• The Korean Journal of Pain
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• 제8권2호
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• pp.331-335
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• 1995

Asthma is a disease of the airways that is characterized by increased responsiveness of the tracheobronchial tree to a multiplicity of stimuli. A number of causes have been postulated for the increased airway reactivity of asthma is conservative as beta-adrenergic agonist, methylxanthines, glucocorticoids, anticholinergics and mast cell stabilizing agent. Stellate ganglion block for the treatment of bronchial asthma has its controversies. Stellate ganglion block was performed for the treatment of 3 patients with bronchial asthma. After stellate ganglion blocks, dyspnea, coughing and wheezing was markedly reduced. Lung function test improved with 1 st case. Two asthma cases were able to discontinue medication for asthma. No severe aggrevation of bronchial symptoms were noted after stellate ganglion blocks. It suggested that stellate ganglion block can be safely performed on bronchial asthmatic patients.

• Journal of Chest Surgery
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• 제30권8호
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• pp.809-814
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• 1997

마약성 진통제와 국소마취제에 의한 지속적 경막외마취는 개흉술후 통증감소를 위한 방법으로 널리 사용되고 있다. 본 연구에서는 지난 1994년 1월부터 1995년 7월까지 본원 흉부외과에서 츠방 혹은 후측방 개흉술을 받은 환자 38명을 대상으로 19명씩 실험군과 대조군으로 구분하여 실험군에 경막외마취를 시행하여 그 효과를 조사하였다. 먼저 lidocaine과 norphine을 섞어 경막서 지속적 외도관을 통해 주사하고 그후 bupivacaine과 morphine을 섞어 술후 5∼6일간 지속투여를 하였다. 대조군에 비해 실험군에서 환자의 통증수치와 상지거상능력과 호흡수는 주사추 30분부터 통계적으로 의미 있게 변화되어 술후 통증이 경감되고 있음을 알 수 있었고, 말초동맥혈 이산화탄소분압은 2시간 후부터 통계적으로 의미 있게 줄어들어 환자가 효과적인 호흡을 하고 있음을 알 수 있었다. 술후 재원기간도 의미 있게 줄어들었다. 경막외마취의 주요한 합병증으로는 뇨정체가 있었으나 심각하지는 않았다. 이상의 결과로 우리는 개흉술후 경막외마취가 우수한 통증완화 효과가 있어 술후 폐합병증을 예방하고 술후 빠른 회복에도 좋은 영향을 미치는 것으로 생각한다.

• 대한방사선치료학회:학술대회논문집
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• 대한방사선치료학회 2005년도 춘계학술대회 초록집
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• pp.13-17
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• 2005

Lung cancer 환자 중 호흡에 의한 종양의 움직임이 큰 lung lower lobe에서 stetreotactic radiosurgery(SRS)시 호흡 주기 중 종양의 움직임이 적은 호흡 주기에서만 방사선을 조사하기 위해 respiratory gating system을 사용함으로써 그 유용성에 대하여 알아보고자 한다. lung lower lobe의 SRS 환자 2명을 대강으로 하였으며, 환자의 복부에 maker block(sensor)을 부착하고 tracking camera와 real time position management(RPM)를 이용하여 호흡 주기를 측정하면서 1회 호흡주기에서 10 phases의 4D-CT를 촬영 하였다. 종양의 위치 변화가 급격하지 않은 percent($\%$)의 phases를 치료 phases로 결정하였고, 치료 phases의 CT image를 maximum intensity projection(MIP) 기법으로 재구성 후 volume contouring을 하였다. set up 의 재현성 및 GTV의 위치 변화를 확인하기 위해 치료 전과 치료 중 2회의 4D-CT 촬영을 하였다. GTV의 움직임이 가장 큰 Y(longitudinal)축에서 A환자 full($0\%\~90\%$) phases의 9.4mm가 치료 ($30\%\~60\%$) phases 에서는 2.6mm로, B환자 full($0\%\~90\%$) phases의 11.7mm가 치료($30\%\~70\%$) phases 에서는 2.3mm로 줄었다. 2회의 4D-CT 비교 결과 Set up의 X, Y, Z축 오차는 모두 3mm 이내였다. 호흡에 의한 종양의 움직임이 큰 lung lower lobe에서 SRS 시행 시 respiratory gating system의 사용은 종양의 움직임을 5mm 이내로 감소시킬 수 있어 유용하였다.

• Bulletin of the Korean Chemical Society
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• 제25권7호
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• pp.1025-1030
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• 2004

A hybrid linear polymer-dendrimer block copolymer, poly(ethylene glycol)-block-poly(L-lysine) dendrimer, was synthesized and introduced to form polyionic complexes with DNA. The copolymer formed core-shell type nanoparticles with plasmid DNA. From dynamic light scattering experiments, the mean diameter of the polyplexes was observed to be 154.4 nm. The complex showed much increased water solubility compared to poly(L-lysine). The plasmid DNA in polyplexes was efficiently protected from the enzymatic digestion of DNase I. The cytotoxicity and transfection efficiency for 293 cells was measured in comparison with poly(Llysine).

• 대한임베디드공학회논문지
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• 제17권5호
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• pp.265-272
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• 2022

As the risk of lung cancer has increased, early-stage detection and treatment of cancers have received a lot of attention. Among various medical imaging approaches, computer tomography (CT) has been widely utilized to examine the size and growth rate of lung nodules. However, the process of manual examination is a time-consuming task, and it causes physical and mental fatigue for medical professionals. Recently, many computer-aided diagnostic methods have been proposed to reduce the workload of medical professionals. In recent studies, encoder-decoder architectures have shown reliable performances in medical image segmentation, and it is adopted to predict lesion candidates. However, localizing nodules in lung CT images is a challenging problem due to the extremely small sizes and unstructured shapes of nodules. To solve these problems, we utilize atrous spatial pyramid pooling (ASPP) to minimize the loss of information for a general U-Net baseline model to extract rich representations from various receptive fields. Moreover, we propose mixed-up attention mechanism of reverse, boundary and convolutional block attention module (CBAM) to improve the accuracy of segmentation small scale of various shapes. The performance of the proposed model is compared with several previous attention mechanisms on the LIDC-IDRI dataset, and experimental results demonstrate that reverse, boundary, and CBAM (RB-CBAM) are effective in the segmentation of small nodules.

• Journal of Chest Surgery
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• 제30권6호
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• pp.573-579
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• 1997

지난 30년동안 장기이식분야의 괄목할만한 발전과 더불어 국내에서도 신장, 간 등은 물론 심장이식도 활 발히 이루어지고 있다. 그러나 폐 이식만은 많은 제약으로 인하여 답보상태를 면하지 못하고 있으며 그중에 서도 장기공여자의 부족과 상대적으로 허혈-재관류손상에 예민한 폐 자체의 보존시간의 문제가 가장 먼저 해결해야 할 과제로 여겨지고 있다. 일반적으로 폐는 허혈에 견딜수 있는 시간이 4-6시간으로 알려져 있으 며 많은 연구자들이 더 좋은 폐보존방법을 연구하고 평가하기 위한 실험모델을 개발하여 왔다. 그러나 많 은 실험모델의 등장으로 같은 실험도 서로 상반되는 결과를 낳고 있으며 각각의 모델이 가진 단점들로 인 하여 실험모형의 표준화와 결과분석의 기준을 정하는데 있어 완벽한 모델은 정립된 것이 없는 상태이다. 폐 보존후 기능에 영향을 미칠 수 있는 요인들 즉 허혈성 보존기간, 보존 온도, 폐관류액치 구성성분 등 을 분석하는데는 비교적 간단하고, 경비가 적게 들며 실험결과의 신뢰도가 높은 새로운 모형의 개발이 요 구 되었다. 이에 서울대학교병원 흉부외과에서는 빠르게 변화하는 폐 보존 방법의 실험 및 한국에서는 거 \ulcorner이루어지지 않고 있는 폐 보존 방법에 대한 통계 자료를 확보하여 폐 이식 수술에 이를 적용하고자, 연 구노력 끝에 토끼 폐장으로 상기 목적에 적합한 폐장 분리관류 모형을 완성하였다.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2023년도 봄 학술논문 발표대회
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• pp.189-190
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• 2023

Environmental pollution problems are occurring in Jeju Island due to negative treatment of basalt waste. Measures for various approaches and utilization measures are needed to solve the problem of waste stones that occur during basalt processing. In this study, the Properties of permeable blocks with basalt were identified and the applicability and functionality as building materials were reviewed. This experiment is basic data for evaluating the functionality of the permeable block by manufacturing permeable blocks using basalt waste stones and analyzing flexural strength and compressive strength. The higher the basalt waste stone replacement rate, the lower the flexural strength and compressive strength, but it was judged that 20% of basalt waste stone replacement rate that satisfies the minimum flexural strength (4.0MPa) stipulated in KS F 4419 was appropriate. In addition, additional permeability coefficient and absorption rate experiments tended to increase as the basalt lung stone replacement rate increased. Therefore, it is judged that the permeable block using basalt waste stone is superior to the existing permeable block.

• The Korean Journal of Pain
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• 제14권2호
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• pp.257-260
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• 2001

It is well known that bronchogenic carcinoma frequently metastasize to bony skeleton, although it is unusual for it to metastasize to soft tissue in the form of a musculoskeletal abscess. We report a bronchogenic cancer patient presenting with back pain after undergoing a celiac plexus block. Magnetic resonance imaging (MRI) demonstrated inflammation with an abscess of the paraspinal muscle from T12 to L5; however, it was subsequently diagnosed as a metastatic pleomorphic carcinoma by histopathological study.

• The Korean Journal of Pain
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• 제12권1호
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• pp.128-131
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• 1999

Stellate ganglion block is a well established method for the management of certain pain syndromes (e.g., chronic regional pain syndrome, facial pain) in the cervicothoracic region and upper extremity. The stellate ganglion resides between the C7 transverse process and the head of the first rib. Anesthetic injections for the stellate ganglion block are typically made at the level of the transverse process of either the C6 or C7 vertebrae to avoid the pleura, vessels, and nerve roots. Method of positioning the needle tip directly at the ganglion has been described, but are problematic because of the risk of injury to or injection into adjacent structures. It is necessary to know the exact anatomic position of the stellate ganglion when permanent blockade is required by means of radiofrequency thermocoagulation. Whereas fluroscopy shows only bony feature, computerized tomography also images nerves, vessels, and lung, allowing accruate needle placement. We report a case of the percutaneous radiofrequency thermocoagulation of the stellate ganglion after computerized tomography-guided localization.

• Journal of Chest Surgery
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• 제24권6호
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• pp.533-540
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• 1991

We have performed 14 single lung transplantation in mongrel dogs transplanting the left lung exclusively from December 1989 to January 1991, in the department of thoracic surgery of Seoul National University Hospital. In the donor dogs, the main pulmonary artery was divided proximal to its bifurcation, and the left atrium was incised freeing the left veins with a generous atrial cuff. We used cold saline in the first 7 transplantation[group I ] and a Euro Collins solution in the remaining 7 transplantations[group II ] as a lung preservatives. The bronchus was divided at two cartilage rings proximal to the upper lobe bronchus take off. In the recipient procedure, we used a Fogarty catheter as a bronchus block. Left atrial anastomosis was performed first using 5 - 0 prolene and the pulmonary artery was anastomosed using 6 - 0 prolene. The bronchus was anastomosed next with 4 - 0 Vicryl interruptly and covered with a greater omentum which had been prepared previously. In group I the three dogs died at eleven hours, 5 days, and 14 days, postoperatively and the remaining four doings were killed at 5 days, 5 days, 6 days, and 12 days, respectively. In group II the two dogs died during the operation, one dog died at 6 hours, two dogs died at 6 days postoperatively. Two dogs were killed at 5 days, and 7 days. No significant difference was noted between the two groups in survival time, lung infiltration of transplanted lungs, and perfusion defects in perfusion lung scans. Of the 8 dogs which died naturally, the causes of death were as follows: 2 cases of sepsis, 2 cases of ventricular fibrillations, 2 cases of malnutrition, and 2 cases of respiratory failures.