HMAs. We investigated the effects of volasertib on HMA-resistant cell lines (MOLM/AZA-1 and MOLM/DEC-5) derived from MOLM-13, and bone marrow (BM) samples obtained from patients with MDS (BM blasts >5%) or AML evolved from MDS (MDS/AML). Volasertib effectively inhibited the proliferation of HMA-resistant cells with suppression of DNMTs and PI3K/AKT/mTOR and ERK pathways. Volasertib also showed significant inhibitory effects against primary BM cells from patients with MDS or MDS/AML, and the effects of volasertib inversely correlated with DNMT3B expression. The DNMT3B-overexpressed AML cells showed primary resistance to volasertib treatment. Our data suggest that volasertib has a potential role in overcoming HMA resistance in patients with MDS and MDS/AML by suppressing the expression of DNMT3 enzymes and PI3K/AKT/mTOR and ERK pathways. We also found that DNMT3B overexpression might be associated with resistance to volasertib.

블록 암호 알고리즘에서 선형변환 행렬식의 MDS 코드 생성 확인 알고리즘 (MDS code Confirmation Algorithms of Linear Transformation Matrix in Block Cipher Algorithms)

  • 윤성훈;박창수;조경연
    • 한국멀티미디어학회:학술대회논문집
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    • 한국멀티미디어학회 2002년도 추계학술발표논문집
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    • pp.216-219
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    • 2002
  • 정보통신의 발달과 인터넷의 확산으로 인해 정보보안의 필요성이 중요한 문제로 대두되면서 여러 종류의 암호 알고리즘이 개발되어 활용되고 있다. Substitution Permutation Networks(SPN)등의 블록 암호 알고리즘에서는 확산선형변환 행렬을 사용하여 안전성을 높이고 있다. 확산선형변환 행렬이 Maximum Distance Separable(MDS) 코드를 생성하면 선형 공격과 차분 공격에 강한 특성을 보인다. 본 논문에서는 선형변환 행렬이 MDS 코드를 생성하는 가를 판단하는 새로운 알고리즘을 제안한다. 입력 코드는 GF(2/sub□/)상의 원소들로 구성되며, 원소를 변수로 해석하여, 변수를 소거시키면서 선형변환행렬이 MDS 코드를 생성하는 가를 판단한다. 본 논문에서 제안한 알고리즘은 종래의 모든 정방 부분행렬이 정칙인가를 판단하는 알고리즘과 비교하여 연산 수행 시간을 크게 줄였다.

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