• Title/Summary/Keyword: M&A형

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Immunogenicity and Reactogenicity of Inactivated HM175 Strain Hepatitis A Vaccine in Healthy Korean Children (건강한 한국 소아에서 HM175주 A형 간염 불활화 백신의 면역원성 및 이상반응에 관한 연구)

  • Kim, Chang Hwi;Pyun, Bok Yang;Hong, Young Jin;Kang, Jin Han
    • Pediatric Infection and Vaccine
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    • v.7 no.1
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    • pp.120-128
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    • 2000
  • Purpose : Active immunization against hepatitis A with an inactivated vaccine reveals excellent immunogenicity, tolerability and protective efficacy. Inactivated hepatitis A vaccines have been selectively used since 1996 in Korea to prevent hepatitis A. This study was performed to assess the immunogenicity and reactogenicity after two doses of HM175 strain hepatitis A vaccine in healthy Korean children. Methods : 128 healthy children(M/F; 65/63) aged 1 to 15 years, who were seronegative for hepaitatis A, participated in this study. A alum-adsorbed vaccine containing 720 EL.U of antigen form HM175 hepatitis A strain per 0.5 mL dose was injected intramuscularly on the deltoid area. The second dose was given 6 months later, Anti-HAV antibodies were measured by ELISA before and 1 month after each vaccination to assess the immunogenicity. Any local and general adverse events were reported by patients parents with the prepared questionnaire after each vaccination. Results : 120 volunteers(M/F; 60/60) completed the whole series of the study. Seroconversion occurred in all cases after primary and booster vaccination. The mean anti-HAV antibody titer after primary vaccination was 389.2mIU/mL, and 3,609mIU/mL after booster vaccination. And levels of anti-HAV antibodies after booster immunization were significantly higher in female children. The most common local adverse event was soreness on the injection site, but it was mild and resolves within 3 days. Fever was not reported after booster vaccination. Conclusion : Based on these data, we conclude that the inactivated HM175 strain hepatitis A vaccine is highly immunogenic and tolerable in healthy Korean children.

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Structural Analysis for the Container-Shaped Type A Package of Radioactive Materials (컨테이너형태의 방사성물질 A형 운반용기에 대한 구조해석)

  • 이영신;이호철;정성환;이흥영;김용재
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.14 no.2
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    • pp.143-150
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    • 2001
  • 원자력발전소의 1차 계통에서 오염된 장비들을 취급이 용이하고 안전하게 운반하기 위한 운반용기는 내부의 방사성 물질에 대한 방사능 평가에 의하여 방사성물질 A형 운반용기로 분류된다. 방사성물질 A형 운반용기는 IAEA Safety Standard Series No. ST-1 및 국내 원자력법 등 관련규정의 기술기준을 만족하여야 하는데, 운반용기는 중량에 따라 0.3∼1.2m의 높이에서 소성이 일어나지 않는 단단한 바닥면으로 가장 심각한 손상을 주는 방향으로 낙하시키는 정상운반조건(normal transport conditions)에 대하여 구조적 건전성을 유지하여야 한다. 여기서는 ABAQUS/Explicit 코드를 이용하여 컨테이너형태의 A형 운반용기에 대하여 최대손상이 야기되는 0.9m 경사낙하조건에 대한 3차원 충격해석을 수행하고 구조적 건전성을 평가하였는데, 운반용기는 경사낙하시 코너피팅(corner fitting)의 분쇄(crush)에 의하여 대부분의 충격을 흡수하였으며 운반용기의 격납경계는 구조적 건전성을 유지하였다.

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Ultrastructural and Histochemical Study on the Epithelia of Digestive Tract of a Korean Slug, Incilaria fruhstorferi (한국산 산민달팽이 ( Incilaria fruhstorferi ) 소화관 상피조직의 미세구조 및 조직화학적 연구)

  • 이정찬;장남섭;한종민
    • The Korean Journal of Malacology
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    • v.13 no.2
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    • pp.143-160
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    • 1997
  • 한국산 산민달팽이 Incilariafruhstorferi의 소화관을 부위별로 관찰하고, 소화관 상피조직을 구성하는 세포의 종류와 분포수 그리고 분비되는 과립 등을 미세구조적, 조직화학적으로 관찰하고 그 결과를 보고하고자 한다. 산민달팽이의 소화관은 식도, 위, 장, 직장 등으로 구성되어있으며, 식도는 다시 전식도, 소낭, 후식도로 나누어지고, 장은 전장과 중장, 후장 등으로 구분되었다. 소화관을 부위별롸 관찰한 결과 섬모원주상피세포 2종, 녹색과립세포 3종, 청색과립세포, 점액세포, 투명세포, 망상형세포 그리고 괴사형세포 등 모두 10종류가 확인되었다. 섬모원주세포는 A형과 B형 등 두 종으로 나뉘며, A형은 세포의 상단 자유면에 섬모와 미세융모가 밀생된데 비해, B형은 전자밀도가 높아서 검게 보이고, 장과 직장에서만 관찰되는 특징을 보였다. 섬모의 구조는 9 x 2 + 2 axoneme이었다. 녹색과립세포는 미세구조에 의해 A형, B형 그리고 C형등 3종으로 나누어지며, 소낭과 후식도, 위, 직장에서 주로 관찰되었다. A형과 B형은 Sudan black에 양성인 지방과립(1.36 x 1.6$\mu\textrm{m}$)만을 포함하고 있는데비해 C형은 글리코겐 과립도 포함하고 있었다. 청색과립세포는 10종류의 세포 중 가장 키가 크고 (35$\mu\textrm{m}$), Millon반응에 양성을 보이는 둥근과립(직경, 1.3$\mu\textrm{m}$)을 포함하고 있는데 과립들은 단백질성으로 확인되었다. 이들은 중장에서만 관찰되었다. 장과 직장에서 주로 많이 관찰되는 점액세포는 세포질 속에 전자밀도가 낮은 투명한 과립과 전자밀도가 높아서 검게 보이는 둥근과립(크기, 1.33 x 0.89$\mu\textrm{m}$)들을 포함하고 있었는데, 이들은 미성숙 시기에는 투명과립(직경, 2.66$\mu\textrm{m}$)으로 관찰되었다. PAS-alcian blue(pH 2.5)반응에서 투명과립은 alcianophillia로 나타난 반면, 검은 과립은 PAS에 양성반을을 보이며, 각각 산성점액과 중성점액과립으로 확인되었다. 투명세포는 광학현미경 관찰에서 A형과 B형으로 구분되었으나, A형은 전자현미경 관찰에서 신경내분비세포로 확인된 반며, B형은 지방과립을 소지한 지방저장세포로 각각 확인되었다. 신경내분비세포가 소지한 과립의 크기는 0.16$\mu\textrm{m}$ 정도였다. 망상형세포는 주로 위에서 관찰되는 형태가 불규칙한 작은 세포로서 세포질에 비해 큰 핵을 소지하고 있었다. 소량의 세포질 돌기에는 사립체와 과립성소포체를 포함하고 있다. 괴사형세포는 후장과 직장에서 주로 많이 관찰되고, 점액세포의 점액과립이 분비된 후, 붕괴되는 과정에서 형성된 것으로 확인되었다.

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The Model Experiment on Holding Power of the Anchors used in the Set Net (정치망 고정용 닻의 파주력에 대한 모형실험)

  • 윤일부;이주희;권병국;김성훈;신정욱
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.37 no.2
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    • pp.95-105
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    • 2001
  • A series of experiment is carried out to determine the holding power of the existing anchors used in the stationary gear in the coast of the South sea. The experiment apparatus is made of the pulling machine, the load cell, the personal computer and three water tanks the bottom of which are mud, sand and m & s respectively. The result obtained are as follows : 1. On the tension and holding power of the existing anchors, B-type of the stock anchor with two fluke shows the greatest and gets smaller on order of A-type one with a fluke. The holding power of the anchors shows the greatest in the mud and gets smaller in order of m & s, sand. And, the holding power depending upon the length of anchor rope increase as the length does up to the 4 times of depth. 2. On the holding power per fluke area of the existing anchors in case of ration of length of anchor rope to depth is 2, 3 and 4, A-type anchor shows about 310-320 kg/m supper(2), 470-480 kg/m supper(2), 590-640 kg/m supper(2) respectively, B-type one 260-265 kg/m supper(2), 390-450 kg/m supper(2), 630-700 kg/m supper(2) respectively, and C-type one 70-100 kg/m supper(2), 150-180 kg/m supper(2), 210-270 kg/m supper(2) respectively. The holding power per fluke area of the anchors increase as the length of anchor rope does. 3. On the coefficient of holding power of the existing anchors, A-type anchor shows the greatest and gets smaller in the order of B-type one, C-type one.

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Immunogenicity and Safety of a Two Doses of Hepatitis A Vaccine(VAQTATM) in Healthy Children and Adolescents (건강한 소아와 청소년에 대한 A형 간염(VAQTATM) 2회 접종시 면역원성 및 안전성에 대한 연구)

  • Lee, Jin Soo;Park, Ji Ho;Sohn, Young Mo
    • Pediatric Infection and Vaccine
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    • v.8 no.2
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    • pp.160-167
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    • 2001
  • Purpose : To assess the immunogenicity, safety, and tolerability of hepatitis A vaccine ($VAQTA^{TM}$) in healthy children and adolescents. Methods : Eligible subjects aged 2 to 17 years received 25 U/0.5 mL of $VAQTA^{TM}$ intramuscularly at 0 and 24 week schedule. Bleeds were obtained prior to vaccination and 4 weeks after the second dose to ascertain serostatus. To detect antibody to HAV after vaccination with an inactivated HA vaccine, a modification of the $Abbott^{(R)}$ HAVAB kit was used. Sample with titers ${\geq}10$ mIU/mL were considered seroconverted. Adverse experiences were monitored. Results : 102 subjects(54 male, 48 female) were enrolled. The mean age was $6.8{\pm}3.5$ years. Two subjects were seropositive, two were lost of follow up. 88 subjects were available for a per protocol analysis and 90 for all subjects with serology after the second dose, and ten withdral. All subjects(95% CI, 94.8~100) seroconverted. Geometric mean titers was 7,991.1(95% CI, 6,481.1~9,852.7) with very little difference in per protocol analysis and all subjects analysis. Adverse experiences to $VAQTA^{TM}$ were generally mild and transient. Conclusion : The pediatric two-dose regimen of $VAQTA^{TM}$ was found to be highly immunogenic, generally well tolerated and resulted in 100% seroconversion. Regarding Korea is in transition from a high to low risk region resulting in a paradox increase of clinical disease and disease burden, routine vaccination should be considered in order to control hepatitis A effectively.

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M&V(측정 및 평가) 시행 방안에 대하여 ESCOs에게 물었다

  • 에너지절약전문기업협회
    • The Magazine for Energy Service Companies
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    • s.26
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    • pp.62-66
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    • 2004
  • 전미ESCO협회는 현재 미국 내에서 ESCO에 의해 사용되고 있는 M&V방식에 대해 질의하였다. 오늘날 측정평가(M&V)에 있어서 가장 기본적인 방법은 에너지 결정 변수 중의 하나가 측정되는 또는 어쩌면 하나도 측정되지 않는 ''A형 옵션''일 것이다. 이러한 프로젝트에서 절약 보증을 결정하는 데는 사전 설치분석법이 사용되고 있다. 그러나 요구 절감 가치에 대한 분쟁이 발생하는 상황에서 ''A형 옵션''은 상황을 ''조용히'' 해결하는 데 불충분한 정보를 제공할 수 있다. 계약에 충실히 따르는 인기있는 접근법은 설비별 계산서 분석 소프트웨어를 사용하여 건물 전체의 에너지를 분석하는 ''C형 옵션''이다. M&V를 단순화하는 이유는 조명프로젝트의 절약에 대한 이해가 클수록, 신규 설비 위주 프로젝트를 선호하는 고객과 에너지절감 위주 프로젝트를 선호하는 고객간의 대립으로 인한 M&V를 실행하는 비용과 위험성을 감안한 듯 하다.

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A Case of Pleural Effusion Associated with Acute Hepatits A (A형 간염에 동반된 흉막 삼출 1예)

  • Kim, Dong Il;Park, Jae Ock;Kim, Chang Hwi
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.8 no.2
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    • pp.243-246
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    • 2005
  • Pleural effusion represents a rare complication of acute hepatitis A infection. Twelve year-old girl was admitted with complaints of general weakness, nausea and icteric sclerae. She also complained of right chest pain. Right decubitus view of chest radiograph showed pleural fluid accumulation. Laboratory findings were as follows: AST/ALT 1692/1970 IU/L, total/direct bilirubin 4.48/3.66 mg/dL and HA IgM Ab (+). On the seventh day of hospitalization, her general condition was much improved and chest radiography showed resolved pleural effusion.

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A Study on the Survival Rate and Factors of FDI to Korea: Focused on ICT Industry (외국인의 국내 직접투자의 생존율과 생존요인에 관한 연구: 정보통신산업을 중심으로)

  • Kim, Hyun Gyu
    • Journal of Korea Society of Industrial Information Systems
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    • v.20 no.6
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    • pp.67-78
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    • 2015
  • The objective of this paper is to analyze survival rate and factors of FDI(Foreign direct investment) using FDI data of Ministry of Knowledge and Economy. Kaplan-Meier estimation was used. The result was as follows. M&A of FDI was much more risk than Greenfield FDI. .FDI to the IT-service industry was much more risk than FDI to the manufacturing industry. Partnership under 50% was much more risk than partnership over 50%. The accumulated survival rate of M&A was higher then Greenfield until fourth period but was lower than Greenfield after fourth period. The accumulated survival rate of M&A was lower than others from the first period to last period. There was no difference between Partnership under 50% and partnership over 50% to 4th period. After 4th period, Accumulated survival rate of partnership under 50% was higher than accumulated survival partnership over 50%.

Improvement of the Fishing Gear and Fishing Method of the East-Sea Trawl Fishery (동해구 트롤 어구어법의 개량)

  • 권병국;이주희;이춘우;김형석;김용식;안영일;김정문
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.37 no.2
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    • pp.106-116
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    • 2001
  • A serious of studies on the fishing gear and system of the East Sea trawl fishery was carried out to improve the fishing efficiency and the working conditions. As the first step of these studies, the fishing gear and system of the traditional East Sea trawl were checked in order to solve the some problems, such as the poor sheering efficiency of net mouth, the inconvenient fishing system of the side trawl and etc. And then the fishing system was reorganized from the side trawl into the stern trawl by setting up the net drum system on the stern deck, and introduction of two types of new designed nets, one for mainly the midwater trawl and the other for the bottom trawl. The results of the field experiment on the modified system and nets can be summarized as follows : 1. the modified system was well worked and could save the man-labour by about 80%. 2. The sheering efficiency of the improved net, A type was improved to 20 m height and 30 m width in the net mouth, and that of B type net, to 10 m height and 33 m width, compared with 1.5 m height and 15 m width in the traditional net. 3. Catch efficiency of pink shrimp in A or B type net was better about 3 or 5 times than that of traditional net, and in B net, for herring and other bottom fishes is better about 2 times than that of the traditional net.

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A Seroepidemiologic Study on Hepatitis A in Phohang, Korea (포항 지역 소아 및 성인의 A형 간염의 혈청학적 역학조사)

  • Bae, Soon Ho;Kwon, Young Dae;Kang, Ho Seok;Oh, Sei Ho;Lee, Sun Ju;Hong, Ji Yeon
    • Pediatric Infection and Vaccine
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    • v.12 no.1
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    • pp.61-66
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    • 2005
  • Purpose : Since hepatitis A virus almost is transmitted by fecal-to-oral route, individual and public sanitation affects the prevalence and ages of hepatitis A infection. We researched the positivity rate of hepatitis A antibody at Pohang to make the basic data for subclinical infection and vaccination schedule. Methods : From January 2004 to February 2005, a total of 603 patients who were admitted at Hangdong University Sunlin Hospital, Dongguk University Hospital, and Christianity Hospital without any hepatic disease and vaccination of hepatitis A were enrolled. IgG antibody to hepatitis A virus were measured by electrochemiluminescence immunoassay(ECLIA). Results : Among 603 patients, 523 patients were less than 15 year of age and 80 patients were in above 15 years. The prevalence rate was 19.3%(101/523) in pediatric group and 70.0%(56/80) in above 15 years. In detail, the prevalence rate was 73.2%(52/71) in 0~5 months, 14.9%(11/74) in 6~11 month, 8.9%(7/79) in 12~17 month, 7.3%(6/82) in 18~23 month, 5.5%(4/72) in 2~3 years, 12.1%(9/74) in 4~8 years, 16.9%(12/71) in 9~14 years, 52.5%(19/40) in 15~29 years, and 92.5%(37/40) in group aged over 30 years. The prevalence rates in male and female showed no significant differences. Conclusion : The prevalence rate of hepatitis A in the group of 4~8 years and 9~14 years at Pohang was lower comparing with previous reports of other cities in Korea. We can postulate that the sanitation of children living at Pohang is at least not bad than other cities. And for the prevalence rate of hepatitis A is increased after 3 years, we should recommend that the vaccination of hepatitis A may be finished until 3 years.

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