• BMB Reports
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• v.34 no.3
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• pp.268-273
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• 2001

In addition to the recognition site for glutamate, the N-methyl-D-aspartate (NMDA)-preferring glutamate receptor subtype shows a binding site for glycine. In this paper, we present the effects of 3-(4,6-dichloro-2-carboxymethylamino-5,7-dichloroquinoline-2-carboxylic acid (MDL 29951), a potent inhibitor of glycine binding to the NMDA receptor, on glutamate dehydrogenase (GDH) from bovine brains. The incubation of GDH isoproteins from bovine brains with MDL 29951 resulted in a dose-dependent loss of enzyme activity Separately or together, 2-oxoglutarate and NADH did not give an efficient protection against the inhibition, indicating that GDH isoproteins saturated with NADH or 2-oxoglutarate are still open to attack by MDL 29951. MDL 29951 was an uncompetitive inhibitor with respect to both 2-oxoglutarate and NADH for GDH isoproteins. These results suggest that the binding site of MDL 29951 is not directly located at the catalytic site, and the inhibition of GDH isoproteins by MDL 29951 is probably due to a steric hindrance, or a conformational change altered upon the interaction of the enzyme with its inhibitor. The inhibitory effects of MDL 29951 on GDH isoproteins were significantly diminished in the presence of ADP. GDH I reacted more sensitively with ADP than GDH II on the inhibition by MDL 29951. Our results suggest a possibility that the two types of GDHs are differently regulated by MDL 29951, depending on the physiological concentrations of ADP.

• Journal of KIISE:Computing Practices and Letters
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• v.8 no.5
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• pp.574-582
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• 2002

Web technology for next generation, led by W3C, is focusing on overcoming of limitation of Human-oriented Web. With circumstance of dramatic increasing information flow in current existing Web, human view based HTML technology is significantly loosing its value. To overcome limitation of Human-oriented Web, new alternative method is essentially required In this context, Machine-oriented Web which machine is searching for information, has been researched as a new alternative. This thesis reviewed MDL (Meaning Definition Language) which is regarded as most generally using method for implementation of Machine-Oriented Web, and presented modeling concept and implementation method in detail. To verify tile value of this presented implementation method, this thesis includes actual cases which has based on proposed implementation method. As an end, we have tried to give a technical assistance to developer of MDL Editor by suggesting MDL Editor implementation display, which has been founded on the proposed modeling method.

• Journal of KIISE:Computing Practices and Letters
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• v.14 no.5
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• pp.492-496
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• 2008

Much research has been conducted to describe metrics for UML models by extending OCL that was proposed to define structural constraints. However, metrics descriptions in OCL are complex, so they are very difficult to understand. This paper defines MDL4UML by abstracting the conventional OCL. By abstracting OCL constructs, the MDL4UML can produce simpler descriptions of metrics, which can help metrics designer to understand and describe metrics.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.2
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• pp.817-821
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• 2012

In this paper we applied the optimal mixture number estimation technique in GMM(Gaussian mixture model) using BIC(Bayesian information criterion) and MDL(minimum description length) as a model selection criterion for environmental sounds recognition. In the experiment, we extracted 12 MFCC(mel-frequency cepstral coefficients) features from 9 kinds of environmental sounds which amounts to 27747 data and classified them with GMM. As mentioned above, BIC and MDL is applied to estimate the optimal number of mixtures in each environmental sounds class. According to the experimental results, while the recognition performances are maintained, the computational complexity decreases by 17.8% with BIC and 31.7% with MDL. It shows that the computational complexity reduction by BIC and MDL is effective for environmental sounds recognition using GMM.

• The KIPS Transactions:PartD
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• v.15D no.5
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• pp.629-646
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• 2008

Because most metricsin the literatures are described by a natural language, they can be interpreted in an ambigous manner. To cope with this problem, there are some researches to express based on Object Constraint Language(OCL). Because OCL has been proposed to describe structural constraintsfor Unified Modeling Language(UML) diagrams, it is difficult and awkward. In this paper, we propose Metric Description Language(MDL) which is a high level language to describe metrics. MDL supports a modular description of complex metrics, aggregation function, and automatic navigation between entities. Moreover, we develop MetriUs for describing metrics using MDL and supporting an automated computation for UML diagrams. In a case study, we have described a variety of existing metrics using MDL and found that MDL contributes to producing simpler expression of metrics than OCL.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.4
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• pp.397-405
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• 2017

MDL-12330A is a widely used adenylyl cyclase (AC) inhibitor that blocks AC/cAMP signaling. In this study, we demonstrated a novel antitumor activity of this drug in gastric carcinoma (GC) cell lines. In these GC cells, MDL-12330A reduced cell viability and induced cell death in a concentration-dependent manner. At a moderate concentration (${\sim}20{\mu}M$), MDL-12330A mainly induced apoptotic death whereas at concentrations greater than $20{\mu}M$, it increased non-apoptotic cell death. The induction of apoptosis was at least partially regulated by CHOP-mediated DR5 upregulation, as detected by immunoblotting and gene interference assays. More importantly, low concentrations of MDL-12330A effectively enhanced recombinant human tumor necrosis factor (TNF)-related apoptosis-inducing ligand (rhTRAIL)-induced apoptosis and clonogenicity in these gastric cancer cells. This study demonstrates a possible role of MDL-12330A as a potential sensitizer to TRAIL, and suggests a novel therapeutic strategy targeting gastric cancer cells.

• Korean Journal of Food Science and Technology
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• v.54 no.3
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• pp.251-256
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• 2022

This study was conducted to determine whether Diospyros lotus L. fruit could be used as a natural functional food ingredient and whether its use should be increased. D. lotus fruit powder was found to have high acidity in the immature IDL stage and significantly higher sugar content in the mature MDL stage. The levels of crude fat, selenium, and tannins decreased significantly from the IDL stage to the MDL stage in D. lotus fruit powder. However, the levels of magnesium and calcium were significantly greater in the MDL stage than in the IDL stage (p<0.05). The total phenol content was significantly higher in the IDL stage, but the DPPH radical scavenging activity significantly increased in the MDL stage (p<0.05). In conclusion, the fruits of D. lotus. have high nutritional quality in both the immature and mature growth stages. Thus, it is a good candidate for use as a functional food, and its use should be increased because of its high nutritional qualities.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.15 no.10
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• pp.842-849
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• 1990

In this paper, a couple of well-known methods for determination of the number of source signals impinging on sersor array in array processing are introduced and compared in terms of estimation accuracy. The one is the procedure issued by Akaike(Akaike's Information Criterion : AIC) and the other one by Schwartz and Rissanen(Minimum Description Length:MDL). This paper demonstrates, through computer simulation, that the AIC is more reliable than the MDL in such troublesome cases as very closely spaced source signlas, very limited number of sensors in the array, finite data sequences and/or low Signal-to-Noise ratio(S/N).

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.5B
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• pp.286-294
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• 2007

In ASIP design, compiler is required for performance evaluation of processors being designed. The design of machine specific compiler is time consuming. This paper presents the system which generates C compiler from MDL descriptions. Compiler generation using MDL can support user retargetability and concurrency between compiler design and processor design. However, it must overcome semantics gap between compiler and machine. To handle this problem, the proposed system maps behavioral descriptions to library which contains abstract behavior for each tree pattern. Using mapped instructions and information on register file usage, the proposed system generates back-end interface function of the compiler. Generated compilers, for MIPS R3000, ARM9 cores, have been proved by application programs written in C code.

• The Journal of the Korea institute of electronic communication sciences
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• v.16 no.4
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• pp.617-624
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• 2021

The accurate estimation of the number of signals included in the received signal is required for the AOA(: Angle-of-Arrival) estimation, the interference suppression, the signal reception, etc. AIC(: Akaike Information Criterion) and MDL(: Minimum Description Length) algorithms, which are known as the typical algorithms to estimate the signal number, estimate the number of signals according to the minimum of each criterion. As the number of antenna elements increased, the estimation performance is enhanced, but the computational complexity is increased because values of criteria for entire antenna elements should be calculated for finding their minimum. In order to improve this problem, in this paper, we propose AIC and MDL algorithms based on the beamspace, which efficiently estimate the number of signals while reducing the computational complexity by reducing the dimension of an array antenna through the beamspace processing. In addition, we provide computer simulation results based on various scenarios for evaluating and analysing the estimation performance of the proposed algorithms.