• Title/Summary/Keyword: MAGE

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Cancer Genomics Object Model: An Object Model for Cancer Research Using Microarray

  • Park, Yu-Rang;Lee, Hye-Won;Cho, Sung-Bum;Kim, Ju-Han
    • Proceedings of the Korean Society for Bioinformatics Conference
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    • 2005.09a
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    • pp.29-34
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    • 2005
  • DNA microarray becomes a major tool for the investigation of global gene expression in all aspects of cancer and biomedical research. DNA microarray experiment generates enormous amounts of data and they are meaningful only in the context of a detailed description of microarrays, biomaterials, and conditions under which they were generated. MicroArray Gene Expression Data (MGED) society has established microarray standard for structured management of these diverse and large amount data. MGED MAGE-OM (MicroArray Gene Expression Object Model) is an object oriented data model, which attempts to define standard objects for gene expression. To assess the relevance of DNA microarray analysis of cancer research it is required to combine clinical and genomics data. MAGE-OM, however, does not have an appropriate structure to describe clinical information of cancer. For systematic integration of gene expression and clinical data, we create a new model, Cancer Genomics Object Model.

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A Study on the Image Enhancement of OCT Image using Wavelet coefficients (웨이블릿 계수를 적용한 OCT영상의 이미지향상에 관한 연구)

  • 이승용;황대석;류재훈;이영우;류광렬
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2004.05b
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    • pp.140-143
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    • 2004
  • The mage enhancement of dental On image using wavelet coefficients is presented. The processing is that make gray image from On image by preprocessing, extract high frequency from detail coefficient after acquisition detail coefficient by wavelet transform and emphasize edge appling input image. Experimental results show that enhanced contrast of dental On image, improved mage quality.

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Design And Realization For Efficiently Storing Microarray Data Using Structural Similarity (구조적 유사성을 이용한 마이크로어레이 데이터의 효율적인 저장을 위한 기법의 설계 및 구현)

  • Yun, Jong-Han;Shin, Dong-Kyu;Shin, Dong-Il
    • Proceedings of the Korean Information Science Society Conference
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    • 2008.06c
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    • pp.230-235
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    • 2008
  • 생명정보 대량 획득기술의 하나인 마이크로어레이(microarray)는 DNA와 각종 유적자 연구에 사용되는 도구로서 확립되면서, 생명정보학(bioinformatics)분야의 발전에 크게 기여하였다. 그러나 마이크로어레이는 생명정보학분야의 핵심기술 중 하나로 발전하였음에도 불구하고 마이크로어레이 실험으로 생성되는 데이터는 형태가 다양하고 매우 복잡한 형태를 갖기 때문에 데이터의 공유나 저장에서 많은 어려움을 겪는 것이 사실이다. 따라서 마이크로어레이 실험결과 분석을 위한 최소한의 컨텐츠가 정의되고 표준화 되었다. MIAME 데이터, MAGE-OM/ML과 같은 표준화된 공개 저장소는 전문 생물학 연구단체에게 과거부터 지금까지 주요 관심사가 되어왔다. 하지만 많은 공개저장소의 설립되었지만 마이크로어레이 데이터의 구조적 특징을 고려하여 효과적인 설계를 하지 않은 것이 사실이다. 본 논문은 표준을 따르는 동시에 마이크로어레이 데이터의 구조적 빈발 패턴이 반복되는 계층적 특징을 반영하는 전략을 제안한다. 이를 통하여 복잡한 데이터의 구조를 객체들의 빈발 패턴을 파악하여 그 계층을 줄임으로서 복잡도를 줄일 수 있었다. 이 과정에서 관계형 데이터베이스 기반의 공개저장소의 성능에 영향을 주는 관계 테이블(join-table)의 숫자는 줄어든다. 이에 따라, 성능은 개선된다. 이 전략을 통하여 생성된 테이블의 숫자는 원본 데이터를 단순 매핑시켜 저장하는 방법에 비하여 약 31%줄어든다. 결국 MAGE-ML 데이터의 저장과 로딩 시간은 이 논문에서 제시하는 전략을 적용하지 않은 방법에 비해 60%에서 65%를 줄일 수 있었다.

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Photogenie as the duality and mentality of the photographic image: a study based on the theory of Edgar Morin (포토제니 혹은 사진 이미지의 이중성과 정신성 - 에드가 모랭의 논의를 중심으로)

  • Kim, Ho Young
    • Cross-Cultural Studies
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    • v.34
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    • pp.71-92
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    • 2014
  • This article presents a study on the concept of "Photogenie", which refers to the duality and mentality of the photographic image, with the viewpoint regarding the photographic image by Edgar Morin. First, we will look at the evolution of the concept of "Photogenie". From the field of photography, the term "Photogenie" means objects that produce light, enough to impress the photographic plate. But theorists of cinema at the beginning of the 20th century have changed the meaning of the term. For Louis Delluc, the "Photogenie" means the effect of union between the reproduction of real and artistic genius. For Jean Epstein, the "Photogenie" means mental quality, nonmaterial or inderterminable, of the photographic and cinematographic image. But Morin synthesized the arguements of Delluc and Epstein. For him, the "Photogenie" indicates both a double character of the photographic image and its mental quality. Then, based on this concept of "Photogenie," Morin said on particular aspects in the photographic image. Considering photography as a double in the anthropological sense, it puts emphasis not only the dual nature of the photographic image but also mental and spiritual quality. Combining the theory of the mage Henri Bergson and Jean-Paul Sartre, he builds his own theory of the mage that concerns both photography and cinema. In short, to Morin, the photographic image is a place where coexist absence and presence, the real and the imaginary, perception and memory, the material and mental, as well that a place of mentality which appear all our memories, hallucinations, dreams, imagination etc.

A Study On Watershed Region Extraction Based On Edge Information (에지 정보를 이용한 watershed 영역 추출에 관한 연구)

  • 이원효;조상현;설경호;주동현;김두영
    • Proceedings of the IEEK Conference
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    • 2003.11a
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    • pp.449-452
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    • 2003
  • This paper propose a extracting method of the region for image using segmentation and edge information. First propose algorithm extract information using canny edge detector and the image was divided by watershed segmentation. And it extract the mage with edge information by merging region. Finally we compare the proposed method with levelset method. In the result proposed method not only extract the image with accurate region but also reduce operation time.

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A Study on the Visual Interpretation of the Clothing Image as Clothing m Form and Dot Space Variation. (의복형태와 물방울무늬 공간변화에 따른 이미지의 시각적 평가)

  • 문삼련;이경희
    • Journal of the Korean Society of Clothing and Textiles
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    • v.18 no.1
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    • pp.3-14
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    • 1994
  • This study is intended to identify the clothing mage as clothing form and dot space variation. This study consists of pre-experiment for setting the space between dot which shows the difference of the image and main experiment and also is made of factorial design for two variables-clothing form(H-line, A-line, V-line, X-line) dot (dot 1.0, dot 2.2, dot 3.4, dot 5.8) Qestionaire consists of 21 semantic differential scale expressing clothing form and .dot. Data is obtained from 50 female students maforing clothing and textile. The results of this study are as follows. 1) The image by the clothing form and the space dot variation is composed 5 factors' attention, activity, attraction, maturity, boldness. 2) The image by variation in clothing form dot has significant differences in attractive and attention factors, especially shows remarkable differences in attention. By choosing narrow space dot for attentive image, broden space dot for attractive image, you would be able to create the image you want. 3) The image by variation in dot clothing form has almost signific and differences in all factors, especially shows remarkable differences in activity. By choosing A-line for active image, V-line for mature and fashionable image, X-line for attractive, pretty and delicate mage, you would be able to create the image you want. 4) The interaction effect between clothing form and space dot was in attraction and maturity factor, V-line, X-line, dot 3.4 and dot 5.8 intensify attractive image, V-line and dot 1.0 mature image, X-line and dot 5.8 young image.

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Review of Cancer-Testis (CT) Genes (Cancer-testis (CT) 유전자의 고찰)

  • Kim, Mi-Hee;Song, Myung-Ha;Lee, Sang-Yull
    • Journal of Life Science
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    • v.21 no.6
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    • pp.912-922
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    • 2011
  • Cancer-testis (CT) antigens are immunogenic protein antigens with restricted expression in the testes and a wide range of human tumor types, eliciting both humoral and cellular immune responses in cancer patients. They are considered to be ideal targets for vaccine-based immunotherapy, and more than 100 CT antigens, including MAGE, NY-ESO-1, GAGE, BAGE, LAGE, SSX2 and NY-SAR-35 have been identified to date. The CT antigens were identified through various techniques and can be divided in those that are encoded on the X chromosome, the CT-X genes, and those that are not, the non-X-CT genes. CT genes are aberrantly activated and expressed in a proportion of various types of human cancers. The biological role of CT-X in both germ line tissues and tumors remains poorly understood. Cancer vaccine trials based on several CT antigens are currently ongoing. This paper reviews recent advances in and future trends of CT antigens for cancer immunotherapy.

Gache(加髢) Culture and Position of East Asia Women in the 18th and 19th Centuries (18~19세기 동아시아 여성의 가체문화와 의미)

  • Yim, Lynn
    • Human Ecology Research
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    • v.57 no.3
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    • pp.395-406
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    • 2019
  • This study examined what meaning East Asian women showed in their costume history through a discourse of hair adornments such as wigs and that Gache was not just a luxury decoration. In addition, we examined Gache hair trends with Eonjeun-meori (braid wraps around the entire head) in the Joseon dynasty (Korea), Gigye(旗?) hair in the Quing dynasty (China) and Mage(?) hair in the Edo period (Japan) during the $18^{th}$ and $19^{th}$ centuries. The significance of the phenomenon of East Asian Gache culture in the $18^{th}$ and $19^{th}$ centuries was analyzed from the internal desires of women. The details are as follows. First, the magnification by the hair decoration was identified with self-authority and used as a sign to express self-respect or a desire for self-esteem. The extended Gache was an external body extension to raise self-authority and increase activeness. Second, self-satisfaction through showing off was associated with a women's search for identity. There was excessive consumption to boast status, wealth and femininity, but the mania continued because women obtained psychological satisfaction by feeling that their sacrifices for the Confucian order were compensated. Third, the frenzy of Gache was accepted as a way for women to resist social regulations and find themselves as main participants in social activities. Showing their appearance in East Asian Gache culture was a way of inner self-searching and a process for women to find themselves as a social entity.

Lung Cancer Screening (폐암 조기 진단)

  • Kim, Ju Ock
    • Tuberculosis and Respiratory Diseases
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    • v.61 no.3
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    • pp.207-213
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    • 2006
  • 기존의 폐암 발생의 고위험군(나이. 흡연력, $FEV_1$, 가족력, 직업적 발암물질의 노출력, 기존의 폐암 및 두경부 종양)에 대한 저선량 나선식 CT와 기관지 내시경 검사로 선별 검사 시 폐암의 유병률은 높아야 2%내외이고 대부분 그보다 낮은 것으로 알려져 있다. 특이도는 49-90%, 양성예측률은 10%이하로 선별검사 시 불필요한 검사를 초래하고 그에 따른 이환률과 사망률을 증가시키며 비용적인 문제를 야기하는 것으로 알려져 있다. 이에 기존의 고위험군에 대해 대상 환자를 더욱 더 좁힐 필요가 있으며, 이는 실제 임상적으로 이용 가능한 생물학적 표지자의 개발의 필요성이 있다고 하겠다. 그러나 현재까지 알려진 폐암조기검진에 대한 각종 진단 수기 중애서 상기의 3가지 방법(저선량 MDCT, 자가형광기관지경 및 객담내 MAGE)을 한꺼번에 시행하는 program은 비용적인 문제는 있지만 시도해 볼 만한 방법이라고 생각된다.

A Study on the Garment Ease for Pre-School Children's Upper Clothing Construction (취학전 아동의 상의구성을 위한 여유량 연구)

  • 박찬미;서미아
    • The Research Journal of the Costume Culture
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    • v.1 no.2
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    • pp.145-157
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    • 1993
  • This study aimes to investigate the garment ease of pe-school children's clothing in accordance with arm movement. The experiment was done with 4 per-school children fro mage 3 to age 5, and 3 types of experimental clothes were made ; sleeveless, half sleeve, and long sleeve. The waist pattern and the sleeve pattern of each experimental clothes has no garment ease. And experimental clothes were examined to obtain the necessary ease of armcye line and waist lien by cross-cut method. The results of investigation can be summarized as follows ; 1. The resulting movement ranges of experimental clothes with no garment ease were 131.5°(sleeveless), 71.75°(half sleeve), and 62.25°(long sleeve). 2. The size order of cross-cut opening of waist lien movement were (side>front>back), and (half sleeve>long sleeve>sleeveless). 3. When the base point of measurement was set to armpit point by arm the latitudinal length of cross-cut opening of armcye line by arm movement was (anterior armpit part > posterior armpit part), and longitudinal length of cross-cut opening was (upper part>lower part).

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