• Title/Summary/Keyword: M2조석

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Polymorphism of Glutathione S-Transferase(GST)M1, GSTT1, GSTP1 and Genetic Susceptibility to Head and Neck Squamous Cell Carcinoma in Korean Population (한국인 두경부 편평세포암 환자에서 Glutathione S-transferase(GST)M1, GSTT1 및 GSTP1유전자 다형성 및 유전적 감수성)

  • Tae Kyung;Seo In-Seok;Kang Mee-Jeong;Cho Seok-Hyun;Kim Kyung-Rae;Lee Hyung-Seok
    • Korean Journal of Head & Neck Oncology
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    • v.18 no.2
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    • pp.150-156
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    • 2002
  • Objectives: Most of human cancers may result from exposure to environmental carcinogens, and individual effectiveness in the detoxification of these chemicals will influence susceptibility to malignant disease. Glutathione S-Transferases(GSTs) enzymes are involved in the detoxification of active metabolites of many carcinogens from tobacco smoke and may be important in modulating susceptibility to smoke-related cancer. The purpose of this study is to determine the polymorphism of GSTM1, GSTT1, and GSTP1 in control group and head and neck squamous cell carcinoma group of Korean, and to investigate the effect of GSTs polymorphism on the risk of head and neck cancer. Materials and Methods: A hospital-based case-control study was performed with a group of 133 control individual and 136 head and neck squamous cell carcinoma patients. The polymorphisms of GSTs were analysed using polymerase chain reaction in GSTM1 and GSTTl, and polymerase chain reaction-restriction fragment length polymorphism in GSTP1. Results: The relative risk (odds ratio) of GSTM(-) genotype was 1.14(95% CI, 0.70-1.85) compared to GSTM1(+). The odds ratio of GSTTl(-) genotype was 0.91(95% CI, 0.55-1.50). In old age($65$) group, the odds ratio of GSTT1(-) genotype was 5.2(95% CI, 1.53-17.89). The GSTP1 Val/Val genotype conferred a 1.7-fold risk(95% CI, 0.40-7.34) of head and neck cancer compared with GSTP1 Ile/Ile genotype. Among the combined genotypes of GSTs, GSTM1(-)/GSTT1(+)/GSTP1 Val/Val and GSTM1(-)/GSTTl(-)/GSTP1 Ile/Val genotypes conferred a 2.6-fold and 1.3-fold risk(95% CI, 0.24-14.15 and 0.43-3.14) compared with the GSTM1(+)/GSTTl(+)/GSTP1 Ile/Ile genotype, respectively. Conclusion: Polymorphism of GSTs might modulate susceptibility to head and neck cancer in Korean population. The genotype of GSTP1 Val/Val and combined genotypes of GSTM1(-)/GSTT1(+)/GSTP1 Val/Val, and GSTM1(-)/GSTT1(-)/GSTP1 Ile/Val might be important risk factors to determine the individual susceptibility to head and neck squamous cell carcinoma.

Environment of Deposition and Characters of Surface Sediments in the Nearshore off Byun-San Peninsula, Korea (변산반도 연근해 표층 퇴적물의 특성과 퇴적환경)

  • Oh, Jae-Kyung;Choi, Kyu-Hong
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.4 no.2
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    • pp.107-116
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    • 1999
  • To study the characters of surface sediment and to describe the seasonal depositional environment as a result of sedimentation process off Byun-San Peninsula, a total 61 samples of surface sediment (32 samples in summer; 29 samples in winter) were collected and analysed. A digitized depth data from sea chart and echosounding profiles along five trans-sections were helpful for understanding the morphological factors. The types classified by the characters of surface sediment are type I (sand, S), type II (silty sand, zS), and type ill (sandy silt, sZ). Mean grain size varies from 2.11 to 7.81 ${\Phi}$. The positive-skewness shows the typical tide-dominated environment. The sediment type of the northwestern stations is medium sand and the sorting value is 0.5~1.4 ${\Phi}$ of well/moderately sorted. Meanwhile, other stations are composed of muddy sands and sandy muds transported from rivers and offshore. These sediment types toward inshore change gradually from silty sand to sandy silt. According to the C/M diagram, there are three major transport modes of sediment: bed load (Mode A), graded suspension (Mode B), and suspension (Mode C), correlating with north-eastern sandy area, middle part of silty-sand area, and southern sandy-silt area, respectively. The result of Principal Component Analysis shows also similar pattern of sediment types. In result, sediment texture of type III tends to be finer and more poorly-sorted than that of type II and sediment facies are correlateed with sedimentation process.

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Investigation on a Haze Episode of Fine Particulate Matter using Semi-continuous Chemical Composition Data (준 실시간 화학적 조성자료를 이용한 미세입자 연무 에피소드 규명)

  • Park, Seung-Shik;Kim, Sun-Jung;Gong, Bu-Joo;Lee, Kwon-Ho;Cho, Seog-Yeon;Kim, Jong-Choon;Lee, Suk-Jo
    • Journal of Korean Society for Atmospheric Environment
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    • v.29 no.5
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    • pp.642-655
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    • 2013
  • In this study, semi-continuous measurements of $PM_{2.5}$ mass, organic and elemental carbon (OC and EC), black carbon (BC), and ionic species concentrations were made for the period of April 03~13, 2012, at a South Area Supersite at Gwangju. Possible sources causing the high concentrations of major chemical species in $PM_{2.5}$ observed during a haze episode were investigated. The measurement results, along with meteorological parameters, gaseous pollutants data, air mass back trajectory analyses and PSCF (potential source contribution function) results, were used to study the haze episode. Substantial enhancements of OC, EC, BC, $K^+$, $SO{_4}^{2-}$, $NO{_3}{^-}$, $NH{_4}{^+}$, and CO concentrations were closely associated with air masses coming from regions of forest fires in southeastern China, suggesting likely an impact of the forest fires. Also the PSCF maps for EC, OC, $SO{_4}^{2-}$, and $K^+$ demonstrate further that the long-range transport of smoke plumes of forest fires detected over the southeastern China could be a possible source of haze phenomena observed at the site. Another possible source leading to haze formation was likely from photochemistry of precursor gases such as volatile organic compounds, $SO_2$, and $NO_2$, resulting in accumulation of secondary organic aerosol, $SO{_4}^{2-}$ and $NO{_3}{^-}$. Throughout the episode, local wind directions were between 200 and $230^{\circ}C$, where two industrial areas are situated, with moderate wind speeds of 3~5 m/s, resulting in highly elevated concentration of $SO_2$ with a maximum of 15 ppb. The $SO{_4}^{2-}$ peak occurring in the afternoon hours coincided with maximum ambient temperature ($24^{\circ}C$) and ozone concentration (~100 ppb), and were driven by photochemistry of $SO_2$. As a result, the pattern of $SO{_4}^{2-}$ variations in relation to wind direction, $SO_2$ and $O_3$ concentrations, and the strong correlation between $SO_2$ and $SO{_4}^{2-}$ ($R^2=0.76$) suggests that in addition to the impact of smoke plumes from forest fires in the southeastern China, local $SO_2$ emissions were likely an important source of $SO{_4}^{2-}$ leading to haze formation at the site.

Fluvial Deposits Distributed along the Seomjin River (섬진강 유역의 하성 퇴적층에 관한 연구)

  • You, Hoen-Su;Cho, Seok-Hee;Koh, Yeong-Koo
    • Journal of the Korean earth science society
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    • v.21 no.2
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    • pp.174-187
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    • 2000
  • The Quaternary coarse-grained sandy sediments are distributed along the channels of Seomjin River. The fluvial sediments were sedimentologically studied in horizontal and vertical distributions. To analyze depositional environments and facies changes in the sediments, sediment sampling from river mouth to upper stream and desctriptive approaches to the sediment profiles outcropped near Kurye were carried out. The sediments along the stream lines of the river are assigned to very coarse to coarse sand in grain size. The sediment grains are widely scattered in sorting and moderately sorted in average. For skewness and kurtosis, the sediments ranges from very fine to very coarse skewed and from very lepto-kurtic to extremelyl epto-kurtic states, respectively. The sediments are divided into slightly gravelly sand, gravelly sand and sandy gravel in sediment type. The pain shape in the sandy sediments are dominant in equant and tabular forms showing wide varieties. The sandy sediments are mostly poorly sorted and are highly variable in surface texture with SEM. Some smaller grains in the sediments ordinarily show polished surfaces. Of those grains, quartz ones are commonly angular to surounded. On the basis of facies changes and sedimentary structures, outcropped fluvial sediment profiles in Kurye are classified into xGyS, mGyS, gGyS, xSM, xS, mS, mGyM, IgM in facies. These eight facies are reformed as facies assemblage I and ll. The facies assemblage I and II are interpreted as the products of the channel deposits in braided stream and flood plain ones besides channels, respectively. The change facies assemblage I with facies assemblage ll imply that depositional environments hadbeen migrated from braied sream to flood plain ones.

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Wind-and Rain-induced Variations of Water Column Structures and Dispersal Pattern of Suspended Particulate Matter (SPM) in Marian Cove, the South Shetland Islands, West Antarctica during the Austral Summer 2000 (서남극 남 쉐틀랜드 군도 마리안 소만에서 바람 및 강수에 의한 여름철 수층 구조의 변화와 부유물질 분산)

  • 유규철;윤호일;오재경;강천윤;김예동;배성호
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.8 no.4
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    • pp.357-368
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    • 2003
  • Time-series CTDT (Conductivity/Temperature/Depth/Transmissivity) were obtained at one point near tidewater glacier of Marian Cove (King George Islands, Antarctica) to present water column properties and SPM (suspended particulate matter) dispersal pattern in relation with tide, current, meteorological data, and SPM concentration. Four layers were divided from the water column characteristics measured in the interval of an hour for about 2 days: 1) cold, fresh, and turbid surface mixed layer between 0-20 m in water depth, 2) warm, saline, and relatively clean Maxwell Bay inflow between 20-40 m in water depth, 3) turbid/cold tongue of subglacial discharges compared with the ambient waters between 40-70 m in water depth, and 4) cold, saline, and clean bottom water beneath 70 m in water depth. Surface plume, turbid freshwater at coastal/cliff area in late summer (early February), had the characteristic temperature and SPM concentration according to morphology, glacial condition, and composition of sediments. The restrict dispersion only over the input source of meltwater discharges was due to calm wether condition. Due to strong wind-induced surface turbulence, fresh and turbid surface plume, englacial upwelling cold water, glacier-contact meltwater, and Maxwell Bay inflow was mixing at ice-proximal zone and the consequent mixed layer deepened at the surface. Large amount of precipitation, the major controlling factor for increasing short-term glacial discharges, was accompanied by the apparent development of subglacial discharge that resulted in the rapid drop of salinity below the mid depth. Although amount of subglacial discharge and englacial upwelling may be large, however, their low SPM concentration would have small influence on bottom deposition of terrigenous sediments.

Development of Low Temperature Thermal Desorption System and Remediation of Soil Contaminated with Petroleum Hydrocarbon (열순환식 저온열탈착 정화장치의 개발 및 유류오염 토양 현장 적용)

  • Kim, Guk-Jin;Lee, Sun-Hwa;Park, Kwang-Jin;Kim, Chi-Kyung;Lee, Cheol-Hyo;Kim, Do-Sun;Cho, Seok-Hee;Chang, Youn-Young
    • Journal of Soil and Groundwater Environment
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    • v.13 no.4
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    • pp.62-68
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    • 2008
  • The Low Temperature Thermal Desorption (LTTD) System equipped with a soil transfer unit, a rotary kiln, RTO, cyclones and a bag filter etc. was developed. The LTTD system was designed to be economically operated using LPG as a fuel and recirculating the discharged gas from the LTTD system through RTO. For the performance test of LTTD system the soil contaminated with light and heavy oils (2,690 mg TPH/kg soil) and with particle sizes below 50 mm was fed into the rotary kiln of LTTD system at 7$m^3$/hr with retention time of 15 minutes. Operation temperatures of LTTD system for the removal of soil TPH were $567^{\circ}C$ and $692^{\circ}C$. The residual TPH after treatment was 46 mg/kg and 32mg/kg respectively at each temperature condition, which shows high TPH removal efficiencies of the developed LTTD as 98.3% and 98.9%.

Environmental Mobilization Characteristics of Total Gaseous Mercury in the Western Coast of Korea During the Yellow Sand Period, 2001 (2001년 봄철 황사기간 중 서해안지역에서 관측한 대기 중 수은의 환경유동특성 연구)

  • Kim, Min-Young;Shin, Jae-Young;Cho, Suk-Choo;Kim, Joon;Lee, Gang-Woong;Kim, Ki-Hyun
    • Journal of the Korean earth science society
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    • v.22 no.6
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    • pp.480-490
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    • 2001
  • The soil-air exchange processes of Hg were investigated from the Hari area of Kang Hwa Island during the late March 2001. In the course of our study, we determined the concentration gradients of Hg and combined these gradient data with micrometeorological components to derive its fluxes. Results of our study indicate that the concentration levels of Hg in the study area are notably lower than those typically found in urbanized areas of Korea. However, the computed fluxes were seen to be significantly larger for relatively remote areas, reaching over 200 ng/m$^2$/hr. Comparison of environmental conditions shows that the concentrations of most pollutant species including NO$_X$ and PM were significantly higher during emission, while meteorological conditions were characterized by high temperature and low humidity. Results of correlation analysis also indicate that such pollutants as hydrocarbons, nitrogen oxides, and PM generally exhibit strong positive correlations with Hg-related parameters during emission events, while such relationships were reversed during dry deposition events. The results of our present study suggest the possibility that the concentrations and fluxes of total gaseous Hg observed during deposition events can be influenced by the processes that are also important for the fine, rather than coarse, size fraction of particles.

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Potential as a Geological Field Course of the Northwest Coast, Goheung Gun (고흥군 북서 해안의 지질학습장으로서의 활용가능성)

  • Kim, Hai-Gyoung
    • Journal of the Korean Society of Earth Science Education
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    • v.9 no.2
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    • pp.163-172
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    • 2016
  • The aim of this study is to investigate the geological features distributed in the northwest coast, Goheung Gun as a geological field course of all levels. The study area is about 1.6km coast in direction of northwest from Sumundong ferry to Jangsun beach. The learning contents of the geology units in science textbooks from elementary school to high school was analyzed and, geomorphology and geology of study area was investigated for this study. In this study area, lots of geomorphology and geology elements related to the learning contents of the geology units in science textbooks were founded such as gravel beach, sea cliff, granite, rhyolite, andesite, gneiss, sedimentary rocks, fault, unconformity, stratification, cross bedding, graded bedding, intrusion structure, vein, dyke, plant fossil and spheroidal weathering. Characteristically, strata, stratification, granite, sedimentary rocks(conglomerate, sandstone, mudstone and shale), fault, plant fossil and weathering phenomenon were commonly involved with the learning contents of the geology units in elementary school science, middle school science and high school earth science I, II. This area is to be recommended as a site of geological field course for all students from elementary school to high school, as various field work materials for geological learning were distributed and, geological observation trail of about 400m in length for observation of strata and so on was installed along the coast in direction of the northwest from Sumundong ferry.

Field Observation of Morphological Response to Storm Waves and Sensitivity Analysis of XBeach Model at Beach and Crescentic Bar (폭풍파랑에 따른 해빈과 호형 사주 지형변화 현장 관측 및 XBeach 모델 민감도 분석)

  • Jin, Hyeok;Do, Kideok;Chang, Sungyeol;Kim, In Ho
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.32 no.6
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    • pp.446-457
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    • 2020
  • Crescentic sand bar in the coastal zone of eastern Korea is a common morphological feature and the rhythmic patterns exist constantly except for high wave energy events. However, four consecutive typhoons that directly and indirectly affected the East Sea of Korea from September to October in 2019 impacted the formation of longshore uniform sand bar and overall shoreline retreats (approx. 2 m) although repetitive erosion and accretion patterns exist near the shoreline. Widely used XBeach to predict storm erosions in the beach is utilized to investigate the morphological response to a series of storms and each storm impact (NE-E wave incidence). Several calibration processes for improved XBeach modeling are conducted by recently reported calibration methods and the optimal calibration set obtained is applied to the numerical simulation. Using observed wave, tide, and pre & post-storm bathymetries data with optimal calibration set for XBeach input, XBeach successfully reproduces erosion and accretion patterns near MSL (BSS = 0.77 (Erosion profile), 0.87 (Accretion profile)) and observed the formation of the longshore uniform sandbar. As a result of analysis of simulated total sediment transport vectors and bed level changes at each storm peak Hs, the incident wave direction contributes considerable impact to the behavior of crescentic sandbar. Moreover, not only the wave height but also storm duration affects the magnitude of the sediment transport. However, model results suggest that additional calibration processes are needed to predict the exact crest position of bar and bed level changes across the inner surfzone.

Analysis of Coastline Changes in Yeongdong Region Using Aerial Photos and CORONA Satellite Images (항공사진과 CORONA 위성영상을 이용한 영동지역 해안선 변화 분석)

  • Ahn, Seunghyo;Kim, Gihong;Lee, Hanna
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.40 no.3
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    • pp.187-193
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    • 2022
  • In the Yeongdong region of Gangwon-do, coastal areas are important resources in terms of cultural, social and economic aspects. However, the coast of Gangwon-do is experiencing severe erosion, and it is concerned that its adverse effects will gradually increase. In this study, coastline changes of Yangyang and Gangneung in Gangwon-do were tracked and analyzed over a long period of time. In order to build time series image data, aerial photos from the 1940s to the present were mainly used, and data from CORONA satellite, which operated from the 1960s to the early 1970s, were collected and used together. Using 51cm resolution ortho image and 2m resolution Digital Elevation Model(DEM) as reference, ground control points were selected to perform geometric correction on the aerial photos and CORONA images. Subsequently, Canny edge detector applied to these images to extract the coastlines. As a result of analyzing the extracted and vectorized coastlines by overlaying them in chronological order, erosion and deposition occurring around the artificial structures and on the nearby beaches were observed. In this study, the effect of seasonal variation, tide, and various coastal management including the beach filling were not considered. Because coastal erosion is greatly affected by geographic factors, each local government must find its own solution. Continuous research and local data accumulation are required.