• Progress in Superconductivity
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• 제10권1호
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• pp.6-11
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• 2008

Multi-channel magnetocardiography (MCG) has been proposed to detect ischemic heart disease because its sensitivity is quite high comparing with other conventional diagnostic tools. Especially, current map and magnetic field map of MCG provide crucial information on whether myocardiac muscles maintain the normal conduction pathway. In addition, MCG parameters derived from repolarization are useful to detect coronary artery disease. Recently, there was a study reporting that R- and T- wave amplitude are highly correlated with ischemic heart disease. In this study, we studied R- and T-wave amplitude and their ratio as well as MCG parameters. MCG data from 20 young, 20 age-matched controls, and 20 myocardial infarction (MI) patients were analyzed. As a result, MCG parameters showed significant change in MI patients comparing to those of controls. R- and T-wave amplitude of MI patients showed a feature of severe ischemic heart disease even though it was difficult to find consistent values. Further study is needed to reveal the relations between small T-wave amplitude and coronary artery disease.

• 생약학회지
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• 제50권4호
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• pp.272-276
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• 2019

Corylopsis gotoana has been widely used as a traditional medicine for the treatment of lots of disease including cold, edema and vomiting. However pharmacological and phytochemical studies on the C. gotoana are extremely limited. Here in this study, the author investigated the anti-nociceptive effects of the methanolic extract of Corylopsis gotoana (MCG) using various pain models. In the present study, MCG exhibited strong and dose-dependent anti-nociceptive activities on various experimental pain models including thermal nociception and chemical nociception, compared to positive control such as tramadol and indomethacin. In addition, the result from combination test using naloxone, analgesic activity of MCG was slightly reduced, indicating that MCG acts as a partial opioid receptor agonist. These results demonstrated that MCG has potent analgesic potential and thus it may be possibly used as a valuable anti-nociceptive agent.

• 대한유전성대사질환학회지
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• 제11권1호
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• pp.106-109
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• 2011

MCG는 3-methylcrotonyl-CoA의 결핍으로 발생하는 선천성 leucine 대사 장애이다. 무증상에서 간질지속증 등의 다양한 임상양상을 보이며 주로 신생아대사이상선별검사에서 의심되어, 소변 유기산 검사를 통해 3- hydroxyisovaleric acid의 증가의 소견이 보인다. 치료는 leucine 제한 식이와 L-carnitine의 복용 등의 식이요법이 있다. 서울아산병원에서 MCG로 확진된 9가계 11명의 환자를 대상으로 임상상과 분자 유전학적 특성을 조사하였다. 9명은 신생아 대사이상검사로 발견되었으며, 나머지 2명은 가족검사를 통해서 진단되었다. 총 2-10세($2.6{\pm}1.96$년)까지의 관찰 기간 동안 모든 환자는 정상 발달을 보였으며, 신경학적 이상이나 대사불균형의 이상소견은 보이지 않았다. 총 18개의 대립유전자 중 17개에서 돌연변이를 발견하였으며, p.D280Y 돌연변이가 66.7%의 대립유전자에서 확인되어, 한국인 MCG에서 흔한 돌연변이임을 알 수 있었다. 또한 p.S342K, p.P459S, p.552S, p.Q496H, p.T556A 등 대부분의 돌연변이가 이전에 보고된 바가 없던 돌연변이로 한국인 MCG환자의 유전학적 특성이 다른 민족과 다름을 시사한다.

• 임상간호연구
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• 제15권2호
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• pp.67-75
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• 2009

Purpose: Postoperative nausea and vomiting(PONV) is a common problem after general anesthesia. The aim of this prospective, double-blind randomized study was to compare the effect of Propofol-Remifentanil vs. Sevoflurane inhalational anesthetics on PONV after laparoscopic cholecystectomy. Methods: Forty patients (ASA physical status 1, 2) scheduled for elective surgery participated in the study. Twenty of them received total intravenous anesthesia (TIVA group) with Propofol-Remifentanil, and the rest were given Sevoflurane inhalational anesthetics (inhalation group). The TIVA group was induced with Propofol 5mcg/ml and Remifentanil 3~4mcg/ml. The anesthesia was maintained with the continuous infusion of Propofol 2~3mcg/ml and Remifentanil 2~3mcg/ml IV. The inhalation group was induced with Pentotal Sodium 5mg/kg and 3~4mcg/kg/hr IV Remifentanil. Maintenance was obtained with 1.5~2.0 vol% Sevoflurane. Results: The subjects in TIVA group reported less PONV than those in Sevoflurane inhalation anesthesia group. Conclusion: Propofol-Remifentanil anesthesia (TIVA group) was considered a satisfactory anesthetic technique in reducing PONV in patients with laparoscopic cholecystectomy.

• Journal of Applied Biological Chemistry
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• 제64권4호
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• pp.453-463
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• 2021

5년근 이상의 인삼(CG), 산양삼(MCG) 및 산양삼 전초(WPMCG)의 지방산, 아미노산, 무기질, ginsenosides, 총 phenolics, 총 flavonoids 및 항산화 활성을 비교하여 분석하였다. 총 지방산 및 불포화 지방산 함량은 MCG (1215.9 및 751.2 mg/100 g)에서, 포화 지방산은 WPMCG (486.4 mg/100 g)에서 각각 높았으며 α-linolenic acid 함량은 특징적으로 CG (18.1 mg/100 g)에 비해 MCG (139.3 mg/100 g) 및 WPMCG (194.4 mg/100 g)에서 최대 10배 높게 검출되었다. 총 유리아미노산 및 필수 아미노산 함량은 CG < MCG < WPMCG (1006.35 및 839.46 mg/100 g) 순으로 높았으며, γ-aminobutyric acid 및 arginine이 주된 비필수 아미노산으로 각각 WPMCG (163.10 mg/100 g)와 MCG (305.23 mg/100 g)에서 가장 높게 검출되었다. 총 무기질 함량은 CG (30.36 mg/100 g)와 WPMCG (29.82 mg/100 g)에서 높게 검출되었으며, 칼슘(Ca)은 CG 및 MCG와 비교하여 WPMCG (6.68 mg/100 g)에서 약 2배 이상의 높게 검출되었다. 총 phenolics (5.12 GAE mg/g), 총 flavonoids (3.04 RE mg/g) 및 ginsenosides (42.44 mg/g) 함량은 WPMCG에서 공통적으로 가장 높은 함량이 검출되었으며 이와 유의적으로 항산화 활성 역시 WPMCG에서 가장 높은 활성을 나타내었다.

• Journal of Information Technology Applications and Management
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• 제12권4호
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• pp.25-31
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• 2005

We know that the Hurst Exponent (HE) is a real number in [0, 1] which denotes randomness of time series. in this research, we suggest non-linear analysis of human biological signals through HE. The feasibility of human biological signals using inductive incitement provides Some diagnosis for active treatment. In our experiment, we measured the heartbeat through the MCG, 29 healthy and 34 abnormal subjects ostensibly. The raw data of acupuncture incitement are supported by opinions of gross examination and pathological diagnosis. The mean values of HE are 0.345, 0.755 and 0.805 for the periods of before, during and after acupuncture treatment, respectively in case of abnormal subjects. On the other hand, the mean values, 0.808, 0.797 and 0.785 are for normal cases, correspondingly. From this data, we show that HE is very significant in abnormal controls according to an acupuncture incitement, and the incitement effect is evidently extracted in abnormal subjects. But, in normal subjects, the incitement effect is meaningless.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 학술대회 논문집 정보 및 제어부문
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• pp.538-540
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• 2004

Electrical currents generated by human heart activities create magnetic fields represented by MCG(MagnetoCardioGram). Since an MCG signal acquisition system requires precise and stable operation, the system adopts hundreds of SQUID(Superconducting QUantum Interface Device) sensors for signal acquisition. Such a system requires fast real-time data acquisition in a required sampling interval, i.e., 1 mili-second for each sensor. This paper presents designed hardware to acquire data from 256-channel analog signal with 1 ksamples/sec speed, using 12-bit 8-channel ADC devices, SPI interfaces, parallel interfaces, 8-bit microprocessors, and a DSP processor. We implemented SPI interface between ADCs and a microprocessor, parallel interfaces between microprocessors. Our result concludes that the data collection can be done in $168{\mu}sec$ time-interval for 256 SQUID sensors, which can be interpreted to 6 ksamples/sec speed.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 신호처리소사이어티 추계학술대회 논문집
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• pp.549-552
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• 2003

The electrical current generated by heart creates not only electric potential but also a magnetic field. We have observed electrophysiological phenomena of the heart by measuring tangential components of magnetocardiogram(MCG) using 61 channel superconducting quantum interference device(SQUD) system. In this paper, we developed a new analysis method, which is based on the theory of electromagnetic field. We show some differences of the current direction between the normal MCG and the abnormal(ischemic heart disease) MCG.

• Progress in Superconductivity
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• 제4권1호
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• pp.48-52
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• 2002

When applying a SQUID system for diagnosing heart disease, it is informative to obtain the source current distributions from the measured MCG (magnetocardiogram) signals since the bioelectric activity in the heart is generally represented by distributed current sources. In order to estimate the Primary current distribution in a heart, the minimum norm estimate was computed, assuming a source plane below the chest surface. In the simulation, current distributions, which were computed for the test dipoles represented well the essential feature of the test-current configurations. Source current reconstruction was performed for MCG signal of a healthy volunteer, which was recorded using a 40-channel SQUID system in a magnetically shielded room. It was found that the obtained current distribution is consistent with the electrical activity in a heart.

• 한국초전도학회:학술대회논문집
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• 한국초전도학회 2008년도 High Temperature Superconductivity Vol.XVIII
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• pp.9-9
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• 2008