• 대한치과재료학회지
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• 제44권3호
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• pp.263-272
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• 2017

본 연구에서는 타이타늄 상에 항균제 클로르헥시딘(chlorhexidine; CHX)이 함유된 수산화인회석을 코팅하고 그 특성을 규명하였다. CHX를 혼합한 개조된 생체유사용액(modified simulated body fluid; mSBF)에 타이타늄 디스크를 침적하여 Ti-mSBF-CHX 시편군을 준비하였다. CHX를 함유하지 않은 mSBF에 침적하여 코팅한 Ti-mSBF 시편군을 다시 CHX 용액에 침적하여 Ti-mSBF-adCHX 시편군을 준비하였다. Ti-mSBF 시편 표면에 나노 형태의 결정들로 구성된 구형의 클러스터들이 균일하게 코팅되었다. Ti-mSBF-CHX 시편에서는 이러한 클러스터들과 함께 리본형상의 결정들이 관찰되었으며, 이 결정들에서 높은 CHX 조성이 측정되었다. 두 시편 모두 HAp 결정구조가 지배적이었으며, ${\beta}-TCP$ (tricalcium phosphate)와 OCP (octacalcium phosphate) 결정구조가 Ti-mSBF-CHX 시편에서 관찰되었다. FT-IR 스펙트럼은 Ti-mSBF-adCHX와 Ti-mSBF-CHX 시편군에서 CHX의 피크가 강하게 관찰되었다. 그러나 인산완충식염수(phosphate buffered saline;PBS)에 침적한 후, CHX가 Ti-mSBF-CHX 시편에서는 천천히 용출된 반면, Ti-mSBF-adCHX 시편에서는 빠르게 용출되었다. 따라서 Ti-mSBF-CHX 시편은 골과 유사한 HAp 구조를 가지며 함유된 CHX가 지속적으로 방출될수 있기 때문에 향후 임플란트 시술에서 염증을 방지할 수 있는 코팅법으로 기대된다.

• Radiation Oncology Journal
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• 제20권1호
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• pp.41-52
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• 2002

목적 : 호흡주기에 따른 위치변동 감지센서를 이용하여 종양의 위치가 일정워치에 있을 때만 방사선을 치료하는 호흡 동기치료기구를 제작하고 일정한 호흡주기 상태에서 수행된 CT simulation과 3차원 입체조형치료계획에 따라 방사선을 치료하는 시스템을 개발하고자 하였다. 호흡유무에 따른 종양의 치료 마진(margin)을 측정하고 계획용표적체적(planning target volume:PTV)의 크기에 따른 선량체적표(dose volume histogram:DVH)와 종양억제확률(tumor control probability:NTCP), 건강조직손상확률(normal tissue complication probability:NTCP) 및 선량 통계자료를 통하여 치료성과를 평가하고 선량증강 범위를 예측하고자 하였다. 대상 및 방법 : 종양이 비교적 작고 전이가 없는(T1N0M0) 5명의 폐암환자를 선택하여 X-선 조준장치를 이용하여 횡격막의 이동거리를 측정하는 방법으로 내부장기의 운동을 평가하였다. 호흡동기치료기구는 끌어당김 센서가 부착된 허리띠 모양으로 구성되었으며 이를 흉곽 또는 복부에 부착하여 호흡주기에 의한 흉곽의 크기변동에 따라 센서의 회로가 개폐되고 이것을 선형가속기의 조종간에 연결하는 간단한 기구로서 감도와 재현성이 높았다. 호흡을 배기한 후 일시적 호흡이 정지된 상태에서 Spiral-CT (PQ-5000)로 3차원 영상을 획득하고 Virtual CT-simulator (AcQ-SIM)에 의하여 종양의 위치와 주위 장기들을 확인 도시하였으며 3차원 치료계획장치(Pinnacle, ADAC Co.)를 이용하여 3차원 입체조형치료를 계획하였다. 치료계획의 평가는 호흡동기치료기구의 사용유무에 따른 PTV의 크기에 따라 최적 선량분포를 구사하였으며 각각의 DVH, TCP, NTCP 및 선량통계자료를 도출 비교 검토하였다. 결과 : X-선 simulation에서 폐암환자의 횡격막 이동은 약 1 cm에서 2.5 cm로서 평균 1.5 cm로 측정되었고 자유호흡시 PTV는 CTV (clinical target volume)에 약 2 cm 마진을 주었으며 호흡동기치료기구를 사용하였을 때는 0.5 cm 마진이 적당한 것으로 측정되었다. 종양의 PTV는 연장 마진의 거의 자승비로 증가하였으며 TCP의 값은 마진 범위 $(0.5\~2.0\;cm)$에 관계없이 거의 일정하였고 NTCP의 값은 마진 크기에 따라 평균 $65\%$로 급속히 증가하였다. 결론 : 호흡주기에 따른 위치변동 감지센서를 이용한 호흡동기치료기구는 종양의 위치가 일정할 때만 방사선이 조사되는 간단하고 정확한 장치로서 3차원 입체조형치료 및 강도변조방사선치료에서 매우 유용한 장치임을 확인할 수 있었다. 또한 호흡조절 방사선입체조형치료방법의 기술과 시술절차를 확립시키고 정량적인 선량평가를 위하여 DVH, TCP, NTCP 등의 정량분석과 종양의 투여 선량 증가량(dose escalation)을 예측하는 기초자료를 제공할 수 있었다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회A
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• pp.1783-1786
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• 2007

The copper film coated by Sn is often used in various applications such as LCD, Mobile Phone and etc. Especially, when the film is used as tape carrier package(TCP) of LCD panel, the film is repeatedly applied by mechanical or(and) thermal stress and then is often failed. Therefore, to guarantee the reliability of the electrical devices using the film, the tensile and fatigue characteristics of the film are important. In this study, to obtain the tensile and fatigue characteristics of the film, the specimen was fabricated by etching process to make a smooth specimen of 2000 ${\mu}m$ width, 8000 ${\mu}m$ length and 15.26 ${\mu}m$ thickness. The 2 kinds of specimen were fabricated by other manufacturing process. These specimens had values of Young's modulus(80.2GPa) lower than literature values(108${\sim}$145GPa) for bulk values, but had high values of the yield and ultimate strength as 317MPa and 437MPa, respectively. And fatigue test of load-control with 20Hz frequency was performed.

• 한국군사과학기술학회지
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• 제8권4호
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• pp.58-67
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• 2005

To overcome limitations of test scope, schedule and cost, M&S(Modeling & Simulation) technique has been applied for T&E(Test and Evaluation) of the state-of-art weapon systems. This paper proposes an air defense simulation software framework to reduce both redundancy an[1 programming errors in system simulator. The proposed framework consists of a 'model' and a 'middleware' The 'middleware' is a reliable communication service layer that supports not only HLA(High Level Architecture) which is an international standard in M&S but also TCP/IP, UDP and etc. The main role of 'model' is to schedule and to run the real-time distributed simulation. The proposed framework has been applied to M-SAM(Middle range Surface to Air Missile) system simulator. The proposed framework's scheduling and communication performance results are satisfactory and were measured by hardwired NTP(Network Timer Protocol) time-stamp with GPS(Global Positioning System) timer for better precision.

• Translational and Clinical Pharmacology
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• 제26권3호
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• pp.134-140
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• 2018

This study aimed to develop a UPLC-MS/MS method for determining plasma levels of L-aspartic acid and L-asparagine and the activity of L-asparaginase. L-aspartic acid, L-asparagine, and L-aspartic acid-2,3,3-$d_3$ were extracted from human plasma by protein precipitation with sulfosalicylic acid (30%, v/v). The plasma samples were analyzed using an Imtakt Intrada amino acid analysis column with 25 mM ammonium formate and 0.5% formic acid in acetonitrile as the mobile phase with step gradient method at a flow rate of 0.5 mL/min. The injection volume was $5{\mu}L$, and the total run time was 15 min. Inter- and intra-batch accuracies (%) ranged from 96.62-106.0% for L-aspartic acid and 89.85-104.8%, for L-asparagine, and the coefficient of variation (CV%) did not exceed 7%. The validation results for L-aspartic acid and L-asparagine satisfied the specified criterion, however, the results for L-asparaginase activity assay showed a borderline validity. This study could be a foundation for further development of therapeutic drug monitoring systems using UPLC-MS/MS.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2010년도 추계학술대회 초록집
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• pp.169.1-169.1
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• 2010

Due to global warming, the need to secure an alternative resource has become the international issue. Not like other renewable energy sources, TCP is the high reliable and predictable and continuous energy source as the current pattern and speed can be predicted throughout the year. Having very strong tidal current speeds, there are many suitable site for the application of TCP (Tidal Current Power) on the west and south coastal region in Korea. The maximum current speed in the south is recorded up to 6.5m/s. Due to the high tidal current speed on the west coast of Korea, numerous tidal current projects are being planned. To extract a significant quantity of power, a tidal current farm with number of devices is required in the ocean. However, it is important to estimate the potential quantity of energy in the area. Also the realistic quantity that can be extracted is to be investigated. Based on the estimated energy production considering the number of devices and the interactional effects, system type, the water depth and etc., the cost of the development and the benefit from SMP can be estimated. The feasibility study for the 200MW tidal in Incheon, Korea has been performed recently. Based on the actual feasibility study, the procedure and the key points for the application of tidal current power farm are introduced in the paper.

• Journal of Periodontal and Implant Science
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• 제45권2호
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• pp.46-55
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• 2015

Purpose: This study evaluated the mechanical and structural properties of biphasic calcium phosphate (BCP) blocks processed using a modified extrusion method, and assessed their in vivo effectiveness using a rabbit calvarial defect model. Methods: BCP blocks with three distinct ratios of hydroxyapatite (HA):tricalcium phosphate (TCP) were produced using a modified extrusion method:HA8 (8%:92%), HA48 (48%:52%), and HA80 (80%:20%). The blocks were examined using scanning electron microscopy, X-ray diffractometry, and a universal test machine. Four circular defects 8 mm in diameter were made in 12 rabbits. One defect in each animal served as a control, and the other three defects received the BCP blocks. The rabbits were sacrificed at either two weeks (n=6) or eight weeks (n=6) postoperatively. Results: The pore size, porosity, and compressive strength of the three types of bone block were $140-170{\mu}m$, >70%, and 4-9 MPa, respectively. Histologic and histomorphometric observations revealed that the augmented space was well maintained, but limited bone formation was observed around the defect base and defect margins. No significant differences were found in the amount of new bone formation, graft material resorption, or bone infiltration among the three types of BCP block at either of the postoperative healing points. Conclusions: Block bone substitutes with three distinct compositions (i.e., HA:TCP ratios) processed by a modified extrusion method exhibited limited osteoconductive potency, but excellent space-maintaining capability. Further investigations are required to improve the processing method.

• 한국해양공학회지
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• 제26권4호
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• pp.37-41
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• 2012

Due to global warming, the need to secure alternative resources has become more important nationally. Because of the very strong current on the west coast, with a tidal range of up to 10 m, there are many suitable sites for the application of TCP (tidal current power) in Korea. In the southwest region, a strong current is created in the narrow channels between the numerous islands. A rotor is an essential component that can convert tidal current energy into rotational energy to generate electricity. The design optimization of a rotor is very important to maximize the power production. The performance of a rotor can be determined using various parameters, including the number of blades, shape, sectional size, diameter, etc. There are many offshore jetties and piers with high current velocities. Thus, a VAT (vertical axis turbine) system, which can generate power regardless of flow direction changes, could be effectively applied to cylindrical structures. A VAT system could give an advantage to a caisson-type breakwater because it allows water to circulate well. This paper introduces a multi-layer vertical axis tidal current power system. A Savonius turbine was designed, and a performance analysis was carried out using CFD. A physical model was also demonstrated in CWC, and the results are compared with CFD.

• 신재생에너지
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• 제8권1호
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• pp.44-51
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• 2012

Due to a high tidal range of up to 10 m on the west coast of Korea, numerous tidal current projects are being planned and constructed. The turbine, which initially converts the tidal energy, is an important component because it affects the efficiency of the entire system. Its performance is determined by design variables such as the number of blades, the shape of foils, and the size of a hub. To design a turbine that can extract the maximum power on the site, the depth and duration of current velocity with respect to direction should be considered. Verifying the performance of a designed turbine is important, and requires a circulating water channel (CWC) facility. A physical model for the performance test of the turbine should be carefully designed and compared to results from computational fluid dynamics (CFD) analysis. In this study, a horizontal axis tidal current turbine is designed based on the blade element theory. The proposed turbine's performance is evaluated using both CFD and a CWC experiment. The sealing system, power train, measuring devices, and generator are arranged in a nacelle, and the complete TCP system is demonstrated in a laboratory scale.

• 한국통신학회논문지
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• 제31권10B호
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• pp.909-918
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• 2006

최근 인터넷 유선망 뿐 아니라 무선 IP 이동 망에서의 통화 품질 및 서비스 품질(QoS)의 지원 및 관리체계는 매우 중요한 문제로 대두되고 있다. 지금까지 연구된 인터넷 망의 QoS 제공 모델들은 통합서비스(IntServ) 모델, 차등서비스(DiffServ)모델 및 MPLS 등이 대표적이다. 한편, 무선 인터넷 망의 이동성 관리를 위해서 IETF에서는 MIPv4(Mobile IPv4)와 MIPv6 권고안들을 제안하고 있다. 그러나, 이들은 TCP 및 UDP/IP 환경을 근간으로 하여 QoS를 관리하고 이동성의 핸드오버(handover)등을 관리하기 위한 체계들로 많은 중요한 문제들을 야기하고 있다. 본 논문에서는 멀티홈잉와 멀티 스트리밍 기능을 제공하는 전송계층 프로토콜로 설계된 SCTP(Stream Control Transport Protocol)을 이용하여 IP 이동 환경에서 끊김없는(seamless) 서비스 품질을 제공할 수 있는 관리구조(mSCTP)를 언급하고, 이 환경에서의 종단간 QoS 관리체계를 제안한다. 이를 위해서 본 논문에서는 종단간 통신은 SCTP의 멀티홈잉 기능을 이용하고, 이를 통합서비스 모델과 결합하여 IP 이동성환경에서 끊김 없는 QoS 관리 서비스 목적을 달성할 수 있도록 설계하고 이를 평가한다.