• Journal of Periodontal and Implant Science
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• v.52 no.3
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• pp.242-257
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• 2022

Purpose: This study investigated periodontal ligament (PDL) restoration in osseointegrated implants using stem cells. Methods: Commercial pure titanium and zirconium oxide (zirconia) were coated with beta-tricalcium phosphate (β-TCP) using a long-pulse Nd:YAG laser (1,064 nm). Isolated bone marrow mesenchymal cells (BMMSCs) from rabbit tibia and femur, isolated PDL stem cells (PDLSCs) from the lower right incisor, and co-cultured BMMSCs and PDLSCs were tested for periostin markers using an immunofluorescent assay. Implants with 3D-engineered tissue were implanted into the lower right central incisors after extraction from rabbits. Forty implants (Ti or zirconia) were subdivided according to the duration of implantation (healing period: 45 or 90 days). Each subgroup (20 implants) was subdivided into 4 groups (without cells, PDLSC sheets, BMMSC sheets, and co-culture cell sheets). All groups underwent histological testing involving haematoxylin and eosin staining and immunohistochemistry, stereoscopic analysis to measure the PDL width, and field emission scanning electron microscopy (FESEM). The natural lower central incisors were used as controls. Results: The BMMSCs co-cultured with PDLSCs generated a well-formed PDL tissue that exhibited positive periostin expression. Histological analysis showed that the implantation of coated (Ti and zirconia) dental implants without a cell sheet resulted in a well-osseointegrated implant at both healing intervals, which was confirmed with FESEM analysis and negative periostin expression. The mesenchymal tissue structured from PDLSCs only or co-cultured (BMMSCs and PDLSCs) could form a natural periodontal tissue with no significant difference between Ti and zirconia implants, consequently forming a biohybrid dental implant. Green fluorescence for periostin was clearly detected around the biohybrid implants after 45 and 90 days. FESEM showed the invasion of PDL-like fibres perpendicular to the cementum of the bio-hybrid implants. Conclusions: β-TCP-coated (Ti and zirconia) implants generated periodontal tissue and formed biohybrid implants when mesenchymal-tissue-layered cell sheets were isolated from PDLSCs alone or co-cultured BMMSCs and PDLSCs.

• The korean journal of orthodontics
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• v.24 no.2
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• pp.275-294
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• 1994

The occlusal interference during adolescent period makes some effects on growth and development and morphological changes. And so, if we could predict the the timing and results of orthodontic treatment who have occlusal interference during adolescent period, it may be helpful for diagnosis and treatment planning of orthodontic treatment. For about those, the purpose of this study was to evaluate the effects of the posterolateral displacement by the metal casting crown with inclined pathway on the mandibular condyle and morphologic changes of mandible in the rat. The experimental animals were thirty six Sprague-Dawley male rats of 8 weeks old. Eight of them was used as control group, and experimental group 1 ( continuous appliance wearing group ) was composed of sixteen and experimental group 2 ( appliance removal group after worn the appliances during 3 months ) was composed of remaining twelve. The animals of experimental grouop 1 were sacrificed after 1, 2, 3, 6 months from beginning of the experiment and experimental group 2 were sacrificed 1, 2, 3 months after removal of the appliance from worn the appliance during 3 months. Both of mandible and temporomandibular joint were observed histologically and radiologically. The results were as follows : 1. In experimental group 1, the mandibular length and lower posterior height were decreased with experimental period, while the lower anterior height was increased, and the curvature of lower incisors and lingual inclination of anterior alveolar bone were profound as compared with control group. 2. In experimental group 1, both of the thickness of the condylar cartilage were thinned in the posterosuperior region, and this phenomenon was more prominent on right than left in 3-Mo experimental period and both sides were marked thinned in 6-Mo experimental period. 3. In experimental group 2, the lower anterior height was low and lower posterior height was high as compared with experimental group 1, and the curvature of lower incisors and lingual inclination of anterior alveolar bone were recovered to control group. 4. In experimental group 2, both of the thickness of the condylar cartilage were thickened in the posterosuperior region, and this phenomenon was more prominent with experimental period. 5. In experimental group 2, the mandibular length was short, lower anterior height was hight, the curvature of lower incisors were profound, and in histologically, both of the thickness of the condylar cartilage were thickened in the posterosuperior region as compared with control group. As shown above, the occlusal interfemce affected the condylar cartilage, curvature of lower incisor, inclination of anterior alveolar bone, mandibular length, and anterior and posterior height. When the interference was removed, significant recover was found in condylar cartilage, mandibular length, and posterior height. Although no significance was found, other items of measurement showed trends for recovery.

• The korean journal of orthodontics
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• v.30 no.2 s.79
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• pp.175-183
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• 2000

The purpose of this study was to identify the compensatory adaptation of dentoalveolar structure according to the various skeletal relation through the statistical correlation between the anteroposterior, vertical skeletal and dentoalveolar relation. For this study, the sample were consisted of 101 adult subjects (51male and 50 female, mean age; male 23.6 years, female 21.5 years) who had good occlusion with the range of normal overjet and overbite and acceptable Angle's class I molar relationship which had not been related orthodontically The results were as follows : 1. Even though acceptable normal occlusion, the range of measurements which represent anteroposterior, vertical skeletal relation and dentoalveolar relation were very wide. 2. Upper and lower incisor axis were significantly correlated with anteroposterior skeletal relation, which means the mote lingual inclination of upper anterior teeth and the more labial inclination of lower anterior teeth according to the more anterior position of mandible to the maxilla (P<0.01). 3. Upper and 1ower anterior alveolar bone height was statistically correlated with the lower anterior vertical skeletal height. 4. Upper and 1ower alveolar bone height were not correlated with anteroposterior skeletal relation (P>0.05). 5. The correlation between the incisor axis and vertical skeletal was more closely related in upper anterior teeth than the lower anterior teeth. To summarize the above results, even though acceptable normal occlusion, skeletal and dentoalveolar relation was very widely ranged, and there were close relationship between the anteroposterior skeletal relation and the inclination of upper and lower anterior teeth and between the vertical skeletal relation and upper and lower anterior alveolar bone height. These finding can be concluded as compensatory adaptation to the different skeletal relationship.

• The korean journal of orthodontics
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• v.34 no.2 s.103
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• pp.109-119
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• 2004

This study aimed at investigating the skeletal, dentoalveolar, and soft tissue changes of Class III malocclusion cases treated by second molar extraction. The lateral cephalograms of 15 subjects with moderate Class III malocclusion by average ANB $-1.4^{\circ}\;and\;IMPA\;85^{\circ}$ were traced and the computerized superimposition of average craniofacial change was made. The data was gathered and statistically analyzed. The results were as follows: 1 Lower anterior facial height/anterior facial height increased by 0.6%(P<0.01), mandibular plane increased by $1.5^{\circ}$(P<0.05). 2. There was a slightly downward & backward rotation of the mandible. 3. Lower first molar tipped distally by 4.nm(P<0.001), lower anterior teeth lingually tipped by $3.2^{\circ}$(P<0.05). 4. Retracted lower lip improved facial profile. This study may suggest that second molar extraction could be effective for a moderate Class III malocclusion to make distalization of the lower first molar easier and avoid severe lingual tipping of the lower incisor, if the lower third molar has a normal shape, good direction of eruption and adequate time for lower second molar extraction

• The korean journal of orthodontics
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• v.29 no.1 s.72
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• pp.51-72
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• 1999

In orthodontic field, it is very important to understand the normal growth. Such an understanding can be derived from observation of normal growth in various samples from childhood to adulthood, and this builds a foundation from which growth abnormality or variation can be defined. Thus, a broad data collection of normal children, as well as basic study reviewing such data become necessary. The relationship between the mean values of cephalometric measurements in Growth and Development was studied among the groups(boys and girls) of Korean chidren from the ages 6-years to 16-years. 220 boys 170 girls were chosen as subjects : Cephalometric X-ray were taken for 3 years and hard tissue analysis on McNamara and Ricketts Analysis which was divided into measurements of 5 parts(Cranial base, Cranial base and Maxilla & Mandible, Maxilla and Mandible, Mandible, Dental measurements). The relationship of craniofacial growth was studied. The following conclusions were obtained: 1. There were statistically significant differences in anterior cranial base between the two sexes of 14 and 15-year grouips. 2. In comparison of growth amounts among different age groups, statistically singnificant difference in Posterior facial height exhisted among $10\~11,\;12\~13\;and\;14\~15$ year-old interval groups. This pattern increased with aging. 3. Na perpendicular to A showed earlier growth peak in females(11-12years) than males(12-13years). When horizontal measurements of point A and Pogonion are compared, mandibular growth appeared to be greater. 4. Maximum growth peak of cranial base and mandible was earlier in females (11-12years) than males(13-14 years). 5. Upper central incisor flared out with aging, and there were increases in lower incisor to A-Pg, and lower incisor inclination There was significant difference between the two sexes in 10-year-old group.

• Journal of Korean Dental Science
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• v.2 no.2
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• pp.18-23
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• 2009

Introduction : The purposes of this study were to analyze the differences between the anterior and posterior overjets using bracket slot points, and compare two methods of overjet calculation according to different reference points using clinical bracket points on three-dimensional digital models. Methods : A total of 35 normal occlusion models were scanned using a three-dimensional scanner (Orapix$^{(R)}$, Orapix Co., Ltd, Seoul, Korea) and then, virtual brackets (0.022" Slot MBT preadjusted brackets, 3 M Co.CA. USA) were placed on the digital models using virtual setup program (3Txer$^{(R)}$ ver. 1.9.6, Orapix co., Ltd). Archwire-like curves were designed to analyze labial and buccal overjet. Results : There were no statistically significance differences between the right and left overjet and between genders. The average overjet was found to be $1.67{\pm}0.85mm$ at the central incisor area, $2.16{\pm}0.88mm$ at the second premolar and $1.53{\pm}0.71mm$ at the first molar. Conclusion : It is recommended that overjet of individualized upper and lower arch to be 2.0mm at the anterior and posterior teeth.

• The korean journal of orthodontics
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• v.22 no.3 s.38
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• pp.703-713
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• 1992

Researches in pathologic entities and syndromes that describe temporomandibular joint (TMJ) or TMJ-related pain and dysfunction, have been hampered by confusion and conflict over the pathogenesis of myofascial and joint pain, the character and causes of joint noises, and the lack of scientific methods. Investigators have more recently correlated clinical diagnosis and arthrographic and surgical findings to demonstrate 'internal derangements' of the TMJ. It is thought that the structural and functional changes characteristic of internal derangements constitute the principal pathologic entity of the TMJ. Cephalometric data from a group of 34 subjects with documented functional changes in the TMJ were compared with those of a group of 35 subjects from a control sample. The results were as follows: 1. Comparison of a group which shows Class I relationship, there was a tendency to show clock-wise rotation of mandible and linguoversion of upper and lower anterior teeth in the experimental sample. 2. Excluding the vertical relationship, there was a tendency to show low values of the lingual surface slope of the upper central incisor and high values of the interincisor angle in the experimental sample.

• Journal of the korean academy of Pediatric Dentistry
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• v.7 no.1
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• pp.41-45
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• 1980

The term "Oligodontia" or "Hypodontia" have been used to describe variable degrees of reduction in number of teeth. Oligodontia may occur alone or as a result of some syndrome. Although the teeth are derived in part from ectoderm, the current opinion of reason of oligodontia should be reserved for those disorders in which there is abnormal development of one or more ectodermal tissues. 7 year 5 months old female was refered to the department of pedodontics, college of dentistry Yonsei university for evaluation and replacement of absent teeth. She had no special inf.ectious disease in her childhood, and her parents were healthy. She had no special syndrome of ectodermal disorders except the saddle nose, yellow and fine hair, and notched upper anterior central incisor. Panex radiogram was showing 6 anterior primary teeth, 2 permanent first molars and 2 unerupted first bicuspid in mandible. Another permanent teeth were absent. and normal number of primary and permanent teeth in maxilla. Lateral cephalogram showed no special abnormality in growth pattern. We had evaluated lower anterior decayed teeth with jacket resin and chrome steel crown and removable partial denture at missing area. We had got good results for rehabilitation of function and aesthetic.

• The korean journal of orthodontics
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• v.14 no.2
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• pp.217-231
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• 1984

Many investigators have studied the growth changes of craniofacial complex to obtain important informations and standard values with which attempts at prediction of growth and treatment results have been under exploration. The author analyzed 360 cephalometric roentgenograms of 40 boys and 50 girls taken from the ages of 6 to 9 to assess the growth changes of craniofacial complex and to establish Korean norms by Ricketts' analysis method. 17 Landmarks, 10 planes and 8 angles were plotted and measured by linearly and angularly. The results were as follows: 1. The author made the tables of means, standard deviations from the measured values. 2. The item which showed significant difference between males and females in longitudinal study was facial axis length. 3. Items which show significant changes during 3 years were cranial base length, facial axis length, lower incisor to APO, Upper molar to PTV in males, and cranial base length, facial axis length, upper molar to PTV in females. 4. The correlations between cranial base length and facial axis length to body height and weight were higher in males than in females throughout the items.

• The korean journal of orthodontics
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• v.21 no.1 s.33
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• pp.185-195
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• 1991

This study was undertaken to grope the correlation of the maximal bite force and tooth-craniofacial structure. The maximal bite force of 76 adult male, aged 18-28 (mean aged: $23.4{\pm}2.2$) years, was estimated and cephalometric headplates were measured, tabulated and statistically analyzed. The results were as follows. 1. 59.61kg of bite force in first molar, 45.38kg in premolar and 17.10kg in central incisor were arranged. 2. The bite force was negatively correlated to genial angle, mandibular plane angle, the angle between occlusal plane and mandibular plane, the angle between palatal plane and mandibular plane, and positively correlated to posterior height of face, length of mandibular body, length of ramus, facial depth in craniofacial structure. 3. The group with strong bite force showed small genial angle, mandibular plane angle, the angle between occlusal plane and mandibular plane, the angle between palatal plane and mandibular plane, and long posterior height of face, length of mandibular body, length of ramus, facial depth. So they manifested the tendency to brachycephalic pattern, on the other hand, the group with weak bite force manifested the tendency to dolichocephalic pattern. 4. There is no correlationships between bite force and mesial inclination of premolar axis in this subject. 5. It is considered bite force have an effect upon craniofacial pattern, especially upon the lower face.