• Bulletin of the Korean Chemical Society
• /
• 제26권9호
• /
• pp.1395-1402
• /
• 2005

The reaction of cis-[Cr([14]-decane)$(OH)_2]^+$ ([14]-decane = rac-5,5,7,12,12,14-hexamethyl-1,4,8,11-teraazacyclotetradecane) with auxiliary ligands {$L_a$ = acetylacetonate (acac), oxalate (ox) or malonate (mal)} leads to a new cis-[Cr([14]-decane)(acac)]$(ClO_4)_2{\cdot}(1/2)H_2O\;(1),\;cis-[Cr([14]-decane)(ox)]ClO_4{\cdot}(1/2)H_2O\;(2)\;or\;cis-[Cr([14]-decane)(mal)]ClO_4{\cdot}(1/4)H_2O\;(3)$. These complexes have been characterized by a combination of elemental analysis, conductivity, IR and Vis spectroscopy, mass spectrometry, and X-ray crystallography. Analysis of the crystal structure of cis-[Cr([14]-decane)(acac)]$(ClO_4)_2{\cdot}(1/2)H_2O$ reveals that central chromium(III) has a distorted octahedral coordination environment and two acetylacetonate-oxygen atoms are bonded to the chromium(III) ion in the cis positions. The angle $N_{axial}-Cr-N_{axial}$ deviates by $11^{\circ}$ from the ideal value of $180^{\circ}$ for a perfect octahedron. The bond angle O-Cr-O between the chromium(III) ion and the two acetylacetonate-oxygen atoms is close to $90^{\circ}$. The bond lengths of Cr-O between the chromium and the acetylacetonate-oxygen atoms are 1.950(3) and 1.954(2) $\AA$. They are shorter than those between chromium and nitrogen atoms of the macrocycle. The IR spectra of 1, 2 and 3 display bands at 1560 {ν (C=O)}, 1710 {${\nu}_{as}$(OCO)} and 1660 $cm^{-1}$ {${\nu}_{as}$(OCO)} attributed to the acac, ox and mal auxiliary ligands stretching vibrations, respectively.

• 대한통합의학회지
• /
• 제8권2호
• /
• pp.11-20
• /
• 2020

Purpose : The purpose of this study was to research the effects of dual-hemisphere transcranial direct current stimulation (dual tDCS) and modified constraint-induced movement therapy (mCIMT) to improve upper extremity motor function after stroke. Methods : The study period was from August 2019 to November 2019, and included 24 patients who met the selection criteria. Participants were divided into 2 groups: dual tDCS and mCIMT, and sham dual tDCS and mCIMT group. Dual tDCS and mCIMT group performed mCIMT immediately after applying dual tDCS for 20 minutes, and sham dual tDCS and mCIMT group performed mCIMT immediately after applying sham tDCS for 20 minutes without turning on the power source. Total interventions were conducted 5 times per week for 4 weeks, and mCIMT was conducted for 30 minutes per session for both experimental and control groups. Fugl-Meyer assessment (FMA) and Motor Activity Log scale (MAL) were analyzed before and after 4 weeks of intervention. Results : Both experimental and control groups showed significant changes in FMA, Amount of Use (AOU), and Quality of Movement (QOM) of MAL. When the differences between groups was compared using ANCOVA, the experimental group showed a greater improvement in FMA and AOU of MAL than the control group. Conclusion : In order to enhance the effect of improving upper limb function of stroke patients, dual tDCS could be applied to provide more effective treatment in the clinical setting. Further studies will be needed in larger groups of stroke patients, including long-term follow-up, and multi-group comparisons through the establishment of anodal tDCS and mCIMT, cathodal tDCS, and mCIMT groups to clarify the effects of dual tDCS. In addition, research is needed to establish a protocol for tDCS, and this evidence-based intervention protocol is expected to be used in the clinical setting as an interventional method for various purposes.

• 융합정보논문지
• /
• 제10권8호
• /
• pp.229-238
• /
• 2020

본 연구는 점진적 관찰감소 동작 관찰훈련이 만성기 뇌졸중 환자의 상지 기능과 일상생활 활동에 미치는 영향을 알아보고자 실시하였다. 만성기 뇌졸중 환자를 대상으로 점진적 관찰감소 동작 관찰훈련을 하는 실험군 4명과 기존의 동작 관찰 훈련을 받는 3명의 대조군으로 구분하여, 주 6회, 회당 30분씩, 총 2주간 실시하였다. 상지 기능 평가는 상자와 나무토막 검사(BBT)와 푸글 마이어 상지 운동기능평가 (FMA)를, 일상생활 활동 수행능력 평가는 한글판 수정바델지수(K-MBI)와 운동 활동 지표 (MAL)를 사용하였다. 그룹 별 중재 전·후 차이의 비교 결과와 두 그룹 간의 비교 결과는 BBT, FMA, K-MBI, MAL에서 통계적으로 유의한 차이를 보이진 않았으나, 실험군이 대조군에 비해 평균 점수 측면에서 더 큰 차이가 나타났다. 결과적으로 점진적 관찰감소 동작 관찰훈련은 기존의 동작관찰훈련 보다 더욱 긍정적인 영향을 끼칠 수 있음을 확인할 수 있었다.

• 대한통합의학회지
• /
• 제9권2호
• /
• pp.93-103
• /
• 2021

Purpose : This study aimed to investigate the effect of trunk postural stability maintained wearing a spiral elastic band on the upper extremity function of patients with stroke who undertook a functional activity program and to provide fundamental data useful for the application of therapeutic interventions in the clinical environment of occupational therapy. Methods : The research subjects included 16 patients with stroke who were evenly divided into an experimental group and a control group. The eight-week intervention consisted of a functional activity program aimed at improving the function of the affected-side upper extremity. The experimental group performed the functional activity program while maintaining a stable trunk posture by wearing a spiral elastic band. The control group followed the program without wearing the band. Upper extremity function was assessed before and after the intervention using a manual function test (MFT) and a motor activity log (MAL), and the effectiveness on the upper extremity function of the affected side was confirmed. Results : First, in the within-group comparison of the upper extremity function scores before and after the intervention, the experimental group showed a statistically significant difference in the MFT and MAL assessment(p<.05). The control group showed a statistically significant difference in the MAL assessment(p<.05). Second, in the between-group comparison of the change in scores after the intervention, a statistically significant difference was observed between the two groups in all assessments(p<.05). Conclusion : This study confirmed the positive effect on upper extremity function of trunk stabilization posture using a spiral elastic band. The results could be useful when implementing a task-oriented training program in the clinical environment of occupational therapy in the future, as application of the training while maintaining trunk postural stability by wearing a spiral elastic band could be more effective for improving the upper extremity function of patients with stroke.

• PNF and Movement
• /
• 제16권3호
• /
• pp.451-460
• /
• 2018

Purpose: The purpose of this study was to investigate the effects of a modified constraint induced movement therapy (mCIMT) using proprioceptive neuromuscular facilitation (PNF) on the upper extremity function and activities of daily living (ADLs) in patients with subacute stroke. Methods: Fourteen participants with subacute stroke were randomly assigned to a group using both mCIMT and PNF or a group using mCIMT alone. Each group underwent twenty sessions (1 h/d, 5 d/wk) for 4 weeks. Patients were assessed with the action research arm test (ARAT), the Fugl-Meyer assessment for the upper extremities (FMA-UE), the Modified Barthel Index (MBI), and motor activity logs (MALs; amount of use [AOU] and quality of movement [QOM]). Results: Both the experimental group and the control group showed significant intragroup improvement in the ARAT, FMA-UE, MBI, and MAL-AOU (p<0.05). The group using both mCIMT and PNF exhibited greater improvement in the ARAT, FMA-UE, MBI, and MAL-AOU than did the group using mCIMT alone. Statistical analyses showed significant differences in the ARAT (p=0.01), FMA-UE (p=0.01), MBI (p=0.00), and MAL-AOU (p=0.01) between the groups. Conclusion: This study applied mCIMT combined with PNF for subacute stroke patients, and the results showed significant improvements in the patients' upper extremity function and ADLs. Therefore, mCIMT using PNF may be more effective than mCIMT alone in improving upper limb function and ADLs in patients with subacute stroke.

• 대한정형도수물리치료학회지
• /
• 제27권3호
• /
• pp.25-36
• /
• 2021

Background: This study aimed to investigate the effect of modified constraint-induced movement therapy (mCIMT) and resistive exercise using elastic band with pressure belt on improving upper extremity function in stroke patients. Methods: Sixteen patients with stroke were randomly assigned to a control group that received mCIMT and resistive exercise using elastic band (n=8) and an experimental group that received mCIMT and resistive exercise using elastic band with pressure belt (n=8). Over the course of four weeks, mCIMT were conducted 60 minute three times per week and resistive exercise using elastic band (with pressure belt) were conducted twice daily, three times per week. The function of the upper extremities were evaluated before, after 2 weeks and 4 weeks using the grip strength test (GST), the box and block test (BBT), and motor activity log (MAL). Results: The values for the GST, the BBT, and MAL increased in both groups as the treatment period progressed. The values for the GST (p<.01), the BBT (p<.001), and MAL (p<.001) were significantly higher in the experimental group than in the control group at 4 weeks after initiating the treatment. Conclusion: We found that mCIMT and wearing a pressure belt during resistive exercise was very useful in improving the function of the upper extremities in patients with stroke.

• 재활치료과학
• /
• 제3권1호
• /
• pp.47-55
• /
• 2014

목적 : 본 연구는 에비안스-함베르크 스트레칭이 아급성 뇌졸중 환자의 환측 상지기능과 일상생활활동에 미치는 영향에 대해 알아보고자 단일 사례연구를 실시하였다. 연구방법 : 본 연구의 대상자는 대구광역시에 소재한 K재활병원에서 입원치료를 받고 있는 만 39세 남성 뇌졸중 환자이다. 에비안스-함베르크 스트레칭을 4주간 주 5회 1일 1회 30분간 적용하여 중재 전후 상지기능과 일상생활활동을 비교하였다. 상지기능의 평가는 뇌졸중상지기능평가(manual function test; MFT), 운동활동측정표(motor activity log; MAL)를 사용하였고, 일상생활활동 평가는 기능적 독립 척도(functional independence measure; FIM)를 사용하였다. 결과 : 대상자는 중재 후 평가에서 MFT는 향상 없이 유지되었으며, MAL에서는 사용빈도와 움직임의 질에서 각각 3점씩 향상되었다. FIM은 73점에서 94점으로 21점이 향상되었다. 결론 : 본 연구의 결과를 통해 에비안스-함베르크 스트레칭이 아급성 뇌졸중 환자의 상지기능과 일상생활활동을 증진시키는데 효과가 있음을 알 수 있었으며, 기존의 작업치료와 에비안스-함베르크 스트레칭을 적절히 활용한다면 환자의 기능 회복에 많은 도움이 될 것이라 사료된다.

• 한국산학기술학회논문지
• /
• 제13권7호
• /
• pp.3023-3029
• /
• 2012

본 연구의 목적은 만성 편마비 뇌졸중 환자를 대상으로 상지 운동기능 회복을 위하여 적용한 가상현실 가정운동프로그램의 가능성을 알아보기 위함이다. 만성 뇌졸중 환자 2명을 대상으로, 한 명의 참여자는 가상현실운동프로그램을 가정운동프로그램으로 처방하여 실행하였고, 다른 한 명의 참여자는 강제-유도운동치료를 가정운동프로그램으로 처방하여 실행하였다. 치료기간은 4주간으로 1주일에 총, 5회로 1회에 4시간씩 실시하였다. 평가는 뇌졸중 기능회복평가(Fugl-Meyer Assessment; FMA), 운동활동척도검사(Motor Activity Log, MAL), 그리고 울프운동기능검사(Wolf Motor Function Test; WMFT)를 이용하였다. 가상현실 운동프로그램을 가정운동프로그램으로 실시한 대상자가 모든 운동기능평가에서 상당한 기능적 회복을 보여주었다. 특히, FMA 점수는 가상현실프로그램을 사용한 대상자는 17% 향상된 반면, 강제유도운동치료를 가정운동프로그램으로 실시한 대상자는 5% 증가하였다. 또한, MAL 점수의 환측 상지를 이용하는 양(Amount of Use; AOU)와 움직임의 질(Quality of Movement; QOM)점수에서도 가정중심 가상현실 프로그램을 이용한 대상자가 각 40%, 20% 향상된 반면, 강제유도운동치료를 받은 대상자는 각각 0%, 20% 증가하였다. 가상현실 프로그램을 사용한 대상자와 강제유도운동치료를 받은 대상자의 WMFT 점수가 모두 20%증가하였다. 본 연구결과, 만성 편마비 뇌졸중 환자의 상지 운동 기능 향상을 목적으로 가정운동프로그램을 설계할 때 가상현실 운동프로그램이 강제-유도운동치료보다 더욱 효과적인 것으로 사료된다.

• 국제물리치료학회지
• /
• 제4권2호
• /
• pp.573-587
• /
• 2013

The purpose of this study was conducted in order to analyze the effects of the manual intervention and self-corrective exercise models of general coordinative manipulation(GCM) on the balance restoration of spine & extremities joints with distortions and mal-alignment areas. The subjects were the members who visited GCM Musculoskeletal Prevent Exercise Center from March 1 2012 to December 31 2013 because of spine & extremities joints distortion and mal-alignments, poor posture, and body type correction. All subjects were diagnosed with the four types of the GBT diagnosis. And according to the standards of the mobility vs stability types of the upper & lower body, they were classified into Group 1(40 persons) and Group 2(24 persons). For every other day for three times a week, GCM intervention models were applied to all subjects for four weeks, adding up to 12 times in total. Then the balance restoration effects were re-evaluated with the same methods. The results are as follows. 1) Balance restoration effects of VASdp(Visual analysis scale pain & discomfort) and ER(Equilibrium reaction: ER) came out higher in GCM body type(GBT) II III IV of Group 1. 2) In case of balance restoration effects in Moire and postural evaluation areas, Group 1 was higher and cervical and scapular girdle were higher in Group 2. The balance restoration of the four GBT types was significant in all regions(p<.05), and the scapular girdle came out as high in the order of GBTII IV I. 3) In case of thoracic-lumbar scoliosis and head rotation facial asymmetric cervical scoliosis ribcage forward, the balance restoration effects of the upper body postural evaluation areas came out the highest in Group 1 and Group 2, respectively. The balance restoration effects of the four GBT types were significant in all regions(p<.05), and came out the highest in lumbar scoliosis GBTIII I, ribcage forward and thoracic scoliosis GBTII IV. 4) The balance restoration effects of the lower body postural evaluation areas came out higher in Group 1 and Group 2 for pelvis girdle deviation patella high umbilicus tilt and hallux valgus foot longitudinal arch: FLA patella direction, respectively. The balance restoration effects of the four GBT types were significant in all regions(p<.05), and came out the highest in pelvis girdle deviation GBTIII I and patella high-direction GBTIV II I. 5) The balance restoration effects between the same GBT came out significant (p<.05) in all evaluation areas and items. The conclusions of this study was the manual intervention and self-corrective exercise models of the GCM about the mal-alignment of the spine & extremities joints across the whole body indicated high balance restoration effects(p<.05) in spine & extremities joints in all evaluation areas.

• 대한방사성의약품학회지
• /
• 제7권2호
• /
• pp.105-111
• /
• 2021

⁸⁹Zr is a positron-emitting radioisotope, which has known as well-suited radioisotope for use in a monoclonal antibody-based imaging agent for immuno-PET. The purpose of this study was to quantitatively evaluate the diagnostic ability of general trastuzumab and thio-trastuzumab as HER2 positive receptors based on Df hexadentate iron chelator. Desferrioxamine-p-SCN (Df-Bz-NCS) and desferroixamine-maleimide (Df-Mal) were purchased from Macrocyclics (Dallas, TX, USA). The trastuzumab was purchased from Roche (Schweiz), and thio-trastuzumab was obtained from professor Hyo-Jeong Hong group (Kangwon National University). The radioisotope ⁸⁹Zr was produced by domestic purification system and KIRAMS using medical cyclotron (50 MeV, Scantronix). The conjugates of Df-trastuzumab and Df-thio-trastuzumab were prepared with Df-Bz-NCS and Df-Mal under basic aqueous solution (pH 8-9) at room temperature, respectively. The conjugates purified by PD-10 column were mixed with dried ⁸⁹Zr chloride. ⁸⁹Zr-labeled conjugates were purified and concentrated by Amicon ultra centrifugal filter. The preparation step and time of ⁸⁹Zr-labeled conjugates was shorted as 4 steps within 2 hours. ⁸⁹Zr-labeled conjugates showed the highly radiochemical purity of over 98%, and were very stable until 7 days by the analysis of radio-ITLC method. Each radio-labeled conjugates were also exhibited the highly stability in both PBS buffer and mouse serum. Immuno-PET imaging of ⁸⁹Zr-labeled conjugates in mice bearing gastric cancer xenograft tumors with HER2 expression showed high tumor uptake in the NCI-N87 HER2-expressing. However, ⁸⁹Zr-Df-Mal-thio-trastuzumab showed a relatively lower tumor-to-background ratio than ⁸⁹Zr-Df-Bz-trastuzumab, as well as whole-body distribution. In the results, ⁸⁹Zr-Df-Bz-trastuzumab was evaluated to have a relatively higher HER2 diagnostic ability than ⁸⁹Zr-Df-Mal-thio-trastuzumab.